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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mephedrone
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Accession:CHEBI:59331 term browser browse the term
Definition:An aromatic ketone that is propiophenone substituted at C-4 and at C-beta with methyl and methylamino groups respectively. It is a synthetic stimulant and entactogen drug of the amphetamine and cathinone classes.
Synonyms:exact_synonym: 2-(methylamino)-1-(4-methylphenyl)propan-1-one
 related_synonym: 4-MMC;   4-methylephedrone;   4-methylmethcathinone;   Formula=C11H15NO;   InChI=1S/C11H15NO/c1-8-4-6-10(7-5-8)11(13)9(2)12-3/h4-7,9,12H,1-3H3;   InChIKey=YELGFTGWJGBAQU-UHFFFAOYSA-N;   SMILES=CNC(C)C(=O)c1ccc(C)cc1
 xref: Beilstein:2717770;   CAS:1189805-46-6;   HMDB:HMDB0041923
 xref_mesh: MESH:C548233
 xref: PMID:23949206;   PMID:24446273;   PMID:24456744;   Patent:US2012094316;   Reaxys:2717770;   Wikipedia:Mephedrone


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mephedrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO mephedrone results in increased activity of CASP3 protein CTD PMID:32382956 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression
increases expression
EXP
ISO
mephedrone results in decreased expression of CAT protein
mephedrone results in increased expression of CAT protein
CTD PMID:25817894 PMID:26747301 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP mephedrone results in decreased expression of DRD2 protein CTD PMID:25817894 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
increases expression
EXP
ISO
mephedrone results in decreased expression of GPX1 protein
mephedrone results in increased expression of GPX1 protein
CTD PMID:25817894 PMID:26747301 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression EXP mephedrone affects the expression of NOS1 protein CTD PMID:25817894 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
multiple interactions
EXP
ISO
mephedrone results in decreased expression of SLC6A3 protein
Ethanol promotes the reaction [mephedrone results in decreased expression of SLC6A3 protein]
CTD PMID:25817894 PMID:26747301 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
decreases expression
ISO
EXP
Ethanol promotes the reaction [mephedrone results in decreased expression of SLC6A4 protein] CTD PMID:25817894 PMID:26747301 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Sod1 superoxide dismutase 1 affects expression EXP mephedrone affects the expression of SOD1 protein CTD PMID:25817894 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression
ISO
EXP
Ethanol promotes the reaction [mephedrone results in decreased expression of TH protein] CTD PMID:25817894 PMID:26747301 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions
decreases expression
ISO
EXP
Ethanol promotes the reaction [mephedrone results in decreased expression of TPH2 protein] CTD PMID:25817894 PMID:26747301 NCBI chr 7:58,042,279...58,149,220
Ensembl chr 7:58,042,281...58,149,061
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        xenobiotic 18396
          mephedrone 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            inorganic hydride 17457
                              pnictogen hydride 17432
                                nitrogen hydride 17277
                                  azane 17009
                                    ammonia 17008
                                      organic amino compound 17007
                                        amine 7796
                                          amphetamines 5716
                                            mephedrone 10
paths to the root