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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:irilone
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Accession:CHEBI:5970 term browser browse the term
Definition:A hydroxyisoflavone that is 6,7-methylenedioxyisoflavone substituted by hydroxy groups at positions 5 and 4'.
Synonyms:exact_synonym: 9-hydroxy-7-(4-hydroxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromen-8-one
 related_synonym: 5,4'-dihydroxy-6,7-methylenedioxyisoflavone;   9-Hydroxy-7-(4-hydroxyphenyl)-8H-1,3-dioxolo[4,5-g]-1-benzopyran-8-one;   Formula=C16H10O6;   InChI=1S/C16H10O6/c17-9-3-1-8(2-4-9)10-6-20-11-5-12-16(22-7-21-12)15(19)13(11)14(10)18/h1-6,17,19H,7H2;   InChIKey=NUGRQNBDTZWXTP-UHFFFAOYSA-N;   Irolone;   SMILES=Oc1ccc(cc1)-c1coc2cc3OCOc3c(O)c2c1=O
 xref: CAS:41653-81-0;   HMDB:HMDB0033820;   KEGG:C10467;   KNApSAcK:C00002539;   LIPID_MAPS_instance:LMPK12050383
 xref_mesh: MESH:C530234
 xref: PMID:12567273;   PMID:19003948;   PMID:20349151;   PMID:21495101;   PMID:22388969;   Reaxys:1264266;   Wikipedia:Irilone


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irilone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases expression ISO irilone results in increased expression of AR mRNA CTD PMID:23982890 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO irilone results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO irilone results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO irilone results in increased expression of ESR2 mRNA CTD PMID:23982890 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Pgr progesterone receptor increases expression ISO irilone results in increased expression of PGR mRNA CTD PMID:23982890 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        immunomodulator 14903
          irilone 5
            irilone-4'-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside] 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        cyclic ketone 15393
                                          isoflavones 3758
                                            hydroxyisoflavone 3691
                                              irilone 5
                                                irilone-4'-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside] 0
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