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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:irbesartan
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Accession:CHEBI:5959 term browser browse the term
Definition:A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
Synonyms:exact_synonym: 2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
 related_synonym: 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one;   Avapro;   BMS 186295;   Formula=C25H28N6O;   InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30);   InChIKey=YOSHYTLCDANDAN-UHFFFAOYSA-N;   SMILES=CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
 xref: Beilstein:6620400;   CAS:138402-11-6;   DrugBank:DB01029;   Drug_Central:1481;   KEGG:C07469;   KEGG:D00523;   LINCS:LSM-3338
 xref_mesh: MESH:C081309
 xref: PMID:15101793;   PMID:15210574;   PMID:15526904;   Patent:US5270317;   Patent:WO9114679;   Reaxys:6620400;   Wikipedia:Irbesartan



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irbesartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO irbesartan results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Ace2 angiotensin I converting enzyme 2 affects response to substance ISO ACE2 gene polymorphism affects the susceptibility to irbesartan CTD PMID:11593098 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein CTD PMID:15149348 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen affects response to substance
multiple interactions
increases expression
ISO
EXP
AGT gene polymorphism affects the susceptibility to irbesartan; AGT gene SNP affects the susceptibility to irbesartan
irbesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]
irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
irbesartan results in increased expression of AGT protein
Cholesterol inhibits the reaction [irbesartan results in increased expression of AGT protein]
CTD PMID:10082498 PMID:11910301 PMID:14639093 PMID:15614026 PMID:16794485 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects response to substance
multiple interactions
ISO AGTR1 gene polymorphism affects the susceptibility to irbesartan
Cholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA]
irbesartan binds to and results in decreased activity of AGTR1 protein
CTD PMID:11910301 PMID:12022239 PMID:19028402 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of AKT1 protein] CTD PMID:19028402 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions ISO Irbesartan inhibits the reaction [Acetaminophen results in increased expression of ALB protein] CTD PMID:31967706 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Apob apolipoprotein B affects response to substance ISO APOB gene SNP affects the susceptibility to irbesartan CTD PMID:15453913 PMID:15614026 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
irbesartan inhibits the reaction [ioversol results in increased expression of BAX mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
CTD PMID:16828304 PMID:31967706 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
irbesartan inhibits the reaction [ioversol results in decreased expression of BCL2 mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]
CTD PMID:16828304 PMID:31967706 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance ISO BDKRB2 exon polymorphism affects the susceptibility to irbesartan CTD PMID:12640257 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO irbesartan results in decreased activity of CA1 protein CTD PMID:11196069 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Irbesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Irbesartan inhibits the reaction [Indomethacin results in increased expression of CASP3 mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]
CTD PMID:23300732 PMID:29523851 PMID:31967706 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 protein] CTD PMID:19028402 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein] CTD PMID:33380422 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases response to substance ISO CYP11B2 gene SNP results in increased susceptibility to irbesartan CTD PMID:12022239 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing
decreases response to substance
ISO CYP2C9 protein results in increased metabolism of Irbesartan
CYP2C9 gene polymorphism results in decreased susceptibility to Irbesartan
CTD PMID:12359989 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO irbesartan results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Irbesartan inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein] CTD PMID:31967706 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in decreased expression of DDAH1 mRNA] CTD PMID:29523851 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
JBrowse link
G Edn1 endothelin 1 affects response to substance ISO EDN1 gene polymorphism affects the susceptibility to irbesartan CTD PMID:15188945 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in increased expression of EGFR mRNA] CTD PMID:29523851 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 affects response to substance ISO ERAP1 gene polymorphism affects the susceptibility to irbesartan CTD PMID:13678427 NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of F3 mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of F3 protein CTD PMID:21229253 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Irbesartan inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:31967706 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Ifng interferon gamma decreases expression ISO irbesartan results in decreased expression of IFNG protein CTD PMID:15210574 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 protein] CTD PMID:19028402 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein]
Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]
CTD PMID:33380422 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in increased expression of MMP9 protein] CTD PMID:29523851 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 protein] CTD PMID:19028402 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of NFKB1 protein] CTD PMID:19028402 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased phosphorylation of NFKBIB protein] CTD PMID:19028402 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nppa natriuretic peptide A increases expression ISO irbesartan results in increased expression of NPPA protein CTD PMID:12035877 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA] CTD PMID:29523851 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of RAC1 mRNA] CTD PMID:19028402 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of RELA protein] CTD PMID:19028402 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin increases expression ISO irbesartan results in increased expression of REN protein CTD PMID:14639093 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Ret ret proto-oncogene increases expression ISO irbesartan results in increased expression of RET protein CTD PMID:16164579 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Smad2 SMAD family member 2 multiple interactions
affects expression
EXP [benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein
irbesartan affects the expression of SMAD2 mRNA; irbesartan affects the expression of SMAD2 protein
CTD PMID:16635409 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
affects expression
EXP [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein
irbesartan affects the expression of SMAD3 mRNA; irbesartan affects the expression of SMAD3 protein
CTD PMID:16635409 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Tfpi tissue factor pathway inhibitor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of TFPI mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of TFPI protein CTD PMID:21229253 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects response to substance
multiple interactions
affects expression
decreases expression
ISO
EXP
TGFB1 gene SNP affects the susceptibility to irbesartan
[benazepril co-treated with irbesartan] affects the expression of TGFB1 mRNA
irbesartan affects the expression of TGFB1 mRNA
irbesartan results in decreased expression of TGFB1 mRNA
CTD PMID:11352773 PMID:15049387 PMID:16635409 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
irbesartan results in decreased expression of TNF protein
Irbesartan inhibits the reaction [Indomethacin results in increased expression of TNF protein]
Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF mRNA]; Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF protein]; Irbesartan inhibits the reaction [Acetaminophen results in increased expression of TNF protein]
CTD PMID:15210574 PMID:19028402 PMID:29523851 PMID:31967706 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 protein] CTD PMID:19028402 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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    role 19746
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          irbesartan 45
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  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
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              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  heteroarene 16539
                                    monocyclic heteroarene 13505
                                      azole 12710
                                        tetrazoles 346
                                          biphenylyltetrazole 315
                                            irbesartan 45
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