CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: mephedrone
Accession: CHEBI:59331
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Definition: An aromatic ketone that is propiophenone substituted at C-4 and at C-beta with methyl and methylamino groups respectively. It is a synthetic stimulant and entactogen drug of the amphetamine and cathinone classes.
Synonyms: exact_synonym: 2-(methylamino)-1-(4-methylphenyl)propan-1-one
related_synonym: 4-MMC; 4-methylephedrone; 4-methylmethcathinone; Formula=C11H15NO; InChI=1S/C11H15NO/c1-8-4-6-10(7-5-8)11(13)9(2)12-3/h4-7,9,12H,1-3H3; InChIKey=YELGFTGWJGBAQU-UHFFFAOYSA-N; SMILES=CNC(C)C(=O)c1ccc(C)cc1
xref: Beilstein:2717770; CAS:1189805-46-6; HMDB:HMDB0041923
xref_mesh: MESH:C548233
xref: PMID:23949206; PMID:24446273; PMID:24456744; Patent:US2012094316; Reaxys:2717770; Wikipedia:Mephedrone
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Casp3
caspase 3
increases activity
ISO
mephedrone results in increased activity of CASP3 protein
CTD
PMID:32382956
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
decreases expression increases expression
EXP ISO
mephedrone results in decreased expression of CAT protein mephedrone results in increased expression of CAT protein
CTD
PMID:25817894 PMID:26747301
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
affects expression
EXP
mephedrone affects the expression of CCL2 protein
CTD
PMID:34742947
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Drd2
dopamine receptor D2
decreases expression
EXP
mephedrone results in decreased expression of DRD2 protein
CTD
PMID:25817894
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Gpx1
glutathione peroxidase 1
decreases expression increases expression
EXP ISO
mephedrone results in decreased expression of GPX1 protein mephedrone results in increased expression of GPX1 protein
CTD
PMID:25817894 PMID:26747301
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Il1a
interleukin 1 alpha
affects expression
EXP
mephedrone affects the expression of IL1A protein
CTD
PMID:34742947
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
affects expression
EXP
mephedrone affects the expression of IL1B protein
CTD
PMID:34742947
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
affects expression
EXP
mephedrone affects the expression of IL6 protein
CTD
PMID:34742947
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Nos1
nitric oxide synthase 1
affects expression
EXP
mephedrone affects the expression of NOS1 protein
CTD
PMID:25817894
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Slc6a3
solute carrier family 6 member 3
decreases expression multiple interactions
EXP ISO
mephedrone results in decreased expression of SLC6A3 protein Ethanol promotes the reaction [mephedrone results in decreased expression of SLC6A3 protein]
CTD
PMID:25817894 PMID:26747301
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Slc6a4
solute carrier family 6 member 4
multiple interactions decreases expression
ISO EXP
Ethanol promotes the reaction [mephedrone results in decreased expression of SLC6A4 protein]
CTD
PMID:25817894 PMID:26747301
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Sod1
superoxide dismutase 1
affects expression
EXP
mephedrone affects the expression of SOD1 protein
CTD
PMID:25817894
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Th
tyrosine hydroxylase
multiple interactions decreases expression
ISO EXP
Ethanol promotes the reaction [mephedrone results in decreased expression of TH protein]
CTD
PMID:25817894 PMID:26747301
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tnf
tumor necrosis factor
affects expression
EXP
mephedrone affects the expression of TNF protein
CTD
PMID:34742947
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tph2
tryptophan hydroxylase 2
multiple interactions decreases expression
ISO EXP
Ethanol promotes the reaction [mephedrone results in decreased expression of TPH2 protein]
CTD
PMID:25817894 PMID:26747301
NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
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