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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kappa-opioid receptor agonist
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Accession:CHEBI:59282 term browser browse the term
Definition:A compound that exhibits agonist activity at the kappa-opioid receptor.
Synonyms:related_synonym: kappa-opioid agonist;   kappa-opioid receptor agonists


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(R,R)-tramadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases expression EXP Tramadol results in increased expression of ADRA1A protein CTD PMID:15464068 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Tramadol results in increased expression of BAX protein CTD PMID:25550769 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Tramadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 affects activity
decreases activity
ISO
EXP
Tramadol affects the activity of CASP3 protein
Tramadol results in decreased activity of CASP3 protein
CTD PMID:27317026 PMID:28499616 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP Tramadol results in decreased expression of CAT mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
CTD PMID:25550769 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ckb creatine kinase B decreases expression ISO Tramadol results in decreased expression of CKB mRNA CTD PMID:27317026 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Tramadol results in decreased activity of CYP17A1 protein CTD PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing
ISO CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CTD PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 PMID:17361124 PMID:17470523 PMID:17570739 PMID:18204346 PMID:18520597 PMID:18713907 PMID:29555325 PMID:31173123 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Tramadol results in increased expression of DRD2 protein CTD PMID:15464068 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Tramadol results in increased expression of DRD3 protein CTD PMID:15464068 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Tramadol results in increased activity of GPT protein CTD PMID:28689766 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases activity
increases expression
multiple interactions
EXP Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
CTD PMID:18417104 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Tramadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Tramadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding
multiple interactions
EXP Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO Tramadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:62,836,131...62,904,114
Ensembl chr  X:62,836,131...62,903,554
JBrowse link
G Pdyn prodynorphin decreases expression EXP Tramadol results in decreased expression of PDYN mRNA CTD PMID:17401159 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:11723065 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Tramadol results in decreased expression of SOD1 mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
CTD PMID:25550769 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA
CTD PMID:25550769 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein] CTD PMID:17377112 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
butorphanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects activity EXP Butorphanol affects the activity of OPRD1 protein CTD PMID:17909753 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity EXP Butorphanol affects the activity of OPRK1 protein CTD PMID:17909753 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 affects activity
increases activity
ISO
EXP
Butorphanol affects the activity of OPRM1 protein
Butorphanol results in increased activity of OPRM1 protein
CTD PMID:17909753 PMID:32734307 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Butorphanol affects the localization of PRKCD protein CTD PMID:29669290 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
eluxadoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to eluxadoline CTD PMID:25261794 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
pethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D affects binding
increases hydrolysis
ISO Meperidine binds to CES1 protein
CES1 protein results in increased hydrolysis of Meperidine
CTD PMID:10381793 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Meperidine binds to CES2 protein CTD PMID:10381793 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
tramadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases expression EXP Tramadol results in increased expression of ADRA1A protein CTD PMID:15464068 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Tramadol results in increased expression of BAX protein CTD PMID:25550769 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Tramadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 affects activity
decreases activity
ISO
EXP
Tramadol affects the activity of CASP3 protein
Tramadol results in decreased activity of CASP3 protein
CTD PMID:27317026 PMID:28499616 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP Tramadol results in decreased expression of CAT mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
CTD PMID:25550769 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ckb creatine kinase B decreases expression ISO Tramadol results in decreased expression of CKB mRNA CTD PMID:27317026 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Tramadol results in decreased activity of CYP17A1 protein CTD PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases response to substance
affects metabolic processing
decreases response to substance
affects response to substance
multiple interactions
decreases methylation
increases metabolic processing
affects methylation
ISO CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
CTD PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 PMID:17361124 PMID:17470523 PMID:17570739 PMID:18204346 PMID:18520597 PMID:18713907 PMID:29555325 PMID:31173123 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Tramadol results in increased expression of DRD2 protein CTD PMID:15464068 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Tramadol results in increased expression of DRD3 protein CTD PMID:15464068 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Tramadol results in increased activity of GPT protein CTD PMID:28689766 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
increases activity
EXP Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
Tramadol results in increased expression of HTR2A mRNA
CTD PMID:18417104 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Tramadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Tramadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding
EXP [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO Tramadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:62,836,131...62,904,114
Ensembl chr  X:62,836,131...62,903,554
JBrowse link
G Pdyn prodynorphin decreases expression EXP Tramadol results in decreased expression of PDYN mRNA CTD PMID:17401159 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:11723065 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Tramadol results in decreased expression of SOD1 mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
CTD PMID:25550769 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA
CTD PMID:25550769 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein] CTD PMID:17377112 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
U50488 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grpr gastrin releasing peptide receptor increases phosphorylation
multiple interactions
ISO 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased phosphorylation of GRPR protein
bisindolylmaleimide inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased phosphorylation of GRPR protein]
CTD PMID:29669290 NCBI chr  X:32,746,259...32,786,266
Ensembl chr  X:32,745,873...32,786,359
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
increases activity
affects response to substance
ISO 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein; [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein] which results in increased phosphorylation of STAT3 protein
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased activity of OPRK1 protein
OPRK1 protein affects the susceptibility to 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein; 7-hydroxymitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]; mitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]
CTD PMID:18385270 PMID:27192616 PMID:27231154 PMID:29669290 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
affects localization
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer affects the localization of PRKCD protein] CTD PMID:29669290 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein] which results in increased phosphorylation of STAT3 protein CTD PMID:18385270 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
U69593 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO U 69593 results in increased phosphorylation of MAPK1 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK1 protein]
CTD PMID:16954126 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO U 69593 results in increased phosphorylation of MAPK3 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK3 protein]
CTD PMID:16954126 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP U 69593 binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP
ISO
U 69593 binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]; U 69593 binds to and results in increased activity of OPRK1 protein
[U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]; U 69593 binds to and results in increased activity of OPRK1 protein
CTD PMID:7562497 PMID:11113311 PMID:15456805 PMID:21866885 PMID:21958337 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP U 69593 binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdyn prodynorphin multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA] CTD PMID:11532335 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PENK mRNA] CTD PMID:11532335 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of TAC1 mRNA] CTD PMID:11532335 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        pharmacological role 18833
          agonist 18256
            opioid receptor agonist 644
              kappa-opioid receptor agonist 34
                (R,R)-tramadol + 25
                (R,R)-tramadol hydrochloride + 0
                (S,S)-tramadol + 25
                (S,S)-tramadol hydrochloride + 0
                U50488 4
                U69593 8
                buprenorphine hydrochlorie 0
                butorphanol + 4
                butorphanol D-tartrate 0
                eluxadoline 1
                noribogaine 0
                pethidine 2
                pethidine hydrochloride 0
                tramadol 25
                tramadol hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      application 19413
        pharmaceutical 19301
          drug 19301
            neurotransmitter agent 16447
              opioid agent 677
                kappa-opioid agent 44
                  kappa-opioid receptor agonist 34
                    (R,R)-tramadol + 25
                    (R,R)-tramadol hydrochloride + 0
                    (S,S)-tramadol + 25
                    (S,S)-tramadol hydrochloride + 0
                    U50488 4
                    U69593 8
                    buprenorphine hydrochlorie 0
                    butorphanol + 4
                    butorphanol D-tartrate 0
                    eluxadoline 1
                    noribogaine 0
                    pethidine 2
                    pethidine hydrochloride 0
                    tramadol 25
                    tramadol hydrochloride 0
paths to the root