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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-methylglucamine
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Accession:CHEBI:59732 term browser browse the term
Definition:A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, while its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.
Synonyms:exact_synonym: 1-deoxy-1-(methylamino)-D-glucitol
 related_synonym: 1-deoxy-1-methylaminosorbitol;   Formula=C7H17NO5;   InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1;   InChIKey=MBBZMMPHUWSWHV-BDVNFPICSA-N;   N-methyl-D-glucamine;   SMILES=CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO;   meglumina;   meglumine;   megluminum
 alt_id: CHEBI:31811
 xref: Beilstein:385906;   CAS:6284-40-8;   KEGG:D01796;   LINCS:LSM-5424;   PMID:24257040;   PMID:24273165;   Reaxys:385906;   Wikipedia:Meglumine


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meglumine amidotrizoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Diatrizoate Meglumine results in increased expression of BAX protein CTD PMID:17173243 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
ISO
EXP
Diatrizoate Meglumine results in increased expression of BCL2 protein
Diatrizoate Meglumine results in decreased expression of BCL2 mRNA
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in decreased expression of BCL2 mRNA]
CTD PMID:17173243 PMID:28412091 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp12 caspase 12 increases cleavage EXP Diatrizoate Meglumine results in increased cleavage of CASP12 protein CTD PMID:20071420 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
ISO
EXP
Diatrizoate Meglumine results in increased activity of CASP3 protein
Diatrizoate Meglumine results in increased expression of CASP3 mRNA
[Diatrizoate Meglumine co-treated with Gentamicins] results in increased cleavage of CASP3 protein; [sulforaphane co-treated with Diatrizoate Meglumine] results in increased activity of CASP3 protein; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased cleavage of CASP3 protein]; Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of CASP3 mRNA]; NFE2L2 protein affects the reaction [[sulforaphane co-treated with Diatrizoate Meglumine] results in increased activity of CASP3 protein]
CTD PMID:17173243 PMID:23335628 PMID:28412091 PMID:31173751 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased cleavage of CASP3 protein]; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of HAVCR1 protein]; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein] CTD PMID:23335628 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation EXP Diatrizoate Meglumine results in increased phosphorylation of EIF2A protein CTD PMID:20071420 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP Diatrizoate Meglumine results in increased phosphorylation of EIF2AK3 protein CTD PMID:20071420 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Diatrizoate Meglumine results in increased expression of GSTA2 mRNA CTD PMID:28412091 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of HAVCR1 protein; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of HAVCR1 protein] CTD PMID:23335628 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
multiple interactions
EXP Diatrizoate Meglumine results in increased expression of HMOX1 mRNA
Diatrizoate Meglumine results in decreased expression of HMOX1 protein
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of HMOX1 mRNA]
CTD PMID:28412091 PMID:31173751 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression EXP Diatrizoate Meglumine results in increased expression of HSP90B1 protein CTD PMID:20071420 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Diatrizoate Meglumine results in increased expression of HSPA5 protein CTD PMID:20071420 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [sulforaphane inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 protein]]; sulforaphane inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 protein]
Diatrizoate Meglumine results in increased expression of IL6 mRNA; Diatrizoate Meglumine results in increased expression of IL6 protein
CTD PMID:28412091 PMID:31173751 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
increases expression
EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [[sulforaphane co-treated with Diatrizoate Meglumine] results in increased activity of CASP3 protein]; NFE2L2 protein affects the reaction [sulforaphane inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 protein]]
Diatrizoate Meglumine results in decreased expression of NFE2L2 protein
CTD PMID:28412091 PMID:31173751 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein] CTD PMID:23335628 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
EXP Diatrizoate Meglumine results in increased expression of TP53 mRNA
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of TP53 mRNA]
CTD PMID:28412091 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        refrigerant 17691
          ammonia 17278
            organic amino compound 17278
              secondary amino compound 6586
                N-methylglucamine 16
                  meglumine amidotrizoate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organooxygen compound 19004
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11945
                                        amino sugar 1298
                                          amino monosaccharide 1293
                                            hexosamine 1293
                                              N-methylglucamine 16
                                                meglumine amidotrizoate 16
paths to the root