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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iron chelate
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Accession:CHEBI:5975 term browser browse the term
Synonyms:xref: KEGG:C06704


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ferrichrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO Calcium Chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
iron(III) citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
increases secretion
increases expression
ISO Alcohols inhibits the reaction [ferric citrate results in increased expression of ALB mRNA]; Alcohols inhibits the reaction [ferric citrate results in increased secretion of ALB protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased secretion of ALB protein] CTD PMID:24025710 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Aldob aldolase B, fructose-bisphosphate multiple interactions
increases expression
ISO Alcohols inhibits the reaction [ferric citrate results in increased expression of ALDOB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALDOB mRNA] CTD PMID:24025710 NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546
JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO ferric citrate results in decreased expression of AQP4 mRNA CTD PMID:29959986 NCBI chr18:15,389,394...15,410,982
Ensembl chr18:15,389,496...15,410,982
JBrowse link
G Car9 carbonic anhydrase 9 decreases expression ISO ferric citrate results in decreased expression of CA9 mRNA CTD PMID:29959986 NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases expression ISO ferric citrate results in decreased expression of CCL2 mRNA CTD PMID:29959986 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator decreases expression ISO ferric citrate results in decreased expression of CFTR mRNA CTD PMID:29959986 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO ferric citrate results in increased expression of CRP mRNA CTD PMID:29959986 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
decreases expression
ISO ferric citrate inhibits the reaction [Deferoxamine results in increased expression of CXCL8 mRNA]; ferric citrate inhibits the reaction [Deferoxamine results in increased secretion of CXCL8 protein]
ferric citrate results in decreased expression of CXCL8 mRNA
CTD PMID:17097691 PMID:29959986 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP2E1 mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP2E1 mRNA] CTD PMID:24025710 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of DDIT3 mRNA CTD PMID:29959986 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Edn1 endothelin 1 decreases expression ISO ferric citrate results in decreased expression of EDN1 mRNA CTD PMID:29959986 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Epo erythropoietin increases expression ISO ferric citrate results in increased expression of EPO mRNA CTD PMID:29959986 NCBI chr 5:137,483,020...137,485,816
Ensembl chr 5:137,483,020...137,533,242
JBrowse link
G F10 coagulation factor X decreases activity ISO ferric citrate results in decreased activity of F10 protein CTD PMID:6421970 NCBI chr 8:13,037,308...13,056,676
Ensembl chr 8:13,037,308...13,056,676
JBrowse link
G F2 coagulation factor II decreases activity ISO ferric citrate results in decreased activity of F2 protein CTD PMID:6421970 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Fth1 ferritin heavy polypeptide 1 increases expression
multiple interactions
ISO ferric citrate results in increased expression of FTH1 mRNA
[trigonelline co-treated with ferric citrate] results in increased expression of FTH1 mRNA
CTD PMID:29959986 NCBI chr19:9,980,600...9,985,111
Ensembl chr19:9,980,598...9,985,098
JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of FTL mRNA CTD PMID:29959986 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO ferric citrate results in increased expression of GCLM mRNA CTD PMID:29959986 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions EXP
ISO
ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]
ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A mRNA]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A protein]
CTD PMID:16527254 PMID:17015263 PMID:17364964 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO ferric citrate results in increased expression of HMOX1 mRNA CTD PMID:29959986 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO ferric citrate results in decreased expression of IL1A mRNA CTD PMID:29959986 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361
JBrowse link
G Klk1 kallikrein 1 decreases activity ISO ferric citrate results in decreased activity of KLK1 protein CTD PMID:6421970 NCBI chr 7:44,225,360...44,229,622
Ensembl chr 7:44,225,360...44,229,618
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
affects localization
ISO trigonelline inhibits the reaction [ferric citrate affects the localization of NFE2L2 protein] CTD PMID:29959986 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions
ISO ferric citrate results in increased expression of NQO1 mRNA; ferric citrate results in increased expression of NQO1 protein
trigonelline inhibits the reaction [ferric citrate results in increased expression of NQO1 protein]
CTD PMID:29959986 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
ferric citrate inhibits the reaction [Deferoxamine results in increased expression of PTGS2 protein] CTD PMID:16527254 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 decreases expression ISO ferric citrate results in decreased expression of SERPINE1 mRNA CTD PMID:29959986 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO ferric citrate results in increased expression of SQSTM1 mRNA CTD PMID:29959986 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Tfrc transferrin receptor multiple interactions
increases expression
ISO ferric citrate inhibits the reaction [Quercetin results in increased expression of TFRC protein]
ferric citrate results in increased expression of TFRC protein
CTD PMID:17364964 PMID:29959986 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO ferric citrate results in decreased expression of TNF mRNA CTD PMID:29959986 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trf transferrin increases expression ISO ferric citrate results in increased expression of TF mRNA CTD PMID:24025710 NCBI chr 9:103,208,876...103,230,286
Ensembl chr 9:103,204,001...103,230,444
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO ferric citrate results in increased expression of TXNRD1 mRNA CTD PMID:29959986 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
iron(III) nitrilotriacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased expression of ABCB1 protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased expression of ABCB1 protein] CTD PMID:18385176 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 increases expression EXP ferric nitrilotriacetate results in increased expression of ABCC1 mRNA CTD PMID:18617210 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases expression EXP ferric nitrilotriacetate results in increased expression of ABCC2 mRNA CTD PMID:18617210 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 increases expression EXP ferric nitrilotriacetate results in increased expression of ABCC4 mRNA CTD PMID:18617210 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Anxa2 annexin A2 increases expression ISO ferric nitrilotriacetate results in increased expression of ANXA2 mRNA CTD PMID:10854235 NCBI chr 9:69,453,683...69,491,792
Ensembl chr 9:69,453,620...69,491,795
JBrowse link
G Bax BCL2-associated X protein increases expression ISO ferric nitrilotriacetate results in increased expression of BAX mRNA CTD PMID:23208426 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO ferric nitrilotriacetate results in increased expression of BBC3 mRNA CTD PMID:23208426 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bik BCL2-interacting killer increases expression ISO ferric nitrilotriacetate results in increased expression of BIK mRNA CTD PMID:23208426 NCBI chr15:83,526,790...83,544,635
Ensembl chr15:83,526,862...83,544,634
JBrowse link
G Cald1 caldesmon 1 increases expression ISO ferric nitrilotriacetate results in increased expression of CALD1 mRNA CTD PMID:10854235 NCBI chr 6:34,598,495...34,775,469
Ensembl chr 6:34,598,500...34,775,473
JBrowse link
G Canx calnexin increases expression ISO ferric nitrilotriacetate results in increased expression of CANX protein CTD PMID:16908007 NCBI chr11:50,293,957...50,325,673
Ensembl chr11:50,293,961...50,325,673
JBrowse link
G Casp12 caspase 12 increases expression ISO ferric nitrilotriacetate results in increased expression of CASP12 mRNA CTD PMID:23208426 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA] CTD PMID:21907755 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA] CTD PMID:21907755 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA] CTD PMID:21907755 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; geraniol inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein] CTD PMID:9667754 PMID:15198074 PMID:18684806 PMID:21907755 PMID:23194824 PMID:30098279 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO ferric nitrilotriacetate results in increased expression of CCND1 mRNA; ferric nitrilotriacetate results in increased expression of CCND1 protein CTD PMID:18055543 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cd44 CD44 antigen increases expression ISO ferric nitrilotriacetate results in increased expression of CD44 mRNA; ferric nitrilotriacetate results in increased expression of CD44 protein CTD PMID:18055543 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) increases expression ISO ferric nitrilotriacetate results in increased expression of CD47 mRNA CTD PMID:9119739 NCBI chr16:49,851,328...49,912,503
Ensembl chr16:49,800,533...49,915,010
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO ferric nitrilotriacetate results in increased expression of CDKN1A mRNA CTD PMID:23208426 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS decreases expression ISO ferric nitrilotriacetate results in decreased expression of CHRM1 mRNA CTD PMID:19490752 NCBI chr19:8,664,005...8,683,606
Ensembl chr19:8,663,789...8,683,587
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac decreases expression ISO ferric nitrilotriacetate results in decreased expression of CHRM2 mRNA CTD PMID:19490752 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression
multiple interactions
ISO ferric nitrilotriacetate results in increased expression of COL1A1 protein
ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein]
CTD PMID:11159895 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Cygb cytoglobin multiple interactions ISO CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]; CYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid] CTD PMID:16581302 NCBI chr11:116,645,595...116,654,504
Ensembl chr11:116,645,595...116,654,313
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]] CTD PMID:12086689 PMID:17034788 PMID:21352821 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO ferric nitrilotriacetate results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosl1 fos-like antigen 1 increases expression ISO ferric nitrilotriacetate results in increased expression of FOSL1 mRNA; ferric nitrilotriacetate results in increased expression of FOSL1 protein CTD PMID:18055543 NCBI chr19:5,447,698...5,455,938
Ensembl chr19:5,447,547...5,455,946
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked decreases activity ISO ferric nitrilotriacetate results in decreased activity of G6PD protein CTD PMID:9667754 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP ferric nitrilotriacetate results in increased expression of GCLC mRNA CTD PMID:18617210 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gsr glutathione reductase decreases activity
multiple interactions
ISO ferric nitrilotriacetate results in decreased activity of GSR protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of GSR protein]
CTD PMID:9667754 PMID:15198074 PMID:30098279 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gtse1 G two S phase expressed protein 1 increases expression ISO ferric nitrilotriacetate results in increased expression of GTSE1 mRNA CTD PMID:23208426 NCBI chr15:85,859,691...85,876,573
Ensembl chr15:85,859,745...85,876,573
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein] CTD PMID:21907755 PMID:30098279 NCBI chr11:46,739,822...46,779,578
Ensembl chr11:46,735,080...46,779,578
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased activity of HIF1A protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased activity of HIF1A protein] CTD PMID:18385176 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP
ferric nitrilotriacetate results in increased expression of HMOX1 mRNA CTD PMID:18617210 PMID:19490752 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 increases expression ISO ferric nitrilotriacetate results in increased expression of HSP90AA1 mRNA CTD PMID:10854235 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Il24 interleukin 24 increases expression ISO ferric nitrilotriacetate results in increased expression of IL24 mRNA CTD PMID:23208426 NCBI chr 1:130,882,074...130,887,411
Ensembl chr 1:130,882,074...130,887,454
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP
ISO
ferric nitrilotriacetate results in increased expression of IL6 protein
ferric nitrilotriacetate results in increased expression of IL6 mRNA
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]
CTD PMID:15781289 PMID:19490752 PMID:23194824 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Jun jun proto-oncogene increases expression ISO ferric nitrilotriacetate results in increased expression of JUN mRNA; ferric nitrilotriacetate results in increased expression of JUN protein CTD PMID:18055543 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Krt18 keratin 18 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein CTD PMID:17034788 NCBI chr15:102,028,216...102,032,026
Ensembl chr15:102,028,180...102,032,027
JBrowse link
G Krt8 keratin 8 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein CTD PMID:17034788 NCBI chr15:101,996,711...102,004,342
Ensembl chr15:101,996,698...102,004,482
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO ferric nitrilotriacetate results in increased expression of MCM3 mRNA CTD PMID:23208426 NCBI chr 1:20,802,966...20,820,312
Ensembl chr 1:20,802,968...20,820,312
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Cadmium]; [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Zinc]; ferric nitrilotriacetate results in increased oxidation of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Mt2 metallothionein 2 multiple interactions EXP [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT2 protein binds to Cadmium] CTD PMID:22001350 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO MT3 protein results in decreased susceptibility to ferric nitrilotriacetate CTD PMID:12383939 NCBI chr 8:94,152,607...94,154,148
Ensembl chr 8:94,152,607...94,154,146
JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO ferric nitrilotriacetate results in increased expression of MYC mRNA; ferric nitrilotriacetate results in increased expression of MYC protein CTD PMID:18055543 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization EXP ferric nitrilotriacetate affects the localization of NFE2L2 protein CTD PMID:18617210 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA] CTD PMID:21907755 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
EXP
ISO
ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; ferric nitrilotriacetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
ferric nitrilotriacetate results in increased expression of NOS2 protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; ferric nitrilotriacetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD PMID:11461780 PMID:11746204 PMID:12490132 PMID:23194824 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP ferric nitrilotriacetate results in increased expression of NQO1 mRNA; ferric nitrilotriacetate results in increased expression of NQO1 protein CTD PMID:18617210 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 multiple interactions
increases activity
ISO [ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein; Active Hexose Correlated Compound inhibits the reaction [[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein]; Vitamin E inhibits the reaction [ferric nitrilotriacetate results in increased activity of ODC1 protein] CTD PMID:9667754 PMID:14623030 PMID:15949125 NCBI chr12:17,544,808...17,551,502
Ensembl chr12:17,544,794...17,551,505
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic increases expression ISO ferric nitrilotriacetate results in increased expression of PCK1 mRNA CTD PMID:16960379 NCBI chr 2:173,153,073...173,159,274
Ensembl chr 2:173,153,048...173,159,273
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:21907755 PMID:23194824 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Phlda3 pleckstrin homology like domain, family A, member 3 increases expression ISO ferric nitrilotriacetate results in increased expression of PHLDA3 mRNA CTD PMID:23208426 NCBI chr 1:135,766,085...135,769,134
Ensembl chr 1:135,766,119...135,769,136
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression
increases activity
ISO Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased activity of PLAU mRNA]; Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased expression of PLAU mRNA] CTD PMID:17571974 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Plk2 polo like kinase 2 increases expression ISO ferric nitrilotriacetate results in increased expression of PLK2 mRNA CTD PMID:23208426 NCBI chr13:110,395,044...110,400,844
Ensembl chr13:110,395,046...110,400,844
JBrowse link
G Pola1 polymerase (DNA directed), alpha 1 increases expression ISO ferric nitrilotriacetate results in increased expression of POLA1 mRNA CTD PMID:10854235 NCBI chr  X:93,304,766...93,632,387
Ensembl chr  X:93,304,767...93,632,155
JBrowse link
G Ppia peptidylprolyl isomerase A increases expression ISO ferric nitrilotriacetate results in increased expression of PPIA protein CTD PMID:16908007 NCBI chr11:6,415,867...6,419,817
Ensembl chr11:6,415,443...6,419,817
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein] CTD PMID:23194824 PMID:30098279 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B decreases expression ISO ferric nitrilotriacetate results in decreased expression of PTPRB mRNA CTD PMID:10854235 NCBI chr10:116,275,502...116,389,538
Ensembl chr10:116,275,523...116,389,535
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z, polypeptide 1 increases expression ISO ferric nitrilotriacetate results in increased expression of PTPRZ1 mRNA; ferric nitrilotriacetate results in increased expression of PTPRZ1 protein CTD PMID:18055543 NCBI chr 6:22,875,315...23,052,916
Ensembl chr 6:22,875,502...23,052,916
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein] CTD PMID:23194824 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rpl19 ribosomal protein L19 increases expression ISO ferric nitrilotriacetate results in increased expression of RPL19 mRNA CTD PMID:10854235 NCBI chr11:98,022,003...98,030,493
Ensembl chr11:98,026,710...98,030,492
JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator candidate increases expression ISO ferric nitrilotriacetate results in increased expression of RPRM mRNA CTD PMID:23208426 NCBI chr 2:54,084,093...54,085,552
Ensembl chr 2:54,084,093...54,085,552
JBrowse link
G Rps13 ribosomal protein S13 increases expression ISO ferric nitrilotriacetate results in increased expression of RPS13 mRNA CTD PMID:10854235 NCBI chr 7:116,331,507...116,334,190
Ensembl chr 7:116,331,505...116,334,195
JBrowse link
G Rps15 ribosomal protein S15 increases expression ISO ferric nitrilotriacetate results in increased expression of RPS15 mRNA CTD PMID:10854235 NCBI chr10:80,292,431...80,294,114
Ensembl chr10:80,292,453...80,294,114
JBrowse link
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 decreases expression ISO ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA CTD PMID:11925462 NCBI chr15:100,387,898...100,424,209
Ensembl chr15:100,387,898...100,425,072
JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 decreases expression ISO ferric nitrilotriacetate results in decreased expression of SLC40A1 mRNA CTD PMID:11925462 NCBI chr 1:45,908,070...45,926,532
Ensembl chr 1:45,908,068...45,926,523
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein] CTD PMID:15842777 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Ssrp1 structure specific recognition protein 1 increases expression ISO ferric nitrilotriacetate results in increased expression of SSRP1 mRNA CTD PMID:8844983 NCBI chr 2:85,037,120...85,047,114
Ensembl chr 2:85,037,234...85,047,109
JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO ferric nitrilotriacetate results in increased expression of TGFA mRNA; ferric nitrilotriacetate results in increased expression of TGFA protein CTD PMID:8340253 NCBI chr 6:86,195,038...86,275,744
Ensembl chr 6:86,195,223...86,275,719
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA] CTD PMID:16581302 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO ferric nitrilotriacetate results in increased expression of TGFB2 mRNA CTD PMID:23208426 NCBI chr 1:186,622,787...186,709,697
Ensembl chr 1:186,622,792...186,705,989
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA] CTD PMID:16581302 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP
ISO
ferric nitrilotriacetate results in increased expression of TNF protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]
CTD PMID:15781289 PMID:23194824 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein] CTD PMID:21907755 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO ferric nitrilotriacetate results in increased expression of TXN protein CTD PMID:15834431 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txnip thioredoxin interacting protein decreases expression
increases methylation
ISO ferric nitrilotriacetate results in decreased expression of TXNIP protein
ferric nitrilotriacetate results in increased methylation of TXNIP promoter
CTD PMID:15834431 NCBI chr 3:96,557,957...96,561,857
Ensembl chr 3:96,557,957...96,561,883
JBrowse link
G Ubd ubiquitin D increases expression ISO ferric nitrilotriacetate results in increased expression of UBD mRNA CTD PMID:23208426 NCBI chr17:37,193,892...37,196,101
Ensembl chr17:37,193,892...37,196,095
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21569
    chemical entity 21567
      molecular entity 21552
        transition element molecular entity 17219
          transition element coordination entity 11491
            iron coordination entity 375
              iron chelate 102
                Fe(III)-complexed siderophore + 1
                iron(III) citrate + 31
                iron(III) hydroxamate + 1
                iron(III) nitrilotriacetate 77
                pulcherrimin 0
                sodium feredetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21569
    subatomic particle 21555
      composite particle 21555
        hadron 21555
          baryon 21555
            nucleon 21555
              atomic nucleus 21555
                atom 21555
                  metal atom 18172
                    transition element atom 17564
                      d-block element atom 17551
                        iron group element atom 880
                          iron atom 858
                            iron molecular entity 858
                              iron coordination entity 375
                                iron chelate 102
                                  Fe(III)-complexed siderophore + 1
                                  iron(III) citrate + 31
                                  iron(III) hydroxamate + 1
                                  iron(III) nitrilotriacetate 77
                                  pulcherrimin 0
                                  sodium feredetate 0
paths to the root