CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: irilone
Accession: CHEBI:5970
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Definition: A hydroxyisoflavone that is 6,7-methylenedioxyisoflavone substituted by hydroxy groups at positions 5 and 4'.
Synonyms: exact_synonym: 9-hydroxy-7-(4-hydroxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromen-8-one
related_synonym: 5,4'-dihydroxy-6,7-methylenedioxyisoflavone; 9-Hydroxy-7-(4-hydroxyphenyl)-8H-1,3-dioxolo[4,5-g]-1-benzopyran-8-one; Formula=C16H10O6; InChI=1S/C16H10O6/c17-9-3-1-8(2-4-9)10-6-20-11-5-12-16(22-7-21-12)15(19)13(11)14(10)18/h1-6,17,19H,7H2; InChIKey=NUGRQNBDTZWXTP-UHFFFAOYSA-N; Irolone; SMILES=Oc1ccc(cc1)-c1coc2cc3OCOc3c(O)c2c1=O
xref: CAS:41653-81-0; HMDB:HMDB0033820; KEGG:C10467; KNApSAcK:C00002539; LIPID_MAPS_instance:LMPK12050383
xref_mesh: MESH:C530234
xref: PMID:12567273; PMID:19003948; PMID:20349151; PMID:21495101; PMID:22388969; Reaxys:1264266; Wikipedia:Irilone
G
Ar
androgen receptor
increases expression
ISO
irilone results in increased expression of AR mRNA
CTD
PMID:23982890
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
irilone results in decreased activity of CYP1A2 protein
CTD
PMID:29753067
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
irilone results in decreased activity of CYP3A4 protein
CTD
PMID:29753067
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Esr2
estrogen receptor 2
increases expression
ISO
irilone results in increased expression of ESR2 mRNA
CTD
PMID:23982890
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Pgr
progesterone receptor
increases expression
ISO
irilone results in increased expression of PGR mRNA
CTD
PMID:23982890
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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