Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4'-hydroxydiclofenac
go back to main search page
Accession:CHEBI:59613 term browser browse the term
Definition:A monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac.
Synonyms:exact_synonym: {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
 related_synonym: (o-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid;   4'-OH DCF;   4'-hydroxy diclofenac;   Formula=C14H11Cl2NO3;   InChI=1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20);   InChIKey=KGVXVPRLBMWZLG-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccccc1Nc1c(Cl)cc(O)cc1Cl
 xref: Beilstein:4198042;   CAS:64118-84-9
 xref_mesh: MESH:C108036
 xref: PMID:10027798;   PMID:10709153;   PMID:10807502;   PMID:12966366;   PMID:14609740;   PMID:15139759;   PMID:15265128;   PMID:15455182;   PMID:17123753;   PMID:18548238;   PMID:2118185;   PMID:9226412;   PMID:9862754;   Reaxys:4198042


show annotations for term's descendants           Sort by:
 
4'-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 4'-hydroxydiclofenac results in increased expression of CCL2 mRNA CTD PMID:24104198 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases chemical synthesis
multiple interactions
ISO CYP2C9 protein results in increased chemical synthesis of 4'-hydroxydiclofenac
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Diclofenac] which affects the abundance of 4'-hydroxydiclofenac; [CYP2C9 mRNA results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]
CTD PMID:12401345 PMID:15155557 PMID:24104198 PMID:24246759 PMID:25084468 More... NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO 4'-hydroxydiclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases glutathionylation
multiple interactions
ISO GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]
CTD PMID:24246759 PMID:24552538 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Il10 interleukin 10 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein] CTD PMID:29777833 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il2 interleukin 2 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein] CTD PMID:29777833 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein] CTD PMID:29777833 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac] CTD PMID:24552538 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein CTD PMID:29777833 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Tnf tumor necrosis factor increases response to substance
multiple interactions
EXP
ISO
TNF protein results in increased susceptibility to 4'-hydroxydiclofenac
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]
CTD PMID:23939143 PMID:29777833 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        xenobiotic 18442
          diclofenac 1007
            4'-hydroxydiclofenac 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          acetic acid 10854
                                            phenylacetic acid 1163
                                              diclofenac 1007
                                                4'-hydroxydiclofenac 15
paths to the root