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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.13.* (dipeptidase) inhibitor
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Accession:CHEBI:59499 term browser browse the term
Definition:Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that inhibits the action of a dipeptidase (EC 3.4.13.*).
Synonyms:related_synonym: EC 3.4.13.* (dipeptidase) inhibitors;   EC 3.4.13.* inhibitor;   EC 3.4.13.* inhibitors;   dipeptidase inhibitor;   dipeptidase inhibitors

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cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Cilastatin inhibits the reaction [Vancomycin results in decreased expression of and affects the localization of ABCB1 protein]; Cilastatin results in increased expression of and affects the localization of ABCB1 protein CTD PMID:28549670 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G Dpep1 dipeptidase 1 decreases activity ISO Cilastatin results in decreased activity of DPEP1 protein CTD PMID:30664745 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19887
      biological role 19885
        biochemical role 19581
          enzyme inhibitor 18765
            EC 3.* (hydrolase) inhibitor 18360
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 4425
                EC 3.4.13.* (dipeptidase) inhibitor 2
                  EC (membrane dipeptidase) inhibitor + 2
paths to the root