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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:irilone
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Accession:CHEBI:5970 term browser browse the term
Definition:A hydroxyisoflavone that is 6,7-methylenedioxyisoflavone substituted by hydroxy groups at positions 5 and 4'.
Synonyms:exact_synonym: 9-hydroxy-7-(4-hydroxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromen-8-one
 related_synonym: 5,4'-dihydroxy-6,7-methylenedioxyisoflavone;   9-Hydroxy-7-(4-hydroxyphenyl)-8H-1,3-dioxolo[4,5-g]-1-benzopyran-8-one;   Formula=C16H10O6;   InChI=1S/C16H10O6/c17-9-3-1-8(2-4-9)10-6-20-11-5-12-16(22-7-21-12)15(19)13(11)14(10)18/h1-6,17,19H,7H2;   InChIKey=NUGRQNBDTZWXTP-UHFFFAOYSA-N;   Irolone;   SMILES=Oc1ccc(cc1)-c1coc2cc3OCOc3c(O)c2c1=O
 xref: CAS:41653-81-0;   HMDB:HMDB0033820;   KEGG:C10467;   KNApSAcK:C00002539;   LIPID_MAPS_instance:LMPK12050383
 xref_mesh: MESH:C530234
 xref: PMID:12567273;   PMID:19003948;   PMID:20349151;   PMID:21495101;   PMID:22388969;   Reaxys:1264266;   Wikipedia:Irilone


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irilone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases expression ISO irilone results in increased expression of AR mRNA CTD PMID:23982890 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO irilone results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO irilone results in increased expression of ESR2 mRNA CTD PMID:23982890 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Pgr progesterone receptor increases expression ISO irilone results in increased expression of PGR mRNA CTD PMID:23982890 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        immunomodulator 13691
          irilone 4
            irilone-4'-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside] 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        cyclic ketone 13813
                                          isoflavones 3731
                                            hydroxyisoflavone 3663
                                              irilone 4
                                                irilone-4'-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside] 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.