nucleophilic reagent - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	nucleophilic reagent	go back to main search page
Accession:	CHEBI:59740	browse the term
Definition:	A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
Synonyms:	related_synonym:	nucleophile; nucleophiles; nucleophilic reagents

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Rat (17888) Mouse (18482) Human (20005) Chinchilla (0) Bonobo (0) Dog (324) Squirrel (0) Pig (415) Green Monkey (1) Naked Mole-rat (0) All
Genes (415)

(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin

term browser

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G

opioid receptor mu 1

multiple interactions

Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]; omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]

NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443

(S)-nicotine

term browser

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G

adenylate cyclase activating polypeptide 1

multiple interactions

Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein]

NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294

G

ADCYAP receptor type I

decreases expression

Nicotine results in decreased expression of ADCYAP1R1 protein

NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,428...41,972,301

G

anti-Mullerian hormone

decreases expression
decreases secretion

Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein

NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,414,427...76,418,312

G

BCL2 apoptosis regulator

decreases expression

Nicotine results in decreased expression of BCL2 mRNA

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein]

NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,195,228...11,207,650

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein]

NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,899...47,384,303

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein]

NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123

G

cholinergic receptor nicotinic alpha 9 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein]

NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein]

NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037

G

cytochrome P450 19A3

decreases expression

Nicotine results in decreased expression of CYP19A1 mRNA

NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899

G

follicle stimulating hormone receptor

decreases expression

Nicotine results in decreased expression of FSHR mRNA

NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683

G

inhibin subunit beta B

decreases expression
decreases secretion

Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein

NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405

G

integrin subunit beta 1

decreases expression

Nicotine results in decreased expression of ITGB1 mRNA

NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,396...56,173,326

G

laminin subunit beta 1

decreases expression

Nicotine results in decreased expression of LAMB1 mRNA

NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269

G

mitogen-activated protein kinase 1

decreases phosphorylation
decreases expression

Nicotine results in decreased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 mRNA

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

decreases phosphorylation
decreases expression

Nicotine results in decreased phosphorylation of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

decreases phosphorylation
decreases expression

Nicotine results in decreased phosphorylation of MAPK8 protein
Nicotine results in decreased expression of MAPK8 mRNA

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

matrix metallopeptidase 9

increases expression

Nicotine results in increased expression of MMP9 mRNA

NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788

G

occludin

decreases expression

Nicotine results in decreased expression of OCLN mRNA

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

ribonuclease P/MRP subunit p38

decreases expression

Nicotine results in decreased expression of RPP38 mRNA

NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,197...46,725,920

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile

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G

ATP binding cassette subfamily B member 4

multiple interactions

Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]

NCBI chr 9:93,171,371...93,262,124

6-anilino-5,8-quinolinedione

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G

superoxide dismutase 1

multiple interactions

SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

actinomycin D

term browser

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G

calpain 1

multiple interactions

Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of CAPN1 mRNA]

NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,985...7,022,684

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of FOS mRNA]

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

ageladine A

term browser

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G

casein kinase 1 alpha 1

decreases activity
affects activity

Ageladine A analog results in decreased activity of CSNK1A1 protein
Ageladine A affects the activity of CSNK1A1 protein

NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,077...150,662,284

alachlor

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G

cytochrome P450 2C49

decreases response to substance

CYP2C49 protein results in decreased susceptibility to alachlor

NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455

alpha-(methylamino)isobutyric acid

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G

insulin

increases uptake
multiple interactions

INS protein results in increased uptake of 2-(methylamino)isobutyric acid
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]

NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841

amastatin

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G

glutamyl aminopeptidase

multiple interactions

amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]

NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510

amiloride

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G

CF transmembrane conductance regulator

increases activity

Amiloride results in increased activity of CFTR protein

NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950

G

plasminogen activator, urokinase

multiple interactions

Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]

NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172

G

plasminogen

multiple interactions

Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Serpentine results in increased cleavage of PLG protein]

NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,192...7,110,555

G

solute carrier family 2 member 1

multiple interactions

Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]

NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867

amino acid

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G

claudin 3

multiple interactions

Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein]

NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102

G

claudin 4

multiple interactions

Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein]

NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925

G

solute carrier family 1 member 1

increases expression

Amino Acids results in increased expression of SLC1A1 mRNA; Amino Acids results in increased expression of SLC1A1 protein

NCBI chr 1:217,366,493...217,441,643
Ensembl chr 1:217,366,499...217,441,674

G

tight junction protein 2

multiple interactions

Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP2 protein]

NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983

G

tight junction protein 3

multiple interactions

Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP3 protein]

NCBI chr 2:74,938,153...74,971,431
Ensembl chr 2:74,938,152...74,971,531

aminoglutethimide

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G

ghrelin and obestatin prepropeptide

multiple interactions

Aminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone]

NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,445,992...66,452,917

ammonia

term browser

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G

ABI family member 3 binding protein

decreases expression

Ammonia results in decreased expression of ABI3BP mRNA

NCBI chr13:158,013,704...158,291,093
Ensembl chr13:158,013,726...158,291,103

G

albumin

increases expression

Ammonia results in increased expression of ALB mRNA

NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696

G

ankyrin repeat and sterile alpha motif domain containing 1A

increases expression

Ammonia results in increased expression of ANKS1A mRNA

NCBI chr 7:30,812,925...30,995,369
Ensembl chr 7:30,812,920...30,995,360

G

apolipoprotein B

increases expression

Ammonia results in increased expression of APOB mRNA

NCBI chr 3:117,250,096...117,316,200
Ensembl chr 3:117,250,096...117,316,200

G

apolipoprotein C3

increases expression

Ammonia results in increased expression of APOC3 mRNA

NCBI chr 9:44,211,171...44,213,538
Ensembl chr 9:44,211,194...44,213,533

G

apolipoprotein H

increases expression

Ammonia results in increased expression of APOH mRNA

NCBI chr12:12,827,195...12,839,172
Ensembl chr12:12,827,201...12,839,175

G

asparaginase and isoaspartyl peptidase 1

increases expression

Ammonia results in increased expression of ASRGL1 mRNA

NCBI chr 2:9,328,260...9,353,384
Ensembl chr 2:9,328,269...9,353,340

G

activating transcription factor 3

increases expression

Ammonia results in increased expression of ATF3 mRNA

NCBI chr 9:130,772,259...130,829,678
Ensembl chr 9:130,772,262...130,785,506

G

vasopressin

increases expression

Ammonia results in increased expression of AVP mRNA

NCBI chr17:32,581,234...32,583,145
Ensembl chr17:32,581,234...32,583,185

G

bone morphogenetic protein 4

decreases expression

Ammonia results in decreased expression of BMP4 mRNA

NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637

G

bactericidal permeability increasing protein

increases expression

Ammonia results in increased expression of BPI mRNA

NCBI chr17:41,344,878...41,392,103
Ensembl chr17:41,344,939...41,392,100

G

BTG anti-proliferation factor 2

increases expression

Ammonia results in increased expression of BTG2 mRNA

NCBI chr 9:64,033,853...64,037,795
Ensembl chr 9:64,031,832...64,035,837

G

complement C7

decreases expression

Ammonia results in decreased expression of C7 mRNA

NCBI chr16:25,846,860...25,902,707
Ensembl chr16:25,846,860...25,903,980

G

carbonic anhydrase 12

decreases expression

Ammonia results in decreased expression of CA12 mRNA

NCBI chr 1:108,649,277...108,710,658
Ensembl chr 1:108,649,271...108,710,651

G

calcium binding and coiled-coil domain 1

decreases expression

Ammonia results in decreased expression of CALCOCO1 mRNA

NCBI chr 5:18,910,698...18,930,402
Ensembl chr 5:18,910,700...18,930,321

G

carnosine synthase 1

increases expression

Ammonia results in increased expression of CARNS1 mRNA

NCBI chr 2:5,097,238...5,105,697
Ensembl chr 2:5,097,243...5,105,696

G

coiled-coil domain containing 158

increases expression

Ammonia results in increased expression of CCDC158 mRNA

NCBI chr 8:71,990,113...72,088,966
Ensembl chr 8:71,990,119...72,088,829

G

C-C motif chemokine ligand 16

increases expression

Ammonia results in increased expression of CCL16 mRNA

NCBI chr12:39,618,187...39,621,557
Ensembl chr12:39,618,414...39,621,409

G

C-C motif chemokine receptor 2

decreases expression

Ammonia results in decreased expression of CCR2 mRNA

NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,285,012...29,376,343

G

CD3 epsilon subunit of T-cell receptor complex

decreases expression

Ammonia results in decreased expression of CD3E mRNA

NCBI chr 9:45,619,730...45,633,972
Ensembl chr 9:45,619,482...45,633,968

G

carnitine palmitoyltransferase 1A

decreases expression

Ammonia results in decreased expression of CPT1A mRNA

NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,911

G

C-X-C motif chemokine ligand 10

decreases expression

Ammonia results in decreased expression of CXCL10 mRNA

NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948

G

C-X-C motif chemokine ligand 11

decreases expression

Ammonia results in decreased expression of CXCL11 mRNA

NCBI chr 8:71,713,790...71,725,669
Ensembl chr 8:71,713,803...71,725,674

G

C-X-C motif chemokine ligand 14

decreases expression

Ammonia results in decreased expression of CXCL14 mRNA

NCBI chr 2:137,803,988...137,813,118
Ensembl chr 2:137,803,992...137,813,118

G

C-X-C motif chemokine ligand 9

decreases expression

Ammonia results in decreased expression of CXCL9 mRNA

NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271

G

cytochrome P450 family 1 subfamily A member 1

decreases expression

Ammonia results in decreased expression of CYP1A1 mRNA

NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775

G

cytochrome P450 family 1 subfamily B member 1

decreases expression

Ammonia results in decreased expression of CYP1B1 mRNA

NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683

G

cytochrome P450 2C49

increases expression

Ammonia results in increased expression of CYP2C49 mRNA

NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455

G

cytochrome P450 family 2 subfamily E member 1

increases expression

Ammonia results in increased expression of CYP2E1 mRNA

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

G

cytochrome P450 3A39

increases expression

Ammonia results in increased expression of CYP3A39 mRNA

G

DAB2 interacting protein

decreases expression

Ammonia results in decreased expression of DAB2IP mRNA

NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,660...261,859,022

G

DDB1 and CUL4 associated factor 8

increases expression

Ammonia results in increased expression of DCAF8 mRNA

NCBI chr 4:90,214,916...90,263,259
Ensembl chr 4:90,214,973...90,261,737

G

defective in cullin neddylation 1 domain containing 1

decreases expression

Ammonia results in decreased expression of DCUN1D1 mRNA

NCBI chr13:120,914,001...120,950,825

G

DEAD-box helicase 20

decreases expression

Ammonia results in decreased expression of DDX20 mRNA

NCBI chr 4:108,625,121...108,636,382
Ensembl chr 4:108,624,987...108,647,342

G

dimethylglycine dehydrogenase

decreases expression

Ammonia results in decreased expression of DMGDH mRNA

NCBI chr 2:87,791,827...87,867,189
Ensembl chr 2:87,791,943...87,866,679

G

dedicator of cytokinesis 2

decreases expression

Ammonia results in decreased expression of DOCK2 mRNA

NCBI chr16:53,843,248...54,248,708
Ensembl chr16:53,843,252...54,248,638

G

dual oxidase 2

decreases expression

Ammonia results in decreased expression of DUOX2 mRNA

NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406

G

dual specificity phosphatase 1

increases expression

Ammonia results in increased expression of DUSP1 mRNA

NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086

G

early growth response 1

increases expression

Ammonia results in increased expression of EGR1 mRNA

NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296

G

coagulation factor XII

decreases expression

Ammonia results in decreased expression of F12 mRNA

NCBI chr 2:80,527,451...80,544,835
Ensembl chr 2:80,527,446...80,544,828

G

family with sequence similarity 177 member A1

decreases expression

Ammonia results in decreased expression of FAM177A1 mRNA

NCBI chr 7:64,788,829...64,808,640
Ensembl chr 7:64,788,077...64,808,473

G

family with sequence similarity 180 member B

decreases expression

Ammonia results in decreased expression of FAM180B mRNA

NCBI chr 2:15,027,360...15,029,999
Ensembl chr 2:15,027,362...15,029,982

G

Fc fragment of IgG, high affinity Ia, receptor (CD64)

decreases expression

Ammonia results in decreased expression of FCGR1A mRNA

NCBI chr 4:99,233,632...99,242,531
Ensembl chr 4:99,233,611...99,242,586

G

fibrinogen alpha chain

increases expression

Ammonia results in increased expression of FGA mRNA

NCBI chr 8:74,574,870...74,584,202
Ensembl chr 8:74,574,882...74,584,202

G

fibrinogen beta chain

increases expression

Ammonia results in increased expression of FGB mRNA

NCBI chr 8:74,598,170...74,607,409
Ensembl chr 8:74,595,688...74,607,409

G

fibrinogen gamma chain

increases expression

Ammonia results in increased expression of FGG mRNA

NCBI chr 8:74,553,040...74,562,151
Ensembl chr 8:74,553,105...74,563,688

G

folliculin interacting protein 1

increases expression

Ammonia results in increased expression of FNIP1 mRNA

NCBI chr 2:133,958,112...134,093,408
Ensembl chr 2:133,957,553...134,093,413

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Ammonia results in increased expression of FOS mRNA

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Ammonia results in increased expression of FOSB mRNA

NCBI chr 6:51,836,780...51,844,531
Ensembl chr 6:51,837,719...51,844,529

G

forkhead box J1

increases expression

Ammonia results in increased expression of FOXJ1 mRNA

NCBI chr12:5,307,370...5,312,117
Ensembl chr12:5,307,374...5,312,106

G

golgi reassembly stacking protein 1

increases expression

Ammonia results in increased expression of GORASP1 mRNA

NCBI chr13:23,786,245...23,797,508
Ensembl chr13:23,786,248...23,797,487

G

G protein-coupled receptor 182

increases expression

Ammonia results in increased expression of GPR182 mRNA

NCBI chr 5:22,303,466...22,309,652
Ensembl chr 5:22,304,588...22,311,028

G

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

decreases expression

Ammonia results in decreased expression of GZMA mRNA

NCBI chr16:34,282,160...34,290,422
Ensembl chr16:34,282,120...34,290,477

G

hepatocyte nuclear factor 4 gamma

increases expression

Ammonia results in increased expression of HNF4G mRNA

NCBI chr 4:60,505,388...60,641,052
Ensembl chr 4:60,505,385...60,595,789

G

15-hydroxyprostaglandin dehydrogenase

decreases expression

Ammonia results in decreased expression of HPGD mRNA

NCBI chr14:15,718,261...15,773,534
Ensembl chr14:15,718,678...15,760,767

G

hemopexin

increases expression

Ammonia results in increased expression of HPX mRNA

NCBI chr 9:3,288,288...3,297,051
Ensembl chr 9:3,288,172...3,297,047

G

interleukin 4 receptor

increases expression

Ammonia results in increased expression of IL4R mRNA

NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544

G

inositol-trisphosphate 3-kinase B

decreases expression

Ammonia results in decreased expression of ITPKB mRNA

NCBI chr10:14,362,883...14,469,586

G

potassium voltage-gated channel subfamily A regulatory beta subunit 1

increases expression

Ammonia results in increased expression of KCNAB1 mRNA

NCBI chr13:95,981,820...96,375,089
Ensembl chr13:95,959,378...96,375,856

G

potassium two pore domain channel subfamily K member 5

increases expression

Ammonia results in increased expression of KCNK5 mRNA

NCBI chr 7:34,617,948...34,656,705
Ensembl chr 7:34,617,956...34,656,697

G

lysine demethylase 5A

increases expression

Ammonia results in increased expression of KDM5A mRNA

NCBI chr 5:67,628,791...67,716,143
Ensembl chr 5:67,629,380...67,715,905

G

lysine demethylase 5C

decreases expression

Ammonia results in decreased expression of KDM5C mRNA

NCBI chr X:45,968,812...46,003,215
Ensembl chr X:45,968,814...46,003,215

G

kinesin family member 20A

increases expression

Ammonia results in increased expression of KIF20A mRNA

NCBI chr 2:140,202,316...140,213,144
Ensembl chr 2:140,202,015...140,211,155

G

KRAS proto-oncogene, GTPase

increases expression

Ammonia results in increased expression of KRAS mRNA

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

lymphocyte transmembrane adaptor 1

decreases expression

Ammonia results in decreased expression of LAX1 mRNA

NCBI chr 9:64,460,548...64,473,232
Ensembl chr 9:64,460,693...64,475,179

G

muscleblind like splicing regulator 2

decreases expression

Ammonia results in decreased expression of MBNL2 mRNA

NCBI chr11:66,481,923...66,641,653
Ensembl chr11:66,481,923...66,641,653

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like

decreases expression

Ammonia results in decreased expression of MTHFD1L mRNA

NCBI chr 1:15,140,929...15,330,265
Ensembl chr 1:15,140,899...15,329,986

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

increases expression

Ammonia results in increased expression of MTRR mRNA

NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783

G

MYB binding protein 1a

decreases expression

Ammonia results in decreased expression of MYBBP1A mRNA

NCBI chr12:50,491,042...50,506,085
Ensembl chr12:50,491,044...50,506,050

G

nucleus accumbens associated 1

decreases expression

Ammonia results in decreased expression of NACC1 mRNA

NCBI chr 2:65,920,352...65,938,840
Ensembl chr 2:65,922,126...65,938,759

G

nuclear receptor coactivator 1

increases expression

Ammonia results in increased expression of NCOA1 mRNA

NCBI chr 3:113,997,214...114,251,080
Ensembl chr 3:113,999,253...114,250,298

G

neuralized E3 ubiquitin protein ligase 1

decreases expression

Ammonia results in decreased expression of NEURL1 mRNA

NCBI chr14:114,436,887...114,515,713
Ensembl chr14:114,437,045...114,516,721

G

nuclear factor I X

decreases expression

Ammonia results in decreased expression of NFIX mRNA

NCBI chr 2:65,954,808...66,056,591
Ensembl chr 2:65,954,811...66,056,567

G

nuclear receptor subfamily 4 group A member 2

increases expression

Ammonia results in increased expression of NR4A2 mRNA

NCBI chr15:63,487,051...63,506,249
Ensembl chr15:63,487,731...63,495,299

G

neuronal regeneration related protein

increases expression

Ammonia results in increased expression of NREP mRNA

NCBI chr 2:117,505,851...117,867,805
Ensembl chr 2:117,838,660...117,867,801

G

prolyl 4-hydroxylase subunit alpha 1

decreases expression

Ammonia results in decreased expression of P4HA1 mRNA

NCBI chr14:75,827,207...75,919,121
Ensembl chr14:75,825,148...75,919,016

G

phosphate cytidylyltransferase 1A, choline

decreases expression

Ammonia results in decreased expression of PCYT1A mRNA

NCBI chr13:133,794,337...133,851,004
Ensembl chr13:133,818,761...133,850,996

G

proline rich acidic protein 1

decreases expression

Ammonia results in decreased expression of PRAP1 mRNA

NCBI chr14:141,325,965...141,329,955

G

protein tyrosine phosphatase receptor type C

decreases expression

Ammonia results in decreased expression of PTPRC mRNA

NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308

G

RAS like proto-oncogene B

increases expression

Ammonia results in increased expression of RALB mRNA

NCBI chr15:31,064,341...31,118,437
Ensembl chr15:31,064,355...31,122,621

G

RAS like family 12

decreases expression

Ammonia results in decreased expression of RASL12 mRNA

NCBI chr 1:163,089,440...163,104,027
Ensembl chr 1:163,089,444...163,103,523

G

RB transcriptional corepressor like 2

decreases expression

Ammonia results in decreased expression of RBL2 mRNA

NCBI chr 6:31,757,718...31,802,047
Ensembl chr 6:31,748,739...31,802,022

G

retinol binding protein 4

increases expression

Ammonia results in increased expression of RBP4 mRNA

NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,037,464...105,044,765

G

recombination signal binding protein for immunoglobulin kappa J region

decreases expression

Ammonia results in decreased expression of RBPJ mRNA

NCBI chr 8:19,933,035...20,166,746
Ensembl chr 8:19,922,779...20,166,754

G

replication factor C subunit 1

decreases expression

Ammonia results in decreased expression of RFC1 mRNA

NCBI chr 8:30,552,369...30,635,932
Ensembl chr 8:30,552,400...30,635,867

G

salivary lipocalin

increases expression

Ammonia results in increased expression of SAL1 mRNA

NCBI chr 1:253,638,017...253,642,835
Ensembl chr 1:253,638,015...253,642,866

G

stearoyl-CoA desaturase

decreases expression

Ammonia results in decreased expression of SCD mRNA

NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,569...111,478,020

G

secreted frizzled related protein 2

decreases expression

Ammonia results in decreased expression of SFRP2 mRNA

NCBI chr 8:75,337,311...75,345,926
Ensembl chr 8:75,337,144...75,345,921

G

secreted frizzled related protein 4

decreases expression

Ammonia results in decreased expression of SFRP4 mRNA

NCBI chr 9:108,404,314...108,414,335
Ensembl chr 9:108,404,040...108,414,307

G

solute carrier family 13 member 4

decreases expression

Ammonia results in decreased expression of SLC13A4 mRNA

NCBI chr18:13,593,735...13,641,649
Ensembl chr18:13,593,756...13,636,180

G

solute carrier family 22 member 7

increases expression

Ammonia results in increased expression of SLC22A7 mRNA

NCBI chr 7:38,328,474...38,334,879
Ensembl chr 7:38,328,419...38,334,878

G

solute carrier family 25 member 12

increases expression

Ammonia results in increased expression of SLC25A12 mRNA

NCBI chr15:77,895,935...78,021,930
Ensembl chr15:77,895,938...78,098,383

G

solute carrier family 46 member 3

decreases expression

Ammonia results in decreased expression of SLC46A3 mRNA

NCBI chr11:5,983,198...6,000,728
Ensembl chr11:5,982,443...6,000,701

G

solute carrier family 47 member 1

increases expression

Ammonia results in increased expression of SLC47A1 mRNA

NCBI chr12:60,021,176...60,114,488
Ensembl chr12:60,021,188...60,056,938

G

solute carrier family 7 member 8

decreases expression

Ammonia results in decreased expression of SLC7A8 mRNA

NCBI chr 7:75,854,700...75,921,931
Ensembl chr 7:75,854,882...75,921,931

G

solute carrier family 9 member A3

decreases expression

Ammonia results in decreased expression of SLC9A3 mRNA

NCBI chr16:79,625,555...79,704,084
Ensembl chr16:79,666,825...79,700,658

G

slit guidance ligand 2

decreases expression

Ammonia results in decreased expression of SLIT2 mRNA

NCBI chr 8:14,758,426...15,149,515
Ensembl chr 8:14,758,335...15,149,510

G

superoxide dismutase 3

increases expression

Ammonia results in increased expression of SOD3 mRNA

NCBI chr 8:18,796,633...18,802,156
Ensembl chr 8:18,796,637...18,802,152

G

sortilin related VPS10 domain containing receptor 2

decreases expression

Ammonia results in decreased expression of SORCS2 mRNA

NCBI chr 8:3,207,087...3,715,002
Ensembl chr 8:3,207,098...3,760,393

G

steroid 5 alpha-reductase 2

increases expression

Ammonia results in increased expression of SRD5A2 mRNA

NCBI chr 3:107,840,200...107,918,351
Ensembl chr 3:107,840,200...107,918,350

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

increases expression

Ammonia results in increased expression of ST3GAL6 mRNA

NCBI chr13:160,158,238...160,225,355
Ensembl chr13:160,158,259...160,224,819

G

transcription elongation factor A like 2

decreases expression

Ammonia results in decreased expression of TCEAL2 mRNA

NCBI chr X:83,577,181...83,582,946

G

transmembrane protein 33

increases expression

Ammonia results in increased expression of TMEM33 mRNA

NCBI chr 8:33,012,540...33,036,448
Ensembl chr 8:33,012,390...33,036,993

G

trafficking kinesin protein 2

increases expression

Ammonia results in increased expression of TRAK2 mRNA

NCBI chr15:104,991,261...105,056,054
Ensembl chr15:104,991,726...105,055,025

G

tetratricopeptide repeat domain 31

decreases expression

Ammonia results in decreased expression of TTC31 mRNA

NCBI chr 3:68,555,230...68,570,912
Ensembl chr 3:68,555,232...68,564,007

G

vacuolar protein sorting 36 homolog

decreases expression

Ammonia results in decreased expression of VPS36 mRNA

NCBI chr11:15,701,370...15,735,469
Ensembl chr11:15,701,373...15,735,474

G

vitronectin

increases expression

Ammonia results in increased expression of VTN mRNA

NCBI chr12:44,650,532...44,653,916
Ensembl chr12:44,650,534...44,655,355

G

WAPL cohesin release factor

decreases expression

Ammonia results in decreased expression of WAPL mRNA

NCBI chr14:87,492,452...87,588,678
Ensembl chr14:87,492,458...87,588,543

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

decreases expression

Ammonia results in decreased expression of YWHAZ mRNA

NCBI chr 4:35,975,513...36,009,909
Ensembl chr 4:35,975,508...36,009,887

G

zinc finger protein 24

decreases expression

Ammonia results in decreased expression of ZNF24 mRNA

NCBI chr 6:119,156,507...119,167,240
Ensembl chr 6:119,160,530...119,167,187

G

zinc finger protein 436

decreases expression

Ammonia results in decreased expression of ZNF436 mRNA

NCBI chr 6:81,250,203...81,262,346
Ensembl chr 6:81,250,629...81,262,351

G

zinc finger protein 79

increases expression

Ammonia results in increased expression of ZNF79 mRNA

NCBI chr 1:267,941,953...267,959,754
Ensembl chr 1:267,942,101...267,966,192

aspartame

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamyl aminopeptidase

multiple interactions
increases hydrolysis

1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame]

NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510

BAPTA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

myosin light chain 9

multiple interactions

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; [Calcium co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased phosphorylation of MYL9 protein

NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293

beauvericin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B (MDR/TAP), member 1

increases expression
decreases activity

beauvericin results in increased expression of ABCB1 mRNA
beauvericin results in decreased activity of ABCB1 protein

NCBI chr 9:93,049,955...93,146,469

G

cytochrome P450 family 11 subfamily A member 1

increases expression

beauvericin results in increased expression of CYP11A1 mRNA

NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478

G

mitochondrially encoded cytochrome c oxidase I

increases expression

beauvericin results in increased expression of COX1 mRNA

NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055

Belnacasan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gasdermin D

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

interleukin 18

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 protein]

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

interleukin-1 beta-like

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B protein]

brimonidine tartrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions

Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]

NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728

carvedilol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cadherin 5

decreases expression
increases expression

Carvedilol results in decreased expression of CDH5 mRNA
Carvedilol results in increased expression of CDH5 protein

NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,597...27,142,177

G

catenin beta 1

decreases expression
increases expression

Carvedilol results in decreased expression of CTNNB1 mRNA
Carvedilol results in increased expression of CTNNB1 protein

NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311

G

endothelin 1

decreases expression
multiple interactions

Carvedilol results in decreased expression of EDN1 protein
Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

G

junction plakoglobin

increases expression
decreases expression

Carvedilol results in increased expression of JUP protein
Carvedilol results in decreased expression of JUP mRNA

NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,210

chloroquine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

heat shock protein family D (Hsp60) member 1

multiple interactions

Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein]

NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,526

G

interferon induced protein with tetratricopeptide repeats 3

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFIT1 mRNA]

NCBI chr14:101,237,403...101,249,486
Ensembl chr14:101,237,571...101,249,498

G

interferon beta 1

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNB1 mRNA]

NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495

G

interferon gamma

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNG mRNA]

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 12B

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL12B mRNA]

NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929

G

interleukin 6

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interferon regulatory factor 7

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IRF7 mRNA]

NCBI chr 2:372,235...375,572
Ensembl chr 2:372,238...375,378

G

ISG15 ubiquitin like modifier

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of ISG15 mRNA]

NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208

G

interleukin-1 beta-like

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL1B mRNA]

G

poly(ADP-ribose) polymerase 1

multiple interactions

Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]

NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

sequestosome 1

increases expression
multiple interactions

Chloroquine results in increased expression of SQSTM1 protein
Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

toll like receptor 7

multiple interactions

Chloroquine affects the localization of and results in decreased activity of TLR7 protein

NCBI chr X:9,573,178...9,576,987

chlorpromazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

D-amino acid oxidase

decreases activity

Chlorpromazine results in decreased activity of DAO protein

NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633

G

flavin containing dimethylaniline monoxygenase 1

increases oxidation

FMO1 protein results in increased oxidation of Chlorpromazine

NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076

chlortetracycline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier organic anion transporter family member 1A2

multiple interactions
increases uptake

Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]

NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730

cilastatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 8

multiple interactions

Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

Fas ligand

multiple interactions

Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein]

NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464

cinaciguat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]

NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,290...44,518,135

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein]

NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687

clorgyline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

monoamine oxidase A

decreases activity

Clorgyline analog results in decreased activity of MAOA protein

NCBI chr X:38,930,452...39,006,220

cocaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

increases expression
multiple interactions

Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

crizotinib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

neurotrophic receptor tyrosine kinase 1

decreases activity

Crizotinib results in decreased activity of NTRK1 protein

NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,255,981

G

neurotrophic receptor tyrosine kinase 2

decreases activity

Crizotinib results in decreased activity of NTRK2 protein

NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,405...30,429,882

cyclosporin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects localization

Vitamin E inhibits the reaction [Cyclosporine affects the localization of BAX protein]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

caspase 6

multiple interactions
increases expression

Vitamin E inhibits the reaction [Cyclosporine results in increased expression of CASP6 mRNA]

NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045

G

cytochrome c, somatic

multiple interactions
affects localization

Vitamin E inhibits the reaction [Cyclosporine affects the localization of CYCS protein]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

endothelin 1

increases secretion

Cyclosporine results in increased secretion of EDN1 protein

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

G

FYVE, RhoGEF and PH domain containing 4

multiple interactions
increases expression

Vitamin E inhibits the reaction [Cyclosporine results in increased expression of DNM1L protein]

NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028

G

mitofusin 2

multiple interactions
decreases expression

Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of MFN2 protein]

NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438

G

nitric oxide synthase 3

decreases expression

Cyclosporine results in decreased expression of NOS3 protein

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

G

OPA1 mitochondrial dynamin like GTPase

decreases expression
multiple interactions

Cyclosporine results in decreased expression of OPA1 protein
Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of OPA1 protein]

NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083

G

Rac family small GTPase 1

affects localization

Cyclosporine affects the localization of RAC1 protein

NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543

G

solute carrier family 2 member 1

decreases response to substance
multiple interactions
increases expression

SLC2A1 protein results in decreased susceptibility to Cyclosporine
Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 protein]
Cyclosporine results in increased expression of SLC2A1 mRNA; Cyclosporine results in increased expression of SLC2A1 protein

NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867

cysteamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

flavin containing dimethylaniline monoxygenase 1

increases metabolic processing

FMO1 protein results in increased metabolism of Cysteamine

NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076

dobutamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hexokinase 2

decreases expression

Dobutamine results in decreased expression of HK2 protein

NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,153,835...68,231,615

G

nitric oxide synthase 2

affects response to substance

NOS2 protein affects the susceptibility to Dobutamine

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

glycogen phosphorylase, muscle associated

decreases expression

Dobutamine results in decreased expression of PYGM protein

NCBI chr 2:7,409,330...7,421,256
Ensembl chr 2:7,409,116...7,421,254

DPDPE

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions

Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [AGT protein results in increased secretion of Aldosterone]

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

G

opioid receptor delta 1

multiple interactions

Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [OPRD1 protein results in increased transport of Barium]

NCBI chr 6:85,775,576...85,827,170
Ensembl chr 6:85,785,276...85,830,877

enalapril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

affects activity

Enalapril affects the activity of AGT protein

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

enalaprilat dihydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

decreases activity

Enalaprilat results in decreased activity of AGT protein modified form

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

G

kininogen 1

increases activity

Enalaprilat results in increased activity of KNG1 protein modified form

NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958

ethylenediaminetetraacetic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl aminopeptidase, membrane

multiple interactions

Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]

NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881

G

leukotriene A4 hydrolase

decreases activity

Edetic Acid results in decreased activity of LTA4H protein

NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515

folic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cystathionine beta-synthase

multiple interactions
increases activity

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein
Folic Acid deficiency results in increased activity of CBS protein

NCBI chr13:206,205,942...206,231,363
Ensembl chr13:206,205,946...206,230,248

G

colony stimulating factor 2

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA

NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155

G

cystathionine gamma-lyase

multiple interactions

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of CTH protein

NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,454,914...142,486,367

G

DNA methyltransferase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

glutamate-cysteine ligase catalytic subunit

multiple interactions

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA

NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530

G

glutathione peroxidase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione-disulfide reductase

multiple interactions
increases activity
increases expression

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSR protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSR mRNA
Folic Acid deficiency results in increased activity of GSR protein
Folic Acid deficiency results in increased expression of GSR mRNA

NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984

G

glutathione synthetase

multiple interactions

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA

NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,298

G

glutathione S-transferase alpha 1

increases expression
multiple interactions

Folic Acid deficiency results in increased expression of GSTA1 mRNA
[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSTA1 mRNA

NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,548,670

G

glycogen synthase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter

NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261

G

lactate dehydrogenase A

multiple interactions

[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

methylenetetrahydrofolate reductase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of PTGS1

NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Folic Acid co-treated with Glycine] results in increased expression of PTGS2

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

sucrase-isomaltase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA

NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478

G

solute carrier family 15 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 5 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA

NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841

G

superoxide dismutase 1

decreases activity
multiple interactions

Folic Acid deficiency results in decreased activity of SOD1 protein
[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA; [Ethanol co-treated with Folic Acid deficiency] results in decreased activity of SOD1 protein

PMID:16792574 PMID:29129240

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

multiple interactions
increases activity

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of SOD2 protein
Folic Acid deficiency results in increased activity of SOD2 protein; Folic Acid results in increased activity of SOD2 protein

PMID:16792574 PMID:22889112

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

fumonisin B1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

advanced glycosylation end-product specific receptor

increases expression

fumonisin B1 results in increased expression of AGER mRNA

NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162

G

apoptotic peptidase activating factor 1

multiple interactions
increases expression

fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 protein]
fumonisin B1 results in increased expression of APAF1 mRNA; fumonisin B1 results in increased expression of APAF1 protein

NCBI chr 5:85,166,616...85,258,751
Ensembl chr 5:85,166,628...85,258,364

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in increased expression of BAX protein]
fumonisin B1 results in increased expression of BAX mRNA; fumonisin B1 results in increased expression of BAX protein

PMID:33905761 PMID:36397609 PMID:37955343

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of BCL2 mRNA; fumonisin B1 results in decreased expression of BCL2 protein
[Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein; [fumonisin B1 co-treated with Zearalenone co-treated with deoxynivalenol] results in decreased expression of BCL2 protein; [fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]; fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; fumonisin B1 inhibits the reaction [Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 protein]; fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Zearalenone inhibits the reaction [fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]]; Zearalenone inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]

PMID:29109043 PMID:33905761 PMID:36397609

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 1, apoptosis-related cysteine peptidase

multiple interactions

N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP1 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP1 protein]

NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328

G

caspase 10

multiple interactions
increases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP10 mRNA]

NCBI chr15:104,858,082...104,895,941
Ensembl chr15:104,858,100...104,894,933

G

caspase 3

multiple interactions
increases cleavage
increases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP3 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP3 protein]; [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form; [fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]; [fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; fumonisin B1 promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [fumonisin B1 results in increased cleavage of CASP3 protein]; Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]
fumonisin B1 results in increased expression of CASP3 mRNA; fumonisin B1 results in increased expression of CASP3 protein; fumonisin B1 results in increased expression of CASP3 protein modified form

PMID:29109043 PMID:32198028 PMID:33905761 PMID:36397609 PMID:37955343

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 8

multiple interactions
increases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP8 mRNA]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

caspase 9

multiple interactions
increases expression

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]
fumonisin B1 results in increased expression of CASP9 mRNA; fumonisin B1 results in increased expression of CASP9 protein; fumonisin B1 results in increased expression of CASP9 protein modified form

PMID:33905761 PMID:36397609

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

chemokine (C-C motif) ligand 2

multiple interactions
decreases expression
increases expression

[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]
fumonisin B1 results in decreased expression of CCL2 mRNA
fumonisin B1 metabolite results in increased expression of CCL2 mRNA; fumonisin B1 results in increased expression of CCL2 mRNA

PMID:23688591 PMID:30708112

NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026

G

C-C motif chemokine ligand 20

increases expression
multiple interactions

fumonisin B1 results in increased expression of CCL20 mRNA
fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]

NCBI chr15:129,172,743...129,176,069

G

component of inhibitor of nuclear factor kappa B kinase complex

increases expression

fumonisin B1 results in increased expression of CHUK mRNA

NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868

G

claudin 1

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of CLDN1 mRNA; fumonisin B1 results in decreased expression of CLDN1 protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of CLDN1 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of CLDN1 protein]

PMID:31557363 PMID:37955343

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

C-X-C motif chemokine ligand 8

multiple interactions
increases expression

[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]
fumonisin B1 results in increased expression of CXCL8 mRNA

PMID:23688591 PMID:30708112

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

cytochrome c, somatic

multiple interactions

[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CYCS mRNA]; Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]

PMID:29109043 PMID:36397609

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

FYVE, RhoGEF and PH domain containing 4

multiple interactions
increases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of DNM1L mRNA]

NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028

G

gasdermin D

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

glutathione-disulfide reductase

multiple interactions

Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]

NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984

G

hepatitis A virus cellular receptor 1

multiple interactions

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of HAVCR1 mRNA

NCBI chr16:66,162,318...66,208,868

G

interferon gamma

decreases expression

fumonisin B1 metabolite results in decreased expression of IFNG protein

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 17A

multiple interactions

fumonisin B1 inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein]; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein]

NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153

G

interleukin 18

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 protein]

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

interleukin 1 alpha

multiple interactions
increases expression
decreases expression

[deoxynivalenol co-treated with fumonisin B1] results in decreased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA
fumonisin B1 results in increased expression of IL1A mRNA
fumonisin B1 results in decreased expression of IL1A mRNA

NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119

G

interleukin 6

multiple interactions
decreases expression
increases expression

[deoxynivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [nivalenol co-treated with fumonisin B1] results in decreased expression of IL6 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
fumonisin B1 results in decreased expression of IL6 mRNA

PMID:23688591 PMID:30708112 PMID:37955343 PMID:38705344

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

lipocalin 2

multiple interactions
increases expression

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of LCN2 mRNA; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of LCN2 mRNA]

PMID:33905761 PMID:38705344

NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644

G

interleukin-1 beta-like

increases expression
multiple interactions

fumonisin B1 results in increased expression of IL1B mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B protein]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]

PMID:23688591 PMID:36309173 PMID:37955343 PMID:38705344

G

microtubule associated protein 1 light chain 3 beta

increases expression
multiple interactions

fumonisin B1 results in increased expression of MAP1LC3B mRNA
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of MAP1LC3B mRNA]; fumonisin B1 results in increased lipidation of and results in increased localization of MAP1LC3B protein

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

mitogen-activated protein kinase kinase kinase 14

increases expression

fumonisin B1 results in increased expression of MAP3K14 mRNA

NCBI chr12:18,142,899...18,182,931
Ensembl chr12:18,142,952...18,182,928

G

mitogen-activated protein kinase 1

increases phosphorylation

fumonisin B1 results in increased phosphorylation of MAPK1 protein

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 10

increases expression
multiple interactions

fumonisin B1 results in increased expression of MAPK10 mRNA
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK10 mRNA]

NCBI chr 8:132,445,818...132,751,575
Ensembl chr 8:132,298,299...132,776,820

G

mitogen-activated protein kinase 3

increases phosphorylation

fumonisin B1 results in increased phosphorylation of MAPK3 protein

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

increases expression
multiple interactions

fumonisin B1 results in increased expression of MAPK8 mRNA; fumonisin B1 results in increased expression of MAPK8 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK8 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK8 protein]

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

mitogen-activated protein kinase 9

increases expression
multiple interactions

fumonisin B1 results in increased expression of MAPK9 mRNA
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK9 mRNA]

NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100

G

mitofusin 2

increases expression

fumonisin B1 results in increased expression of MFN2 mRNA

NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438

G

mixed lineage kinase domain like pseudokinase

increases expression
multiple interactions

fumonisin B1 results in increased expression of MLKL mRNA; fumonisin B1 results in increased expression of MLKL protein
necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of MLKL mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of MLKL protein]

NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173

G

mucin 1, cell surface associated

decreases expression

fumonisin B1 results in decreased expression of MUC1 mRNA

NCBI chr 4:94,626,317...94,631,194

G

mucin 2, oligomeric mucus/gel-forming

increases expression

fumonisin B1 results in increased expression of MUC2 mRNA

NCBI chr 2:689,363...719,542
Ensembl chr 2:689,364...710,330

G

NFE2 like bZIP transcription factor 1

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of NFE2L1 mRNA
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of NFE2L1 mRNA]

NCBI chr12:24,303,381...24,316,765
Ensembl chr12:24,303,399...24,316,763

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of NFE2L2 protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of NFE2L2 protein]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

nuclear factor kappa B subunit 1

increases expression
multiple interactions

fumonisin B1 results in increased expression of NFKB1 mRNA; fumonisin B1 results in increased expression of NFKB1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of NFKB1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of NFKB1 protein]

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

NAD(P)H quinone dehydrogenase 1

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of NQO1 mRNA; fumonisin B1 results in decreased expression of NQO1 protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of NQO1 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of NQO1 protein]

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

netrin 1

multiple interactions
increases expression

fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of NTN1 mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of NTN1 mRNA]

PMID:33905761 PMID:38705344

NCBI chr12:54,089,444...54,292,191
Ensembl chr12:54,089,472...54,292,193

G

occludin

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of OCLN mRNA; fumonisin B1 results in decreased expression of OCLN protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of OCLN mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of OCLN protein]

PMID:31557363 PMID:37955343

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

OPA1 mitochondrial dynamin like GTPase

increases expression

fumonisin B1 results in increased expression of OPA1 mRNA

NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083

G

PTEN induced kinase 1

multiple interactions
increases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of PINK1 mRNA]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of PINK1 protein]
fumonisin B1 results in increased expression of PINK1 mRNA; fumonisin B1 results in increased expression of PINK1 protein

NCBI chr 6:78,863,195...78,884,663
Ensembl chr 6:78,863,190...78,884,640

G

PPARG coactivator 1 alpha

multiple interactions
decreases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of PPARGC1A mRNA]

NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,946,992

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions
increases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of PRKN mRNA]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of PRKN protein]
fumonisin B1 results in increased expression of PRKN mRNA; fumonisin B1 results in increased expression of PRKN protein

NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872

G

receptor interacting serine/threonine kinase 1

multiple interactions
increases expression

necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of RIPK1 mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of RIPK1 protein]
fumonisin B1 results in increased expression of RIPK1 mRNA; fumonisin B1 results in increased expression of RIPK1 protein

NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699

G

receptor interacting serine/threonine kinase 3

increases expression
multiple interactions

fumonisin B1 results in increased expression of RIPK3 mRNA; fumonisin B1 results in increased expression of RIPK3 protein
necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of RIPK3 mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of RIPK3 protein]

NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251

G

solute carrier family 15 member 1

increases expression

fumonisin B1 results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 1 member 1

decreases expression

fumonisin B1 results in decreased expression of SLC1A1 mRNA

NCBI chr 1:217,366,493...217,441,643
Ensembl chr 1:217,366,499...217,441,674

G

solute carrier family 27 member 4

decreases expression

fumonisin B1 results in decreased expression of SLC27A4 mRNA

NCBI chr 1:268,773,792...268,788,208
Ensembl chr 1:268,773,806...268,788,731

G

solute carrier family 2 member 2

decreases expression

fumonisin B1 results in decreased expression of SLC2A2 mRNA

NCBI chr13:109,592,595...109,614,105
Ensembl chr13:109,587,258...109,638,510

G

solute carrier family 7 member 1

decreases expression

fumonisin B1 results in decreased expression of SLC7A1 mRNA

NCBI chr11:6,538,053...6,604,654
Ensembl chr11:6,538,045...6,604,658

G

solute carrier family 7 member 7

decreases expression

fumonisin B1 results in decreased expression of SLC7A7 mRNA

NCBI chr 7:76,195,774...76,235,406
Ensembl chr 7:76,198,256...76,235,402

G

superoxide dismutase 1

multiple interactions
decreases expression

Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of SOD1 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of SOD1 protein]
fumonisin B1 results in decreased expression of SOD1 mRNA; fumonisin B1 results in decreased expression of SOD1 protein

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

secreted phosphoprotein 1

increases expression
multiple interactions

fumonisin B1 results in increased expression of SPP1 mRNA
fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of SPP1 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of SPP1 mRNA]

NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340

G

sequestosome 1

increases expression
multiple interactions

fumonisin B1 results in increased expression of SQSTM1 mRNA; fumonisin B1 results in increased expression of SQSTM1 protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of SQSTM1 mRNA]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of SQSTM1 protein]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased lipidation of and results in increased localization of SQSTM1 protein]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

transcription factor A, mitochondrial

multiple interactions
decreases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of TFAM mRNA]

NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,731

G

tight junction protein 1

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of TJP1 mRNA; fumonisin B1 results in decreased expression of TJP1 protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of TJP1 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of TJP1 protein]

PMID:31557363 PMID:37955343

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

multiple interactions
increases expression

[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF protein; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of TNF mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of TNF protein]; Resveratrol inhibits the reaction [fumonisin B1 results in increased expression of TNF mRNA]
fumonisin B1 results in increased expression of TNF mRNA; fumonisin B1 results in increased expression of TNF protein

PMID:23688591 PMID:30708112 PMID:32198028 PMID:37955343 PMID:38705344

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

G

tumor protein p53

increases expression
multiple interactions

fumonisin B1 results in increased expression of TP53 mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; fumonisin B1 inhibits the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]]; fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]; Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA]; Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

TNFRSF1A associated via death domain

increases expression

fumonisin B1 results in increased expression of TRADD mRNA

NCBI chr 6:27,797,594...27,804,654
Ensembl chr 6:27,797,607...27,804,423

G

TNF receptor associated factor 2

increases expression

fumonisin B1 results in increased expression of TRAF2 mRNA

gabapentin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

affects binding

Gabapentin binds to CACNA2D1 protein

NCBI chr 9:97,781,057...98,265,925
Ensembl chr 9:97,781,090...98,266,969

gefitinib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

FES proto-oncogene, tyrosine kinase

multiple interactions
decreases phosphorylation

Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]; Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]
Gefitinib results in decreased phosphorylation of FES protein

NCBI chr 7:53,472,947...53,485,084
Ensembl chr 7:53,472,947...53,485,082

G

fibroblast growth factor 2

multiple interactions

Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]

NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916

G

vascular endothelial growth factor A

multiple interactions

Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]

NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366

glutathione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amine oxidase copper containing 1

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased expression of AOC1 protein]

NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974

G

cytochrome P450 family 2 subfamily B member 6B

multiple interactions

[Glutathione co-treated with Paraquat] results in decreased expression of CYP2B6B mRNA

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

G

cytochrome P450 3A39

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased expression of CYP3A39 mRNA]

G

DnaJ heat shock protein family (Hsp40) member C7

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of DNAJC7 mRNA

NCBI chr12:20,725,937...20,756,295
Ensembl chr12:20,725,975...20,759,000

G

fatty acid binding protein 2

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased activity of FABP2 protein]

NCBI chr 8:104,464,342...104,468,059
Ensembl chr 8:104,464,342...104,470,480

G

glutamate-cysteine ligase modifier subunit

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of GCLM mRNA

NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131

G

glutathione peroxidase 4

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of GPX4 mRNA

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

glutathione S-transferase alpha 1

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of GSTA2 mRNA; Glutathione inhibits the reaction [Paraquat results in decreased expression of GSTA1 mRNA]

NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,548,670

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Glutathione co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]

NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554

G

interferon gamma

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased expression of IFNG mRNA]

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 10

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of IL10 mRNA

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

glutathione S-transferase P-like

multiple interactions

GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione]

NCBI chr 2:5,005,498...5,009,247

G

nuclear receptor subfamily 1 group I member 3

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased expression of NR1I3 mRNA]

NCBI chr 4:89,226,314...89,231,781
Ensembl chr 4:89,226,690...89,236,431

G

occludin

multiple interactions

Glutathione inhibits the reaction [Paraquat results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

superoxide dismutase 2

multiple interactions

[Glutathione co-treated with Paraquat] affects the expression of SOD2 mRNA

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

tight junction protein 1

multiple interactions

Glutathione inhibits the reaction [Paraquat results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

glycine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor mitochondria associated 1

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of AIFM1 mRNA]

NCBI chr X:106,676,596...106,708,290
Ensembl chr X:106,670,520...106,708,317

G

BCL2 associated X, apoptosis regulator

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

caspase 3

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of and results in increased activity of CASP3 protein]; Glycine inhibits the reaction [monobutyl phthalate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

catalase

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of CAT mRNA]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cell division cycle 26

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of CDC26 mRNA]

NCBI chr 1:253,893,666...253,906,659
Ensembl chr 1:253,895,885...253,906,632

G

colony stimulating factor 2

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA

NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155

G

mitofusin 1

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN1 mRNA]; Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN1 protein]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

mitofusin 2

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN2 mRNA]; Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN2 protein]

NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of PTGS1

NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Folic Acid co-treated with Glycine] results in increased expression of PTGS2

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

tubulin alpha 1b

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of TUBA1B mRNA]

NCBI chr 5:15,150,229...15,153,620
Ensembl chr 5:15,149,099...15,153,620

glycine betaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF6 mRNA]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of BAX mRNA

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

caspase 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP9 mRNA]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein; Betaine inhibits the reaction [Glyphosate results in increased expression of CAT mRNA]

PMID:29129240 PMID:36584959

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

DNA damage inducible transcript 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of DDIT3 mRNA]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

DNA methyltransferase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 protein]

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 protein]

NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ERN1 mRNA]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

glutathione peroxidase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 2

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of GPX2 mRNA

NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620

G

glycogen synthase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter

NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261

G

heat shock protein 90 beta family member 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 protein]

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

lactate dehydrogenase A

multiple interactions

[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

mitofusin 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of MFN1 mRNA]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

methylenetetrahydrofolate reductase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

NFE2 like bZIP transcription factor 2

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of NFE2L2 mRNA]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of NQO1 mRNA]

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

proliferating cell nuclear antigen

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA protein]

NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of SDHA mRNA]

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

G

sucrase-isomaltase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA

NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478

G

solute carrier family 15 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 5 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA

NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841

G

superoxide dismutase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Betaine co-treated with Glyphosate] results in decreased expression of UQCRB mRNA

NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057

G

X-box binding protein 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of XBP1 mRNA]

NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526

glyphosate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

increases expression
multiple interactions

Glyphosate results in increased expression of ATF4 mRNA; Glyphosate results in increased expression of ATF4 protein
Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF6 mRNA]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Betaine co-treated with Glyphosate] results in increased expression of BAX mRNA
Glyphosate results in increased expression of BAX mRNA

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

caspase 3

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP9 mRNA]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

increases expression
multiple interactions
increases activity

Glyphosate results in increased expression of CAT mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of CAT mRNA]
Glyphosate results in increased activity of CAT protein

PMID:31677563 PMID:36584959

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

multiple interactions
decreases expression

Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 protein]
Glyphosate results in decreased expression of CLDN1 mRNA; Glyphosate results in decreased expression of CLDN1 protein

PMID:31677563 PMID:36584959

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

C-X-C motif chemokine ligand 8

increases expression
multiple interactions

Glyphosate results in increased expression of CXCL8 mRNA
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of CXCL8 mRNA]

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

DNA damage inducible transcript 3

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of DDIT3 mRNA]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 protein]
Glyphosate results in increased expression of EIF2AK3 mRNA; Glyphosate results in increased expression of EIF2AK3 protein

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 protein]
Glyphosate results in increased expression of EIF2S1 mRNA; Glyphosate results in increased expression of EIF2S1 protein

NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827

G

endoplasmic reticulum to nucleus signaling 1

increases expression
multiple interactions

Glyphosate results in increased expression of ERN1 mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of ERN1 mRNA]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

glutamate-cysteine ligase modifier subunit

decreases expression

Glyphosate results in decreased expression of GCLM mRNA

PMID:31677563 PMID:35388968

NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131

G

glutathione peroxidase 1

decreases expression
decreases activity

Glyphosate results in decreased expression of GPX1 mRNA
Glyphosate results in decreased activity of GPX1 protein

PMID:31677563 PMID:35388968

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 2

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of GPX2 mRNA

NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620

G

glutathione S-transferase omega 1

increases expression

Glyphosate results in increased expression of GSTO1 mRNA

NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613

G

heme oxygenase 1

decreases expression
multiple interactions
increases expression

Glyphosate results in decreased expression of HMOX1 mRNA
Glyphosate results in increased expression of and affects the localization of HMOX1 protein
Glyphosate results in increased expression of HMOX1 mRNA

PMID:31677563 PMID:35388968 PMID:36584959

G

heat shock protein 90 beta family member 1

increases expression
multiple interactions

Glyphosate results in increased expression of HSP90B1 mRNA; Glyphosate results in increased expression of HSP90B1 protein
Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 protein]

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

interleukin 10

increases expression

Glyphosate results in increased expression of IL10 protein

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 6

increases expression
multiple interactions
affects secretion

Glyphosate results in increased expression of IL6 mRNA; Glyphosate results in increased expression of IL6 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL6 mRNA]
Glyphosate affects the secretion of IL6 protein

PMID:31677563 PMID:35388968 PMID:36584959

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

kelch like ECH associated protein 1

decreases expression

Glyphosate results in decreased expression of KEAP1 mRNA

NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382

G

interleukin-1 beta-like

increases expression
multiple interactions
increases secretion

Glyphosate results in increased expression of IL1B mRNA; Glyphosate results in increased expression of IL1B protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL1B mRNA]
Glyphosate results in increased secretion of IL1B protein

PMID:35388968 PMID:36584959

G

mitofusin 1

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of MFN1 mRNA]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of NFE2L2 mRNA]; Glyphosate results in increased expression of and affects the localization of NFE2L2 protein
Glyphosate results in increased expression of NFE2L2 mRNA; Glyphosate results in increased expression of NFE2L2 protein

PMID:31677563 PMID:35388968 PMID:36584959

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

nuclear factor kappa B subunit 1

increases expression

Glyphosate results in increased expression of NFKB1 mRNA

PMID:31677563 PMID:35388968

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

NFKB inhibitor alpha

multiple interactions

Glyphosate results in decreased expression of and results in increased phosphorylation of NFKBIA protein

NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277

G

nitric oxide synthase 2

increases expression

Glyphosate results in increased expression of NOS2 mRNA

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Glyphosate results in increased expression of NQO1 mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of NQO1 mRNA]

PMID:31677563 PMID:35388968 PMID:36584959

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

proliferating cell nuclear antigen

increases expression
multiple interactions

Glyphosate results in increased expression of PCNA mRNA; Glyphosate results in increased expression of PCNA protein
Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA protein]

NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation

Glyphosate results in increased phosphorylation of RELA protein

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of SDHA mRNA]

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

G

superoxide dismutase 1

decreases activity

Glyphosate results in decreased activity of SOD1 protein

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

increases expression
multiple interactions

Glyphosate results in increased expression of SOD2 mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

sequestosome 1

decreases expression
multiple interactions

Glyphosate results in decreased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of SQSTM1 protein]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

tight junction protein 1

decreases expression

Glyphosate results in decreased expression of TJP1 mRNA

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

affects secretion
increases expression

Glyphosate affects the secretion of TNF protein
Glyphosate results in increased expression of TNF protein

PMID:35388968 PMID:36584959

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Betaine co-treated with Glyphosate] results in decreased expression of UQCRB mRNA

NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057

G

X-box binding protein 1

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of XBP1 mRNA]

NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526

histamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

histamine receptor H2

multiple interactions

[Histamine affects the activity of HRH2 protein] which affects the secretion of Chlorides

NCBI chr 2:81,883,670...81,932,464
Ensembl chr 2:81,883,673...81,932,275

icatibant

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

kininogen 1

decreases activity

icatibant results in decreased activity of KNG1 protein modified form

NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958

itraconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

multiple interactions

Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]

NCBI chr 9:93,171,371...93,262,124

ketoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 3 subfamily A member 29

multiple interactions

Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine]

NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944

KT 5823

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

collagen type IV alpha 2 chain

multiple interactions
decreases expression

KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]
KT 5823 results in decreased expression of COL4A2 protein

NCBI chr11:76,996,885...77,161,617
Ensembl chr11:76,997,516...77,161,614

G

collagen type IV alpha 3 chain

decreases expression
multiple interactions

KT 5823 results in decreased expression of COL4A3 mRNA
KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A3 mRNA]

NCBI chr15:128,611,640...128,763,331
Ensembl chr15:128,611,866...128,763,122

G

integrin subunit alpha V

multiple interactions

KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]]

NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,851

G

integrin subunit beta 3

multiple interactions

KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]]

NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292

L-cysteine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of ALB protein]

NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696

G

claudin 1

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of CLDN1 mRNA]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

glutamate-cysteine ligase catalytic subunit

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in increased expression of GCLC mRNA]

NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530

G

glutamate-cysteine ligase modifier subunit

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in increased expression of GCLM mRNA]

NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131

G

heme oxygenase 1

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of HMOX1 mRNA]

G

kelch like ECH associated protein 1

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in increased expression of KEAP1 mRNA]

NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382

G

NADPH oxidase 1

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of NOX1 mRNA]

NCBI chr X:82,540,664...82,575,811
Ensembl chr X:82,540,667...82,586,532

G

protein phosphatase 1 regulatory subunit 16A

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in increased activity of GPT protein]

NCBI chr 4:302,621...320,048
Ensembl chr 4:297,748...320,056

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of SDHA mRNA]

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

G

superoxide dismutase 2

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

tight junction protein 2

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of TJP2 mRNA]

NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983

L-glutamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 10

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in decreased secretion of IL10 protein]

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 6

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Glutamine inhibits the reaction [bisphenol A results in increased secretion of IL6 protein]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interleukin-1 beta-like

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased secretion of IL1B protein]

G

MYD88 innate immune signal transduction adaptor

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of MYD88 mRNA]

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

nuclear factor kappa B subunit 1

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of NFKB1 mRNA]

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

trefoil factor 3

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in decreased expression of TFF3 protein]

NCBI chr13:205,641,038...205,644,333
Ensembl chr13:205,641,038...205,644,333

G

toll like receptor 4

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of TLR4 mRNA]; Glutamine inhibits the reaction [bisphenol A results in increased expression of TLR4 protein]

NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970

G

tumor necrosis factor

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Glutamine inhibits the reaction [bisphenol A results in increased secretion of TNF protein]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

mastoparan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

selectin E

increases expression

mastoparan results in increased expression of SELE mRNA

NCBI chr 4:81,289,061...81,299,657

melatonin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased phosphorylation of AKT1 protein]

G

ARB2 cotranscriptional regulator A

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of ARB2A mRNA]

NCBI chr 2:100,477,770...100,893,594
Ensembl chr 2:100,477,775...100,893,580

G

autophagy related 5

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of ATG5 protein]

NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396

G

BCL2 associated X, apoptosis regulator

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX protein]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

BCL2 apoptosis regulator

multiple interactions
increases expression

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]
Melatonin results in increased expression of BCL2 mRNA

PMID:31535366 PMID:37120089

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

beclin 1

increases expression
multiple interactions

Melatonin results in increased expression of BECN1 protein
Melatonin inhibits the reaction [deoxynivalenol results in increased expression of BECN1 protein]

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

caspase 3

decreases expression
multiple interactions

Melatonin results in decreased expression of CASP3 mRNA
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 protein]

PMID:31535366 PMID:35665993

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 8

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 protein]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

caspase 9

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 protein]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

multiple interactions
increases activity

Melatonin inhibits the reaction [deoxynivalenol results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA]
Melatonin results in increased activity of CAT protein

PMID:31535366 PMID:37120089

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of CHUK mRNA]

NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868

G

claudin 1

multiple interactions
increases expression

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]
Melatonin results in increased expression of CLDN1 protein

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

cytochrome c oxidase subunit 7A2 like

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of COX7A2L mRNA]

NCBI chr 3:97,951,115...97,983,309
Ensembl chr 3:97,951,114...97,983,309

G

glutathione peroxidase 4

increases expression

Melatonin results in increased expression of GPX4 mRNA

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

interleukin 18

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of IL18 mRNA]

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

interleukin 6

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of IL6 protein]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

KLF transcription factor 5

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of KLF5 mRNA]

NCBI chr11:45,370,009...45,386,673
Ensembl chr11:45,369,810...45,388,314

G

interleukin-1 beta-like

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of IL1B protein]

G

microtubule associated protein 1 light chain 3 beta

multiple interactions

Melatonin affects the reaction [deoxynivalenol results in increased expression of and results in increased lipidation of MAP1LC3B protein]

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

mitogen-activated protein kinase kinase 1

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of MAP2K1 mRNA]

NCBI chr 1:164,381,892...164,469,313
Ensembl chr 1:164,381,845...164,471,226

G

mixed lineage kinase domain like pseudokinase

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL protein]

NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

Melatonin inhibits the reaction [deoxynivalenol results in decreased phosphorylation of MTOR protein]
Melatonin results in decreased phosphorylation of MTOR protein

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

G

occludin

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

perilipin 2

multiple interactions

Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein]

NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,273

G

peroxisome proliferator activated receptor gamma

multiple interactions

Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein]

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

phosphatase and tensin homolog

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN protein]

NCBI chr14:99,929,590...100,021,619

G

receptor interacting serine/threonine kinase 1

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 protein]

NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699

G

receptor interacting serine/threonine kinase 3

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 protein]

NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251

G

superoxide dismutase 2

increases expression
multiple interactions

Melatonin results in increased expression of SOD2 mRNA
Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of SOD2 mRNA]

PMID:31535366 PMID:37120089

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

tight junction protein 1

increases expression
multiple interactions

Melatonin results in increased expression of TJP1 protein
Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of TNF protein]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

G

tumor protein p53

multiple interactions
decreases expression

Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
Melatonin results in decreased expression of TP53 mRNA

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

ZFP36 ring finger protein like 2

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of ZFP36L2 mRNA]

NCBI chr 3:97,200,395...97,203,094
Ensembl chr 3:97,200,407...97,204,698

melittin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 4

decreases response to substance

IL4 protein results in decreased susceptibility to Melitten

NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365

G

phospholipase A2 group IB

increases activity

Melitten results in increased activity of PLA2G1B protein

NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315

G

selectin E

increases expression

Melitten results in increased expression of SELE mRNA

NCBI chr 4:81,289,061...81,299,657

mesulergine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5-hydroxytryptamine receptor 2C

affects binding
multiple interactions

mesulergine binds to HTR2C protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]

NCBI chr X:94,053,415...94,313,352
Ensembl chr X:94,053,456...94,313,355

N(5)-ethyl-L-glutamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

BCL2 apoptosis regulator

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 mRNA]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 3

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

claudin 1

multiple interactions

[N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 protein]; theanine inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]

PMID:37271275 PMID:38438008

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

interleukin 6

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

lactate dehydrogenase A

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased activity of LDHA protein]

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

interleukin-1 beta-like

multiple interactions

[N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]; theanine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

PMID:37271275 PMID:38438008

G

mitogen-activated protein kinase 14

multiple interactions

[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK14 protein]; theanine inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]

PMID:37271275 PMID:38438008

NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031

G

NLR family pyrin domain containing 3

multiple interactions

[N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; theanine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]

NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228

G

occludin

multiple interactions

[N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN protein]; theanine inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]

PMID:37271275 PMID:38438008

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

tight junction protein 1

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

annexin A5

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]

NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750

G

caspase 3

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

interleukin 6

multiple interactions
increases expression

[Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6 protein]

PMID:14519784 PMID:15226458

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

peroxisome proliferator activated receptor alpha

decreases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA]

NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239

G

peroxisome proliferator activated receptor gamma

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of and results in increased activity of PPARG protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of PPARG mRNA]

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein
caffeic acid phenethyl ester inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA]

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

selectin E

multiple interactions
increases expression

Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SELE mRNA]

NCBI chr 4:81,289,061...81,299,657

G

tumor necrosis factor

multiple interactions
increases activity

[2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]]

PMID:10617950 PMID:15226458

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

G

vascular cell adhesion molecule 1

multiple interactions

[Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]

NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222

N,N-dimethylaniline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

flavin containing dimethylaniline monoxygenase 1

increases metabolic processing

FMO1 protein results in increased metabolism of N,N-dimethylaniline

NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cAMP responsive element binding protein 1

multiple interactions

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]

NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728

G

interleukin 6

decreases expression
multiple interactions

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

N-acetyl-L-cysteine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAX protein]

PMID:19135140 PMID:33905761

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

BCL2 apoptosis regulator

multiple interactions

[Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]

PMID:19135140 PMID:29109043 PMID:33905761

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

bone morphogenetic protein 15

multiple interactions

Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of BMP15 mRNA]

NCBI chr X:44,613,122...44,620,575
Ensembl chr X:44,613,122...44,620,575

G

caspase 1, apoptosis-related cysteine peptidase

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein]

NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328

G

caspase 3

multiple interactions

[Acetylcysteine co-treated with Zearalenone] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]

PMID:17383151 PMID:19135140 PMID:29109043 PMID:33905761

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions

Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP9 protein]

PMID:19135140 PMID:33905761

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

chemokine (C-C motif) ligand 2

multiple interactions

Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]

NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026

G

cytochrome c, somatic

multiple interactions

Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

DNA damage inducible transcript 3

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

G

glutathione peroxidase 1

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 4

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA]

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

gasdermin D

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

glutathione-disulfide reductase

multiple interactions

Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]

NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984

G

heat shock protein 90 beta family member 1

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA]

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

interleukin-1 beta-like

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]

G

mitogen-activated protein kinase 8

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

mitogen-activated protein kinase 9

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]

NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC]

NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078

G

NFE2 like bZIP transcription factor 2

multiple interactions

Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

NLR family pyrin domain containing 3

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]

NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228

G

nitric oxide synthase 2

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of INOS mRNA]

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PTGS2 mRNA]

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

pentraxin 3

multiple interactions

Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA]

NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569

G

PYD and CARD domain containing

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]

NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786

G

sequestosome 1

multiple interactions

Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of SQSTM1 protein]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

TNF alpha induced protein 6

multiple interactions

Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of TNFAIP6 mRNA]

NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461

G

tumor protein p53

multiple interactions

Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; Acetylcysteine promotes the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

zona pellucida glycoprotein 3

multiple interactions

Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of ZP3 mRNA]

NCBI chr 3:9,934,760...9,944,924
Ensembl chr 3:9,934,761...9,944,941

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases expression
multiple interactions

benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKT1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of AKT1 protein]

G

chloride intracellular channel 5

multiple interactions

benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]

NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886

G

LDL receptor related protein 2

multiple interactions

benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]

NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694

G

nitric oxide synthase 3

multiple interactions
increases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of NOS3 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NOS3 protein

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

nicotine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

multiple interactions

Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein]

NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294

G

ADCYAP receptor type I

decreases expression

Nicotine results in decreased expression of ADCYAP1R1 protein

NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,428...41,972,301

G

anti-Mullerian hormone

decreases expression
decreases secretion

Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein

NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,414,427...76,418,312

G

BCL2 apoptosis regulator

decreases expression

Nicotine results in decreased expression of BCL2 mRNA

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein]

NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,195,228...11,207,650

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein]

NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,899...47,384,303

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein]

NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123

G

cholinergic receptor nicotinic alpha 9 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein]

NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein]

NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037

G

cytochrome P450 19A3

decreases expression

Nicotine results in decreased expression of CYP19A1 mRNA

NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899

G

follicle stimulating hormone receptor

decreases expression

Nicotine results in decreased expression of FSHR mRNA

NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683

G

inhibin subunit beta B

decreases expression
decreases secretion

Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein

NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405

G

integrin subunit beta 1

decreases expression

Nicotine results in decreased expression of ITGB1 mRNA

NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,396...56,173,326

G

laminin subunit beta 1

decreases expression

Nicotine results in decreased expression of LAMB1 mRNA

NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269

G

mitogen-activated protein kinase 1

decreases expression
decreases phosphorylation

Nicotine results in decreased expression of MAPK1 mRNA
Nicotine results in decreased phosphorylation of MAPK1 protein

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

decreases phosphorylation
decreases expression

Nicotine results in decreased phosphorylation of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

decreases expression
decreases phosphorylation

Nicotine results in decreased expression of MAPK8 mRNA
Nicotine results in decreased phosphorylation of MAPK8 protein

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

matrix metallopeptidase 9

increases expression

Nicotine results in increased expression of MMP9 mRNA

NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788

G

occludin

decreases expression

Nicotine results in decreased expression of OCLN mRNA

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

ribonuclease P/MRP subunit p38

decreases expression

Nicotine results in decreased expression of RPP38 mRNA

NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,197...46,725,920

norflurazon

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

norflurazone results in decreased phosphorylation of AKT1 protein

G

AKT serine/threonine kinase 2

decreases phosphorylation

norflurazone results in decreased phosphorylation of AKT2 protein

NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,795...48,587,919

G

AKT serine/threonine kinase 3

decreases phosphorylation

norflurazone results in decreased phosphorylation of AKT3 protein

NCBI chr10:16,441,465...16,741,745
Ensembl chr10:16,441,447...16,741,337

G

autophagy related 5

increases expression

norflurazone results in increased expression of ATG5 protein

NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396

G

ATP synthase F1 subunit alpha

decreases expression

norflurazone results in decreased expression of ATP5F1A mRNA

NCBI chr 1:95,738,789...95,750,835
Ensembl chr 1:95,733,090...95,750,841

G

ATP synthase membrane subunit c locus 1

decreases expression

norflurazone results in decreased expression of ATP5MC1 mRNA

NCBI chr12:25,110,540...25,113,481
Ensembl chr12:25,110,528...25,113,478

G

ATP synthase membrane subunit c locus 2

decreases expression

norflurazone results in decreased expression of ATP5MC2 mRNA

NCBI chr 5:18,871,025...18,879,933
Ensembl chr 5:18,871,026...18,879,609

G

ATP synthase peripheral stalk-membrane subunit b

decreases expression

norflurazone results in decreased expression of ATP5PB mRNA

NCBI chr 4:108,896,063...108,907,626
Ensembl chr 4:108,896,057...108,907,805

G

beclin 1

increases expression

norflurazone results in increased expression of BECN1 protein

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

cytochrome P450 2C49

multiple interactions

CYP2C49 protein results in increased metabolism of and results in decreased susceptibility to norflurazone

NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455

G

eukaryotic translation initiation factor 2A

increases phosphorylation

norflurazone results in increased phosphorylation of EIF2A protein

NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274

G

heat shock protein family A (Hsp70) member 5

multiple interactions

norflurazone results in increased expression of and results in increased phosphorylation of HSPA5 protein

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

inositol 1,4,5-trisphosphate receptor type 1

increases expression

norflurazone results in increased expression of ITPR1 protein

NCBI chr13:61,068,131...61,398,918
Ensembl chr13:61,068,126...61,398,912

G

mitogen-activated protein kinase 1

decreases phosphorylation

norflurazone results in decreased phosphorylation of MAPK1 protein

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 14

increases phosphorylation

norflurazone results in increased phosphorylation of MAPK14 protein

NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031

G

mitogen-activated protein kinase 3

decreases phosphorylation

norflurazone results in decreased phosphorylation of MAPK3 protein

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitochondrially encoded ATP synthase membrane subunit 6

decreases expression

norflurazone results in decreased expression of ATP6 mRNA

NCBI chr MT:9,120...9,800
Ensembl chr MT:9,120...9,800

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

norflurazone results in decreased expression of NDUFS2 mRNA

NCBI chr 4:89,246,958...89,257,090
Ensembl chr 4:89,246,960...89,257,085

G

NADH:ubiquinone oxidoreductase core subunit S3

decreases expression

norflurazone results in decreased expression of NDUFS3 mRNA

NCBI chr 2:15,031,147...15,036,880
Ensembl chr 2:15,031,149...15,036,880

G

NADH:ubiquinone oxidoreductase core subunit V1

decreases expression

norflurazone results in decreased expression of NDUFV1 mRNA

NCBI chr 2:4,958,508...4,964,211
Ensembl chr 2:4,958,522...4,964,216

G

ribosomal protein S6 kinase B1

decreases phosphorylation

norflurazone results in decreased phosphorylation of RPS6KB1 protein

NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376

G

SMAD family member 2

decreases expression

norflurazone results in decreased expression of SMAD2 mRNA

NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,357

G

SMAD family member 4

decreases expression

norflurazone results in decreased expression of SMAD4 mRNA

NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029

G

secreted phosphoprotein 1

decreases expression

norflurazone results in decreased expression of SPP1 mRNA

NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340

G

sequestosome 1

increases phosphorylation

norflurazone results in increased phosphorylation of SQSTM1 protein

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

ubiquinol-cytochrome c reductase binding protein

decreases expression

norflurazone results in decreased expression of UQCRB mRNA

NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057

G

ubiquinol-cytochrome c reductase core protein 2

decreases expression

norflurazone results in decreased expression of UQCRC2 mRNA

NCBI chr 3:24,197,743...24,228,831
Ensembl chr 3:24,197,747...24,228,832

G

ubiquinol-cytochrome c reductase complex III subunit VII

decreases expression

norflurazone results in decreased expression of UQCRQ mRNA

NCBI chr 2:135,186,366...135,188,237
Ensembl chr 2:135,186,501...135,188,293

G

voltage dependent anion channel 1

increases expression

norflurazone results in increased expression of VDAC1 protein

NCBI chr 2:136,302,188...136,334,461
Ensembl chr 2:136,302,191...136,396,301

o-aminoacetophenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily A member 19

multiple interactions

2-aminoacetophenone inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; 2-aminoacetophenone inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin]

NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107

G

cytochrome P450 family 2 subfamily E member 1

multiple interactions

2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; 2-aminoacetophenone inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

ochratoxin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

ochratoxin A results in decreased phosphorylation of AKT1 protein

G

annexin A5

decreases expression

ochratoxin A results in decreased expression of ANXA5 mRNA

NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

ochratoxin A results in increased expression of APAF1 mRNA; ochratoxin A results in increased expression of APAF1 protein
fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 protein]

NCBI chr 5:85,166,616...85,258,751
Ensembl chr 5:85,166,628...85,258,364

G

autophagy related 5

multiple interactions
increases expression

ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of ATG5 protein

PMID:28699257 PMID:30287338

NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]
ochratoxin A results in increased expression of BAX mRNA; ochratoxin A results in increased expression of BAX protein

PMID:33905761 PMID:36397609

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

BCL2 apoptosis regulator

multiple interactions
decreases expression
affects expression

[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 protein]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]
ochratoxin A results in decreased expression of BCL2 mRNA; ochratoxin A results in decreased expression of BCL2 protein

PMID:28528741 PMID:29080797 PMID:33905761 PMID:36397609

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

beclin 1

multiple interactions
increases expression

BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of BECN1 protein

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

BRCA1 DNA repair associated

increases expression

ochratoxin A results in increased expression of BRCA1 protein

NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,854,668

G

caspase 1, apoptosis-related cysteine peptidase

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein]; ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein; Taurine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein]

NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328

G

caspase 3

multiple interactions
increases expression
increases cleavage

3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]
ochratoxin A results in increased expression of CASP3 mRNA; ochratoxin A results in increased expression of CASP3 protein; ochratoxin A results in increased expression of CASP3 protein modified form

PMID:30287338 PMID:33905761 PMID:36397609

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions
increases expression

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]
ochratoxin A results in increased expression of CASP9 mRNA; ochratoxin A results in increased expression of CASP9 protein; ochratoxin A results in increased expression of CASP9 protein modified form

PMID:33905761 PMID:36397609

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

decreases expression
multiple interactions

ochratoxin A results in decreased expression of CAT mRNA; ochratoxin A results in decreased expression of CAT protein
Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA]; Taurine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA]

PMID:18547704 PMID:36281498

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

crystallin alpha B

increases expression

ochratoxin A results in increased expression of CRYAB mRNA

NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,506...39,643,530

G

cytochrome c, somatic

multiple interactions
increases expression

fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CYCS mRNA]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

cytochrome P450 family 2 subfamily G member 2

decreases expression

ochratoxin A results in decreased expression of CYP2A6 mRNA

NCBI chr 6:49,069,613...49,084,953

G

defender against cell death 1

decreases expression

ochratoxin A results in decreased expression of DAD1 mRNA

NCBI chr 7:76,432,040...76,457,403
Ensembl chr 7:76,432,051...76,457,192

G

DNA methyltransferase 1

increases expression
multiple interactions

ochratoxin A results in increased expression of DNMT1 mRNA; ochratoxin A results in increased expression of DNMT1 protein
Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]

PMID:29080797 PMID:30923867

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

increases expression

ochratoxin A results in increased expression of DNMT3A mRNA

PMID:29080797 PMID:30923867

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

glutamate-cysteine ligase catalytic subunit

decreases expression
multiple interactions

ochratoxin A results in decreased expression of GCLC mRNA
ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA]

NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530

G

glomulin, FKBP associated protein

increases expression

ochratoxin A results in increased expression of GLMN mRNA

NCBI chr 4:124,773,957...124,813,336
Ensembl chr 4:124,773,980...124,813,335

G

glutathione peroxidase 1

decreases expression
multiple interactions

ochratoxin A results in decreased expression of GPX1 mRNA
Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]; Taurine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 4

decreases expression
multiple interactions

ochratoxin A results in decreased expression of GPX4 mRNA
Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA]; Taurine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA]

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

gasdermin D

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]; Taurine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

glutathione S-transferase alpha 1

multiple interactions
decreases expression

ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GSTA1 mRNA]
ochratoxin A results in decreased expression of GSTA1 mRNA

NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,548,670

G

H2A.X variant histone

multiple interactions
increases expression

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein]

PMID:30923867 PMID:32454083

NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084

G

hepatitis A virus cellular receptor 1

multiple interactions

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of HAVCR1 mRNA

NCBI chr16:66,162,318...66,208,868