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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diflorasone
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Accession:CHEBI:59750 term browser browse the term
Definition:The 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders.
Synonyms:exact_synonym: 6alpha,9-difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
 related_synonym: (6alpha,11beta,16beta)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;   Formula=C22H28F2O5;   InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1;   InChIKey=WXURHACBFYSXBI-XHIJKXOTSA-N;   SMILES=[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C;   diflorasona;   diflorasonum
 xref: Beilstein:5645455;   CAS:2557-49-5;   DrugBank:DB00223;   KEGG:D07827
 xref_mesh: MESH:C014477
 xref: Patent:GB881334;   Patent:GB898293;   Patent:GB912015;   Patent:US3557158;   Wikipedia:Diflorasone


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diflorasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]; diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein] CTD PMID:15491423 NCBI chr19:10,202,317...10,203,768
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL5 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein] CTD PMID:15491423 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein] CTD PMID:12956900 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:12956900 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein] CTD PMID:12956900 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        anti-inflammatory agent 16505
          anti-inflammatory drug 14949
            diflorasone 5
              diflorasone diacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      ketone 17140
                                        oxyketone 8803
                                          alpha-oxyketone 8803
                                            alpha-hydroxy ketone 8803
                                              primary alpha-hydroxy ketone 7680
                                                diflorasone 5
                                                  diflorasone diacetate 0
paths to the root