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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-methylglucamine
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Accession:CHEBI:59732 term browser browse the term
Definition:A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, while its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.
Synonyms:exact_synonym: 1-deoxy-1-(methylamino)-D-glucitol
 related_synonym: 1-deoxy-1-methylaminosorbitol;   Formula=C7H17NO5;   InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1;   InChIKey=MBBZMMPHUWSWHV-BDVNFPICSA-N;   N-methyl-D-glucamine;   SMILES=CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO;   meglumina;   meglumine;   megluminum
 alt_id: CHEBI:31811
 xref: Beilstein:385906;   CAS:6284-40-8;   KEGG:D01796;   LINCS:LSM-5424;   PMID:24257040;   PMID:24273165;   Reaxys:385906;   Wikipedia:Meglumine


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meglumine amidotrizoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Diatrizoate Meglumine results in increased expression of BAX protein CTD PMID:17173243 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
ISO
EXP
Diatrizoate Meglumine results in increased expression of BCL2 protein
Diatrizoate Meglumine results in decreased expression of BCL2 mRNA
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in decreased expression of BCL2 mRNA]
CTD PMID:17173243, PMID:28412091 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp12 caspase 12 increases cleavage EXP Diatrizoate Meglumine results in increased cleavage of CASP12 protein CTD PMID:20071420 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
ISO
EXP
Diatrizoate Meglumine results in increased activity of CASP3 protein
Diatrizoate Meglumine results in increased expression of CASP3 mRNA
[Diatrizoate Meglumine co-treated with Gentamicins] results in increased cleavage of CASP3 protein; [sulforafan co-treated with Diatrizoate Meglumine] results in increased activity of CASP3 protein; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased cleavage of CASP3 protein]; Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of CASP3 mRNA]; NFE2L2 protein affects the reaction [[sulforafan co-treated with Diatrizoate Meglumine] results in increased activity of CASP3 protein]
CTD PMID:17173243, PMID:23335628, PMID:28412091, PMID:31173751 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased cleavage of CASP3 protein]; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of HAVCR1 protein]; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein] CTD PMID:23335628 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation EXP Diatrizoate Meglumine results in increased phosphorylation of EIF2A protein CTD PMID:20071420 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP Diatrizoate Meglumine results in increased phosphorylation of EIF2AK3 protein CTD PMID:20071420 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Diatrizoate Meglumine results in increased expression of GSTA2 mRNA CTD PMID:28412091 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of HAVCR1 protein; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of HAVCR1 protein] CTD PMID:23335628 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
multiple interactions
EXP Diatrizoate Meglumine results in increased expression of HMOX1 mRNA
Diatrizoate Meglumine results in decreased expression of HMOX1 protein
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of HMOX1 mRNA]
CTD PMID:28412091, PMID:31173751 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression EXP Diatrizoate Meglumine results in increased expression of HSP90B1 protein CTD PMID:20071420 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Diatrizoate Meglumine results in increased expression of HSPA5 protein CTD PMID:20071420 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [sulforafan inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 protein]]; sulforafan inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 protein]
Diatrizoate Meglumine results in increased expression of IL6 mRNA; Diatrizoate Meglumine results in increased expression of IL6 protein
CTD PMID:28412091, PMID:31173751 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
increases expression
EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [[sulforafan co-treated with Diatrizoate Meglumine] results in increased activity of CASP3 protein]; NFE2L2 protein affects the reaction [sulforafan inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 protein]]
Diatrizoate Meglumine results in decreased expression of NFE2L2 protein
CTD PMID:28412091, PMID:31173751 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein; CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein] CTD PMID:23335628 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
EXP Diatrizoate Meglumine results in increased expression of TP53 mRNA
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of TP53 mRNA]
CTD PMID:28412091 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        refrigerant 17418
          ammonia 16939
            organic amino compound 16938
              secondary amino compound 6515
                N-methylglucamine 16
                  meglumine amidotrizoate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      carbohydrate derivative 11802
                                        amino sugar 1180
                                          amino monosaccharide 1174
                                            hexosamine 1174
                                              N-methylglucamine 16
                                                meglumine amidotrizoate 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.