Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mephedrone
go back to main search page
Accession:CHEBI:59331 term browser browse the term
Definition:An aromatic ketone that is propiophenone substituted at C-4 and at C-beta with methyl and methylamino groups respectively. It is a synthetic stimulant and entactogen drug of the amphetamine and cathinone classes.
Synonyms:exact_synonym: 2-(methylamino)-1-(4-methylphenyl)propan-1-one
 related_synonym: 4-MMC;   4-methylephedrone;   4-methylmethcathinone;   Formula=C11H15NO;   InChI=1S/C11H15NO/c1-8-4-6-10(7-5-8)11(13)9(2)12-3/h4-7,9,12H,1-3H3;   InChIKey=YELGFTGWJGBAQU-UHFFFAOYSA-N;   SMILES=CNC(C)C(=O)c1ccc(C)cc1
 xref: Beilstein:2717770;   CAS:1189805-46-6;   HMDB:HMDB0041923
 xref_mesh: MESH:C548233
 xref: PMID:23949206;   PMID:24446273;   PMID:24456744;   Patent:US2012094316;   Reaxys:2717770;   Wikipedia:Mephedrone



show annotations for term's descendants           Sort by:
 
mephedrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO mephedrone results in increased activity of CASP3 protein CTD PMID:32382956 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases expression
increases expression
EXP
ISO
mephedrone results in decreased expression of CAT protein
mephedrone results in increased expression of CAT protein
CTD PMID:25817894 PMID:26747301 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects expression EXP mephedrone affects the expression of CCL2 protein CTD PMID:34742947 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP mephedrone results in decreased expression of DRD2 protein CTD PMID:25817894 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
increases expression
EXP
ISO
mephedrone results in decreased expression of GPX1 protein
mephedrone results in increased expression of GPX1 protein
CTD PMID:25817894 PMID:26747301 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Il1a interleukin 1 alpha affects expression EXP mephedrone affects the expression of IL1A protein CTD PMID:34742947 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta affects expression EXP mephedrone affects the expression of IL1B protein CTD PMID:34742947 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 affects expression EXP mephedrone affects the expression of IL6 protein CTD PMID:34742947 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression EXP mephedrone affects the expression of NOS1 protein CTD PMID:25817894 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
multiple interactions
EXP
ISO
mephedrone results in decreased expression of SLC6A3 protein
Ethanol promotes the reaction [mephedrone results in decreased expression of SLC6A3 protein]
CTD PMID:25817894 PMID:26747301 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
decreases expression
ISO
EXP
Ethanol promotes the reaction [mephedrone results in decreased expression of SLC6A4 protein] CTD PMID:25817894 PMID:26747301 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Sod1 superoxide dismutase 1 affects expression EXP mephedrone affects the expression of SOD1 protein CTD PMID:25817894 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression
ISO
EXP
Ethanol promotes the reaction [mephedrone results in decreased expression of TH protein] CTD PMID:25817894 PMID:26747301 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor affects expression EXP mephedrone affects the expression of TNF protein CTD PMID:34742947 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions
decreases expression
ISO
EXP
Ethanol promotes the reaction [mephedrone results in decreased expression of TPH2 protein] CTD PMID:25817894 PMID:26747301 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        xenobiotic 18699
          mephedrone 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            inorganic hydride 17901
                              pnictogen hydride 17884
                                nitrogen hydride 17773
                                  azane 17503
                                    ammonia 17521
                                      organic amino compound 17521
                                        amine 7919
                                          amphetamines 5740
                                            mephedrone 15
paths to the root