|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
4'-hydroxydiclofenac binds to and affects the activity of AR protein |
CTD |
PMID:29777833 |
|
NCBI chr X:63,104,771...63,273,934
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
4'-hydroxydiclofenac results in increased expression of CCL2 mRNA |
CTD |
PMID:24104198 |
|
NCBI chr10:67,503,077...67,504,875
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac |
CTD |
PMID:24246759 |
|
NCBI chr 7:115,762,662...115,771,832
|
|
G |
Esr1 |
estrogen receptor 1 |
affects activity |
ISO |
4'-hydroxydiclofenac affects the activity of ESR1 protein |
CTD |
PMID:29777833 |
|
NCBI chr 1:43,511,685...43,904,454
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
increases glutathionylation multiple interactions |
ISO |
GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] |
CTD |
PMID:24246759 PMID:24552538 |
|
NCBI chr 1:210,767,237...210,770,242
|
|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein] |
CTD |
PMID:29777833 |
|
NCBI chr13:45,024,921...45,029,586
|
|
G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] |
CTD |
PMID:29777833 |
|
NCBI chr 2:121,932,968...121,937,672
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein] |
CTD |
PMID:29777833 |
|
NCBI chr10:38,272,003...38,277,549
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein] |
CTD |
PMID:29777833 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac |
CTD |
PMID:28754375 |
|
NCBI chr10:73,092,124...73,102,057
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac] |
CTD |
PMID:24552538 |
|
NCBI chr19:52,205,374...52,220,267
|
|
G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
multiple interactions |
ISO |
NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac |
CTD |
PMID:29281794 |
|
NCBI chr17:30,909,482...30,938,725
|
|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein |
CTD |
PMID:29777833 |
|
NCBI chr18:31,522,783...31,644,508
|
|
G |
Tnf |
tumor necrosis factor |
increases response to substance multiple interactions |
EXP ISO |
TNF protein results in increased susceptibility to 4'-hydroxydiclofenac 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein] |
CTD |
PMID:23939143 PMID:29777833 |
|
NCBI chr20:3,626,685...3,629,303
|
|