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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4'-hydroxydiclofenac
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Accession:CHEBI:59613 term browser browse the term
Definition:A monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac.
Synonyms:exact_synonym: {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
 related_synonym: (o-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid;   4'-OH DCF;   4'-hydroxy diclofenac;   Formula=C14H11Cl2NO3;   InChI=1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20);   InChIKey=KGVXVPRLBMWZLG-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccccc1Nc1c(Cl)cc(O)cc1Cl
 xref: Beilstein:4198042;   CAS:64118-84-9
 xref_mesh: MESH:C108036
 xref: PMID:10027798;   PMID:10709153;   PMID:10807502;   PMID:12966366;   PMID:14609740;   PMID:15139759;   PMID:15265128;   PMID:15455182;   PMID:17123753;   PMID:18548238;   PMID:2118185;   PMID:9226412;   PMID:9862754;   Reaxys:4198042


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4'-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 4'-hydroxydiclofenac results in increased expression of CCL2 mRNA CTD PMID:24104198 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO 4'-hydroxydiclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases glutathionylation
multiple interactions
ISO GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]
CTD PMID:24246759, PMID:24552538 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il10 interleukin 10 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein] CTD PMID:29777833 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il2 interleukin 2 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein] CTD PMID:29777833 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein] CTD PMID:29777833 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac] CTD PMID:24552538 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac CTD PMID:29281794 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein CTD PMID:29777833 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Tnf tumor necrosis factor increases response to substance
multiple interactions
EXP
ISO
TNF protein results in increased susceptibility to 4'-hydroxydiclofenac
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]
CTD PMID:23939143, PMID:29777833 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        xenobiotic 18381
          diclofenac 996
            4'-hydroxydiclofenac 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          acetic acid 10697
                                            phenylacetic acid 1151
                                              diclofenac 996
                                                4'-hydroxydiclofenac 14
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