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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iron chelate
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Accession:CHEBI:5975 term browser browse the term
Synonyms:xref: KEGG:C06704


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ferrichrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases activity
EXP Calcium Chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
iron(III) citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin increases secretion
multiple interactions
increases expression
EXP ferric citrate results in increased secretion of ALB protein
Alcohols inhibits the reaction [ferric citrate results in increased expression of ALB mRNA]; Alcohols inhibits the reaction [ferric citrate results in increased secretion of ALB protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased secretion of ALB protein]
CTD PMID:24025710 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALDOB aldolase, fructose-bisphosphate B increases expression
multiple interactions
EXP ferric citrate results in increased expression of ALDOB mRNA
Alcohols inhibits the reaction [ferric citrate results in increased expression of ALDOB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALDOB mRNA]
CTD PMID:24025710 NCBI chr 9:101,420,560...101,435,774
Ensembl chr 9:101,420,560...101,449,664
JBrowse link
G AQP4 aquaporin 4 decreases expression EXP ferric citrate results in decreased expression of AQP4 mRNA CTD PMID:29959986 NCBI chr18:26,852,038...26,865,803
Ensembl chr18:26,852,043...26,865,771
JBrowse link
G CA9 carbonic anhydrase 9 decreases expression EXP ferric citrate results in decreased expression of CA9 mRNA CTD PMID:29959986 NCBI chr 9:35,673,809...35,681,159
Ensembl chr 9:35,673,918...35,681,159
JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression EXP ferric citrate results in decreased expression of CCL2 mRNA CTD PMID:29959986 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CFTR CF transmembrane conductance regulator decreases expression EXP ferric citrate results in decreased expression of CFTR mRNA CTD PMID:29959986 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CRP C-reactive protein increases expression EXP ferric citrate results in increased expression of CRP mRNA CTD PMID:29959986 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
decreases expression
EXP ferric citrate inhibits the reaction [Deferoxamine results in increased expression of CXCL8 mRNA]; ferric citrate inhibits the reaction [Deferoxamine results in increased secretion of CXCL8 protein]
ferric citrate results in decreased expression of CXCL8 mRNA
CTD PMID:17097691 PMID:29959986 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression
multiple interactions
EXP ferric citrate results in increased expression of CYP2E1 mRNA
Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP2E1 mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP2E1 mRNA]
CTD PMID:24025710 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases expression
EXP Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP3A4 mRNA]; Alcohols promotes the reaction [ferric citrate results in increased expression of CYP3A4 protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP3A4 mRNA]; ferric citrate promotes the reaction [Alcohols results in increased expression of CYP3A4 protein]
ferric citrate results in increased expression of CYP3A4 mRNA; ferric citrate results in increased expression of CYP3A4 protein
CTD PMID:24025710 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP [trigonelline co-treated with ferric citrate] results in increased expression of DDIT3 mRNA CTD PMID:29959986 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G EDN1 endothelin 1 decreases expression EXP ferric citrate results in decreased expression of EDN1 mRNA CTD PMID:29959986 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EPO erythropoietin increases expression EXP ferric citrate results in increased expression of EPO mRNA CTD PMID:29959986 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G F10 coagulation factor X decreases activity EXP ferric citrate results in decreased activity of F10 protein CTD PMID:6421970 NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529
JBrowse link
G F2 coagulation factor II, thrombin decreases activity EXP ferric citrate results in decreased activity of F2 protein CTD PMID:6421970 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions
increases expression
EXP [trigonelline co-treated with ferric citrate] results in increased expression of FTH1 mRNA
ferric citrate results in increased expression of FTH1 mRNA
CTD PMID:29959986 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G FTL ferritin light chain multiple interactions EXP [trigonelline co-treated with ferric citrate] results in increased expression of FTL mRNA CTD PMID:29959986 NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP ferric citrate results in increased expression of GCLM mRNA CTD PMID:29959986 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP
ISO
ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A mRNA]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A protein] CTD PMID:16527254 PMID:17015263 PMID:17364964 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP ferric citrate results in increased expression of HMOX1 mRNA CTD PMID:29959986 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IL1A interleukin 1 alpha decreases expression EXP ferric citrate results in decreased expression of IL1A mRNA CTD PMID:29959986 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions EXP [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G KLK1 kallikrein 1 decreases activity EXP ferric citrate results in decreased activity of KLK1 protein CTD PMID:6421970 NCBI chr19:50,819,146...50,823,787
Ensembl chr19:50,819,146...50,823,787
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects localization
multiple interactions
EXP ferric citrate affects the localization of NFE2L2 protein
trigonelline inhibits the reaction [ferric citrate affects the localization of NFE2L2 protein]
CTD PMID:29959986 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP ferric citrate results in increased expression of NQO1 mRNA; ferric citrate results in increased expression of NQO1 protein
trigonelline inhibits the reaction [ferric citrate results in increased expression of NQO1 protein]
CTD PMID:29959986 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
ferric citrate inhibits the reaction [Deferoxamine results in increased expression of PTGS2 protein] CTD PMID:16527254 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G SERPINE1 serpin family E member 1 decreases expression EXP ferric citrate results in decreased expression of SERPINE1 mRNA CTD PMID:29959986 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SQSTM1 sequestosome 1 increases expression EXP ferric citrate results in increased expression of SQSTM1 mRNA CTD PMID:29959986 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G TF transferrin increases expression EXP ferric citrate results in increased expression of TF mRNA CTD PMID:24025710 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
JBrowse link
G TFRC transferrin receptor multiple interactions
increases expression
EXP ferric citrate inhibits the reaction [Quercetin results in increased expression of TFRC protein]
ferric citrate results in increased expression of TFRC protein
CTD PMID:17364964 PMID:29959986 NCBI chr 3:196,018,694...196,082,123
Ensembl chr 3:196,027,183...196,082,096
JBrowse link
G TNF tumor necrosis factor decreases expression EXP ferric citrate results in decreased expression of TNF mRNA CTD PMID:29959986 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP ferric citrate results in increased expression of TXNRD1 mRNA CTD PMID:29959986 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
iron(III) nitrilotriacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased expression of ABCB1 protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased expression of ABCB1 protein] CTD PMID:18385176 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC1 mRNA CTD PMID:18617210 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC2 mRNA CTD PMID:18617210 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC4 mRNA CTD PMID:18617210 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ANXA2 annexin A2 increases expression ISO ferric nitrilotriacetate results in increased expression of ANXA2 mRNA CTD PMID:10854235 NCBI chr15:60,347,151...60,398,025
Ensembl chr15:60,347,134...60,402,883
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression ISO ferric nitrilotriacetate results in increased expression of BAX mRNA CTD PMID:23208426 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 increases expression ISO ferric nitrilotriacetate results in increased expression of BBC3 mRNA CTD PMID:23208426 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BIK BCL2 interacting killer increases expression ISO ferric nitrilotriacetate results in increased expression of BIK mRNA CTD PMID:23208426 NCBI chr22:43,110,750...43,129,712
Ensembl chr22:43,110,750...43,129,712
JBrowse link
G CALD1 caldesmon 1 increases expression ISO ferric nitrilotriacetate results in increased expression of CALD1 mRNA CTD PMID:10854235 NCBI chr 7:134,779,629...134,970,729
Ensembl chr 7:134,744,252...134,970,729
JBrowse link
G CANX calnexin increases expression ISO ferric nitrilotriacetate results in increased expression of CANX protein CTD PMID:16908007 NCBI chr 5:179,678,646...179,731,641
Ensembl chr 5:179,678,628...179,731,641
JBrowse link
G CASP12 caspase 12 (gene/pseudogene) increases expression ISO ferric nitrilotriacetate results in increased expression of CASP12 mRNA CTD PMID:23208426 NCBI chr11:104,885,718...104,898,460
Ensembl chr11:104,885,718...104,898,670
JBrowse link
G CASP3 caspase 3 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA] CTD PMID:21907755 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA] CTD PMID:21907755 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA] CTD PMID:21907755 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases activity
ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; geraniol inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein] CTD PMID:9667754 PMID:15198074 PMID:18684806 PMID:21907755 PMID:23194824 PMID:30098279 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCND1 cyclin D1 increases expression ISO ferric nitrilotriacetate results in increased expression of CCND1 mRNA; ferric nitrilotriacetate results in increased expression of CCND1 protein CTD PMID:18055543 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CD44 CD44 molecule (Indian blood group) increases expression ISO ferric nitrilotriacetate results in increased expression of CD44 mRNA; ferric nitrilotriacetate results in increased expression of CD44 protein CTD PMID:18055543 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CD47 CD47 molecule increases expression ISO ferric nitrilotriacetate results in increased expression of CD47 mRNA CTD PMID:9119739 NCBI chr 3:108,043,091...108,094,200
Ensembl chr 3:108,043,091...108,091,862
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression ISO ferric nitrilotriacetate results in increased expression of CDKN1A mRNA CTD PMID:23208426 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 decreases expression ISO ferric nitrilotriacetate results in decreased expression of CHRM1 mRNA CTD PMID:19490752 NCBI chr11:62,908,675...62,921,861
Ensembl chr11:62,908,679...62,921,807
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 decreases expression ISO ferric nitrilotriacetate results in decreased expression of CHRM2 mRNA CTD PMID:19490752 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,669...137,020,255
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO ferric nitrilotriacetate results in increased expression of COL1A1 protein
ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein]
CTD PMID:11159895 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G CYGB cytoglobin multiple interactions ISO CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]; CYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid] CTD PMID:16581302 NCBI chr17:76,527,356...76,557,692
Ensembl chr17:76,527,356...76,551,175
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]] CTD PMID:12086689 PMID:17034788 PMID:21352821 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP ferric nitrilotriacetate results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit increases expression ISO ferric nitrilotriacetate results in increased expression of FOSL1 mRNA; ferric nitrilotriacetate results in increased expression of FOSL1 protein CTD PMID:18055543 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase decreases activity ISO ferric nitrilotriacetate results in decreased activity of G6PD protein CTD PMID:9667754 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression ISO ferric nitrilotriacetate results in increased expression of GCLC mRNA CTD PMID:18617210 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GSR glutathione-disulfide reductase decreases activity
multiple interactions
ISO ferric nitrilotriacetate results in decreased activity of GSR protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of GSR protein]
CTD PMID:9667754 PMID:15198074 PMID:30098279 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GTSE1 G2 and S-phase expressed 1 increases expression ISO ferric nitrilotriacetate results in increased expression of GTSE1 mRNA CTD PMID:23208426 NCBI chr22:46,295,143...46,333,699
Ensembl chr22:46,296,870...46,330,810
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein] CTD PMID:21907755 PMID:30098279 NCBI chr 5:157,028,383...157,069,633
Ensembl chr 5:157,029,413...157,059,119
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased activity of HIF1A protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased activity of HIF1A protein] CTD PMID:18385176 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO ferric nitrilotriacetate results in increased expression of HMOX1 mRNA CTD PMID:18617210 PMID:19490752 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 increases expression ISO ferric nitrilotriacetate results in increased expression of HSP90AA1 mRNA CTD PMID:10854235 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G IL24 interleukin 24 increases expression ISO ferric nitrilotriacetate results in increased expression of IL24 mRNA CTD PMID:23208426 NCBI chr 1:206,897,404...206,904,139
Ensembl chr 1:206,897,443...206,904,139
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
ISO ferric nitrilotriacetate results in increased expression of IL6 protein
ferric nitrilotriacetate results in increased expression of IL6 mRNA
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]
CTD PMID:15781289 PMID:19490752 PMID:23194824 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferric nitrilotriacetate results in increased expression of JUN mRNA; ferric nitrilotriacetate results in increased expression of JUN protein CTD PMID:18055543 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KRT18 keratin 18 multiple interactions EXP [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein CTD PMID:17034788 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906
JBrowse link
G KRT8 keratin 8 multiple interactions EXP [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein CTD PMID:17034788 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954
JBrowse link
G MCM3 minichromosome maintenance complex component 3 increases expression ISO ferric nitrilotriacetate results in increased expression of MCM3 mRNA CTD PMID:23208426 NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881
JBrowse link
G MT1X metallothionein 1X multiple interactions ISO [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Cadmium]; [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Zinc]; ferric nitrilotriacetate results in increased oxidation of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MT2A metallothionein 2A multiple interactions ISO [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT2 protein binds to Cadmium] CTD PMID:22001350 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G MT3 metallothionein 3 decreases response to substance EXP MT3 protein results in decreased susceptibility to ferric nitrilotriacetate CTD PMID:12383939 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression ISO ferric nitrilotriacetate results in increased expression of MYC mRNA; ferric nitrilotriacetate results in increased expression of MYC protein CTD PMID:18055543 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects localization ISO ferric nitrilotriacetate affects the localization of NFE2L2 protein CTD PMID:18617210 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA] CTD PMID:21907755 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression
ISO ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; ferric nitrilotriacetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
ferric nitrilotriacetate results in increased expression of NOS2 protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; ferric nitrilotriacetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD PMID:11461780 PMID:11746204 PMID:12490132 PMID:23194824 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO ferric nitrilotriacetate results in increased expression of NQO1 mRNA; ferric nitrilotriacetate results in increased expression of NQO1 protein CTD PMID:18617210 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G ODC1 ornithine decarboxylase 1 multiple interactions
increases activity
ISO [ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein; Active Hexose Correlated Compound inhibits the reaction [[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein]; Vitamin E inhibits the reaction [ferric nitrilotriacetate results in increased activity of ODC1 protein] CTD PMID:9667754 PMID:14623030 PMID:15949125 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 increases expression ISO ferric nitrilotriacetate results in increased expression of PCK1 mRNA CTD PMID:16960379 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:21907755 PMID:23194824 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PHLDA3 pleckstrin homology like domain family A member 3 increases expression ISO ferric nitrilotriacetate results in increased expression of PHLDA3 mRNA CTD PMID:23208426 NCBI chr 1:201,464,278...201,469,188
Ensembl chr 1:201,464,278...201,469,237
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions
increases expression
increases activity
EXP Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased activity of PLAU mRNA]; Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased expression of PLAU mRNA] CTD PMID:17571974 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PLK2 polo like kinase 2 increases expression ISO ferric nitrilotriacetate results in increased expression of PLK2 mRNA CTD PMID:23208426 NCBI chr 5:58,453,982...58,460,086
Ensembl chr 5:58,453,982...58,460,139
JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit increases expression ISO ferric nitrilotriacetate results in increased expression of POLA1 mRNA CTD PMID:10854235 NCBI chr  X:24,693,877...24,996,986
Ensembl chr  X:24,693,909...24,996,986
Ensembl chr  X:24,693,909...24,996,986
JBrowse link
G PPIA peptidylprolyl isomerase A increases expression ISO ferric nitrilotriacetate results in increased expression of PPIA protein CTD PMID:16908007 NCBI chr 7:44,795,960...44,803,117
Ensembl chr 7:44,796,680...44,824,564
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein] CTD PMID:23194824 PMID:30098279 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTPRB protein tyrosine phosphatase receptor type B decreases expression ISO ferric nitrilotriacetate results in decreased expression of PTPRB mRNA CTD PMID:10854235 NCBI chr12:70,515,870...70,637,440
Ensembl chr12:70,515,866...70,637,440
Ensembl chr12:70,515,866...70,637,440
JBrowse link
G PTPRZ1 protein tyrosine phosphatase receptor type Z1 increases expression ISO ferric nitrilotriacetate results in increased expression of PTPRZ1 mRNA; ferric nitrilotriacetate results in increased expression of PTPRZ1 protein CTD PMID:18055543 NCBI chr 7:121,873,161...122,062,036
Ensembl chr 7:121,873,089...122,062,036
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein] CTD PMID:23194824 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RPL19 ribosomal protein L19 increases expression ISO ferric nitrilotriacetate results in increased expression of RPL19 mRNA CTD PMID:10854235 NCBI chr17:39,200,283...39,204,732
Ensembl chr17:39,200,283...39,204,732
Ensembl chr17:39,200,283...39,204,732
JBrowse link
G RPRM reprimo, TP53 dependent G2 arrest mediator homolog increases expression ISO ferric nitrilotriacetate results in increased expression of RPRM mRNA CTD PMID:23208426 NCBI chr 2:153,477,338...153,478,762
Ensembl chr 2:153,477,338...153,478,762
JBrowse link
G RPS13 ribosomal protein S13 increases expression ISO ferric nitrilotriacetate results in increased expression of RPS13 mRNA CTD PMID:10854235 NCBI chr11:17,074,388...17,077,667
Ensembl chr11:17,074,388...17,077,715
JBrowse link
G RPS15 ribosomal protein S15 increases expression ISO ferric nitrilotriacetate results in increased expression of RPS15 mRNA CTD PMID:10854235 NCBI chr19:1,438,396...1,440,495
Ensembl chr19:1,438,358...1,440,495
Ensembl chr19:1,438,358...1,440,495
JBrowse link
G SLC11A2 solute carrier family 11 member 2 decreases expression EXP ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA CTD PMID:11925462 NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566
JBrowse link
G SLC40A1 solute carrier family 40 member 1 decreases expression EXP ferric nitrilotriacetate results in decreased expression of SLC40A1 mRNA CTD PMID:11925462 NCBI chr 2:189,560,590...189,580,811
Ensembl chr 2:189,560,579...189,583,758
Ensembl chr 2:189,560,579...189,583,758
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein] CTD PMID:15842777 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SSRP1 structure specific recognition protein 1 increases expression ISO ferric nitrilotriacetate results in increased expression of SSRP1 mRNA CTD PMID:8844983 NCBI chr11:57,325,986...57,335,892
Ensembl chr11:57,325,986...57,335,892
JBrowse link
G TGFA transforming growth factor alpha increases expression ISO ferric nitrilotriacetate results in increased expression of TGFA mRNA; ferric nitrilotriacetate results in increased expression of TGFA protein CTD PMID:8340253 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA] CTD PMID:16581302 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB2 transforming growth factor beta 2 increases expression ISO ferric nitrilotriacetate results in increased expression of TGFB2 mRNA CTD PMID:23208426 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA] CTD PMID:16581302 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
ISO ferric nitrilotriacetate results in increased expression of TNF protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]
CTD PMID:15781289 PMID:23194824 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein] CTD PMID:21907755 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TXN thioredoxin increases expression ISO ferric nitrilotriacetate results in increased expression of TXN protein CTD PMID:15834431 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXNIP thioredoxin interacting protein decreases expression
increases methylation
ISO ferric nitrilotriacetate results in decreased expression of TXNIP protein
ferric nitrilotriacetate results in increased methylation of TXNIP promoter
CTD PMID:15834431 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
JBrowse link
G UBD ubiquitin D increases expression ISO ferric nitrilotriacetate results in increased expression of UBD mRNA CTD PMID:23208426 NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24381
    chemical entity 24349
      molecular entity 24309
        transition element molecular entity 17807
          transition element coordination entity 11990
            iron coordination entity 375
              iron chelate 103
                Fe(III)-complexed siderophore + 1
                iron(III) citrate + 32
                iron(III) hydroxamate + 1
                iron(III) nitrilotriacetate 77
                pulcherrimin 0
                sodium feredetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24381
    subatomic particle 24338
      composite particle 24338
        hadron 24338
          baryon 24338
            nucleon 24338
              atomic nucleus 24338
                atom 24338
                  metal atom 19290
                    transition element atom 18324
                      d-block element atom 18313
                        iron group element atom 877
                          iron atom 855
                            iron molecular entity 855
                              iron coordination entity 375
                                iron chelate 103
                                  Fe(III)-complexed siderophore + 1
                                  iron(III) citrate + 32
                                  iron(III) hydroxamate + 1
                                  iron(III) nitrilotriacetate 77
                                  pulcherrimin 0
                                  sodium feredetate 0
paths to the root