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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diflorasone
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Accession:CHEBI:59750 term browser browse the term
Definition:The 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders.
Synonyms:exact_synonym: 6alpha,9-difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
 related_synonym: (6alpha,11beta,16beta)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;   Formula=C22H28F2O5;   InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1;   InChIKey=WXURHACBFYSXBI-XHIJKXOTSA-N;   SMILES=[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C;   diflorasona;   diflorasonum
 xref: Beilstein:5645455;   CAS:2557-49-5;   DrugBank:DB00223;   KEGG:D07827
 xref_mesh: MESH:C014477
 xref: Patent:GB881334;   Patent:GB898293;   Patent:GB912015;   Patent:US3557158;   Wikipedia:Diflorasone


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diflorasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]; diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein] CTD PMID:15491423 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL5 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein] CTD PMID:15491423 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein] CTD PMID:12956900 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Il4 interleukin 4 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:12956900 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein] CTD PMID:12956900 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19783
    role 19728
      application 19419
        anti-inflammatory agent 15763
          anti-inflammatory drug 13625
            diflorasone 5
              diflorasone diacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19783
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18606
                              organic divalent group 18597
                                organodiyl group 18597
                                  carbonyl group 18510
                                    carbonyl compound 18510
                                      ketone 16828
                                        oxyketone 8663
                                          alpha-oxyketone 8663
                                            alpha-hydroxy ketone 8663
                                              primary alpha-hydroxy ketone 7541
                                                diflorasone 5
                                                  diflorasone diacetate 0
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