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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrenes
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Accession:CHEBI:59659 term browser browse the term


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1,3-Dinitropyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP 1,3-dinitropyrene results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:17240030 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
increases phosphorylation		 EXP 1,3-dinitropyrene results in decreased phosphorylation of BAD protein
1,3-dinitropyrene results in increased phosphorylation of BAD protein		 CTD PMID:17240030 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression EXP 1,3-dinitropyrene results in decreased expression of BCL2L1 protein CTD PMID:17240030 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression EXP 1,3-dinitropyrene results in decreased expression of BID protein CTD PMID:17240030 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP 1,3-dinitropyrene results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:17240030 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP 1,3-dinitropyrene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17240030 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
affects metabolic processing
increases expression		 ISO
EXP		 [CYP1A1 protein co-treated with POR protein] results in decreased metabolism of 1,3-dinitropyrene
CYP1A1 protein affects the metabolism of 1,3-dinitropyrene
1,3-dinitropyrene results in increased expression of CYP1A1 protein
1,3-dinitropyrene results in increased expression of CYP1A1 mRNA		 CTD PMID:2180560 PMID:11113705 PMID:12107646 PMID:17240030 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing		 ISO [CYP1A2 protein co-treated with POR protein] results in decreased metabolism of 1,3-dinitropyrene
CYP1A2 protein affects the metabolism of 1,3-dinitropyrene		 CTD PMID:2180560 PMID:11113705 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 1,3-dinitropyrene CTD PMID:11113705 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP 1,3-dinitropyrene results in increased phosphorylation of MAPK8 protein CTD PMID:17240030 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects response to substance
increases reduction		 ISO NQO1 protein affects the susceptibility to 1,3-dinitropyrene
NQO1 protein results in increased reduction of 1,3-dinitropyrene		 CTD PMID:1774770 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP1A1 protein co-treated with POR protein] results in decreased metabolism of 1,3-dinitropyrene; [CYP1A2 protein co-treated with POR protein] results in decreased metabolism of 1,3-dinitropyrene; [CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 1,3-dinitropyrene CTD PMID:11113705 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Trp53 transformation related protein 53 increases phosphorylation
affects localization		 EXP 1,3-dinitropyrene results in increased phosphorylation of TRP53 protein
1,3-dinitropyrene affects the localization of TRP53 protein		 CTD PMID:17240030 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
1,6-Dinitropyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing
increases expression		 ISO CYP1A1 protein affects the metabolism of 1,6-dinitropyrene
1,6-dinitropyrene results in increased expression of CYP1A1 mRNA		 CTD PMID:2180560 PMID:12107646 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of 1,6-dinitropyrene CTD PMID:2180560 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases response to substance
increases reduction		 ISO NQO1 protein results in increased susceptibility to 1,6-dinitropyrene
NQO1 protein results in increased reduction of 1,6-dinitropyrene		 CTD PMID:1774770 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
1,8-Dinitropyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c18 aldo-keto reductase family 1, member C18 multiple interactions ISO [AKR1C3 protein results in increased degradation of 1,8-dinitropyrene] which results in increased abundance of 1-amino-8-nitropyrene CTD PMID:36399404 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 multiple interactions ISO [AKR1C1 protein results in increased degradation of 1,8-dinitropyrene] which results in increased abundance of 1-amino-8-nitropyrene CTD PMID:36399404 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP 1,8-dinitropyrene results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:17240030 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP 1,8-dinitropyrene results in increased expression of BID protein CTD PMID:17240030 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
affects metabolic processing		 ISO
EXP		 [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1,8-dinitropyrene
1,8-dinitropyrene results in increased expression of CYP1A1 protein
1,8-dinitropyrene results in increased expression of CYP1A1 mRNA
CYP1A1 protein affects the metabolism of 1,8-dinitropyrene		 CTD PMID:2180560 PMID:11113705 PMID:12107646 PMID:17240030 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of 1,8-dinitropyrene CTD PMID:2180560 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions		 ISO 1,8-dinitropyrene results in increased expression of CYP1B1 mRNA
[CYP1B1 protein co-treated with POR protein] results in increased metabolism of 1,8-dinitropyrene		 CTD PMID:11113705 PMID:21887816 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Ereg epiregulin increases expression ISO 1,8-dinitropyrene results in increased expression of EREG mRNA CTD PMID:21887816 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases response to substance
increases reduction		 ISO NQO1 protein results in increased susceptibility to 1,8-dinitropyrene
NQO1 protein results in increased reduction of 1,8-dinitropyrene		 CTD PMID:1774770 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1,8-dinitropyrene; [CYP1B1 protein co-treated with POR protein] results in increased metabolism of 1,8-dinitropyrene CTD PMID:11113705 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO 1,8-dinitropyrene results in increased expression of TIPARP mRNA CTD PMID:21887816 NCBI chr 3:65,435,868...65,462,939
Ensembl chr 3:65,435,831...65,462,939 		JBrowse link
G Trp53 transformation related protein 53 increases phosphorylation EXP 1,8-dinitropyrene results in increased phosphorylation of TRP53 protein CTD PMID:17240030 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
1-Aminopyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO 1-aminopyrene binds to and results in increased activity of AHR protein CTD PMID:28186253 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 multiple interactions ISO [AKR1C3 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene CTD PMID:36399404 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 multiple interactions ISO [AKR1C1 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene CTD PMID:36399404 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Ar androgen receptor multiple interactions ISO 1-aminopyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO 1-aminopyrene results in increased expression of CCL5 mRNA CTD PMID:19879285 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases secretion ISO 1-aminopyrene results in increased secretion of CXCL8 protein CTD PMID:19879285 PMID:23458896 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO CYP1A2 protein results in increased activity of 1-aminopyrene CTD PMID:15728263 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO 1-aminopyrene results in increased expression of CYP1B1 mRNA CTD PMID:12107646 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Il5 interleukin 5 increases secretion ISO 1-aminopyrene results in increased secretion of IL5 protein CTD PMID:19879285 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-aminopyrene CTD PMID:23458896 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
1-Hydroxypyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases secretion
multiple interactions		 ISO ABCG2 protein results in increased secretion of 1-hydroxypyrene metabolite
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased secretion of 1-hydroxypyrene metabolite]		 CTD PMID:24140465 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 decreases expression ISO 1-hydroxypyrene results in decreased expression of AIFM3 mRNA CTD PMID:21854004 NCBI chr16:17,307,418...17,325,349
Ensembl chr16:17,307,475...17,325,349 		JBrowse link
G Ar androgen receptor multiple interactions ISO 1-hydroxypyrene binds to and results in decreased activity of AR protein; 1-hydroxypyrene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; 1-hydroxypyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 PMID:27436773 PMID:33049310 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arfgap2 ADP-ribosylation factor GTPase activating protein 2 decreases expression ISO 1-hydroxypyrene results in decreased expression of ARFGAP2 mRNA CTD PMID:21854004 NCBI chr 2:91,095,460...91,107,716
Ensembl chr 2:91,095,319...91,107,276 		JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO 1-hydroxypyrene results in decreased expression of ASXL2 mRNA CTD PMID:21854004 NCBI chr12:3,476,892...3,560,811
Ensembl chr12:3,476,857...3,556,852 		JBrowse link
G C3 complement component 3 increases expression ISO 1-hydroxypyrene results in increased expression of C3 mRNA CTD PMID:22989670 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Cldn15 claudin 15 decreases expression ISO 1-hydroxypyrene results in decreased expression of CLDN15 mRNA CTD PMID:21854004 NCBI chr 5:136,996,723...137,004,699
Ensembl chr 5:136,995,470...137,004,712 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases secretion ISO CYP1A1 gene polymorphism results in decreased secretion of 1-hydroxypyrene CTD PMID:21787681 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Dazap1 DAZ associated protein 1 decreases expression ISO 1-hydroxypyrene results in decreased expression of DAZAP1 mRNA CTD PMID:21854004 NCBI chr10:80,097,168...80,124,242
Ensembl chr10:80,097,320...80,124,242 		JBrowse link
G E4f1 E4F transcription factor 1 decreases expression ISO 1-hydroxypyrene results in decreased expression of E4F1 mRNA CTD PMID:21854004 NCBI chr17:24,662,752...24,674,366
Ensembl chr17:24,662,752...24,689,287 		JBrowse link
G Erp27 endoplasmic reticulum protein 27 decreases expression ISO 1-hydroxypyrene results in decreased expression of ERP27 mRNA CTD PMID:21854004 NCBI chr 6:136,884,312...136,899,465
Ensembl chr 6:136,884,309...136,899,178 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO 1-hydroxypyrene binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
affects binding		 ISO 1-hydroxypyrene binds to and results in increased activity of ESR2 protein; 1-hydroxypyrene inhibits the reaction [ESR2 protein binds to Estradiol]
ESR2 protein binds to 1-hydroxypyrene		 CTD PMID:22989670 PMID:33049310 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Faap100 Fanconi anemia core complex associated protein 100 decreases expression ISO 1-hydroxypyrene results in decreased expression of FAAP100 mRNA CTD PMID:21854004 NCBI chr11:120,260,388...120,269,572
Ensembl chr11:120,259,881...120,269,590 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in decreased expression of FOXP3 mRNA CTD PMID:30951957 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Fst follistatin multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in increased expression of FST protein CTD PMID:31228248 NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487 		JBrowse link
G Gimap6 GTPase, IMAP family member 6 increases expression ISO 1-hydroxypyrene results in increased expression of GIMAP6 mRNA CTD PMID:21854004 NCBI chr 6:48,678,517...48,685,178
Ensembl chr 6:48,678,516...48,685,159 		JBrowse link
G Gm34066 predicted gene, 34066 decreases expression ISO 1-hydroxypyrene results in decreased expression of C2ORF66 mRNA CTD PMID:21854004 NCBI chr 1:54,481,731...54,495,945
Ensembl chr 1:54,482,563...54,495,922 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases secretion ISO GSTM1 gene polymorphism results in decreased secretion of 1-hydroxypyrene CTD PMID:21787681 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases secretion ISO GSTP1 gene polymorphism results in decreased secretion of 1-hydroxypyrene CTD PMID:21787681 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Haghl hydroxyacylglutathione hydrolase-like decreases expression ISO 1-hydroxypyrene results in decreased expression of HAGHL mRNA CTD PMID:21854004 NCBI chr17:25,998,817...26,004,560
Ensembl chr17:25,998,817...26,004,647 		JBrowse link
G Hspb1 heat shock protein 1 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in increased expression of HSPB1 protein CTD PMID:31228248 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Il16 interleukin 16 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in increased expression of IL16 protein CTD PMID:31228248 NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934 		JBrowse link
G Itsn2 intersectin 2 increases expression ISO 1-hydroxypyrene results in increased expression of ITSN2 mRNA CTD PMID:21854004 NCBI chr12:4,642,792...4,763,952
Ensembl chr12:4,642,638...4,763,962 		JBrowse link
G Jag1 jagged 1 decreases expression ISO 1-hydroxypyrene results in decreased expression of JAG1 mRNA CTD PMID:22989670 NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564 		JBrowse link
G Lrp12 low density lipoprotein-related protein 12 decreases expression ISO 1-hydroxypyrene results in decreased expression of LRP12 mRNA CTD PMID:21854004 NCBI chr15:39,733,985...39,807,417
Ensembl chr15:39,733,985...39,807,390 		JBrowse link
G Myo15b myosin XVB decreases expression ISO 1-hydroxypyrene results in decreased expression of MYO15B mRNA CTD PMID:21854004 NCBI chr11:115,749,002...115,783,443
Ensembl chr11:115,749,232...115,783,429 		JBrowse link
G Nipal4 NIPA-like domain containing 4 increases expression ISO 1-hydroxypyrene results in increased expression of NIPAL4 mRNA CTD PMID:21854004 NCBI chr11:46,038,982...46,057,186
Ensembl chr11:46,038,982...46,057,335 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO
EXP		 1-hydroxypyrene binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 1-hydroxypyrene results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO 1-hydroxypyrene results in increased expression of NRIP1 mRNA CTD PMID:22989670 NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO 1-hydroxypyrene inhibits the reaction [Progesterone binds to PGR protein]; [Progesterone co-treated with 1-hydroxypyrene] results in decreased expression of PGR mRNA CTD PMID:9144411 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Phf2 PHD finger protein 2 increases expression ISO 1-hydroxypyrene results in increased expression of PHF2 mRNA CTD PMID:21854004 NCBI chr13:48,955,226...49,024,361
Ensembl chr13:48,955,226...49,024,595 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP		 1-hydroxypyrene binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO 1-hydroxypyrene results in increased expression of PTGR1 mRNA CTD PMID:21854004 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119 		JBrowse link
G Slc12a7 solute carrier family 12, member 7 decreases expression ISO 1-hydroxypyrene results in decreased expression of SLC12A7 mRNA CTD PMID:21854004 NCBI chr13:73,881,172...73,964,873
Ensembl chr13:73,881,213...73,964,873 		JBrowse link
G Slc25a34 solute carrier family 25, member 34 decreases expression ISO 1-hydroxypyrene results in decreased expression of SLC25A34 mRNA CTD PMID:21854004 NCBI chr 4:141,346,130...141,351,202
Ensembl chr 4:141,346,135...141,351,132 		JBrowse link
G Spns3 SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) decreases expression ISO 1-hydroxypyrene results in decreased expression of SPNS3 mRNA CTD PMID:21854004 NCBI chr11:72,388,979...72,441,334
Ensembl chr11:72,385,745...72,441,332 		JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 increases metabolic processing ISO SULT1A2 protein results in increased metabolism of 1-hydroxypyrene CTD PMID:24140465 NCBI chr 7:126,272,042...126,289,615
Ensembl chr 7:126,272,037...126,275,604 		JBrowse link
G Sult1b1 sulfotransferase family 1B, member 1 increases metabolic processing ISO SULT1B1 protein results in increased metabolism of 1-hydroxypyrene CTD PMID:24140465 NCBI chr 5:87,661,186...87,686,054
Ensembl chr 5:87,661,198...87,686,054 		JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 decreases activity
increases sulfation
multiple interactions		 ISO 1-hydroxypyrene results in decreased activity of SULT1E1 protein
SULT1E1 protein results in increased sulfation of 1-hydroxypyrene
acetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol inhibits the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1E1 protein]		 CTD PMID:14570759 PMID:16914110 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453 		JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 multiple interactions ISO Dimethylformamide inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT2A1 protein] CTD PMID:14570759 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in decreased expression of TGFB1 mRNA CTD PMID:30951957 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO 1-hydroxypyrene binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Tmem234 transmembrane protein 234 decreases expression ISO 1-hydroxypyrene results in decreased expression of TMEM234 mRNA CTD PMID:21854004 NCBI chr 4:129,494,449...129,502,326
Ensembl chr 4:129,494,461...129,517,852 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:21164388 NCBI chr 5:87,607,349...87,638,730
Ensembl chr 5:87,607,349...87,638,730 		JBrowse link
G Vmn1r237 vomeronasal 1 receptor 237 decreases expression ISO 1-hydroxypyrene results in decreased expression of VN1R4 mRNA CTD PMID:21854004 NCBI chr17:21,534,279...21,535,148
Ensembl chr17:21,532,127...21,535,174 		JBrowse link
G Zfp335 zinc finger protein 335 decreases expression ISO 1-hydroxypyrene results in decreased expression of ZNF335 mRNA CTD PMID:21854004 NCBI chr 2:164,733,802...164,756,034
Ensembl chr 2:164,733,802...164,753,677 		JBrowse link
1-Methylpyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with SULT1A1 protein] results in increased susceptibility to 1-methylpyrene CTD PMID:33035519 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]; [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene; Pentachlorophenol inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene] CTD PMID:25243916 PMID:27913846 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]; [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene; Pentachlorophenol inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene] CTD PMID:25243916 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
4-Nitropyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor multiple interactions EXP [Particulate Matter results in increased abundance of 4-nitropyrene] which results in increased secretion of TNF protein CTD PMID:32007923 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Benzo[a]pyrene-7,8-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions
increases expression
increases export		 ISO [ABCC4 protein results in increased export of benzo(a)pyrene 7,8-dihydrodiol] which results in decreased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA
benzo(a)pyrene 7,8-dihydrodiol results in increased expression of ABCC4 mRNA; benzo(a)pyrene 7,8-dihydrodiol results in increased expression of ABCC4 protein		 CTD PMID:22155354 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 multiple interactions
decreases response to substance		 ISO [AKR1A1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol; AKR1A1 protein affects the metabolism of and results in increased activity of benzo(a)pyrene 7,8-dihydrodiol; NAD promotes the reaction [AKR1A1 protein affects the metabolism of and results in increased activity of benzo(a)pyrene 7,8-dihydrodiol]; NADP promotes the reaction [AKR1A1 protein affects the metabolism of and results in increased activity of benzo(a)pyrene 7,8-dihydrodiol]; ponalrestat inhibits the reaction [AKR1A1 protein results in decreased susceptibility to benzo(a)pyrene 7,8-dihydrodiol] CTD PMID:15720144 PMID:21910479 PMID:22053912 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO [AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:21910479 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413 		JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 multiple interactions ISO [AKR1B10 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:21910479 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 multiple interactions ISO [AKR1C3 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:21910479 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 multiple interactions ISO [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:21910479 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 multiple interactions ISO [AKR1C2 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:21910479 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Akr1c6 aldo-keto reductase family 1, member C6 multiple interactions ISO [AKR1C4 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:21910479 NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
increases phosphorylation		 ISO benzo(a)pyrene 7,8-dihydrodiol results in decreased expression of BAD protein
benzo(a)pyrene 7,8-dihydrodiol results in increased phosphorylation of BAD protein		 CTD PMID:15698582 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO benzo(a)pyrene 7,8-dihydrodiol results in decreased expression of BCL2L1 protein CTD PMID:15698582 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO benzo(a)pyrene 7,8-dihydrodiol results in decreased expression of BID protein CTD PMID:15698582 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
increases chemical synthesis		 ISO
EXP		 benzo(a)pyrene 7,8-dihydrodiol results in increased expression of CYP1A1 mRNA
[CYP1A1 protein results in increased metabolism of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol
[[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol
[Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] which results in increased secretion of benzo(a)pyrene 7,8-dihydrodiol; benzo(a)pyrene 7,8-dihydrodiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; CYP1A1 protein affects the metabolism of and results in increased activity of benzo(a)pyrene 7,8-dihydrodiol; CYP1A1 protein promotes the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased mutagenesis of HPRT1 gene]; GSTM1 protein inhibits the reaction [CYP1A1 protein promotes the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased mutagenesis of HPRT1 gene]]; hyperforin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]; hypericin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]; Medroxyprogesterone Acetate inhibits the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased expression of CYP1A1 mRNA]; pseudohypericin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]; Quercetin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]; Ursodeoxycholic Acid inhibits the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol		 CTD PMID:2154339 PMID:10706104 PMID:14633740 PMID:15720144 PMID:17525473 More... NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
affects metabolic processing
increases chemical synthesis
increases oxidation
multiple interactions		 ISO benzo(a)pyrene 7,8-dihydrodiol results in increased expression of CYP1B1 mRNA
CYP1B1 affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol
CYP1B1 protein results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol
CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol
benzo(a)pyrene 7,8-dihydrodiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; bergamottin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]; CYP1B1 protein affects the metabolism of and results in increased activity of benzo(a)pyrene 7,8-dihydrodiol; imperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]; isoimperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]; isopimpinellin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]; NADP promotes the reaction [CYP1B1 protein affects the metabolism of and results in increased activity of benzo(a)pyrene 7,8-dihydrodiol]		 CTD PMID:15720144 PMID:15861043 PMID:19879933 PMID:21028851 PMID:24025706 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 multiple interactions ISO [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol; [[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:19713358 NCBI chr 7:25,501,894...25,515,950
Ensembl chr 7:25,501,900...25,516,338 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal multiple interactions ISO [[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:24530354 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO GSTM1 protein inhibits the reaction [CYP1A1 protein promotes the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased mutagenesis of HPRT1 gene]] CTD PMID:17525473 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO CYP1A1 protein promotes the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased mutagenesis of HPRT1 gene]; GSTM1 protein inhibits the reaction [CYP1A1 protein promotes the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased mutagenesis of HPRT1 gene]] CTD PMID:17525473 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene increases expression ISO benzo(a)pyrene 7,8-dihydrodiol results in increased expression of HRAS mRNA CTD PMID:11008122 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 increases phosphorylation ISO benzo(a)pyrene 7,8-dihydrodiol results in increased phosphorylation of MAPK14 protein CTD PMID:15698582 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO benzo(a)pyrene 7,8-dihydrodiol results in increased phosphorylation of MAPK8 protein CTD PMID:15698582 PMID:22053912 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO benzo(a)pyrene 7,8-dihydrodiol results in increased expression of NQO1 mRNA CTD PMID:11008122 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [benzo(a)pyrene 7,8-dihydrodiol binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; benzo(a)pyrene 7,8-dihydrodiol binds to and results in increased activity of NR1I2 protein CTD PMID:23845848 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased cleavage of PARP1 protein] CTD PMID:15572374 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:24530354 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:11159734 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:11159734 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein inhibits the reaction [Benzo(a)pyrene results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol] CTD PMID:24025706 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases chemical synthesis		 ISO [TP53 protein results in increased susceptibility to Etoposide] which results in decreased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol; benzo(a)pyrene 7,8-dihydrodiol results in increased expression of and results in increased phosphorylation of TP53 protein; Etoposide promotes the reaction [TP53 protein results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol] CTD PMID:15698582 PMID:29471073 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of benzo(a)pyrene 7,8-dihydrodiol CTD PMID:21164388 NCBI chr 5:87,607,349...87,638,730
Ensembl chr 5:87,607,349...87,638,730 		JBrowse link
benzo[a]pyrene-7,8-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor affects localization
multiple interactions		 ISO
EXP		 benzo(a)pyrene-7,8-dione affects the localization of AHR protein
AHR protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]		 CTD PMID:10706104 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 increases chemical synthesis
multiple interactions
affects chemical synthesis
increases expression		 ISO AKR1A1 protein results in increased chemical synthesis of benzo(a)pyrene-7,8-dione
[AKR1A1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione; AKR1A1 protein results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione; NAD promotes the reaction [AKR1A1 protein affects the chemical synthesis of benzo(a)pyrene-7,8-dione]
benzo(a)pyrene-7,8-dione results in increased expression of AKR1A1 mRNA		 CTD PMID:9973208 PMID:15720144 PMID:16411658 PMID:21910479 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO [AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413 		JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 multiple interactions ISO [AKR1B10 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 multiple interactions ISO [AKR1C3 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 multiple interactions
increases expression		 ISO [AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione
benzo(a)pyrene-7,8-dione results in increased expression of AKR1C1 mRNA		 CTD PMID:9973208 PMID:21910479 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 multiple interactions ISO [AKR1C2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Akr1c6 aldo-keto reductase family 1, member C6 multiple interactions ISO [AKR1C4 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876 		JBrowse link
G Akr7a5 aldo-keto reductase family 7, member A5 multiple interactions ISO [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in decreased abundance of Oxygen; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Hydrogen Peroxide; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides; [AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 4:139,038,005...139,046,097
Ensembl chr 4:139,038,055...139,045,737 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP ARNT protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA] CTD PMID:10706104 NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 EXP
ISO		 AHR protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]; ARNT protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA] CTD PMID:9973208 PMID:10706104 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO benzo(a)pyrene-7,8-dione results in increased expression of and results in increased activity of CYP1B1 protein
benzo(a)pyrene-7,8-dione results in increased expression of CYP1B1 mRNA		 CTD PMID:16411658 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO alpha-Tocopherol inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]
benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 mRNA; benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein		 CTD PMID:22053912 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP benzo(a)pyrene-7,8-dione results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:12213569 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP benzo(a)pyrene-7,8-dione results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:12213569 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions		 ISO benzo(a)pyrene-7,8-dione results in increased expression of NQO1 mRNA; benzo(a)pyrene-7,8-dione results in increased expression of NQO1 protein
[NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione		 CTD PMID:21910479 PMID:22053912 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 increases metabolic processing ISO SULT1E1 protein results in increased metabolism of benzo(a)pyrene-7,8-dione CTD PMID:22782890 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453 		JBrowse link
Benzo[a]pyrene-7,8-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene multiple interactions ISO CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of benzo(a)pyrene 7,8-oxide] CTD PMID:12051674 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal multiple interactions ISO CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of benzo(a)pyrene 7,8-oxide] CTD PMID:12051674 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
Cyclopenta[cd]pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO cyclopenta(c,d)pyrene binds to and results in increased activity of AHR protein CTD PMID:11525907 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog increases mutagenesis EXP cyclopenta(c,d)pyrene results in increased mutagenesis of KRAS gene CTD PMID:9659573 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
Indeno[1,2,3-cd]pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP-binding cassette, sub-family C member 5 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of ABCC5 mRNA CTD PMID:32251684 NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144 		JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ACSM3 mRNA CTD PMID:26377693 NCBI chr 7:119,360,106...119,384,119
Ensembl chr 7:119,360,146...119,386,736 		JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif 15 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ADAMTS15 mRNA CTD PMID:26377693 NCBI chr 9:30,810,451...30,833,853
Ensembl chr 9:30,810,451...30,833,748 		JBrowse link
G Adig adipogenin decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ADIG mRNA CTD PMID:26377693 NCBI chr 2:158,344,532...158,350,118
Ensembl chr 2:158,344,532...158,350,118 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ADIPOQ mRNA CTD PMID:26377693 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adora1 adenosine A1 receptor decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of ADORA1 mRNA CTD PMID:32251684 NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases expression
increases activity		 ISO
EXP		 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of AHR protein]; 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [indeno(1,2,3-cd)pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene] promotes the reaction [pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with pyrene] promotes the reaction [fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [chrysene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(k)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(j)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benz(a)anthracene results in increased activity of AHR protein]; [indeno(1,2,3-cd)pyrene results in increased expression of AHR protein] which results in increased abundance of Kynurenine; AHR promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of IKZF1 protein]; AHR promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CCND1 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of E2F1 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETV6 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MKI67 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MYC protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of RUNX1 protein]; epacadostat inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of AHR protein]; indeno(1,2,3-cd)pyrene promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]; U 0126 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of AHR protein]
AHR protein affects the reaction [[indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of IRF4 mRNA]; AHR protein affects the reaction [indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of BCL6 mRNA]]; AHR protein affects the reaction [indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL21 mRNA]]
indeno(1,2,3-cd)pyrene results in increased expression of AHR mRNA; indeno(1,2,3-cd)pyrene results in increased expression of AHR protein
indeno(1,2,3-cd)pyrene binds to and results in increased activity of AHR protein		 CTD PMID:11525907 PMID:12371477 PMID:12850102 PMID:17665671 PMID:21781905 More... NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of AHRR mRNA CTD PMID:32251684 NCBI chr13:74,359,237...74,440,450
Ensembl chr13:74,359,237...74,440,450 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ALDH1A2 mRNA CTD PMID:26377693 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of ALDH1A3 mRNA CTD PMID:32251684 NCBI chr 7:66,040,640...66,077,225
Ensembl chr 7:66,040,638...66,077,265 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of ALDH3A1 mRNA CTD PMID:32251684 NCBI chr11:61,099,336...61,109,244
Ensembl chr11:61,098,363...61,109,247 		JBrowse link
G Amer2 APC membrane recruitment 2 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of AMER2 mRNA CTD PMID:32251684 NCBI chr14:60,615,141...60,625,642
Ensembl chr14:60,610,708...60,625,646 		JBrowse link
G Amy1 amylase 1, salivary decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of AMY1 mRNA CTD PMID:26377693 NCBI chr 3:113,349,601...113,371,399
Ensembl chr 3:113,349,359...113,400,348 		JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ANGPTL4 mRNA CTD PMID:26377693 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804 		JBrowse link
G Areg amphiregulin decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of AREG mRNA CTD PMID:26377693 NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291 		JBrowse link
G Arl4d ADP-ribosylation factor-like 4D decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ARL4D mRNA CTD PMID:26377693 NCBI chr11:101,556,367...101,558,658
Ensembl chr11:101,556,367...101,558,658 		JBrowse link
G Arxes2 adipocyte-related X-chromosome expressed sequence 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ARXES2 mRNA CTD PMID:26377693 NCBI chr  X:134,894,569...134,896,108
Ensembl chr  X:134,894,573...134,896,104 		JBrowse link
G Asgr2 asialoglycoprotein receptor 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ASGR2 mRNA CTD PMID:26377693 NCBI chr11:69,983,470...69,997,013
Ensembl chr11:69,983,470...69,997,013 		JBrowse link
G Atoh8 atonal bHLH transcription factor 8 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of ATOH8 mRNA CTD PMID:32251684 NCBI chr 6:72,183,158...72,212,765
Ensembl chr 6:72,183,161...72,212,561 		JBrowse link
G Baiap2l1 BAI1-associated protein 2-like 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of BAIAP2L1 mRNA CTD PMID:26377693 NCBI chr 5:144,201,335...144,294,922
Ensembl chr 5:144,201,336...144,294,922 		JBrowse link
G Batf basic leucine zipper transcription factor, ATF-like multiple interactions EXP [indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of BATF mRNA CTD PMID:36975775 NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861 		JBrowse link
G Bche butyrylcholinesterase decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of BCHE mRNA CTD PMID:26377693 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bcl6 B cell leukemia/lymphoma 6 decreases expression
multiple interactions		 EXP indeno(1,2,3-cd)pyrene results in decreased expression of BCL6 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of BCL6 mRNA]]; AHR protein affects the reaction [indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of BCL6 mRNA]]; indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of BCL6 mRNA]		 CTD PMID:26377693 PMID:36975775 NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of BMAL1 mRNA CTD PMID:26377693 NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333 		JBrowse link
G Bnc1 basonuclin zinc finger protein 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of BNC1 mRNA CTD PMID:26377693 NCBI chr 7:81,616,401...81,642,047
Ensembl chr 7:81,616,401...81,642,055 		JBrowse link
G Bpifa1 BPI fold containing family A, member 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of BPIFA1 mRNA CTD PMID:26377693 NCBI chr 2:153,984,800...153,991,137
Ensembl chr 2:153,984,800...153,991,139 		JBrowse link
G C2 complement C2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of C2 mRNA CTD PMID:26377693 NCBI chr17:35,081,578...35,101,076
Ensembl chr17:35,081,580...35,117,241 		JBrowse link
G Cacybp calcyclin binding protein decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CACYBP mRNA CTD PMID:26377693 NCBI chr 1:160,029,171...160,040,391
Ensembl chr 1:160,029,937...160,040,445 		JBrowse link
G Cadm1 cell adhesion molecule 1 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of CADM1 mRNA CTD PMID:21635667 NCBI chr 9:47,441,468...47,773,578
Ensembl chr 9:47,441,471...47,769,413 		JBrowse link
G Car14 carbonic anhydrase 14 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CAR14 mRNA CTD PMID:26377693 NCBI chr 3:95,805,080...95,812,443
Ensembl chr 3:95,805,080...95,812,003 		JBrowse link
G Car3 carbonic anhydrase 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CAR3 mRNA CTD PMID:26377693 NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583 		JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CCDC80 mRNA CTD PMID:26377693 NCBI chr16:44,913,770...44,948,287
Ensembl chr16:44,913,765...44,948,440 		JBrowse link
G Ccdc85a coiled-coil domain containing 85A decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CCDC85A mRNA CTD PMID:26377693 NCBI chr11:28,335,688...28,537,234
Ensembl chr11:28,335,685...28,534,324 		JBrowse link
G Ccl8 C-C motif chemokine ligand 8 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CCL8 mRNA CTD PMID:26377693 NCBI chr11:82,006,011...82,007,625
Ensembl chr11:82,006,011...82,007,625 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of CCNA2 mRNA CTD PMID:32251684 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 ISO indeno(1,2,3-cd)pyrene results in increased expression of CCND1 mRNA
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CCND1 protein]; 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CCND1 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CCND1 protein]; epacadostat inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CCND1 protein]; U 0126 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CCND1 protein]		 CTD PMID:35687267 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of CCNG2 mRNA CTD PMID:32251684 NCBI chr 5:93,415,432...93,424,090
Ensembl chr 5:93,415,116...93,424,090 		JBrowse link
G Ccnjl cyclin J-like decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CCNJL mRNA CTD PMID:26377693 NCBI chr11:43,419,576...43,477,826
Ensembl chr11:43,419,611...43,477,824 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of CEBPB mRNA CTD PMID:32251684 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CEBPD mRNA CTD PMID:26377693 NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895 		JBrowse link
G Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of CELSR2 mRNA CTD PMID:21635667 PMID:32251684 NCBI chr 3:108,298,164...108,323,416
Ensembl chr 3:108,298,167...108,323,383 		JBrowse link
G Cenpa centromere protein A decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of CENPA mRNA CTD PMID:32251684 NCBI chr 5:30,824,214...30,832,181
Ensembl chr 5:30,824,121...30,832,174 		JBrowse link
G Cfd complement factor D decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CFD mRNA CTD PMID:26377693 NCBI chr10:79,726,687...79,728,489
Ensembl chr10:79,726,687...79,728,489 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CHORDC1 mRNA CTD PMID:26377693 NCBI chr 9:18,203,563...18,225,296
Ensembl chr 9:18,203,421...18,228,738 		JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CIDEA mRNA CTD PMID:26377693 NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855 		JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CKMT2 mRNA CTD PMID:26377693 NCBI chr13:92,001,510...92,025,001
Ensembl chr13:92,001,506...92,025,004 		JBrowse link
G Cldn17 claudin 17 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of CLDN17 mRNA CTD PMID:21635667 NCBI chr16:88,302,695...88,303,866
Ensembl chr16:88,302,695...88,303,866 		JBrowse link
G Clec10a C-type lectin domain family 10, member A decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CLEC10A mRNA CTD PMID:26377693 NCBI chr11:70,057,449...70,061,662
Ensembl chr11:70,047,023...70,061,660 		JBrowse link
G Clec9a C-type lectin domain family 9, member a decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CLEC9A mRNA CTD PMID:26377693 NCBI chr 6:129,385,825...129,401,727
Ensembl chr 6:129,385,825...129,401,726 		JBrowse link
G Clic4 chloride intracellular channel 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CLIC4 mRNA CTD PMID:26377693 NCBI chr 4:134,941,280...135,000,071
Ensembl chr 4:134,941,280...135,000,125 		JBrowse link
G Col2a1 collagen, type II, alpha 1 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of COL2A1 mRNA CTD PMID:21635667 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576 		JBrowse link
G Col4a6 collagen, type IV, alpha 6 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of COL4A6 mRNA CTD PMID:21635667 NCBI chr  X:139,948,399...140,257,091
Ensembl chr  X:139,948,399...140,257,072 		JBrowse link
G Cox7a1 cytochrome c oxidase subunit 7A1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of COX7A1 mRNA CTD PMID:26377693 NCBI chr 7:29,883,596...29,885,455
Ensembl chr 7:29,883,569...29,885,503 		JBrowse link
G Cox8b cytochrome c oxidase subunit 8B decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of COX8B mRNA CTD PMID:26377693 NCBI chr 7:140,478,855...140,480,359
Ensembl chr 7:140,478,858...140,480,359 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of CREB1 mRNA CTD PMID:32251684 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CSRP3 mRNA CTD PMID:26377693 NCBI chr 7:48,480,146...48,497,799
Ensembl chr 7:48,480,146...48,497,781 		JBrowse link
G Ctsb cathepsin B decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of CTSB mRNA CTD PMID:32251684 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Ctsd cathepsin D decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of CTSD mRNA CTD PMID:32251684 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of CXCL12 mRNA CTD PMID:32251684 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of CXCL5 mRNA CTD PMID:26377693 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity		 ISO
EXP		 Dexamethasone inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CYP1A1 protein]; indeno(1,2,3-cd)pyrene promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]
[indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of CYP1A1 mRNA
indeno(1,2,3-cd)pyrene results in increased activity of CYP1A1 protein
indeno(1,2,3-cd)pyrene results in increased expression of CYP1A1 mRNA; indeno(1,2,3-cd)pyrene results in increased expression of CYP1A1 protein		 CTD PMID:10190573 PMID:17253728 PMID:19463884 PMID:21781905 PMID:26377693 More... NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of CYP1A2 mRNA CTD PMID:17253728 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions		 ISO indeno(1,2,3-cd)pyrene results in increased expression of CYP1B1 mRNA; indeno(1,2,3-cd)pyrene results in increased expression of CYP1B1 protein
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CYP1B1 protein]; 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CYP1B1 protein]; epacadostat inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CYP1B1 protein]; U 0126 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CYP1B1 protein]		 CTD PMID:17253728 PMID:27196671 PMID:35687267 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of DDIT4 mRNA CTD PMID:32251684 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of DGAT2 mRNA CTD PMID:26377693 NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926 		JBrowse link
G Dnaaf10 dynein axonemal assembly factor 10 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of DNAAF10 mRNA CTD PMID:26377693 NCBI chr11:17,161,893...17,185,200
Ensembl chr11:17,132,107...17,183,796 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of DNAJA1 mRNA CTD PMID:26377693 NCBI chr 4:40,722,468...40,734,965
Ensembl chr 4:40,722,150...40,737,149 		JBrowse link
G Dpt dermatopontin decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of DPT mRNA CTD PMID:26377693 NCBI chr 1:164,624,232...164,651,843
Ensembl chr 1:164,624,213...164,651,835 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of DVL3 mRNA CTD PMID:26377693 NCBI chr16:20,335,694...20,352,763
Ensembl chr16:20,335,732...20,352,760 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of DYNLL1 mRNA CTD PMID:26377693 NCBI chr 5:115,435,129...115,438,995
Ensembl chr 5:115,435,169...115,439,058 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression		 ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of E2F1 protein]; 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of E2F1 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of E2F1 protein]; epacadostat inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of E2F1 protein]; U 0126 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of E2F1 protein]
indeno(1,2,3-cd)pyrene results in increased expression of E2F1 mRNA; indeno(1,2,3-cd)pyrene results in increased expression of E2F1 protein		 CTD PMID:35687267 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Efemp1 epidermal growth factor-containing fibulin-like extracellular matrix protein 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of EFEMP1 mRNA CTD PMID:26377693 NCBI chr11:28,803,154...28,876,743
Ensembl chr11:28,803,204...28,876,743 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ELOVL6 mRNA CTD PMID:26377693 NCBI chr 3:129,326,035...129,432,144
Ensembl chr 3:129,326,004...129,432,144 		JBrowse link
G Ephb6 Eph receptor B6 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of EPHB6 mRNA CTD PMID:26377693 NCBI chr 6:41,581,940...41,597,445
Ensembl chr 6:41,582,416...41,597,443 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of ERBB2 mRNA CTD PMID:21635667 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ERRFI1 mRNA CTD PMID:26377693 NCBI chr 4:150,938,253...150,953,346
Ensembl chr 4:150,938,376...150,953,349 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) affects binding ISO indeno(1,2,3-cd)pyrene binds to ESR1 protein CTD PMID:32251684 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Ets1 E26 avian leukemia oncogene 1, 5' domain multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETS1 mRNA]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETS1 mRNA] CTD PMID:21635667 NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116 		JBrowse link
G Etv6 ets variant 6 multiple interactions
increases expression		 ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETV6 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETV6 protein]; epacadostat inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETV6 protein]
indeno(1,2,3-cd)pyrene results in increased expression of ETV6 mRNA; indeno(1,2,3-cd)pyrene results in increased expression of ETV6 protein		 CTD PMID:35687267 NCBI chr 6:134,012,663...134,247,121
Ensembl chr 6:134,012,663...134,247,121 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of FABP4 mRNA CTD PMID:26377693 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Fam181b family with sequence similarity 181, member B decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of FAM181B mRNA CTD PMID:26377693 NCBI chr 7:92,729,087...92,730,929
Ensembl chr 7:92,729,073...92,731,074 		JBrowse link
G Fibin fin bud initiation factor homolog (zebrafish) decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of FIBIN mRNA CTD PMID:26377693 NCBI chr 2:110,191,270...110,193,338
Ensembl chr 2:110,191,262...110,193,528 		JBrowse link
G Fos FBJ osteosarcoma oncogene decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of FOS mRNA CTD PMID:32251684 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Frem1 Fras1 related extracellular matrix protein 1 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of FREM1 mRNA CTD PMID:21635667 NCBI chr 4:82,816,157...82,970,743
Ensembl chr 4:82,816,164...82,970,576 		JBrowse link
G Fsbp fibrinogen silencer binding protein increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of FSBP mRNA CTD PMID:32251684 NCBI chr 4:11,579,662...11,587,802
Ensembl chr 4:11,579,665...11,587,591 		JBrowse link
G Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of GDPD2 mRNA CTD PMID:26377693 NCBI chr  X:99,773,442...99,782,507
Ensembl chr  X:99,773,479...99,782,501 		JBrowse link
G Gfpt2 glutamine fructose-6-phosphate transaminase 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of GFPT2 mRNA CTD PMID:26377693 NCBI chr11:49,684,981...49,729,448
Ensembl chr11:49,685,005...49,729,440 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of GJB2 mRNA CTD PMID:32251684 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159 		JBrowse link
G Golph3l golgi phosphoprotein 3-like decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of GOLPH3L mRNA CTD PMID:26377693 NCBI chr 3:95,496,280...95,526,553
Ensembl chr 3:95,496,245...95,526,553 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of GPD1 mRNA CTD PMID:26377693 NCBI chr15:99,615,468...99,622,895
Ensembl chr15:99,615,396...99,622,886 		JBrowse link
G Gpm6a glycoprotein m6a decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of GPM6A mRNA CTD PMID:26377693 NCBI chr 8:55,232,469...55,513,913
Ensembl chr 8:55,407,878...55,513,906 		JBrowse link
G Grifin galectin-related inter-fiber protein decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of GRIFIN mRNA CTD PMID:26377693 NCBI chr 5:140,548,872...140,553,280
Ensembl chr 5:140,548,874...140,550,826 		JBrowse link
G Grp gastrin releasing peptide decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of GRP mRNA CTD PMID:26377693 NCBI chr18:66,005,826...66,019,670
Ensembl chr18:66,005,891...66,019,667 		JBrowse link
G Gxylt2 glucoside xylosyltransferase 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of GXYLT2 mRNA CTD PMID:26377693 NCBI chr 6:100,681,638...100,787,738
Ensembl chr 6:100,681,695...100,787,874 		JBrowse link
G Gzma granzyme A decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of GZMA mRNA CTD PMID:26377693 NCBI chr13:113,230,358...113,237,515
Ensembl chr13:113,230,359...113,237,515 		JBrowse link
G Has1 hyaluronan synthase 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of HAS1 mRNA CTD PMID:26377693 NCBI chr17:18,063,588...18,075,450
Ensembl chr17:18,063,585...18,075,467 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of HMOX1 mRNA CTD PMID:32251684 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hrc histidine rich calcium binding protein decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of HRC mRNA CTD PMID:26377693 NCBI chr 7:44,984,693...44,988,397
Ensembl chr 7:44,984,714...44,988,398 		JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of HSP90AA1 mRNA CTD PMID:26377693 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162 		JBrowse link
G Hspa1a heat shock protein 1A decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of HSPA1A mRNA CTD PMID:26377693 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa8 heat shock protein 8 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of HSPA8 mRNA CTD PMID:26377693 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of HSPD1 mRNA CTD PMID:26377693 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of HSPH1 mRNA CTD PMID:26377693 NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of IDO1 protein CTD PMID:35687267 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of IDO2 protein CTD PMID:35687267 NCBI chr 8:25,021,908...25,066,430
Ensembl chr 8:25,021,908...25,066,349 		JBrowse link
G Ier3 immediate early response 3 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of IER3 mRNA CTD PMID:22579512 PMID:32251684 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815 		JBrowse link
G Ifi211 interferon activated gene 211 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MNDA mRNA CTD PMID:26377693 NCBI chr 1:173,723,907...173,740,650
Ensembl chr 1:173,723,911...173,740,612 		JBrowse link
G Igf1r insulin-like growth factor I receptor increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of IGF1R mRNA CTD PMID:32251684 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of IGFBP5 mRNA CTD PMID:26377693 NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043 		JBrowse link
G Igh-VJ558 immunoglobulin heavy chain (J558 family) decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of IGH-VJ558 mRNA CTD PMID:26377693
G Ighg2a immunoglobulin heavy constant gamma 2A decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of IGHG2A mRNA CTD PMID:26377693
G Ikzf1 IKAROS family zinc finger 1 multiple interactions
increases expression		 ISO AHR promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of IKZF1 protein]
indeno(1,2,3-cd)pyrene results in increased expression of IKZF1 mRNA; indeno(1,2,3-cd)pyrene results in increased expression of IKZF1 protein		 CTD PMID:35687267 NCBI chr11:11,634,970...11,722,930
Ensembl chr11:11,634,980...11,722,926 		JBrowse link
G Il21 interleukin 21 multiple interactions EXP 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL21 mRNA]]; AHR protein affects the reaction [indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL21 mRNA]]; indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL21 mRNA]; MAF protein affects the reaction [indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL21 mRNA]] CTD PMID:36975775 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP [indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of IL4 mRNA; MAF protein affects the reaction [[indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of IL4 mRNA] CTD PMID:36975775 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Iqsec1 IQ motif and Sec7 domain 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of IQSEC1 mRNA CTD PMID:26377693 NCBI chr 6:90,636,578...90,965,766
Ensembl chr 6:90,633,070...90,965,667 		JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of IRF2BP2 mRNA CTD PMID:26377693 NCBI chr 8:127,315,035...127,320,725
Ensembl chr 8:127,315,035...127,320,725 		JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions EXP 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of IRF4 mRNA]; [indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of IRF4 mRNA; AHR protein affects the reaction [[indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of IRF4 mRNA] CTD PMID:36975775 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959 		JBrowse link
G Isx intestine specific homeobox increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of ISX protein CTD PMID:35687267 NCBI chr 8:75,599,326...75,620,134
Ensembl chr 8:75,599,801...75,620,134 		JBrowse link
G Itga2 integrin alpha 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA] CTD PMID:21635667 NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636 		JBrowse link
G Itga6 integrin alpha 6 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ITGA6 mRNA CTD PMID:26377693 NCBI chr 2:71,617,236...71,688,761
Ensembl chr 2:71,575,960...71,688,760 		JBrowse link
G Itgb6 integrin beta 6 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ITGB6 mRNA CTD PMID:26377693 NCBI chr 2:60,428,636...60,553,005
Ensembl chr 2:60,428,636...60,552,987 		JBrowse link
G Jchain immunoglobulin joining chain decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of JCHAIN mRNA CTD PMID:26377693 NCBI chr 5:88,667,663...88,675,667
Ensembl chr 5:88,667,668...88,675,750 		JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of JUN mRNA] CTD PMID:21635667 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kdm1b lysine (K)-specific demethylase 1B decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of KDM1B mRNA CTD PMID:26377693 NCBI chr13:47,196,849...47,238,085
Ensembl chr13:47,196,975...47,238,755 		JBrowse link
G Kitl kit ligand decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of KITL mRNA CTD PMID:26377693 NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278 		JBrowse link
G Klhl23 kelch-like 23 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of PHOSPHO2-KLHL23 mRNA CTD PMID:32251684 NCBI chr 2:69,652,285...69,666,995
Ensembl chr 2:69,652,288...69,666,995 		JBrowse link
G Klk1 kallikrein 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of KLK1 mRNA CTD PMID:26377693 NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042 		JBrowse link
G Klra15 killer cell lectin-like receptor, subfamily A, member 15 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of KLRA15 mRNA CTD PMID:26377693
G Klra16 killer cell lectin-like receptor, subfamily A, member 16 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of KLRA16 mRNA CTD PMID:26377693
G Klra22 killer cell lectin-like receptor subfamily A, member 22 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of KLRA22 mRNA CTD PMID:26377693
G Klra4 killer cell lectin-like receptor, subfamily A, member 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of KLRA4 mRNA CTD PMID:26377693 NCBI chr 6:130,020,693...130,044,242
Ensembl chr 6:130,020,694...130,044,234 		JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of KNSTRN mRNA CTD PMID:26377693 NCBI chr 2:118,644,470...118,667,691
Ensembl chr 2:118,644,484...118,684,438 		JBrowse link
G Krt19 keratin 19 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of KRT19 mRNA CTD PMID:32251684 NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491 		JBrowse link
G Lgals1 lectin, galactose binding, soluble 1 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of LGALS1 mRNA CTD PMID:22579512 NCBI chr15:78,810,925...78,814,665
Ensembl chr15:78,810,925...78,814,665 		JBrowse link
G Lonrf3 LON peptidase N-terminal domain and ring finger 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of LONRF3 mRNA CTD PMID:26377693 NCBI chr  X:35,592,011...35,630,510
Ensembl chr  X:35,592,006...35,625,994 		JBrowse link
G Lpin2 lipin 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of LPIN2 mRNA CTD PMID:26377693 NCBI chr17:71,490,527...71,556,813
Ensembl chr17:71,489,555...71,556,812 		JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of LRRN4 mRNA CTD PMID:26377693 NCBI chr 2:132,710,436...132,735,930
Ensembl chr 2:132,710,225...132,722,811 		JBrowse link
G Maf MAF bZIP transcription factor multiple interactions EXP indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of MAF mRNA]; MAF protein affects the reaction [[indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of IL4 mRNA]; MAF protein affects the reaction [indeno(1,2,3-cd)pyrene promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL21 mRNA]] CTD PMID:36975775 NCBI chr 8:116,429,992...116,433,633
Ensembl chr 8:116,409,681...116,434,533 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 increases phosphorylation
multiple interactions		 ISO indeno(1,2,3-cd)pyrene results in increased phosphorylation of MAPK14 protein
Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased phosphorylation of MAPK14 protein]		 CTD PMID:21635667 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mb myoglobin decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MB mRNA CTD PMID:26377693 NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of MDM2 mRNA CTD PMID:32251684 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Mef2b myocyte enhancer factor 2B increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of MEF2B mRNA CTD PMID:32251684 NCBI chr 8:70,605,411...70,620,138
Ensembl chr 8:70,592,361...70,620,138 		JBrowse link
G Mfap2 microfibrillar-associated protein 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MFAP2 mRNA CTD PMID:26377693 NCBI chr 4:140,737,735...140,743,284
Ensembl chr 4:140,737,729...140,743,295 		JBrowse link
G Mgat1 mannoside acetylglucosaminyltransferase 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MGAT1 mRNA CTD PMID:26377693 NCBI chr11:49,135,018...49,153,854
Ensembl chr11:49,135,018...49,153,857 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 increases expression
multiple interactions		 ISO indeno(1,2,3-cd)pyrene results in increased expression of MKI67 mRNA; indeno(1,2,3-cd)pyrene results in increased expression of MKI67 protein
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MKI67 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MKI67 protein]; epacadostat inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MKI67 protein]		 CTD PMID:35687267 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MMP2 mRNA] CTD PMID:21635667 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MMP3 mRNA CTD PMID:26377693 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mrap melanocortin 2 receptor accessory protein decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MRAP mRNA CTD PMID:26377693 NCBI chr16:90,535,095...90,546,673
Ensembl chr16:90,535,095...90,546,673 		JBrowse link
G Msln mesothelin decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MSLN mRNA CTD PMID:26377693 NCBI chr17:25,967,587...25,973,352
Ensembl chr17:25,967,587...25,973,352 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MTARC1 mRNA CTD PMID:26377693 NCBI chr 1:184,518,964...184,543,622
Ensembl chr 1:184,518,964...184,543,394 		JBrowse link
G Muc16 mucin 16 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MUC16 mRNA CTD PMID:26377693 NCBI chr 9:18,406,741...18,586,117
Ensembl chr 9:18,406,751...18,585,826 		JBrowse link
G Mybpc3 myosin binding protein C, cardiac decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MYBPC3 mRNA CTD PMID:26377693 NCBI chr 2:90,948,459...90,966,862
Ensembl chr 2:90,948,489...90,966,861 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MYC protein] CTD PMID:35687267 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MYH6 mRNA CTD PMID:26377693 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384 		JBrowse link
G Myl1 myosin, light polypeptide 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MYL1 mRNA CTD PMID:26377693 NCBI chr 1:66,963,454...66,987,091
Ensembl chr 1:66,963,454...66,984,563 		JBrowse link
G Myl4 myosin, light polypeptide 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MYL4 mRNA CTD PMID:26377693 NCBI chr11:104,427,604...104,478,041
Ensembl chr11:104,441,489...104,486,579 		JBrowse link
G Myl7 myosin, light polypeptide 7, regulatory decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of MYL7 mRNA CTD PMID:26377693 NCBI chr11:5,846,637...5,848,782
Ensembl chr11:5,846,637...5,848,782 		JBrowse link
G Mylk myosin, light polypeptide kinase decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of MYLK mRNA CTD PMID:21635667 NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790 		JBrowse link
G Nanog Nanog homeobox increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of NANOG mRNA CTD PMID:35687267 NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592 		JBrowse link
G Ndc80 NDC80 kinetochore complex component decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of NDC80 mRNA CTD PMID:22579512 NCBI chr17:71,803,095...71,833,852
Ensembl chr17:71,803,095...71,833,852 		JBrowse link
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of NEDD4 mRNA CTD PMID:26377693 NCBI chr 9:72,569,613...72,657,133
Ensembl chr 9:72,569,628...72,657,134 		JBrowse link
G Nfil3 nuclear factor, interleukin 3, regulated decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of NFIL3 mRNA CTD PMID:26377693 NCBI chr13:53,121,245...53,136,914
Ensembl chr13:53,121,245...53,135,109 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of NQO1 mRNA CTD PMID:17253728 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Oasl1 2'-5' oligoadenylate synthetase-like 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of OASL1 mRNA CTD PMID:26377693 NCBI chr 5:115,061,236...115,075,970
Ensembl chr 5:115,061,299...115,075,974 		JBrowse link
G Otop1 otopetrin 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of OTOP1 mRNA CTD PMID:26377693 NCBI chr 5:38,434,748...38,461,560
Ensembl chr 5:38,433,316...38,461,552 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of PAH mRNA CTD PMID:22579512 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998 		JBrowse link
G Pals2 protein associated with LIN7 2, MAGUK family member decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PALS2 mRNA CTD PMID:26377693 NCBI chr 6:50,087,206...50,176,134
Ensembl chr 6:50,087,221...50,175,919 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO indeno(1,2,3-cd)pyrene results in increased cleavage of PARP1 protein CTD PMID:21132278 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pbx1 pre B cell leukemia homeobox 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PBX1 mRNA CTD PMID:26377693 NCBI chr 1:167,946,933...168,259,898
Ensembl chr 1:167,946,933...168,259,839 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PCK1 mRNA CTD PMID:26377693 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PDE5A mRNA CTD PMID:26377693 NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PDK4 mRNA CTD PMID:26377693 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Pdzd2 PDZ domain containing 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PDZD2 mRNA CTD PMID:26377693 NCBI chr15:12,359,797...12,740,052
Ensembl chr15:12,359,797...12,740,010 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PEBP1 mRNA CTD PMID:26377693 NCBI chr 5:117,420,716...117,425,629
Ensembl chr 5:117,420,719...117,425,690 		JBrowse link
G Penk preproenkephalin decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PENK mRNA CTD PMID:26377693 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819 		JBrowse link
G Pgam2 phosphoglycerate mutase 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PGAM2 mRNA CTD PMID:26377693 NCBI chr11:5,751,637...5,753,796
Ensembl chr11:5,751,640...5,753,733 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PGAP2 mRNA CTD PMID:26377693 NCBI chr 7:101,859,153...101,887,771
Ensembl chr 7:101,859,415...101,887,774 		JBrowse link
G Pgr progesterone receptor decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of PGR mRNA CTD PMID:32251684 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Phf19 PHD finger protein 19 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of PHF19 mRNA CTD PMID:32251684 NCBI chr 2:34,783,764...34,804,365
Ensembl chr 2:34,783,769...34,804,038 		JBrowse link
G Pkib protein kinase inhibitor beta, cAMP dependent, testis specific decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of PKIB mRNA CTD PMID:32251684 NCBI chr10:57,508,077...57,617,208
Ensembl chr10:57,508,077...57,617,208 		JBrowse link
G Plin1 perilipin 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PLIN1 mRNA CTD PMID:26377693 NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651 		JBrowse link
G Plin4 perilipin 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PLIN4 mRNA CTD PMID:26377693 NCBI chr17:56,407,587...56,416,947
Ensembl chr17:56,407,591...56,416,803 		JBrowse link
G Polr1b polymerase (RNA) I polypeptide B decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of POLR1B mRNA CTD PMID:26377693 NCBI chr 2:128,942,891...128,969,980
Ensembl chr 2:128,942,915...128,968,514 		JBrowse link
G Popdc2 popeye domain containing 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of POPDC2 mRNA CTD PMID:26377693 NCBI chr16:38,182,523...38,198,578
Ensembl chr16:38,182,571...38,198,578 		JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 increases expression
multiple interactions		 ISO indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 mRNA; indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 protein
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 protein]; 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 protein]; AHR promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 protein]; epacadostat inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 protein]; U 0126 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 protein]		 CTD PMID:35687267 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669 		JBrowse link
G Ppp4r3b protein phosphatase 4 regulatory subunit 3B decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of PPP4R3B mRNA CTD PMID:26377693 NCBI chr11:29,118,053...29,170,797
Ensembl chr11:29,122,890...29,170,797 		JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of RARA mRNA CTD PMID:32251684 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Reln reelin decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of RELN mRNA CTD PMID:21635667 NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700 		JBrowse link
G Ret ret proto-oncogene decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of RET mRNA CTD PMID:32251684 NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679 		JBrowse link
G Retn resistin decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of RETN mRNA CTD PMID:26377693 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Rhoc ras homolog family member C increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of RHOC mRNA CTD PMID:22579512 NCBI chr 3:104,696,350...104,701,775
Ensembl chr 3:104,695,691...104,701,775 		JBrowse link
G Rora RAR-related orphan receptor alpha decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of RORA mRNA CTD PMID:26377693 NCBI chr 9:68,560,627...69,295,528
Ensembl chr 9:68,561,068...69,295,528 		JBrowse link
G Rprml reprimo-like decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of RPRML mRNA CTD PMID:26377693 NCBI chr11:103,540,335...103,541,406
Ensembl chr11:103,540,396...103,541,405 		JBrowse link
G Rsrp1 arginine/serine rich protein 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of RSRP1 mRNA CTD PMID:26377693 NCBI chr 4:134,650,936...134,654,681
Ensembl chr 4:134,650,903...134,654,982 		JBrowse link
G Runx1 runt related transcription factor 1 increases expression
multiple interactions		 ISO indeno(1,2,3-cd)pyrene results in increased expression of RUNX1 mRNA; indeno(1,2,3-cd)pyrene results in increased expression of RUNX1 protein
1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of RUNX1 protein]; AHR protein promotes the reaction [indeno(1,2,3-cd)pyrene results in increased expression of RUNX1 protein]; epacadostat inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of RUNX1 protein]		 CTD PMID:35687267 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Runx2 runt related transcription factor 2 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of RUNX2 mRNA CTD PMID:32251684 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Sbsn suprabasin decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SBSN mRNA CTD PMID:26377693 NCBI chr 7:30,432,099...30,455,559
Ensembl chr 7:30,450,896...30,455,559 		JBrowse link
G Scgb2b20 secretoglobin, family 2B, member 20 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SCGB2B20 mRNA CTD PMID:26377693 NCBI chr 7:33,063,768...33,065,744
Ensembl chr 7:33,063,768...33,065,747 		JBrowse link
G Sdcbp2 syndecan binding protein (syntenin) 2 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SDCBP2 mRNA CTD PMID:26377693 NCBI chr 2:151,414,203...151,431,925
Ensembl chr 2:151,414,542...151,431,925 		JBrowse link
G Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of SEMA3B mRNA CTD PMID:32251684 NCBI chr 9:107,474,868...107,486,440
Ensembl chr 9:107,474,873...107,486,428 		JBrowse link
G Septin3 septin 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SEPTIN3 mRNA CTD PMID:26377693 NCBI chr15:82,153,003...82,178,775
Ensembl chr15:82,153,003...82,178,775 		JBrowse link
G Serpina3m serine (or cysteine) peptidase inhibitor, clade A, member 3M decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SERPINA3M mRNA CTD PMID:26377693 NCBI chr12:104,353,424...104,360,518
Ensembl chr12:104,304,745...104,360,516 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of SGK1 mRNA CTD PMID:32251684 NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802 		JBrowse link
G Shc3 src homology 2 domain-containing transforming protein C3 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of SHC3 mRNA CTD PMID:21635667 NCBI chr13:51,577,422...51,724,909
Ensembl chr13:51,585,077...51,723,523 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of SIAH2 mRNA CTD PMID:32251684 NCBI chr 3:58,582,370...58,599,857
Ensembl chr 3:58,582,359...58,599,821 		JBrowse link
G Siglech sialic acid binding Ig-like lectin H decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SIGLECH mRNA CTD PMID:26377693 NCBI chr 7:55,417,916...55,429,196
Ensembl chr 7:55,417,926...55,428,673 		JBrowse link
G Slc10a6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SLC10A6 mRNA CTD PMID:26377693 NCBI chr 5:103,753,583...103,777,152
Ensembl chr 5:103,753,577...103,777,269 		JBrowse link
G Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SLC1A5 mRNA CTD PMID:26377693 NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SLC2A4 mRNA CTD PMID:26377693 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SLC2A5 mRNA CTD PMID:26377693 NCBI chr 4:150,203,801...150,228,625
Ensembl chr 4:150,203,740...150,228,626 		JBrowse link
G Slc5a12 solute carrier family 5 (sodium/glucose cotransporter), member 12 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SLC5A12 mRNA CTD PMID:26377693 NCBI chr 2:110,427,644...110,479,690
Ensembl chr 2:110,427,643...110,478,124 		JBrowse link
G Slc5a3 solute carrier family 5 (inositol transporters), member 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SLC5A3 mRNA CTD PMID:26377693 NCBI chr16:91,855,210...91,884,361
Ensembl chr16:91,855,210...91,884,361 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of SLC7A11 mRNA CTD PMID:32251684 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of SLC7A5 mRNA CTD PMID:32251684 NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433 		JBrowse link
G Sln sarcolipin decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SLN mRNA CTD PMID:26377693 NCBI chr 9:53,757,535...53,761,133
Ensembl chr 9:53,757,448...53,761,844 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3, neutral decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SMPD3 mRNA CTD PMID:26377693 NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620 		JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA] CTD PMID:21635667 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734 		JBrowse link
G Snord123 small nucleolar RNA, C/D box 123 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SNORD123 mRNA CTD PMID:26377693 NCBI chr15:32,241,991...32,242,078
Ensembl chr15:32,241,999...32,242,069 		JBrowse link
G Sox17 SRY (sex determining region Y)-box 17 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SOX17 mRNA CTD PMID:26377693 NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of SOX2 mRNA CTD PMID:35687267 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of STC2 mRNA CTD PMID:32251684 NCBI chr11:31,309,441...31,320,061
Ensembl chr11:31,307,307...31,320,074 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of STIP1 mRNA CTD PMID:26377693 NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335 		JBrowse link
G Sulf1 sulfatase 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SULF1 mRNA CTD PMID:26377693 NCBI chr 1:12,762,421...12,946,090
Ensembl chr 1:12,762,501...12,931,416 		JBrowse link
G Sult5a1 sulfotransferase family 5A, member 1 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SULT1A1 mRNA CTD PMID:26377693 NCBI chr 8:123,869,582...123,885,170
Ensembl chr 8:123,866,931...123,885,054 		JBrowse link
G Syt1 synaptotagmin I decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of SYT1 mRNA CTD PMID:26377693 NCBI chr10:108,333,511...108,846,852
Ensembl chr10:108,333,511...108,846,843 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions
increases expression		 ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of TDO2 protein]; epacadostat inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of TDO2 protein] CTD PMID:35687267 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509 		JBrowse link
G Tfap2c transcription factor AP-2, gamma decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of TFAP2C mRNA CTD PMID:32251684 NCBI chr 2:172,387,599...172,400,542
Ensembl chr 2:172,391,513...172,400,542 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of TFF1 mRNA CTD PMID:32251684 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
G Tff3 trefoil factor 3, intestinal decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of TFF3 mRNA CTD PMID:26377693 NCBI chr17:31,344,280...31,348,585
Ensembl chr17:31,344,280...31,348,620 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of THRSP mRNA CTD PMID:26377693 NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression
decreases expression		 ISO
EXP		 indeno(1,2,3-cd)pyrene results in increased expression of TIMP1 mRNA
indeno(1,2,3-cd)pyrene results in decreased expression of TIMP1 mRNA		 CTD PMID:22579512 PMID:26377693 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tln2 talin 2 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of TLN2 mRNA CTD PMID:21635667 NCBI chr 9:67,124,371...67,541,357
Ensembl chr 9:67,124,369...67,466,985 		JBrowse link
G Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of TMEFF1 mRNA CTD PMID:32251684 NCBI chr 4:48,585,064...48,663,136
Ensembl chr 4:48,585,174...48,663,131 		JBrowse link
G Tmem245 transmembrane protein 245 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of TMEM245 mRNA CTD PMID:26377693 NCBI chr 4:56,866,923...56,947,456
Ensembl chr 4:56,866,923...56,947,437 		JBrowse link
G Tmem45b transmembrane protein 45b decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of TMEM45B mRNA CTD PMID:26377693 NCBI chr 9:31,336,445...31,375,534
Ensembl chr 9:31,337,492...31,375,758 		JBrowse link
G Tnni3 troponin I, cardiac 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of TNNI3 mRNA CTD PMID:26377693 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
G Tnnt2 troponin T2, cardiac decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of TNNT2 mRNA CTD PMID:26377693 NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998 		JBrowse link
G Tox2 TOX high mobility group box family member 2 multiple interactions EXP [indeno(1,2,3-cd)pyrene co-treated with Antigens, Dermatophagoides] results in increased expression of TOX2 mRNA CTD PMID:36975775 NCBI chr 2:163,045,047...163,166,092
Ensembl chr 2:163,045,045...163,166,090 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of TRPV4 mRNA CTD PMID:26377693 NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of TSC22D3 mRNA CTD PMID:26377693 NCBI chr  X:139,440,277...139,501,257
Ensembl chr  X:139,440,277...139,501,408 		JBrowse link
G Tspear thrombospondin type laminin G domain and EAR repeats increases expression ISO indeno(1,2,3-cd)pyrene results in increased expression of TSPEAR mRNA CTD PMID:32251684 NCBI chr10:77,521,942...77,722,844
Ensembl chr10:77,522,403...77,722,855 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of UCP1 mRNA CTD PMID:26377693 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Upk3b uroplakin 3B decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of UPK3B mRNA CTD PMID:26377693 NCBI chr 5:136,067,350...136,073,847
Ensembl chr 5:136,067,350...136,075,341 		JBrowse link
G Vav3 vav 3 oncogene decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of VAV3 mRNA CTD PMID:21635667 NCBI chr 3:109,247,757...109,593,010
Ensembl chr 3:109,247,969...109,593,014 		JBrowse link
G Wdr62 WD repeat domain 62 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of WDR62 mRNA CTD PMID:26377693 NCBI chr 7:29,939,563...29,980,243
Ensembl chr 7:29,939,563...29,979,844 		JBrowse link
G Wt1 WT1 transcription factor decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of WT1 mRNA CTD PMID:26377693 NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961 		JBrowse link
G Xbp1 X-box binding protein 1 decreases expression ISO indeno(1,2,3-cd)pyrene results in decreased expression of XBP1 mRNA CTD PMID:32251684 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893 		JBrowse link
G Zdhhc22 zinc finger, DHHC-type containing 22 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ZDHHC22 mRNA CTD PMID:26377693 NCBI chr12:87,027,537...87,037,604
Ensembl chr12:87,027,537...87,037,204 		JBrowse link
G Zfp628 zinc finger protein 628 decreases expression EXP indeno(1,2,3-cd)pyrene results in decreased expression of ZFP628 mRNA CTD PMID:26377693 NCBI chr 7:4,918,221...4,925,001
Ensembl chr 7:4,918,216...4,925,001 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      group 22072
        polyatomic entity 22072
          molecule 21699
            cyclic compound 21253
              organic cyclic compound 21252
                organic polycyclic compound 17940
                  pyrenes 335
                    1,2-dihydropyrene-2-carboxylic acid 0
                    1,3-Dinitropyrene 13
                    1,6-Dihydroxypyrene 0
                    1,6-Dimethoxypyrene 0
                    1,6-Dinitropyrene 3
                    1,8-Dihydroxypyrene 0
                    1,8-Dinitropyrene 12
                    1-Aminopyrene 10
                    1-Hydroxy-6-methoxypyrene 0
                    1-Hydroxypyrene 54
                    1-Hydroxypyrene glucuronide 0
                    1-Methoxypyrene 0
                    1-Methylpyrene 3
                    1-Pyrenylsulfate 0
                    10-Oxabenzo[def]chrysen-9-one 0
                    2-(2-pyrenyl)acetonitrile 0
                    2-Hydroxypyrene 0
                    2-Nitropyrene 0
                    4,5-Dihydroxypyrene 0
                    4-(1-Pyrenyl)butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]valinate 0
                    4-Nitropyrene 1
                    Acepyrene 0
                    Benzo[a]pyrene-7,8-diol 29
                    Benzo[a]pyrene-7,8-oxide 2
                    Benzo[a]pyrene-9,10-oxide 0
                    Benzo[a]pyrene-cis-9,10-dihydrodiol 0
                    Cyclopenta[cd]pyrene 2
                    Indeno[1,2,3-cd]pyrene 250
                    N,N'-Bis(1-pyrenylmethyl)isophthalamide 0
                    Pyrene-1,6-dione 0
                    Pyrene-1,8-dione 0
                    Pyrene-4,5-dione 0
                    benzo[a]pyrene-7,8-dione 17
                    benzo[a]pyrene-cis-7,8-dihydrodiol + 17
                    cis-4-(7-Hydroxtpyren-8-yl)-2-oxobut-3-enoate 0
                    cis-4-(8-Hydroxypyren-7-yl)-2-oxobut-3-enoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      p-block molecular entity 22104
                        carbon group molecular entity 21904
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic polycyclic compound 17940
                                  pyrenes 335
                                    1,2-dihydropyrene-2-carboxylic acid 0
                                    1,3-Dinitropyrene 13
                                    1,6-Dihydroxypyrene 0
                                    1,6-Dimethoxypyrene 0
                                    1,6-Dinitropyrene 3
                                    1,8-Dihydroxypyrene 0
                                    1,8-Dinitropyrene 12
                                    1-Aminopyrene 10
                                    1-Hydroxy-6-methoxypyrene 0
                                    1-Hydroxypyrene 54
                                    1-Hydroxypyrene glucuronide 0
                                    1-Methoxypyrene 0
                                    1-Methylpyrene 3
                                    1-Pyrenylsulfate 0
                                    10-Oxabenzo[def]chrysen-9-one 0
                                    2-(2-pyrenyl)acetonitrile 0
                                    2-Hydroxypyrene 0
                                    2-Nitropyrene 0
                                    4,5-Dihydroxypyrene 0
                                    4-(1-Pyrenyl)butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]valinate 0
                                    4-Nitropyrene 1
                                    Acepyrene 0
                                    Benzo[a]pyrene-7,8-diol 29
                                    Benzo[a]pyrene-7,8-oxide 2
                                    Benzo[a]pyrene-9,10-oxide 0
                                    Benzo[a]pyrene-cis-9,10-dihydrodiol 0
                                    Cyclopenta[cd]pyrene 2
                                    Indeno[1,2,3-cd]pyrene 250
                                    N,N'-Bis(1-pyrenylmethyl)isophthalamide 0
                                    Pyrene-1,6-dione 0
                                    Pyrene-1,8-dione 0
                                    Pyrene-4,5-dione 0
                                    benzo[a]pyrene-7,8-dione 17
                                    benzo[a]pyrene-cis-7,8-dihydrodiol + 17
                                    cis-4-(7-Hydroxtpyren-8-yl)-2-oxobut-3-enoate 0
                                    cis-4-(8-Hydroxypyren-7-yl)-2-oxobut-3-enoate 0
paths to the root