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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diflorasone
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Accession:CHEBI:59750 term browser browse the term
Definition:The 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders.
Synonyms:exact_synonym: 6alpha,9-difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
 related_synonym: (6alpha,11beta,16beta)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;   Formula=C22H28F2O5;   InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1;   InChIKey=WXURHACBFYSXBI-XHIJKXOTSA-N;   SMILES=[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C;   diflorasona;   diflorasonum
 xref: Beilstein:5645455;   CAS:2557-49-5;   DrugBank:DB00223;   KEGG:D07827
 xref_mesh: MESH:C014477
 xref: Patent:GB881334;   Patent:GB898293;   Patent:GB912015;   Patent:US3557158;   Wikipedia:Diflorasone



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diflorasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]; diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein] CTD PMID:15491423 NCBI chr19:10,202,317...10,203,768
Ensembl chr19:10,202,128...10,203,819
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL5 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein] CTD PMID:15491423 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein] CTD PMID:12956900 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Il4 interleukin 4 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:12956900 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein] CTD PMID:12956900 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        anti-inflammatory agent 16331
          anti-inflammatory drug 14850
            diflorasone 5
              diflorasone diacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      ketone 17097
                                        oxyketone 8727
                                          alpha-oxyketone 8727
                                            alpha-hydroxy ketone 8727
                                              primary alpha-hydroxy ketone 7589
                                                diflorasone 5
                                                  diflorasone diacetate 0
paths to the root