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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thia fatty acid
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Accession:CHEBI:59643 term browser browse the term
Definition:Any fatty acid having at least one of the chain methylene groups replaced by sulfur. Members of this group are believed to have important pharmacological (antioxidant and antiatherosclerosis) properties.
Synonyms:related_synonym: sulfur-containing fatty acid;   sulfur-containing fatty acids;   thia fatty acids
 xref: PMID:15825830;   PMID:15949791;   PMID:9030189
 cyclic_relationship: is_conjugate_acid_of CHEBI:59848



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(R)-lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein CTD PMID:29128272 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] CTD PMID:22464149 NCBI chr 9:68,333,981...68,372,149 JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]
Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]
CTD PMID:26518973 PMID:27260466 NCBI chr10:91,410,129...91,430,246 JBrowse link
G Ache acetylcholinesterase multiple interactions EXP
ISO
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
CTD PMID:19669875 PMID:20663516 PMID:20730314 PMID:32911022 NCBI chr12:25,042,882...25,050,608 JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22464149 NCBI chr10:101,905,083...101,930,136 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of ACTA2 protein]
CTD PMID:21251946 PMID:24704557 PMID:29760339 PMID:34252510 PMID:35187969 NCBI chr 1:241,159,723...241,172,503 JBrowse link
G Ada adenosine deaminase multiple interactions EXP [Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein CTD PMID:32662911 NCBI chr 3:152,398,745...152,422,854 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein
CTD PMID:22664981 NCBI chr11:91,226,524...91,240,244 JBrowse link
G Agt angiotensinogen multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA CTD PMID:27260466 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]
Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA]
CTD PMID:26518973 PMID:27260466 NCBI chr17:34,383,397...34,435,523 JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Thioctic Acid results in decreased phosphorylation of AKT1 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]
CTD PMID:21351249 PMID:27260466 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Alad aminolevulinate dehydratase multiple interactions EXP Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:19798568 PMID:20026167 PMID:20584200 PMID:21783994 NCBI chr 5:75,961,993...75,972,334 JBrowse link
G Alb albumin multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein]
ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
CTD PMID:24704557 PMID:28433809 NCBI chr14:17,891,564...17,907,043 JBrowse link
G Apln apelin multiple interactions
increases expression
increases secretion
ISO acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:132,058,739...132,091,518 JBrowse link
G Ar androgen receptor multiple interactions EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of AR mRNA] CTD PMID:38342389 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr 7:113,684,681...113,686,739 JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] CTD PMID:23892647 NCBI chr13:85,460,312...85,639,959 JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of ATP1A2 mRNA] CTD PMID:34252510 NCBI chr13:84,729,597...84,754,544 JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions ISO Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] CTD PMID:27260466 NCBI chr13:76,786,580...76,807,096 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] CTD PMID:27260466 NCBI chr12:34,072,710...34,122,142 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA]
CTD PMID:15735709 PMID:23830814 PMID:23892647 PMID:27544635 PMID:30605698 More... NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] CTD PMID:23892647 NCBI chr 1:86,141,450...86,150,666 JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO
EXP
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]
Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of BCHE protein]
CTD PMID:20663516 PMID:32911022 NCBI chr 2:160,607,289...160,699,760 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
ISO
EXP
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein
BCL2 protein results in decreased susceptibility to Thioctic Acid
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]
CTD PMID:16990509 PMID:21600978 PMID:23830814 PMID:27260466 PMID:27544635 More... NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA CTD PMID:23830814 NCBI chr 3:161,713,777...161,764,844 JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] CTD PMID:23608068 NCBI chr12:4,895,092...4,939,340 JBrowse link
G C1qa complement C1q A chain decreases expression ISO Thioctic Acid results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:154,417,086...154,419,933 JBrowse link
G C4b complement C4B decreases expression ISO Thioctic Acid results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,197,371...4,211,684 JBrowse link
G Calb2 calbindin 2 multiple interactions EXP Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] CTD PMID:31068541 NCBI chr19:38,114,435...38,141,438 JBrowse link
G Calm1 calmodulin 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] CTD PMID:26165643 NCBI chr 6:125,217,191...125,227,855 JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of CAMK2A protein] CTD PMID:37739047 NCBI chr18:56,648,779...56,711,505 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
[Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Carbimazole results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
Thioctic Acid results in increased activity of CASP3 protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Thioctic Acid results in increased expression of CASP3 protein modified form
CTD PMID:15909127 PMID:17079870 PMID:19951573 PMID:21062633 PMID:21763304 More... NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]
CTD PMID:23830814 PMID:27544635 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
Thioctic Acid results in increased activity of CASP9 protein
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]
CTD PMID:16990509 PMID:19951573 PMID:23830814 PMID:27544635 PMID:30605698
G Cat catalase multiple interactions
increases activity
increases expression
ISO
EXP
Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of CAT mRNA]
[acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Carbimazole results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Cytarabine results in decreased expression of CAT protein]; Thioctic Acid inhibits the reaction [High Fructose Corn Syrup results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]
Thioctic Acid results in increased activity of CAT protein
[Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA
Thioctic Acid results in increased expression of CAT mRNA
CTD PMID:15998567 PMID:19368863 PMID:19699728 PMID:19715735 PMID:21763304 More... NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] CTD PMID:22488045 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] CTD PMID:21600978 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Cd36 CD36 molecule multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] CTD PMID:21315065 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cd86 CD86 molecule increases expression ISO Thioctic Acid results in increased expression of CD86 protein CTD PMID:19033392 NCBI chr11:77,647,565...77,706,178 JBrowse link
G Cd8a CD8 subunit alpha multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 NCBI chr 4:104,924,116...104,928,353 JBrowse link
G Cdx4 caudal type homeo box 4 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] CTD PMID:23608068 NCBI chr  X:68,326,874...68,335,461 JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP [Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein CTD PMID:19669875 NCBI chr16:7,657,362...7,717,093 JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] CTD PMID:19635391 NCBI chr 1:209,887,854...209,889,877 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA]
CTD PMID:21251946 PMID:23830814 PMID:34252510 PMID:35187969 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL3A1 mRNA] CTD PMID:34252510 NCBI chr 9:54,866,646...54,902,578 JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of COX4I1 mRNA] CTD PMID:34252510 NCBI chr19:65,630,383...65,636,623 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:22464149 NCBI chr 1:209,993,881...210,056,329 JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] CTD PMID:32061141 NCBI chr 9:73,397,333...73,466,339 JBrowse link
G Crp C-reactive protein multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] CTD PMID:26276312 NCBI chr13:87,694,062...87,695,978 JBrowse link
G Cryaa crystallin, alpha A multiple interactions EXP Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] CTD PMID:20597648 NCBI chr20:9,783,605...9,787,351 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of CTNNB1 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of CTNNB1 protein] CTD PMID:34133789 NCBI chr 8:129,517,576...129,544,661 JBrowse link
G Ctsd cathepsin D multiple interactions EXP Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 NCBI chr 1:206,956,945...206,968,821 JBrowse link
G Ctss cathepsin S decreases expression ISO Thioctic Acid results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:185,775,316...185,803,440 JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA]
Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of CYBA mRNA]
CTD PMID:33111558 PMID:35187969 NCBI chr19:50,487,598...50,495,669 JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] CTD PMID:26518973 NCBI chr  X:16,030,596...16,065,065 JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19951573 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] CTD PMID:21932800 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:21932800 PMID:24120545 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] CTD PMID:32061150 NCBI chr 1:205,269,967...205,280,365 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Dab1 DAB adaptor protein 1 multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA CTD PMID:31068541 NCBI chr 5:118,392,953...119,513,625 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr 7:65,001,695...65,006,517 JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] CTD PMID:22464149 NCBI chr 1:153,454,078...153,484,432 JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] CTD PMID:27260466 NCBI chr 5:122,074,285...122,090,983 JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions EXP [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] CTD PMID:21551353 NCBI chr 6:53,631,686...53,655,059 JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein] CTD PMID:34133789 NCBI chr10:55,239,397...55,267,780 JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases expression
ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L mRNA]; Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L protein]
Thioctic Acid results in decreased expression of DNM1L mRNA
CTD PMID:37739047 NCBI chr11:98,084,049...98,135,663 JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] CTD PMID:20730801 NCBI chr 8:58,605,403...58,669,339 JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] CTD PMID:23892647 NCBI chr 2:142,761,303...142,794,767 JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] CTD PMID:30605698 NCBI chr 6:103,405,880...103,430,549 JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] CTD PMID:27544635 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of FIS1 mRNA] CTD PMID:37739047 NCBI chr12:25,345,239...25,360,135 JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 NCBI chr12:12,333,050...12,504,750 JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Diazinon results in decreased expression of FN1 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]
CTD PMID:32911022 PMID:35187969 NCBI chr 9:80,645,507...80,714,200 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Foxo3 forkhead box O3 decreases acetylation
multiple interactions
EXP Thioctic Acid results in decreased acetylation of FOXO3 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein
CTD PMID:22327056 NCBI chr20:47,251,968...47,348,254 JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] CTD PMID:23608068 NCBI chr14:12,791,407...13,200,862 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] CTD PMID:20957662 NCBI chr 3:114,003,262...114,007,072 JBrowse link
G Fxn frataxin increases expression EXP Thioctic Acid results in increased expression of FXN protein CTD PMID:18809400 NCBI chr 1:231,300,457...231,323,989 JBrowse link
G Fzd2 frizzled class receptor 2 multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of FZD2 protein] CTD PMID:34133789 NCBI chr10:88,061,988...88,063,898 JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA CTD PMID:31068541 NCBI chr 3:75,777,260...75,818,099 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GCLC mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein]
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]; Thioctic Acid results in increased expression of and results in increased activity of GCLC protein
CTD PMID:16249512 PMID:17940886 PMID:26365678 PMID:27298056 PMID:32061141 More... NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GCLM mRNA; Thioctic Acid results in increased expression of GCLM protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein]
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA]; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein]
CTD PMID:16249512 PMID:26365678 PMID:32061141 NCBI chr 2:213,032,135...213,052,192 JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Thioctic Acid results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:88,352,987...88,361,661 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] CTD PMID:24704557 NCBI chr20:13,074,695...13,104,095 JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]
CTD PMID:26165643 PMID:27260466 NCBI chr20:36,302,490...36,315,010 JBrowse link
G Gls glutaminase multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] CTD PMID:32061141 NCBI chr 9:49,344,616...49,416,900 JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions EXP Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] CTD PMID:28070105 NCBI chr14:21,856,871...21,874,861 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of GPT protein]
CTD PMID:24704557 PMID:37739047 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GPX1 mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA]
CTD PMID:23649336 PMID:32061141 NCBI chr 8:117,905,462...117,906,588 JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA CTD PMID:23830814 NCBI chr 6:101,226,745...101,230,033 JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
multiple interactions
ISO Thioctic Acid results in increased expression of GPX3 mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA
CTD PMID:23649336 NCBI chr10:39,529,335...39,537,406 JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Thioctic Acid results in increased expression of GPX5 mRNA CTD PMID:23649336 NCBI chr17:43,436,126...43,443,074 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] CTD PMID:32061141 NCBI chr 3:28,501,836...28,528,754 JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] CTD PMID:31068541 PMID:32061141 NCBI chr10:6,136,458...6,560,003 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO
EXP
Thioctic Acid results in increased phosphorylation of GSK3B protein
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of GSK3B protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of GSK3B protein]
CTD PMID:19879292 PMID:27260466 PMID:34133789 NCBI chr11:76,004,502...76,154,665 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
EXP
ISO
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Carbimazole results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]
Thioctic Acid results in increased expression of GSR mRNA
Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]
CTD PMID:19699728 PMID:22623521 PMID:23649336 PMID:27581792 PMID:32061150 More... NCBI chr16:65,185,574...65,228,742 JBrowse link
G Gss glutathione synthetase multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] CTD PMID:32061141 NCBI chr 3:144,047,849...144,078,197 JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
[Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
CTD PMID:18367378 PMID:23830814 NCBI chr 2:198,338,005...198,346,007 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein
Thioctic Acid results in increased expression of GSTP1 mRNA
CTD PMID:20237067 NCBI chr 1:210,767,237...210,770,242 JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 NCBI chr12:32,337,281...32,350,838 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO
EXP
[Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein
Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 mRNA]; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 protein]
CTD PMID:28433809 PMID:33111558 NCBI chr10:31,118,667...31,151,730 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA]
Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein]
CTD PMID:19033392 PMID:21315065 PMID:22488045 PMID:23649336 PMID:23942037 More... NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hs1bp3 HCLS1 binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] CTD PMID:23608068 NCBI chr 6:31,192,568...31,222,835 JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] CTD PMID:28880400 NCBI chr20:3,875,411...3,877,866 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr 3:38,453,016...38,457,475 JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr14:86,270,208...86,277,944 JBrowse link
G Il10 interleukin 10 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] CTD PMID:19735303 PMID:26518973 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA CTD PMID:31068541 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B]
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]
CTD PMID:23830814 PMID:24975507 PMID:26518973 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il2 interleukin 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] CTD PMID:21195065 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] CTD PMID:23608068 NCBI chr 1:14,353,736...14,377,844 JBrowse link
G Il4 interleukin 4 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA CTD PMID:23830814 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA]
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
[Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
CTD PMID:22488045 PMID:26518973 PMID:28433809 PMID:29233029 PMID:29760339 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Ins1 insulin 1 multiple interactions EXP acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] CTD PMID:21461750 PMID:29760339 NCBI chr 1:261,186,119...261,186,686 JBrowse link
G Ins2 insulin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 NCBI chr 1:207,272,738...207,421,998 JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein CTD PMID:24975507 NCBI chr10:38,417,935...38,424,946 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases activity
increases expression
EXP [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]
Thioctic Acid results in increased activity of JUN protein
Thioctic Acid results in increased expression of JUN protein
CTD PMID:20237067 NCBI chr 5:115,009,900...115,012,993 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression
multiple interactions
ISO Thioctic Acid results in increased expression of KEAP1 protein
Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein]
CTD PMID:19033392 PMID:34252510 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions EXP Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] CTD PMID:21195065 PMID:27581792 NCBI chr 1:97,385,984...97,403,382 JBrowse link
G Lep leptin decreases secretion
decreases expression
ISO
EXP
Thioctic Acid results in decreased secretion of LEP protein
Thioctic Acid results in decreased expression of LEP mRNA
Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein
CTD PMID:21351249 NCBI chr 4:58,626,529...58,640,663 JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] CTD PMID:20957662 PMID:28070105 NCBI chr 1:105,037,457...105,038,446 JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases phosphorylation
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] CTD PMID:22941773 NCBI chr 1:80,965,612...80,984,313 JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects activity
multiple interactions
EXP Thioctic Acid affects the activity of MAPK1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein]
CTD PMID:15909127 PMID:21251946 PMID:32061141 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA CTD PMID:23830814 NCBI chr20:6,751,288...6,812,294 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] CTD PMID:21251946 PMID:23830814 PMID:32061141 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA CTD PMID:23830814 NCBI chr16:8,645,171...8,728,225 JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of MAPT protein] CTD PMID:34133789 NCBI chr10:89,638,618...89,736,108 JBrowse link
G Mff mitochondrial fission factor multiple interactions
decreases expression
ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFF mRNA]
Thioctic Acid results in decreased expression of MFF mRNA
CTD PMID:37739047 NCBI chr 9:84,007,798...84,036,039 JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFN2 mRNA] CTD PMID:37739047 NCBI chr 5:158,304,285...158,335,502 JBrowse link
G Mir21 microRNA 21 multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] CTD PMID:26276312 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mir210 microRNA 210 multiple interactions EXP [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] CTD PMID:26276312 NCBI chr 1:196,326,343...196,326,452 JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 NCBI chr 8:4,581,785...4,591,687 JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]
CTD PMID:24975507 PMID:29233029 NCBI chr 8:4,497,960...4,508,239 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA CTD PMID:23830814 NCBI chr19:30,327,643...30,355,856 JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:24975507 NCBI chr 8:12,925,267...12,938,828 JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] CTD PMID:21315065 NCBI chr16:52,717,775...52,803,602 JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA CTD PMID:18367378 NCBI chr19:10,831,959...10,832,975 JBrowse link
G Mvd mevalonate diphosphate decarboxylase multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA CTD PMID:18367378 NCBI chr19:50,496,366...50,506,429 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] CTD PMID:21600978 NCBI chr 7:95,483,105...95,488,031 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] CTD PMID:26518973 NCBI chr12:28,121,816...28,131,080 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
increases expression
increases activity
affects localization
ISO
EXP
[Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein
[Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of NFE2L2 protein]
Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein
[Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]
Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid results in increased activity of NFE2L2 protein
Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid affects the localization of NFE2L2 protein
CTD PMID:17197552 PMID:18258206 PMID:20237067 PMID:22488045 PMID:23649336 More... NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA
CTD PMID:21600978 PMID:31068541 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of NFKBIA protein] CTD PMID:34133789 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Ngfr nerve growth factor receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA] CTD PMID:23608068 NCBI chr10:81,012,077...81,030,305 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Thioctic Acid inhibits the reaction [High Fructose Corn Syrup results in increased expression of NOS2 protein]
CTD PMID:15453632 PMID:21763304 PMID:25825413 PMID:29233029 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:27260466 NCBI chr 4:11,686,088...11,706,604 JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] CTD PMID:29760339 NCBI chr  X:97,279,058...97,332,291 JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP
ISO
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of NOX4 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]
CTD PMID:29760339 PMID:33111558 PMID:35187969 NCBI chr 1:150,313,736...150,491,480 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased activity of NQO1 protein
Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]
[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]
CTD PMID:12180195 PMID:17940886 PMID:19033392 PMID:23649336 PMID:23830814 More... NCBI chr19:52,205,374...52,220,267 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of OPA1 mRNA] CTD PMID:37739047 NCBI chr11:84,612,943...84,690,025 JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr15:21,942,233...21,953,034 JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Thioctic Acid results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:21,933,179...21,998,134 JBrowse link
G Pcdhb13 protocadherin beta 13 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] CTD PMID:23608068 NCBI chr18:29,146,017...29,149,871 JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] CTD PMID:21251946 NCBI chr 3:139,951,948...139,955,820 JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PINK1 mRNA] CTD PMID:37739047 NCBI chr 5:155,813,838...155,825,950 JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 decreases expression
decreases activity
ISO Thioctic Acid results in decreased expression of PLAAT3 mRNA
Thioctic Acid results in decreased activity of PLAAT3 protein
CTD PMID:22941773 NCBI chr 1:204,782,608...204,816,397 JBrowse link
G Plin1 perilipin 1 increases phosphorylation ISO Thioctic Acid results in increased phosphorylation of PLIN1 protein CTD PMID:22941773 NCBI chr 1:143,073,612...143,086,199 JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity
ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:16391466 PMID:21932800 PMID:24120545 NCBI chr12:26,587,674...26,655,612 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22464149 NCBI chr 7:118,712,261...118,780,723 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP [Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA CTD PMID:22464149 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
decreases expression
ISO
EXP
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
Thioctic Acid results in increased expression of PPARGC1A protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]
[Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA]
Thioctic Acid results in decreased expression of PPARGC1A protein
CTD PMID:20414966 PMID:22464149 PMID:34252510 PMID:37739047 NCBI chr14:63,073,505...63,729,215 JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions
decreases acetylation
EXP [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
Thioctic Acid results in decreased acetylation of PPARGC1B protein
CTD PMID:22327056 PMID:22464149 NCBI chr18:54,758,891...54,861,103 JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRDX3 mRNA] CTD PMID:37739047 NCBI chr 1:260,001,642...260,014,064 JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [Thioctic Acid co-treated with Silicon] results in increased expression of PRKAA2 mRNA CTD PMID:34252510 NCBI chr 5:125,036,945...125,109,010 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRKN mRNA] CTD PMID:37739047 NCBI chr 1:51,236,410...52,430,242 JBrowse link
G Psen1 presenilin 1 multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PSEN1 protein] CTD PMID:34133789 NCBI chr 6:109,054,160...109,106,191 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] CTD PMID:19735303 PMID:23830814 PMID:26276312 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]
Thioctic Acid results in decreased phosphorylation of RELA protein
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of RELA protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]
CTD PMID:22488045 PMID:29233029 PMID:34133789 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Reln reelin multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA CTD PMID:31068541 NCBI chr 4:12,736,177...13,162,956 JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr20:12,372,345...12,381,159 JBrowse link
G Sema5a semaphorin 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] CTD PMID:23608068 NCBI chr 2:83,309,843...83,741,084 JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in increased expression of SERPINE1 protein] CTD PMID:34252510 NCBI chr12:25,237,977...25,248,356 JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] CTD PMID:24704557 NCBI chr 1:153,643,500...153,650,853 JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions EXP Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA] CTD PMID:25215149 NCBI chr16:17,008,180...17,011,686 JBrowse link
G Sftpb surfactant protein B multiple interactions EXP Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPB mRNA] CTD PMID:25215149 NCBI chr 4:104,359,303...104,368,439 JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of SIRT1 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA]
Thioctic Acid results in increased expression of SIRT1 mRNA
CTD PMID:22327056 PMID:37739047 NCBI chr20:25,305,953...25,328,000 JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
EXP
ISO
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]
Thioctic Acid results in increased expression of SIRT3 protein
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA]
CTD PMID:22327056 PMID:37739047 NCBI chr 1:195,942,066...195,964,472 JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions
affects activity
EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]
Thioctic Acid affects the activity of SLC12A2 protein
CTD PMID:23880158 NCBI chr18:51,348,282...51,416,448 JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] CTD PMID:32061141 NCBI chr 1:226,549,932...226,631,925 JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr 7:129,730,450...129,742,619 JBrowse link
G Slc5a6 solute carrier family 5 member 6 increases transport
multiple interactions
ISO
EXP
SLC5A6 results in increased transport of Thioctic Acid
Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid]
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
CTD PMID:9516450 PMID:10329687 NCBI chr 6:31,039,865...31,051,671 JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] CTD PMID:32061141 NCBI chr 2:136,532,912...136,668,560 JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:35187969 NCBI chr18:72,124,792...72,193,345 JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Snca synuclein alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:91,026,474...91,127,444 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Glucose results in decreased expression of SOD1 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] CTD PMID:15804455 PMID:26518973 PMID:37944786 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
EXP
ISO
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]
Thioctic Acid results in increased activity of SOD2 protein
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of SOD2 mRNA]
CTD PMID:15804455 PMID:19951573 PMID:22327056 PMID:27260466 PMID:34252510 NCBI chr 1:50,043,323...50,050,168 JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 NCBI chr 7:135,419,864...135,450,513 JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of SRD5A1 mRNA] CTD PMID:38342389 NCBI chr 1:35,514,914...35,548,898 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22464149 NCBI chr10:45,507,152...45,529,164 JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] CTD PMID:28070105 NCBI chr16:72,969,824...72,974,447 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] CTD PMID:19635391 PMID:28086195 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] CTD PMID:19635391 PMID:28086195 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO [Thioctic Acid co-treated with Silicon] results in increased expression of STK11 mRNA CTD PMID:34252510 NCBI chr 7:10,225,204...10,241,965 JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases expression ISO Thioctic Acid results in increased expression of SUMO1 protein CTD PMID:24975507 NCBI chr 9:61,078,790...61,108,697 JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of TFAM mRNA] CTD PMID:34252510 NCBI chr20:17,356,243...17,368,293 JBrowse link
G Tgfa transforming growth factor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFA mRNA] CTD PMID:29233029 NCBI chr 4:120,175,549...120,258,342 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of TGFB1 protein]
CTD PMID:15309289 PMID:21251946 PMID:24704557 PMID:26276312 PMID:29760339 More... NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] CTD PMID:23608068 NCBI chr 1:182,828,553...182,835,465 JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA CTD PMID:23830814 PMID:31068541 NCBI chr13:98,160,075...98,261,771 JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] CTD PMID:27260466 NCBI chr10:84,198,141...84,225,659 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [High Fructose Corn Syrup results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]
CTD PMID:15309289 PMID:23830814 PMID:25215149 PMID:25825413 PMID:26276312 More... NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 multiple interactions EXP Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TNFRSF10B mRNA] CTD PMID:23830814 NCBI chr 1:198,840,452...198,860,713 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA CTD PMID:23830814 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 1:78,342,571...78,346,255 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:19900424 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] CTD PMID:23608068 PMID:23892647 NCBI chr 3:161,269,939...161,275,533 JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:23830814 PMID:31068541 NCBI chr 5:77,507,455...77,519,685 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction
multiple interactions
ISO
EXP
TXNRD1 protein results in increased reduction of Thioctic Acid
Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]
CTD PMID:20810785 PMID:21172426 NCBI chr 7:22,717,620...22,802,553 JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] CTD PMID:22327056 PMID:22464149 NCBI chr 1:164,251,373...164,257,742 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
EXP
ISO
Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]
CTD PMID:11596663 PMID:22488045 PMID:26276312 NCBI chr 9:22,452,854...22,468,194 JBrowse link
G Wnt5a Wnt family member 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of WNT5A protein] CTD PMID:37739047 NCBI chr16:3,702,300...3,724,860 JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:32662911 NCBI chr 6:21,530,463...21,592,172 JBrowse link
lipoamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO lipoamide inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein] CTD PMID:18258206 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction ISO TXNRD1 protein results in increased reduction of lipoamide CTD PMID:21172426 NCBI chr 7:22,717,620...22,802,553 JBrowse link
G Txnrd2 thioredoxin reductase 2 increases reduction ISO TXNRD2 protein results in increased reduction of lipoamide CTD PMID:21172426 NCBI chr11:82,519,996...82,568,156 JBrowse link
lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein CTD PMID:29128272 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] CTD PMID:22464149 NCBI chr 9:68,333,981...68,372,149 JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]
Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]
CTD PMID:26518973 PMID:27260466 NCBI chr10:91,410,129...91,430,246 JBrowse link
G Ache acetylcholinesterase multiple interactions EXP
ISO
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
CTD PMID:19669875 PMID:20663516 PMID:20730314 PMID:32911022 NCBI chr12:25,042,882...25,050,608 JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22464149 NCBI chr10:101,905,083...101,930,136 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of ACTA2 protein]
CTD PMID:21251946 PMID:24704557 PMID:29760339 PMID:34252510 PMID:35187969 NCBI chr 1:241,159,723...241,172,503 JBrowse link
G Ada adenosine deaminase multiple interactions EXP [Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein CTD PMID:32662911 NCBI chr 3:152,398,745...152,422,854 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein
CTD PMID:22664981 NCBI chr11:91,226,524...91,240,244 JBrowse link
G Agt angiotensinogen multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA CTD PMID:27260466 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]
Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA]
CTD PMID:26518973 PMID:27260466 NCBI chr17:34,383,397...34,435,523 JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Thioctic Acid results in decreased phosphorylation of AKT1 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]
CTD PMID:21351249 PMID:27260466 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Alad aminolevulinate dehydratase multiple interactions EXP Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:19798568 PMID:20026167 PMID:20584200 PMID:21783994 NCBI chr 5:75,961,993...75,972,334 JBrowse link
G Alb albumin multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein]
ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
CTD PMID:24704557 PMID:28433809 NCBI chr14:17,891,564...17,907,043 JBrowse link
G Apln apelin multiple interactions
increases secretion
increases expression
ISO acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:132,058,739...132,091,518 JBrowse link
G Ar androgen receptor multiple interactions EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of AR mRNA] CTD PMID:38342389 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr 7:113,684,681...113,686,739 JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] CTD PMID:23892647 NCBI chr13:85,460,312...85,639,959 JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of ATP1A2 mRNA] CTD PMID:34252510 NCBI chr13:84,729,597...84,754,544 JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions ISO Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] CTD PMID:27260466 NCBI chr13:76,786,580...76,807,096 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] CTD PMID:27260466 NCBI chr12:34,072,710...34,122,142 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein]
CTD PMID:15735709 PMID:23830814 PMID:23892647 PMID:27544635 PMID:30605698 More... NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] CTD PMID:23892647 NCBI chr 1:86,141,450...86,150,666 JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO
EXP
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]
Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of BCHE protein]
CTD PMID:20663516 PMID:32911022 NCBI chr 2:160,607,289...160,699,760 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
ISO
EXP
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]
BCL2 protein results in decreased susceptibility to Thioctic Acid
CTD PMID:16990509 PMID:21600978 PMID:23830814 PMID:27260466 PMID:27544635 More... NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA CTD PMID:23830814 NCBI chr 3:161,713,777...161,764,844 JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] CTD PMID:23608068 NCBI chr12:4,895,092...4,939,340 JBrowse link
G C1qa complement C1q A chain decreases expression ISO Thioctic Acid results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:154,417,086...154,419,933 JBrowse link
G C4b complement C4B decreases expression ISO Thioctic Acid results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,197,371...4,211,684 JBrowse link
G Calb2 calbindin 2 multiple interactions EXP Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] CTD PMID:31068541 NCBI chr19:38,114,435...38,141,438 JBrowse link
G Calm1 calmodulin 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] CTD PMID:26165643 NCBI chr 6:125,217,191...125,227,855 JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of CAMK2A protein] CTD PMID:37739047 NCBI chr18:56,648,779...56,711,505 JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
Thioctic Acid results in increased expression of CASP3 protein modified form
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Thioctic Acid results in increased activity of CASP3 protein
[Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Carbimazole results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
CTD PMID:15909127 PMID:17079870 PMID:19951573 PMID:21062633 PMID:21763304 More... NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]
CTD PMID:23830814 PMID:27544635 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
Thioctic Acid results in increased activity of CASP9 protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
CTD PMID:16990509 PMID:19951573 PMID:23830814 PMID:27544635 PMID:30605698
G Cat catalase multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of CAT mRNA]
Thioctic Acid results in increased expression of CAT mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA
Thioctic Acid results in increased activity of CAT protein
[acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Carbimazole results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Cytarabine results in decreased expression of CAT protein]; Thioctic Acid inhibits the reaction [High Fructose Corn Syrup results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]
CTD PMID:15998567 PMID:19368863 PMID:19699728 PMID:19715735 PMID:21763304 More... NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] CTD PMID:22488045 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] CTD PMID:21600978 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Cd36 CD36 molecule multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] CTD PMID:21315065 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cd86 CD86 molecule increases expression ISO Thioctic Acid results in increased expression of CD86 protein CTD PMID:19033392 NCBI chr11:77,647,565...77,706,178 JBrowse link
G Cd8a CD8 subunit alpha multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 NCBI chr 4:104,924,116...104,928,353 JBrowse link
G Cdx4 caudal type homeo box 4 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] CTD PMID:23608068 NCBI chr  X:68,326,874...68,335,461 JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP [Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein CTD PMID:19669875 NCBI chr16:7,657,362...7,717,093 JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] CTD PMID:19635391 NCBI chr 1:209,887,854...209,889,877 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA]
CTD PMID:21251946 PMID:23830814 PMID:34252510 PMID:35187969 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL3A1 mRNA] CTD PMID:34252510 NCBI chr 9:54,866,646...54,902,578 JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of COX4I1 mRNA] CTD PMID:34252510 NCBI chr19:65,630,383...65,636,623 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:22464149 NCBI chr 1:209,993,881...210,056,329 JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] CTD PMID:32061141 NCBI chr 9:73,397,333...73,466,339 JBrowse link
G Crp C-reactive protein multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] CTD PMID:26276312 NCBI chr13:87,694,062...87,695,978 JBrowse link
G Cryaa crystallin, alpha A multiple interactions EXP Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] CTD PMID:20597648 NCBI chr20:9,783,605...9,787,351 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of CTNNB1 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of CTNNB1 protein] CTD PMID:34133789 NCBI chr 8:129,517,576...129,544,661 JBrowse link
G Ctsd cathepsin D multiple interactions EXP Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 NCBI chr 1:206,956,945...206,968,821 JBrowse link
G Ctss cathepsin S decreases expression ISO Thioctic Acid results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:185,775,316...185,803,440 JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA]
Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of CYBA mRNA]
CTD PMID:33111558 PMID:35187969 NCBI chr19:50,487,598...50,495,669 JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] CTD PMID:26518973 NCBI chr  X:16,030,596...16,065,065 JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19951573 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] CTD PMID:21932800 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:21932800 PMID:24120545 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] CTD PMID:32061150 NCBI chr 1:205,269,967...205,280,365 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Dab1 DAB adaptor protein 1 multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA CTD PMID:31068541 NCBI chr 5:118,392,953...119,513,625 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr 7:65,001,695...65,006,517 JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] CTD PMID:22464149 NCBI chr 1:153,454,078...153,484,432 JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] CTD PMID:27260466 NCBI chr 5:122,074,285...122,090,983 JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions EXP [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] CTD PMID:21551353 NCBI chr 6:53,631,686...53,655,059 JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein] CTD PMID:34133789 NCBI chr10:55,239,397...55,267,780 JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases expression
ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L mRNA]; Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L protein]
Thioctic Acid results in decreased expression of DNM1L mRNA
CTD PMID:37739047 NCBI chr11:98,084,049...98,135,663 JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] CTD PMID:20730801 NCBI chr 8:58,605,403...58,669,339 JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] CTD PMID:23892647 NCBI chr 2:142,761,303...142,794,767 JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] CTD PMID:30605698 NCBI chr 6:103,405,880...103,430,549 JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] CTD PMID:27544635 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of FIS1 mRNA] CTD PMID:37739047 NCBI chr12:25,345,239...25,360,135 JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 NCBI chr12:12,333,050...12,504,750 JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Diazinon results in decreased expression of FN1 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]
CTD PMID:32911022 PMID:35187969 NCBI chr 9:80,645,507...80,714,200 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Foxo3 forkhead box O3 decreases acetylation
multiple interactions
EXP Thioctic Acid results in decreased acetylation of FOXO3 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein
CTD PMID:22327056 NCBI chr20:47,251,968...47,348,254 JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] CTD PMID:23608068 NCBI chr14:12,791,407...13,200,862 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] CTD PMID:20957662 NCBI chr 3:114,003,262...114,007,072 JBrowse link
G Fxn frataxin increases expression EXP Thioctic Acid results in increased expression of FXN protein CTD PMID:18809400 NCBI chr 1:231,300,457...231,323,989 JBrowse link
G Fzd2 frizzled class receptor 2 multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of FZD2 protein] CTD PMID:34133789 NCBI chr10:88,061,988...88,063,898 JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA CTD PMID:31068541 NCBI chr 3:75,777,260...75,818,099 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GCLC mRNA
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]; Thioctic Acid results in increased expression of and results in increased activity of GCLC protein
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]
CTD PMID:16249512 PMID:17940886 PMID:26365678 PMID:27298056 PMID:32061141 More... NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GCLM mRNA; Thioctic Acid results in increased expression of GCLM protein
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA]; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein]
CTD PMID:16249512 PMID:26365678 PMID:32061141 NCBI chr 2:213,032,135...213,052,192 JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Thioctic Acid results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:88,352,987...88,361,661 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] CTD PMID:24704557 NCBI chr20:13,074,695...13,104,095 JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]
CTD PMID:26165643 PMID:27260466 NCBI chr20:36,302,490...36,315,010 JBrowse link
G Gls glutaminase multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] CTD PMID:32061141 NCBI chr 9:49,344,616...49,416,900 JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions EXP Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] CTD PMID:28070105 NCBI chr14:21,856,871...21,874,861 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of GPT protein]
CTD PMID:24704557 PMID:37739047 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GPX1 mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA]
CTD PMID:23649336 PMID:32061141 NCBI chr 8:117,905,462...117,906,588 JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA CTD PMID:23830814 NCBI chr 6:101,226,745...101,230,033 JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
multiple interactions
ISO Thioctic Acid results in increased expression of GPX3 mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA
CTD PMID:23649336 NCBI chr10:39,529,335...39,537,406 JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Thioctic Acid results in increased expression of GPX5 mRNA CTD PMID:23649336 NCBI chr17:43,436,126...43,443,074 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] CTD PMID:32061141 NCBI chr 3:28,501,836...28,528,754 JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] CTD PMID:31068541 PMID:32061141 NCBI chr10:6,136,458...6,560,003 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO
EXP
Thioctic Acid results in increased phosphorylation of GSK3B protein
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of GSK3B protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of GSK3B protein]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]
CTD PMID:19879292 PMID:27260466 PMID:34133789 NCBI chr11:76,004,502...76,154,665 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
EXP
ISO
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Carbimazole results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]
Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]
Thioctic Acid results in increased expression of GSR mRNA
CTD PMID:19699728 PMID:22623521 PMID:23649336 PMID:27581792 PMID:32061150 More... NCBI chr16:65,185,574...65,228,742 JBrowse link
G Gss glutathione synthetase multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] CTD PMID:32061141 NCBI chr 3:144,047,849...144,078,197 JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
[Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
CTD PMID:18367378 PMID:23830814 NCBI chr 2:198,338,005...198,346,007 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein
Thioctic Acid results in increased expression of GSTP1 mRNA
CTD PMID:20237067 NCBI chr 1:210,767,237...210,770,242 JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 NCBI chr12:32,337,281...32,350,838 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO
EXP
[Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein
Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 mRNA]; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 protein]
CTD PMID:28433809 PMID:33111558 NCBI chr10:31,118,667...31,151,730 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein]
Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA]
CTD PMID:19033392 PMID:21315065 PMID:22488045 PMID:23649336 PMID:23942037 More... NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hs1bp3 HCLS1 binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] CTD PMID:23608068 NCBI chr 6:31,192,568...31,222,835 JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] CTD PMID:28880400 NCBI chr20:3,875,411...3,877,866 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr 3:38,453,016...38,457,475 JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr14:86,270,208...86,277,944 JBrowse link
G Il10 interleukin 10 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] CTD PMID:19735303 PMID:26518973 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA CTD PMID:31068541 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B]
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]
CTD PMID:23830814 PMID:24975507 PMID:26518973 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il2 interleukin 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] CTD PMID:21195065 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] CTD PMID:23608068 NCBI chr 1:14,353,736...14,377,844 JBrowse link
G Il4 interleukin 4 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA CTD PMID:23830814 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA]
[Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:22488045 PMID:26518973 PMID:28433809 PMID:29233029 PMID:29760339 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Ins1 insulin 1 multiple interactions EXP acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] CTD PMID:21461750 PMID:29760339 NCBI chr 1:261,186,119...261,186,686 JBrowse link
G Ins2 insulin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 NCBI chr 1:207,272,738...207,421,998 JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein CTD PMID:24975507 NCBI chr10:38,417,935...38,424,946 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases activity
EXP [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]
Thioctic Acid results in increased expression of JUN protein
Thioctic Acid results in increased activity of JUN protein
CTD PMID:20237067 NCBI chr 5:115,009,900...115,012,993 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression
multiple interactions
ISO Thioctic Acid results in increased expression of KEAP1 protein
Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein]
CTD PMID:19033392 PMID:34252510 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions EXP Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] CTD PMID:21195065 PMID:27581792 NCBI chr 1:97,385,984...97,403,382 JBrowse link
G Lep leptin decreases secretion
decreases expression
ISO
EXP
Thioctic Acid results in decreased secretion of LEP protein
Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein
CTD PMID:21351249 NCBI chr 4:58,626,529...58,640,663 JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] CTD PMID:20957662 PMID:28070105 NCBI chr 1:105,037,457...105,038,446 JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases phosphorylation
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] CTD PMID:22941773 NCBI chr 1:80,965,612...80,984,313 JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects activity
multiple interactions
EXP Thioctic Acid affects the activity of MAPK1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein]
CTD PMID:15909127 PMID:21251946 PMID:32061141 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA CTD PMID:23830814 NCBI chr20:6,751,288...6,812,294 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] CTD PMID:21251946 PMID:23830814 PMID:32061141 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA CTD PMID:23830814 NCBI chr16:8,645,171...8,728,225 JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of MAPT protein] CTD PMID:34133789 NCBI chr10:89,638,618...89,736,108 JBrowse link
G Mff mitochondrial fission factor multiple interactions
decreases expression
ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFF mRNA]
Thioctic Acid results in decreased expression of MFF mRNA
CTD PMID:37739047 NCBI chr 9:84,007,798...84,036,039 JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFN2 mRNA] CTD PMID:37739047 NCBI chr 5:158,304,285...158,335,502 JBrowse link
G Mir21 microRNA 21 multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] CTD PMID:26276312 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mir210 microRNA 210 multiple interactions EXP [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] CTD PMID:26276312 NCBI chr 1:196,326,343...196,326,452 JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 NCBI chr 8:4,581,785...4,591,687 JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]
CTD PMID:24975507 PMID:29233029 NCBI chr 8:4,497,960...4,508,239 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA CTD PMID:23830814 NCBI chr19:30,327,643...30,355,856 JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:24975507 NCBI chr 8:12,925,267...12,938,828 JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] CTD PMID:21315065 NCBI chr16:52,717,775...52,803,602 JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA CTD PMID:18367378 NCBI chr19:10,831,959...10,832,975 JBrowse link
G Mvd mevalonate diphosphate decarboxylase multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA CTD PMID:18367378 NCBI chr19:50,496,366...50,506,429 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] CTD PMID:21600978 NCBI chr 7:95,483,105...95,488,031 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] CTD PMID:26518973 NCBI chr12:28,121,816...28,131,080 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
increases expression
increases activity
decreases expression
ISO
EXP
[Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein
Thioctic Acid affects the localization of NFE2L2 protein
Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid results in increased activity of NFE2L2 protein
[Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]
Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein
[Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of NFE2L2 protein]
CTD PMID:17197552 PMID:18258206 PMID:20237067 PMID:22488045 PMID:23649336 More... NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA
CTD PMID:21600978 PMID:31068541 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of NFKBIA protein] CTD PMID:34133789 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Ngfr nerve growth factor receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA] CTD PMID:23608068 NCBI chr10:81,012,077...81,030,305 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Thioctic Acid inhibits the reaction [High Fructose Corn Syrup results in increased expression of NOS2 protein]
CTD PMID:15453632 PMID:21763304 PMID:25825413 PMID:29233029 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:27260466 NCBI chr 4:11,686,088...11,706,604 JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] CTD PMID:29760339 NCBI chr  X:97,279,058...97,332,291 JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP
ISO
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of NOX4 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]
CTD PMID:29760339 PMID:33111558 PMID:35187969 NCBI chr 1:150,313,736...150,491,480 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased activity of NQO1 protein
Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein
[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]
CTD PMID:12180195 PMID:17940886 PMID:19033392 PMID:23649336 PMID:23830814 More... NCBI chr19:52,205,374...52,220,267 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of OPA1 mRNA] CTD PMID:37739047 NCBI chr11:84,612,943...84,690,025 JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr15:21,942,233...21,953,034 JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Thioctic Acid results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:21,933,179...21,998,134 JBrowse link
G Pcdhb13 protocadherin beta 13 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] CTD PMID:23608068 NCBI chr18:29,146,017...29,149,871 JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] CTD PMID:21251946 NCBI chr 3:139,951,948...139,955,820 JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PINK1 mRNA] CTD PMID:37739047 NCBI chr 5:155,813,838...155,825,950 JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 decreases expression
decreases activity
ISO Thioctic Acid results in decreased expression of PLAAT3 mRNA
Thioctic Acid results in decreased activity of PLAAT3 protein
CTD PMID:22941773 NCBI chr 1:204,782,608...204,816,397 JBrowse link
G Plin1 perilipin 1 increases phosphorylation ISO Thioctic Acid results in increased phosphorylation of PLIN1 protein CTD PMID:22941773 NCBI chr 1:143,073,612...143,086,199 JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity
ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:16391466 PMID:21932800 PMID:24120545 NCBI chr12:26,587,674...26,655,612 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22464149 NCBI chr 7:118,712,261...118,780,723 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP [Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA CTD PMID:22464149 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression
increases expression
ISO
EXP
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
Thioctic Acid results in decreased expression of PPARGC1A protein
[Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]
Thioctic Acid results in increased expression of PPARGC1A protein
CTD PMID:20414966 PMID:22464149 PMID:34252510 PMID:37739047 NCBI chr14:63,073,505...63,729,215 JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions
decreases acetylation
EXP [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
Thioctic Acid results in decreased acetylation of PPARGC1B protein
CTD PMID:22327056 PMID:22464149 NCBI chr18:54,758,891...54,861,103 JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRDX3 mRNA] CTD PMID:37739047 NCBI chr 1:260,001,642...260,014,064 JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [Thioctic Acid co-treated with Silicon] results in increased expression of PRKAA2 mRNA CTD PMID:34252510 NCBI chr 5:125,036,945...125,109,010 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRKN mRNA] CTD PMID:37739047 NCBI chr 1:51,236,410...52,430,242 JBrowse link
G Psen1 presenilin 1 multiple interactions EXP Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PSEN1 protein] CTD PMID:34133789 NCBI chr 6:109,054,160...109,106,191 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] CTD PMID:19735303 PMID:23830814 PMID:26276312 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of RELA protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]
Thioctic Acid results in decreased phosphorylation of RELA protein
CTD PMID:22488045 PMID:29233029 PMID:34133789 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Reln reelin multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA CTD PMID:31068541 NCBI chr 4:12,736,177...13,162,956 JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr20:12,372,345...12,381,159 JBrowse link
G Sema5a semaphorin 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] CTD PMID:23608068 NCBI chr 2:83,309,843...83,741,084 JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in increased expression of SERPINE1 protein] CTD PMID:34252510 NCBI chr12:25,237,977...25,248,356 JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] CTD PMID:24704557 NCBI chr 1:153,643,500...153,650,853 JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions EXP Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA] CTD PMID:25215149 NCBI chr16:17,008,180...17,011,686 JBrowse link
G Sftpb surfactant protein B multiple interactions EXP Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPB mRNA] CTD PMID:25215149 NCBI chr 4:104,359,303...104,368,439 JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of SIRT1 protein
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA]
Thioctic Acid results in increased expression of SIRT1 mRNA
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA]
CTD PMID:22327056 PMID:37739047 NCBI chr20:25,305,953...25,328,000 JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
EXP
ISO
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA]
Thioctic Acid results in increased expression of SIRT3 protein
CTD PMID:22327056 PMID:37739047 NCBI chr 1:195,942,066...195,964,472 JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions
affects activity
EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]
Thioctic Acid affects the activity of SLC12A2 protein
CTD PMID:23880158 NCBI chr18:51,348,282...51,416,448 JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] CTD PMID:32061141 NCBI chr 1:226,549,932...226,631,925 JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr 7:129,730,450...129,742,619 JBrowse link
G Slc5a6 solute carrier family 5 member 6 increases transport
multiple interactions
ISO
EXP
SLC5A6 results in increased transport of Thioctic Acid
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid]
CTD PMID:9516450 PMID:10329687 NCBI chr 6:31,039,865...31,051,671 JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] CTD PMID:32061141 NCBI chr 2:136,532,912...136,668,560 JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:35187969 NCBI chr18:72,124,792...72,193,345 JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Snca synuclein alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:91,026,474...91,127,444 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Glucose results in decreased expression of SOD1 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] CTD PMID:15804455 PMID:26518973 PMID:37944786 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
EXP
ISO
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of SOD2 mRNA]
Thioctic Acid results in increased activity of SOD2 protein
CTD PMID:15804455 PMID:19951573 PMID:22327056 PMID:27260466 PMID:34252510 NCBI chr 1:50,043,323...50,050,168 JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 NCBI chr 7:135,419,864...135,450,513 JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of SRD5A1 mRNA] CTD PMID:38342389 NCBI chr 1:35,514,914...35,548,898 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22464149 NCBI chr10:45,507,152...45,529,164 JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] CTD PMID:28070105 NCBI chr16:72,969,824...72,974,447 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] CTD PMID:19635391 PMID:28086195 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] CTD PMID:19635391 PMID:28086195 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO [Thioctic Acid co-treated with Silicon] results in increased expression of STK11 mRNA CTD PMID:34252510 NCBI chr 7:10,225,204...10,241,965 JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases expression ISO Thioctic Acid results in increased expression of SUMO1 protein CTD PMID:24975507 NCBI chr 9:61,078,790...61,108,697 JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of TFAM mRNA] CTD PMID:34252510 NCBI chr20:17,356,243...17,368,293 JBrowse link
G Tgfa transforming growth factor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFA mRNA] CTD PMID:29233029 NCBI chr 4:120,175,549...120,258,342 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of TGFB1 protein]
CTD PMID:15309289 PMID:21251946 PMID:24704557 PMID:26276312 PMID:29760339 More... NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] CTD PMID:23608068 NCBI chr 1:182,828,553...182,835,465 JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA CTD PMID:23830814 PMID:31068541 NCBI chr13:98,160,075...98,261,771 JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] CTD PMID:27260466 NCBI chr10:84,198,141...84,225,659 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [High Fructose Corn Syrup results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]
CTD PMID:15309289 PMID:23830814 PMID:25215149 PMID:25825413 PMID:26276312 More... NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 multiple interactions EXP Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TNFRSF10B mRNA] CTD PMID:23830814 NCBI chr 1:198,840,452...198,860,713 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA CTD PMID:23830814 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 1:78,342,571...78,346,255 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:19900424 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] CTD PMID:23608068 PMID:23892647 NCBI chr 3:161,269,939...161,275,533 JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:23830814 PMID:31068541 NCBI chr 5:77,507,455...77,519,685 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction
multiple interactions
ISO
EXP
TXNRD1 protein results in increased reduction of Thioctic Acid
Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]
CTD PMID:20810785 PMID:21172426 NCBI chr 7:22,717,620...22,802,553 JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] CTD PMID:22327056 PMID:22464149 NCBI chr 1:164,251,373...164,257,742 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
EXP
ISO
Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]
CTD PMID:11596663 PMID:22488045 PMID:26276312 NCBI chr 9:22,452,854...22,468,194 JBrowse link
G Wnt5a Wnt family member 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of WNT5A protein] CTD PMID:37739047 NCBI chr16:3,702,300...3,724,860 JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:32662911 NCBI chr 6:21,530,463...21,592,172 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      atom 19896
        nonmetal atom 19818
          sulfur atom 17776
            sulfur molecular entity 17776
              organosulfur compound 17471
                sulfur-containing carboxylic acid 6666
                  thia fatty acid 218
                    (R)-lipoic acid + 217
                    (S)-lipoic acid + 0
                    2-hydroxy-4-(methylthio)butanoic acid 0
                    3-(methylthio)propionic acid + 0
                    4-(Dimethylsulfonio)-2-hydroxybutanoate 0
                    Sulfobutanedioic acid 0
                    Technetium Tc 99m succimer 0
                    lipoic acid + 218
                    malathion diacid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      monocarboxylic acid 18028
                                        fatty acid 16855
                                          thia fatty acid 218
                                            (R)-lipoic acid + 217
                                            (S)-lipoic acid + 0
                                            2-hydroxy-4-(methylthio)butanoic acid 0
                                            3-(methylthio)propionic acid + 0
                                            4-(Dimethylsulfonio)-2-hydroxybutanoate 0
                                            Sulfobutanedioic acid 0
                                            Technetium Tc 99m succimer 0
                                            lipoic acid + 218
                                            malathion diacid 0
paths to the root