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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.13.* (dipeptidase) inhibitor
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Accession:CHEBI:59499 term browser browse the term
Definition:Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that inhibits the action of a dipeptidase (EC 3.4.13.*).
Synonyms:related_synonym: EC 3.4.13.* (dipeptidase) inhibitors;   EC 3.4.13.* inhibitor;   EC 3.4.13.* inhibitors;   dipeptidase inhibitor;   dipeptidase inhibitors


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cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Cilastatin inhibits the reaction [Vancomycin results in decreased expression of and affects the localization of ABCB1 protein]; Cilastatin results in increased expression of and affects the localization of ABCB1 protein CTD PMID:28549670 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G Dpep1 dipeptidase 1 decreases activity ISO Cilastatin results in decreased activity of DPEP1 protein CTD PMID:30664745 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          enzyme inhibitor 18163
            EC 3.* (hydrolase) inhibitor 17660
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 3219
                EC 3.4.13.* (dipeptidase) inhibitor 2
                  EC 3.4.13.19 (membrane dipeptidase) inhibitor + 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.