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ONTOLOGY REPORT - ANNOTATIONS


Term:4'-hydroxydiclofenac
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Accession:CHEBI:59613 term browser browse the term
Definition:A monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac.
Synonyms:exact_synonym: {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
 related_synonym: (o-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid;   4'-OH DCF;   4'-hydroxy diclofenac;   Formula=C14H11Cl2NO3;   InChI=1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20);   InChIKey=KGVXVPRLBMWZLG-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccccc1Nc1c(Cl)cc(O)cc1Cl
 xref: Beilstein:4198042 "Beilstein";   CAS:64118-84-9 "ChemIDplus"
 xref_mesh: MESH:C108036
 xref: PMID:10027798 "Europe PMC";   PMID:10709153 "Europe PMC";   PMID:10807502 "Europe PMC";   PMID:12966366 "Europe PMC";   PMID:14609740 "Europe PMC";   PMID:15139759 "Europe PMC";   PMID:15265128 "Europe PMC";   PMID:15455182 "Europe PMC";   PMID:17123753 "Europe PMC";   PMID:18548238 "Europe PMC";   PMID:2118185 "Europe PMC";   PMID:9226412 "Europe PMC";   PMID:9862754 "Europe PMC";   Reaxys:4198042 "Reaxys"


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4'-hydroxydiclofenac term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 JBrowse link 17 32,131,847 32,158,559 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        xenobiotic 18261
          diclofenac 995
            4'-hydroxydiclofenac 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        monocarboxylic acid 17260
                                          acetic acid 10588
                                            phenylacetic acid 1151
                                              diclofenac 995
                                                4'-hydroxydiclofenac 14
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.