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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:irilone
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Accession:CHEBI:5970 term browser browse the term
Definition:A hydroxyisoflavone that is 6,7-methylenedioxyisoflavone substituted by hydroxy groups at positions 5 and 4'.
Synonyms:exact_synonym: 9-hydroxy-7-(4-hydroxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromen-8-one
 related_synonym: 5,4'-dihydroxy-6,7-methylenedioxyisoflavone;   9-Hydroxy-7-(4-hydroxyphenyl)-8H-1,3-dioxolo[4,5-g]-1-benzopyran-8-one;   Formula=C16H10O6;   InChI=1S/C16H10O6/c17-9-3-1-8(2-4-9)10-6-20-11-5-12-16(22-7-21-12)15(19)13(11)14(10)18/h1-6,17,19H,7H2;   InChIKey=NUGRQNBDTZWXTP-UHFFFAOYSA-N;   Irolone;   SMILES=Oc1ccc(cc1)-c1coc2cc3OCOc3c(O)c2c1=O
 xref: CAS:41653-81-0;   HMDB:HMDB0033820;   KEGG:C10467;   KNApSAcK:C00002539;   LIPID_MAPS_instance:LMPK12050383
 xref_mesh: MESH:C530234
 xref: PMID:12567273;   PMID:19003948;   PMID:20349151;   PMID:21495101;   PMID:22388969;   Reaxys:1264266;   Wikipedia:Irilone



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irilone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases expression ISO irilone results in increased expression of AR mRNA CTD PMID:23982890 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO irilone results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO irilone results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO irilone results in increased expression of ESR2 mRNA CTD PMID:23982890 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Pgr progesterone receptor increases expression ISO irilone results in increased expression of PGR mRNA CTD PMID:23982890 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      biological role 19881
        immunomodulator 15070
          irilone 5
            irilone-4'-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside] 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    p-block element atom 19853
                      carbon group element atom 19799
                        carbon atom 19794
                          organic molecular entity 19794
                            organic group 18960
                              organic divalent group 18941
                                organodiyl group 18941
                                  carbonyl group 18893
                                    carbonyl compound 18893
                                      ketone 17190
                                        cyclic ketone 15706
                                          isoflavones 3786
                                            hydroxyisoflavone 3719
                                              irilone 5
                                                irilone-4'-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside] 0
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