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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclic fatty acid
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Accession:CHEBI:59238 term browser browse the term
Definition:Any fatty acid containing anywhere in its structure a ring of atoms.
Synonyms:related_synonym: acides gras cycliques;   acidos grasos ciclicos;   cyclic fatty acids;   zyklische Fettsaeuren
 xref: PMID:17113094;   PMID:9300789


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(R)-lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein CTD PMID:29128272 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] CTD PMID:22464149 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]
Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]
CTD PMID:26518973, PMID:27260466 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP
ISO
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
CTD PMID:19669875, PMID:20663516, PMID:20730314 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22464149 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:21251946, PMID:24704557, PMID:29760339 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ada adenosine deaminase multiple interactions EXP [Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein CTD PMID:32662911 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein
CTD PMID:22664981 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agt angiotensinogen multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA CTD PMID:27260466 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]
Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA]
CTD PMID:26518973, PMID:27260466 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Thioctic Acid results in decreased phosphorylation of AKT1 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]
CTD PMID:21351249, PMID:27260466 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions EXP Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:19798568, PMID:20026167, PMID:20584200, PMID:21783994 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alb albumin multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein]
ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
CTD PMID:24704557, PMID:28433809 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apln apelin multiple interactions
increases secretion
increases expression
ISO acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]
CTD PMID:23892647, PMID:30605698 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] CTD PMID:23892647 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions ISO Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] CTD PMID:27260466 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] CTD PMID:27260466 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein]
CTD PMID:15735709, PMID:23830814, PMID:23892647, PMID:27544635, PMID:30605698, PMID:32061141 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] CTD PMID:23892647 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein] CTD PMID:20663516 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
ISO
EXP
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]
BCL2 protein results in decreased susceptibility to Thioctic Acid
CTD PMID:16990509, PMID:21600978, PMID:23830814, PMID:27260466, PMID:27544635, PMID:30605698, PMID:32061141 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA CTD PMID:23830814 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] CTD PMID:23608068 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G C1qa complement C1q A chain decreases expression ISO Thioctic Acid results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression ISO Thioctic Acid results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Calb2 calbindin 2 multiple interactions EXP Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] CTD PMID:31068541 NCBI chr19:41,482,743...41,509,617
Ensembl chr19:41,482,728...41,509,658
JBrowse link
G Calm1 calmodulin 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] CTD PMID:26165643 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
Thioctic Acid results in increased expression of CASP3 protein modified form
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Thioctic Acid results in increased activity of CASP3 protein
[Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
CTD PMID:15909127, PMID:17079870, PMID:19951573, PMID:21062633, PMID:21763304, PMID:23892647, PMID:27544635, PMID:29214690, PMID:30605698, PMID:32061141 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]
CTD PMID:23830814, PMID:27544635 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
Thioctic Acid results in increased activity of CASP9 protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
CTD PMID:16990509, PMID:19951573, PMID:23830814, PMID:27544635, PMID:30605698 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]
Thioctic Acid results in increased expression of CAT mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA
Thioctic Acid results in increased activity of CAT protein
[acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]
CTD PMID:15998567, PMID:19368863, PMID:19699728, PMID:19715735, PMID:21763304, PMID:22623521, PMID:23649336, PMID:26276312, PMID:27260466, PMID:27581792, PMID:28880400, PMID:29214690, PMID:29760339, PMID:32662911 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] CTD PMID:22488045 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] CTD PMID:21600978 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] CTD PMID:21315065 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd86 CD86 molecule increases expression ISO Thioctic Acid results in increased expression of CD86 protein CTD PMID:19033392 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cd8a CD8a molecule multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 NCBI chr 4:99,217,640...99,243,352
Ensembl chr 4:99,239,115...99,243,351
JBrowse link
G Cdx4 caudal type homeo box 4 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] CTD PMID:23608068 NCBI chr  X:74,165,172...74,173,758
Ensembl chr  X:74,165,187...74,173,347
JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP [Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein CTD PMID:19669875 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] CTD PMID:19635391 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA] CTD PMID:21251946, PMID:23830814 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:22464149 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] CTD PMID:32061141 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crp C-reactive protein multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] CTD PMID:26276312 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cryaa crystallin, alpha A multiple interactions EXP Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] CTD PMID:20597648 NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctss cathepsin S decreases expression ISO Thioctic Acid results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] CTD PMID:26518973 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19951573 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] CTD PMID:21932800 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:21932800, PMID:24120545 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] CTD PMID:32061150 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dab1 DAB adaptor protein 1 multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA CTD PMID:31068541 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]
CTD PMID:23892647, PMID:30605698 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] CTD PMID:22464149 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] CTD PMID:27260466 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions EXP [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] CTD PMID:21551353 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] CTD PMID:20730801 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] CTD PMID:23892647 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] CTD PMID:30605698 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] CTD PMID:27544635 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo3 forkhead box O3 decreases acetylation
multiple interactions
EXP Thioctic Acid results in decreased acetylation of FOXO3 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein
CTD PMID:22327056 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] CTD PMID:23608068 NCBI chr14:14,438,392...14,853,016
Ensembl chr14:14,439,082...14,689,554
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] CTD PMID:20957662 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA CTD PMID:31068541 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GCLC mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]
CTD PMID:16249512, PMID:17940886, PMID:27298056, PMID:32061141 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GCLM mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein]
CTD PMID:16249512, PMID:32061141 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Thioctic Acid results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] CTD PMID:24704557 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]
CTD PMID:26165643, PMID:27260466 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gls glutaminase multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] CTD PMID:32061141 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions EXP Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] CTD PMID:28070105 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein] CTD PMID:24704557 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GPX1 mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA]
CTD PMID:23649336, PMID:32061141 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA CTD PMID:23830814 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
multiple interactions
ISO Thioctic Acid results in increased expression of GPX3 mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA
CTD PMID:23649336 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Thioctic Acid results in increased expression of GPX5 mRNA CTD PMID:23649336 NCBI chr17:45,508,657...45,518,686
Ensembl chr17:45,467,015...45,518,686
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] CTD PMID:32061141 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] CTD PMID:31068541, PMID:32061141 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO Thioctic Acid results in increased phosphorylation of GSK3B protein
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]
CTD PMID:19879292, PMID:27260466 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
EXP
ISO
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]
Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]
Thioctic Acid results in increased expression of GSR mRNA
CTD PMID:19699728, PMID:22623521, PMID:23649336, PMID:27581792, PMID:32061150 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gss glutathione synthetase multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] CTD PMID:32061141 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
[Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
CTD PMID:18367378, PMID:23830814 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm7 glutathione S-transferase, mu 7 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSTM7 mRNA] CTD PMID:23608068 NCBI chr 2:210,720,719...210,726,179
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein
Thioctic Acid results in increased expression of GSTP1 mRNA
CTD PMID:20237067 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein CTD PMID:28433809 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein]
Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA]
CTD PMID:19033392, PMID:21315065, PMID:22488045, PMID:23649336, PMID:23942037, PMID:24361488, PMID:27260466, PMID:27298056, PMID:30758914, PMID:31319135, PMID:32061141 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hs1bp3 HCLS1 binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] CTD PMID:23608068 NCBI chr 6:33,517,711...33,548,015
Ensembl chr 6:33,517,769...33,548,034
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] CTD PMID:28880400 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]
CTD PMID:23892647, PMID:30605698 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] CTD PMID:19735303, PMID:26518973 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA CTD PMID:31068541 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B]
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]
CTD PMID:23830814, PMID:24975507, PMID:26518973 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] CTD PMID:21195065 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] CTD PMID:23608068 NCBI chr 1:15,084,136...15,107,423
Ensembl chr 1:15,093,599...15,106,954
JBrowse link
G Il4 interleukin 4 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA CTD PMID:23830814 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA]
[Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:22488045, PMID:26518973, PMID:28433809, PMID:29760339 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein CTD PMID:24975507 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases activity
EXP [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]
Thioctic Acid results in increased expression of JUN protein
Thioctic Acid results in increased activity of JUN protein
CTD PMID:20237067 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Thioctic Acid results in increased expression of KEAP1 protein CTD PMID:19033392 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions EXP Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] CTD PMID:21195065, PMID:27581792 NCBI chr 1:102,914,875...102,931,843
Ensembl chr 1:102,915,191...102,931,839
JBrowse link
G Lep leptin decreases secretion
decreases expression
ISO
EXP
Thioctic Acid results in decreased secretion of LEP protein
Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein
CTD PMID:21351249 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] CTD PMID:20957662, PMID:28070105 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases phosphorylation
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] CTD PMID:22941773 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects activity
multiple interactions
EXP Thioctic Acid affects the activity of MAPK1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein]
CTD PMID:15909127, PMID:21251946, PMID:32061141 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA CTD PMID:23830814 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] CTD PMID:21251946, PMID:23830814, PMID:32061141 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA CTD PMID:23830814 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mir21 microRNA 21 multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] CTD PMID:26276312 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir210 microRNA 210 multiple interactions EXP [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] CTD PMID:26276312 NCBI chr 1:214,208,355...214,208,464 JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] CTD PMID:24975507 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA CTD PMID:23830814 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:24975507 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] CTD PMID:21315065 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA CTD PMID:18367378 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mvd mevalonate diphosphate decarboxylase multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA CTD PMID:18367378 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] CTD PMID:21600978 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] CTD PMID:26518973 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
increases expression
increases activity
decreases expression
ISO
EXP
[Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein
Thioctic Acid affects the localization of NFE2L2 protein
Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid results in increased activity of NFE2L2 protein
[Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]
Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein
[Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]
CTD PMID:17197552, PMID:18258206, PMID:20237067, PMID:22488045, PMID:23649336, PMID:24361488, PMID:27260466, PMID:27298056, PMID:30758914, PMID:31319135, PMID:32061141, PMID:32061150 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA
CTD PMID:21600978, PMID:31068541 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA] CTD PMID:23608068 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:15453632, PMID:21763304 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:27260466 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] CTD PMID:29760339 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]] CTD PMID:29760339 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased activity of NQO1 protein
Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein
[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]
CTD PMID:12180195, PMID:17940886, PMID:19033392, PMID:23649336, PMID:23830814, PMID:30758914, PMID:31068541, PMID:31319135 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr15:25,500,037...25,511,619
Ensembl chr15:25,502,019...25,505,691
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Thioctic Acid results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pcdhb6l protocadherin beta-6-like multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] CTD PMID:23608068 NCBI chr18:30,512,507...30,518,524
Ensembl chr18:30,515,962...30,518,352
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] CTD PMID:21251946 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 decreases expression
decreases activity
ISO Thioctic Acid results in decreased expression of PLAAT3 mRNA
Thioctic Acid results in decreased activity of PLAAT3 protein
CTD PMID:22941773 NCBI chr 1:222,844,238...222,877,180
Ensembl chr 1:222,844,144...222,877,193
JBrowse link
G Plin1 perilipin 1 increases phosphorylation ISO Thioctic Acid results in increased phosphorylation of PLIN1 protein CTD PMID:22941773 NCBI chr 1:141,458,907...141,470,927
Ensembl chr 1:141,458,181...141,471,010
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity
ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:16391466, PMID:21932800, PMID:24120545 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22464149 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP [Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA CTD PMID:22464149 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
ISO
EXP
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]
Thioctic Acid results in increased expression of PPARGC1A protein
CTD PMID:20414966, PMID:22464149 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions
decreases acetylation
EXP [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
Thioctic Acid results in decreased acetylation of PPARGC1B protein
CTD PMID:22327056, PMID:22464149 NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] CTD PMID:19735303, PMID:23830814, PMID:26276312 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]
Thioctic Acid results in decreased phosphorylation of RELA protein
CTD PMID:22488045 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Reln reelin multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA CTD PMID:31068541 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Sema5a semaphorin 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] CTD PMID:23608068 NCBI chr 2:85,377,318...85,808,970
Ensembl chr 2:85,377,318...85,808,970
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] CTD PMID:24704557 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions
EXP Thioctic Acid results in increased expression of SIRT1 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA]
CTD PMID:22327056 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
EXP [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]
Thioctic Acid results in increased expression of SIRT3 protein
CTD PMID:22327056 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions
affects activity
EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]
Thioctic Acid affects the activity of SLC12A2 protein
CTD PMID:23880158 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] CTD PMID:32061141 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Slc5a6 solute carrier family 5 member 6 increases transport
multiple interactions
ISO
EXP
SLC5A6 results in increased transport of Thioctic Acid
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid]
CTD PMID:9516450, PMID:10329687 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] CTD PMID:32061141 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Snca synuclein alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] CTD PMID:15804455, PMID:26518973 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
EXP
ISO
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA
Thioctic Acid results in increased activity of SOD2 protein
CTD PMID:15804455, PMID:19951573, PMID:22327056, PMID:27260466 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22464149 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] CTD PMID:28070105 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] CTD PMID:19635391, PMID:28086195 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] CTD PMID:19635391, PMID:28086195 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases expression ISO Thioctic Acid results in increased expression of SUMO1 protein CTD PMID:24975507 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA] CTD PMID:15309289, PMID:21251946, PMID:24704557, PMID:26276312, PMID:29760339 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] CTD PMID:23608068 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA CTD PMID:23830814, PMID:31068541 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] CTD PMID:27260466 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]] CTD PMID:15309289, PMID:23830814, PMID:26276312, PMID:29760339 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA CTD PMID:23830814 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:19900424 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] CTD PMID:23608068, PMID:23892647 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:23830814, PMID:31068541 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction
multiple interactions
ISO
EXP
TXNRD1 protein results in increased reduction of Thioctic Acid
Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]
CTD PMID:20810785, PMID:21172426 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] CTD PMID:22327056, PMID:22464149 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
EXP
ISO
Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]
CTD PMID:11596663, PMID:22488045, PMID:26276312 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:32662911 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
13,14-dihydro-15-keto-PGF2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions
ISO PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
CTD PMID:25619643 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
13,14-dihydro-15-ketoprostaglandin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
ISO 13,14-dihydro-15-ketoprostaglandin D2 results in increased expression of CXCL2 protein
13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of CXCL2 mRNA]
CTD PMID:21094227, PMID:21735453 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO 13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of GATA3 mRNA] CTD PMID:21735453 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of IL4 protein] CTD PMID:21735453 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO 13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR protein; 13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr15:19,195,606...19,196,508 JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 multiple interactions ISO
EXP
13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein]
CTD PMID:12721327, PMID:15528449, PMID:16256979 NCBI chr 1:226,976,455...226,995,641
Ensembl chr 1:226,993,250...226,994,849
JBrowse link
13,14-dihydro-15-oxo-prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions
ISO PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E2] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2
CTD PMID:25619643 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
13,14-dihydro-15-oxoprostaglandin E1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions
ISO PTGR1 protein results in increased abundance of 13,14-dihydro-15-ketoprostaglandin E1
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E] which results in increased abundance of 13,14-dihydro-15-ketoprostaglandin E1
CTD PMID:25619643 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
13,14-dihydro-Delta(12)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
EXP 9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA
Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA]
CTD PMID:22982731 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]; NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA] CTD PMID:22982731 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA] CTD PMID:22982731 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of NGF mRNA] CTD PMID:22982731 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
14,15-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
increases cleavage
EXP
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form
[14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)
14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
CTD PMID:27428043 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein CTD PMID:16286479 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid CTD PMID:12675279 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions
increases abundance
ISO [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
CTD PMID:19896470, PMID:22680237, PMID:24472606 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein CTD PMID:16286479 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein CTD PMID:19464254 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein CTD PMID:19464254 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:16286479 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion
multiple interactions
ISO TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid
12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:28694203 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
15-dehydro-prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases chemical synthesis ISO HPGD protein results in increased chemical synthesis of 15-ketoprostaglandin E2 CTD PMID:20448048 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions
increases metabolic processing
increases reduction
EXP
ISO
15-ketoprostaglandin E2 inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]; Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]; Indomethacin inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E2] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2
CTD PMID:23878198, PMID:25619643 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
15-deoxy-Delta(12,14)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
affects export
affects glutathionylation
increases transport
ISO [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]
ABCC1 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog
ABCC1 protein affects the glutathionylation of 15-deoxy-delta(12,14)-prostaglandin J2
CTD PMID:14979731, PMID:21728338 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects export ISO ABCC3 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog CTD PMID:14979731 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Agt angiotensinogen multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]] CTD PMID:18278065 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2 CTD PMID:19997560 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of AKT1 protein CTD PMID:16611854 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BGLAP mRNA CTD PMID:12021203 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC2 protein CTD PMID:15498850 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC3 protein CTD PMID:15498850 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of CASP3 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of CASP3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of CASP3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:11785780, PMID:15498850, PMID:16299251, PMID:23973622 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15498850 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:15498850 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]] CTD PMID:12847270 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein] CTD PMID:15187150 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]] CTD PMID:19429239 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNA2 protein CTD PMID:15729575 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNB1 protein CTD PMID:15729575 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCND3 protein CTD PMID:15729575 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNE1 protein CTD PMID:15729575 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDK2 protein CTD PMID:15729575 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CDKN1A
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1A protein
CTD PMID:15254749, PMID:15729575 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1B protein CTD PMID:15729575 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CEBPA mRNA CTD PMID:12021203 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CFLAR protein CTD PMID:15498850 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CHUK protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased phosphorylation of CHUK protein]
CTD PMID:15498850, PMID:22245093 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of COL1A1 mRNA CTD PMID:12021203 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]] CTD PMID:12604364, PMID:14998300 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ddx58 DEXD/H-box helicase 58 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of DDX58 mRNA] CTD PMID:16303604 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of EGR1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of EGR1 mRNA] CTD PMID:12468449 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Tretinoin] results in increased expression of FABP4 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FABP4 mRNA
CTD PMID:9543393, PMID:12021203, PMID:16573735 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of FAS mRNA CTD PMID:16712844 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]
CTD PMID:11457450, PMID:11687581 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein
CTD PMID:21728338 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
decreases expression
multiple interactions
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GFAP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of GFAP mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in decreased expression of GFAP mRNA]
CTD PMID:15254749, PMID:15994020 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTA3 mRNA CTD PMID:14652005 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione] CTD PMID:14979731 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein
Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA]; Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein]
CTD PMID:11600134 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC1 mRNA CTD PMID:21957481 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC2 mRNA CTD PMID:21957481 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hdac3 histone deacetylase 3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC3 mRNA CTD PMID:21957481 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects stability
multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 affects the stability of HIF1A protein
Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]
CTD PMID:17658243 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein; [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]
ochratoxin A inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 protein
CTD PMID:11078701, PMID:15618017, PMID:15994020, PMID:19136476 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA] CTD PMID:15618017 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HSPB1 protein CTD PMID:16299251 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
decreases secretion
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IFNG protein
CTD PMID:12847270, PMID:16844232, PMID:19888466 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA] CTD PMID:14998300 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
decreases activity
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in decreased abundance of Prostaglandins]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1B protein
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with IL1B protein] results in decreased secretion of IL1B protein
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of IL1B protein
CTD PMID:11457450, PMID:12604364, PMID:14998300, PMID:15751073, PMID:16461118 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1RN mRNA CTD PMID:15751073 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2] CTD PMID:23688403 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:12604364, PMID:12847270 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of INS mRNA] CTD PMID:14625208 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:12847270 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]] CTD PMID:12847270 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein] CTD PMID:11457450 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Lep leptin multiple interactions
increases secretion
ISO [Dexamethasone co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased secretion of LEP protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased secretion of LEP protein
CTD PMID:11092516 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]] CTD PMID:19922793 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Lpl lipoprotein lipase increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of LPL mRNA CTD PMID:12021203 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK1 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK1 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]
CTD PMID:11687581, PMID:12083801, PMID:16611854, PMID:19888466 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK3 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]
CTD PMID:11687581, PMID:12083801, PMID:16611854, PMID:19888466 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein] CTD PMID:16324150 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Cycloheximide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Dactinomycin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA] CTD PMID:19136476 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of MMP9 mRNA] CTD PMID:19997048 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MTOR protein CTD PMID:16611854 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nes nestin increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NES protein CTD PMID:15212945 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased activity of NFE2L2 protein; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of NFE2L2 protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and affects the localization of NFE2L2 protein; manganese chloride inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NFE2L2 protein]
CTD PMID:19136476, PMID:21728338, PMID:22245093 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases localization
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased localization of NFKB1 protein
CTD PMID:11457450, PMID:16299251 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased degradation of NFKBIA protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of NFKBIA protein
CTD PMID:15498850, PMID:22245093, PMID:23688403 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS2 protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of NOS2 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of NOS2 mRNA]
CTD PMID:11457450, PMID:11890746, PMID:12847270, PMID:15684285, PMID:15994020, PMID:16461118, PMID:19997048 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS3 protein CTD PMID:11890746 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects activity
multiple interactions
ISO 15-deoxy-delta(12,14)-prostaglandin J2 affects the activity of NR3C1 protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Dexamethasone binds to NR3C1 protein]
CTD PMID:15187150 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein] CTD PMID:22245093 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of PARP1 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of PARP1 protein
CTD PMID:15498850, PMID:23973622 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PCK1 mRNA CTD PMID:9518257 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARD protein CTD PMID:17341418 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
decreases response to substance
increases expression
increases activity
multiple interactions
decreases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the expression of PPARG
PPARG protein mutant form results in decreased susceptibility to 15-deoxy-delta(12,14)-prostaglandin J2
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of PPARG mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased expression of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in decreased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased localization of and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [deoxynivalenol results in increased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARG mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; MG 262 promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PPARG protein
CTD PMID:9013583, PMID:10662598, PMID:11030710, PMID:12065695, PMID:12604364, PMID:12839938, PMID:12847270, PMID:14625208, PMID:14979731, PMID:14998300, PMID:15212945, PMID:15254749, PMID:15322177, PMID:15491415, PMID:15707588, PMID:15729575, PMID:15866424, PMID:15994020, PMID:16324150, PMID:16499875, PMID:17341418, PMID:18278065, PMID:18485432, PMID:19922793, PMID:23943857, PMID:26172262, PMID:30138673 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr15:19,195,606...19,196,508 JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
CTD PMID:12721327, PMID:16256979 NCBI chr 1:226,976,455...226,995,641
Ensembl chr 1:226,993,250...226,994,849
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 protein promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2] CTD PMID:17439952 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PTGS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PTGS2
CTD PMID:11457450, PMID:12604364, PMID:15254749, PMID:19997048 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases phosphorylation EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of PTPN11 protein CTD PMID:12584205 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of and results in decreased phosphorylation of RAF1 protein CTD PMID:12083801 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RARB
CTD PMID:12839938, PMID:15254749 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of and results in decreased expression of RB1 protein CTD PMID:15729575 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of RELA protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride affects the localization of RELA protein]
CTD PMID:11457450, PMID:15498850, PMID:20174873, PMID:22245093 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of RPS6KA1 protein CTD PMID:16611854 NCBI chr 5:152,078,217...152,122,684
Ensembl chr 5:152,078,220...152,122,684
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of RUNX2 mRNA CTD PMID:12021203 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Rxra retinoid X receptor alpha increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RXRA CTD PMID:15254749 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]] CTD PMID:18278065 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]] CTD PMID:19429239 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS1 mRNA CTD PMID:12584205 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS3 mRNA CTD PMID:12584205 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of SPP1 mRNA CTD PMID:12021203 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [peroxyvanadate results in increased phosphorylation of STAT1 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]
CTD PMID:12584205, PMID:12847270 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD PMID:12584205, PMID:12847270, PMID:19922793 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions
decreases expression
ISO PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form] CTD PMID:16499875 NCBI chr 7:11,253,153...11,259,233
Ensembl chr 7:11,253,180...11,257,977
JBrowse link
G Tg thyroglobulin multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TG protein
CTD PMID:11078701 NCBI chr 7:107,467,260...107,652,897
Ensembl chr 7:107,467,260...107,652,899
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
decreases response to substance
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TGFB1 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [alitretinoin results in decreased expression of TGFB1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased susceptibility to TGFB1 protein
CTD PMID:16611854, PMID:18278065, PMID:19429239 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TH protein CTD PMID:15212945 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TLR2 mRNA
CTD PMID:20174873 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TNF protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:12604364, PMID:19888466 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein] CTD PMID:11078701 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Vim vimentin decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of VIM CTD PMID:15254749 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wnt10b Wnt family member 10B decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of WNT10B mRNA CTD PMID:12021203 NCBI chr 7:140,448,284...140,466,159
Ensembl chr 7:140,448,465...140,454,268
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of XIAP protein CTD PMID:15498850, PMID:16299251 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
15-oxoprostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases metabolic processing
multiple interactions
ISO PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
CTD PMID:25619643 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
6-oxoprostaglandin F1alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance
multiple interactions
EXP AGT protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha
Dexamethasone inhibits the reaction [AGT protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:4030047 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 6-Ketoprostaglandin F1 alpha CTD PMID:21193584 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Apoe apolipoprotein E increases abundance
multiple interactions
ISO APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha
nimesulide inhibits the reaction [APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:14966570 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Avp arginine vasopressin increases abundance
multiple interactions
EXP AVP protein results in increased abundance of 6-Ketoprostaglandin F1 alpha
Dexamethasone inhibits the reaction [AVP protein results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:4030047 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bdkrb2 bradykinin receptor B2 affects abundance
multiple interactions
ISO
EXP
BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha
[kallidin, des-Arg(10)- binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha; [KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha
PD 123319 affects the reaction [BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:16514058, PMID:29775649 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Calca calcitonin-related polypeptide alpha decreases abundance
increases abundance
ISO
EXP
CALCA protein alternative form results in decreased abundance of 6-Ketoprostaglandin F1 alpha
CALCA protein results in increased abundance of 6-Ketoprostaglandin F1 alpha
CTD PMID:12024109 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Klkb1 kallikrein B1 multiple interactions
increases abundance
ISO 7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:25339356 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Kng2 kininogen 2 increases abundance
multiple interactions
EXP KNG1 protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha
[KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha; Dexamethasone inhibits the reaction [KNG1 protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:4030047, PMID:29775649 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16325209 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgis prostaglandin I2 synthase multiple interactions
increases chemical synthesis
EXP [Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha
PTGIS protein results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha
CTD PMID:19491382 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; PTGS2 gene mutant form inhibits the reaction [[Nanotubes, Carbon co-treated with OVAL protein] results in increased abundance of 6-Ketoprostaglandin F1 alpha]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16325209, PMID:23642096 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor increases abundance ISO TNF protein results in increased abundance of 6-Ketoprostaglandin F1 alpha CTD PMID:1993070 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx1 epoxide hydrolase 1 affects hydrolysis ISO EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
8-epi-prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger4 prostaglandin E receptor 4 affects response to substance ISO PTGER4 protein affects the susceptibility to 8-isoprostaglandin E2 CTD PMID:22565502 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
8-epi-prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E multiple interactions ISO [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha CTD PMID:17118406 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases abundance
ISO [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha
APP protein modified form results in increased abundance of 8-epi-prostaglandin F2alpha
CTD PMID:22610977 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
increases chemical synthesis
ISO
EXP
1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
pyrrolidine dithiocarbamic acid inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]; Rotenone inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
CTD PMID:11530235, PMID:16529823, PMID:19751497 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 affects metabolic processing
multiple interactions
ISO PAFAH2 protein affects the metabolism of 8-epi-prostaglandin F2alpha
PAFAH2 protein affects the reaction [Carbon Tetrachloride results in increased abundance of 8-epi-prostaglandin F2alpha]
CTD PMID:18024956 NCBI chr 5:152,606,850...152,635,956
Ensembl chr 5:152,606,847...152,634,803
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of 8-epi-prostaglandin F2alpha; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha CTD PMID:8621535 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions
affects response to substance
ISO 8-epi-prostaglandin F2alpha binds to and results in increased activity of TBXA2R protein
TBXA2R protein affects the susceptibility to 8-epi-prostaglandin F2alpha
CTD PMID:18158556, PMID:22565502 NCBI chr 7:11,253,153...11,259,233
Ensembl chr 7:11,253,180...11,257,977
JBrowse link
fluprostenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp4 fatty acid binding protein 4 multiple interactions ISO fluprostenol inhibits the reaction [Niacin results in increased expression of FABP4 mRNA] CTD PMID:21236357 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression EXP fluprostenol results in decreased expression of FGFR2 mRNA CTD PMID:15654655 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fluprostenol inhibits the reaction [Niacin results in increased expression of PPARG mRNA] CTD PMID:21236357 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
latanoprost term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO latanoprost results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
leukotriene A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase increases chemical synthesis ISO ALOX5 protein results in increased chemical synthesis of Leukotriene A4 CTD PMID:18295198 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions
increases hydrolysis
ISO cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Leukotriene A4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
lipoamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO lipoamide inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein] CTD PMID:18258206 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction ISO TXNRD1 protein results in increased reduction of lipoamide CTD PMID:21172426 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases reduction ISO TXNRD2 protein results in increased reduction of lipoamide CTD PMID:21172426 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein CTD PMID:29128272 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] CTD PMID:22464149 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]
Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]
CTD PMID:26518973, PMID:27260466 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP
ISO
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
CTD PMID:19669875, PMID:20663516, PMID:20730314 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22464149 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:21251946, PMID:24704557, PMID:29760339 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ada adenosine deaminase multiple interactions EXP [Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein CTD PMID:32662911 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein
CTD PMID:22664981 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agt angiotensinogen multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA CTD PMID:27260466 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]
Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA]
CTD PMID:26518973, PMID:27260466 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Thioctic Acid results in decreased phosphorylation of AKT1 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]
CTD PMID:21351249, PMID:27260466 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions EXP Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:19798568, PMID:20026167, PMID:20584200, PMID:21783994 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alb albumin multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein]
ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
CTD PMID:24704557, PMID:28433809 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apln apelin multiple interactions
increases secretion
increases expression
ISO acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]
CTD PMID:23892647, PMID:30605698 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] CTD PMID:23892647 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions ISO Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] CTD PMID:27260466 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] CTD PMID:27260466 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein]
CTD PMID:15735709, PMID:23830814, PMID:23892647, PMID:27544635, PMID:30605698, PMID:32061141 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] CTD PMID:23892647 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein] CTD PMID:20663516 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
ISO
EXP
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]
BCL2 protein results in decreased susceptibility to Thioctic Acid
CTD PMID:16990509, PMID:21600978, PMID:23830814, PMID:27260466, PMID:27544635, PMID:30605698, PMID:32061141 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA CTD PMID:23830814 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] CTD PMID:23608068 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G C1qa complement C1q A chain decreases expression ISO Thioctic Acid results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression ISO Thioctic Acid results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Calb2 calbindin 2 multiple interactions EXP Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] CTD PMID:31068541 NCBI chr19:41,482,743...41,509,617
Ensembl chr19:41,482,728...41,509,658
JBrowse link
G Calm1 calmodulin 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] CTD PMID:26165643 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
Thioctic Acid results in increased expression of CASP3 protein modified form
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Thioctic Acid results in increased activity of CASP3 protein
[Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
CTD PMID:15909127, PMID:17079870, PMID:19951573, PMID:21062633, PMID:21763304, PMID:23892647, PMID:27544635, PMID:29214690, PMID:30605698, PMID:32061141 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]
CTD PMID:23830814, PMID:27544635 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
Thioctic Acid results in increased activity of CASP9 protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
CTD PMID:16990509, PMID:19951573, PMID:23830814, PMID:27544635, PMID:30605698 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]
Thioctic Acid results in increased expression of CAT mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA
Thioctic Acid results in increased activity of CAT protein
[acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]
CTD PMID:15998567, PMID:19368863, PMID:19699728, PMID:19715735, PMID:21763304, PMID:22623521, PMID:23649336, PMID:26276312, PMID:27260466, PMID:27581792, PMID:28880400, PMID:29214690, PMID:29760339, PMID:32662911 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] CTD PMID:22488045 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] CTD PMID:21600978 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] CTD PMID:21315065 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd86 CD86 molecule increases expression ISO Thioctic Acid results in increased expression of CD86 protein CTD PMID:19033392 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cd8a CD8a molecule multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 NCBI chr 4:99,217,640...99,243,352
Ensembl chr 4:99,239,115...99,243,351
JBrowse link
G Cdx4 caudal type homeo box 4 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] CTD PMID:23608068 NCBI chr  X:74,165,172...74,173,758
Ensembl chr  X:74,165,187...74,173,347
JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP [Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein CTD PMID:19669875 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] CTD PMID:19635391 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA] CTD PMID:21251946, PMID:23830814 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:22464149 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] CTD PMID:32061141 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crp C-reactive protein multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] CTD PMID:26276312 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cryaa crystallin, alpha A multiple interactions EXP Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] CTD PMID:20597648 NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctss cathepsin S decreases expression ISO Thioctic Acid results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] CTD PMID:26518973 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19951573 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] CTD PMID:21932800 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:21932800, PMID:24120545 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] CTD PMID:32061150 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dab1 DAB adaptor protein 1 multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA CTD PMID:31068541 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]
CTD PMID:23892647, PMID:30605698 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] CTD PMID:22464149 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] CTD PMID:27260466 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions EXP [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] CTD PMID:21551353 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] CTD PMID:20730801 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] CTD PMID:23892647 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] CTD PMID:30605698 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] CTD PMID:27544635 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo3 forkhead box O3 decreases acetylation
multiple interactions
EXP Thioctic Acid results in decreased acetylation of FOXO3 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein
CTD PMID:22327056 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] CTD PMID:23608068 NCBI chr14:14,438,392...14,853,016
Ensembl chr14:14,439,082...14,689,554
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] CTD PMID:20957662 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA CTD PMID:31068541 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GCLC mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]
CTD PMID:16249512, PMID:17940886, PMID:27298056, PMID:32061141 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GCLM mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein]
CTD PMID:16249512, PMID:32061141 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Thioctic Acid results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] CTD PMID:24704557 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]
CTD PMID:26165643, PMID:27260466 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gls glutaminase multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] CTD PMID:32061141 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions EXP Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] CTD PMID:28070105 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein] CTD PMID:24704557 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased expression of GPX1 mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA]
CTD PMID:23649336, PMID:32061141 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA CTD PMID:23830814 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
multiple interactions
ISO Thioctic Acid results in increased expression of GPX3 mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA
CTD PMID:23649336 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Thioctic Acid results in increased expression of GPX5 mRNA CTD PMID:23649336 NCBI chr17:45,508,657...45,518,686
Ensembl chr17:45,467,015...45,518,686
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] CTD PMID:32061141 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] CTD PMID:31068541, PMID:32061141 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO Thioctic Acid results in increased phosphorylation of GSK3B protein
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]
CTD PMID:19879292, PMID:27260466 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
EXP
ISO
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]
Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]
Thioctic Acid results in increased expression of GSR mRNA
CTD PMID:19699728, PMID:22623521, PMID:23649336, PMID:27581792, PMID:32061150 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gss glutathione synthetase multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] CTD PMID:32061141 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
[Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
CTD PMID:18367378, PMID:23830814 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm7 glutathione S-transferase, mu 7 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSTM7 mRNA] CTD PMID:23608068 NCBI chr 2:210,720,719...210,726,179
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein
Thioctic Acid results in increased expression of GSTP1 mRNA
CTD PMID:20237067 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein CTD PMID:28433809 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein]
Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA]
CTD PMID:19033392, PMID:21315065, PMID:22488045, PMID:23649336, PMID:23942037, PMID:24361488, PMID:27260466, PMID:27298056, PMID:30758914, PMID:31319135, PMID:32061141 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hs1bp3 HCLS1 binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] CTD PMID:23608068 NCBI chr 6:33,517,711...33,548,015
Ensembl chr 6:33,517,769...33,548,034
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] CTD PMID:28880400 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]
CTD PMID:23892647, PMID:30605698 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] CTD PMID:19735303, PMID:26518973 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA CTD PMID:31068541 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B]
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]
CTD PMID:23830814, PMID:24975507, PMID:26518973 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] CTD PMID:21195065 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] CTD PMID:23608068 NCBI chr 1:15,084,136...15,107,423
Ensembl chr 1:15,093,599...15,106,954
JBrowse link
G Il4 interleukin 4 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA CTD PMID:23830814 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA]
[Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:22488045, PMID:26518973, PMID:28433809, PMID:29760339 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein CTD PMID:24975507 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases activity
EXP [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]
Thioctic Acid results in increased expression of JUN protein
Thioctic Acid results in increased activity of JUN protein
CTD PMID:20237067 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Thioctic Acid results in increased expression of KEAP1 protein CTD PMID:19033392 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions EXP Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] CTD PMID:21195065, PMID:27581792 NCBI chr 1:102,914,875...102,931,843
Ensembl chr 1:102,915,191...102,931,839
JBrowse link
G Lep leptin decreases secretion
decreases expression
ISO
EXP
Thioctic Acid results in decreased secretion of LEP protein
Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein
CTD PMID:21351249 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] CTD PMID:20957662, PMID:28070105 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases phosphorylation
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] CTD PMID:22941773 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects activity
multiple interactions
EXP Thioctic Acid affects the activity of MAPK1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein]
CTD PMID:15909127, PMID:21251946, PMID:32061141 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA CTD PMID:23830814 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] CTD PMID:21251946, PMID:23830814, PMID:32061141 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA CTD PMID:23830814 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mir21 microRNA 21 multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] CTD PMID:26276312 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir210 microRNA 210 multiple interactions EXP [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] CTD PMID:26276312 NCBI chr 1:214,208,355...214,208,464 JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] CTD PMID:24975507 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA CTD PMID:23830814 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:24975507 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] CTD PMID:21315065 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA CTD PMID:18367378 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mvd mevalonate diphosphate decarboxylase multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA CTD PMID:18367378 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] CTD PMID:21600978 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] CTD PMID:26518973 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
increases expression
increases activity
decreases expression
ISO
EXP
[Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein
Thioctic Acid affects the localization of NFE2L2 protein
Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid results in increased activity of NFE2L2 protein
[Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]
Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein
[Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]
CTD PMID:17197552, PMID:18258206, PMID:20237067, PMID:22488045, PMID:23649336, PMID:24361488, PMID:27260466, PMID:27298056, PMID:30758914, PMID:31319135, PMID:32061141, PMID:32061150 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA
CTD PMID:21600978, PMID:31068541 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA] CTD PMID:23608068 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:15453632, PMID:21763304 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:27260466 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] CTD PMID:29760339 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]] CTD PMID:29760339 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
ISO
EXP
Thioctic Acid results in increased activity of NQO1 protein
Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein
[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]
CTD PMID:12180195, PMID:17940886, PMID:19033392, PMID:23649336, PMID:23830814, PMID:30758914, PMID:31068541, PMID:31319135 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr15:25,500,037...25,511,619
Ensembl chr15:25,502,019...25,505,691
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Thioctic Acid results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pcdhb6l protocadherin beta-6-like multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] CTD PMID:23608068 NCBI chr18:30,512,507...30,518,524
Ensembl chr18:30,515,962...30,518,352
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] CTD PMID:21251946 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 decreases expression
decreases activity
ISO Thioctic Acid results in decreased expression of PLAAT3 mRNA
Thioctic Acid results in decreased activity of PLAAT3 protein
CTD PMID:22941773 NCBI chr 1:222,844,238...222,877,180
Ensembl chr 1:222,844,144...222,877,193
JBrowse link
G Plin1 perilipin 1 increases phosphorylation ISO Thioctic Acid results in increased phosphorylation of PLIN1 protein CTD PMID:22941773 NCBI chr 1:141,458,907...141,470,927
Ensembl chr 1:141,458,181...141,471,010
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity
ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:16391466, PMID:21932800, PMID:24120545 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22464149 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP [Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA CTD PMID:22464149 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
ISO
EXP
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]
Thioctic Acid results in increased expression of PPARGC1A protein
CTD PMID:20414966, PMID:22464149 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions
decreases acetylation
EXP [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
Thioctic Acid results in decreased acetylation of PPARGC1B protein
CTD PMID:22327056, PMID:22464149 NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] CTD PMID:19735303, PMID:23830814, PMID:26276312 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]
Thioctic Acid results in decreased phosphorylation of RELA protein
CTD PMID:22488045 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Reln reelin multiple interactions EXP [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA CTD PMID:31068541 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Sema5a semaphorin 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] CTD PMID:23608068 NCBI chr 2:85,377,318...85,808,970
Ensembl chr 2:85,377,318...85,808,970
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] CTD PMID:24704557 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions
EXP Thioctic Acid results in increased expression of SIRT1 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA]
CTD PMID:22327056 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
EXP [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]
Thioctic Acid results in increased expression of SIRT3 protein
CTD PMID:22327056 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions
affects activity
EXP [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]
Thioctic Acid affects the activity of SLC12A2 protein
CTD PMID:23880158 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] CTD PMID:32061141 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Slc5a6 solute carrier family 5 member 6 increases transport
multiple interactions
ISO
EXP
SLC5A6 results in increased transport of Thioctic Acid
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid]
CTD PMID:9516450, PMID:10329687 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] CTD PMID:32061141 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Snca synuclein alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] CTD PMID:15804455, PMID:26518973 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
EXP
ISO
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA
Thioctic Acid results in increased activity of SOD2 protein
CTD PMID:15804455, PMID:19951573, PMID:22327056, PMID:27260466 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22464149 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] CTD PMID:28070105 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] CTD PMID:19635391, PMID:28086195 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] CTD PMID:19635391, PMID:28086195 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases expression ISO Thioctic Acid results in increased expression of SUMO1 protein CTD PMID:24975507 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA] CTD PMID:15309289, PMID:21251946, PMID:24704557, PMID:26276312, PMID:29760339 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] CTD PMID:23608068 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA CTD PMID:23830814, PMID:31068541 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] CTD PMID:27260466 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]] CTD PMID:15309289, PMID:23830814, PMID:26276312, PMID:29760339 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA CTD PMID:23830814 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:19900424 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] CTD PMID:23608068, PMID:23892647 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:23830814, PMID:31068541 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction
multiple interactions
ISO
EXP
TXNRD1 protein results in increased reduction of Thioctic Acid
Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]
CTD PMID:20810785, PMID:21172426 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] CTD PMID:22327056, PMID:22464149 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
EXP
ISO
Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]
CTD PMID:11596663, PMID:22488045, PMID:26276312 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:32662911 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
prostaglandin A1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of AARS protein CTD PMID:19800325 NCBI chr19:43,193,264...43,215,281
Ensembl chr19:43,193,257...43,215,281
JBrowse link
G Actn1 actinin, alpha 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of ACTN1 protein CTD PMID:19800325 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Actn3 actinin alpha 3 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of ACTN3 protein CTD PMID:19800325 NCBI chr 1:220,120,532...220,136,460
Ensembl chr 1:220,120,533...220,136,470
JBrowse link
G Actn4 actinin alpha 4 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of ACTN4 protein CTD PMID:19800325 NCBI chr 1:87,078,012...87,147,347
Ensembl chr 1:87,078,020...87,147,333
JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP prostaglandin A1 promotes the reaction [arsenite results in increased expression of CRYAB mRNA]; prostaglandin A1 promotes the reaction [arsenite results in increased expression of CRYAB protein] CTD PMID:9066782 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of EEF1A1 protein CTD PMID:19800325 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of EEF2 protein CTD PMID:19800325 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Eno1 enolase 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of ENO1 protein CTD PMID:19800325 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of GAPDH protein CTD PMID:19800325 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gpi glucose-6-phosphate isomerase increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of GPI1 protein CTD PMID:19800325 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of HMGCS1 protein CTD PMID:19800325 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO prostaglandin A1 analog results in increased expression of HMOX1 protein; prostaglandin A1 results in increased expression of HMOX1 protein CTD PMID:19800325 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of HSP90AA1 protein CTD PMID:19800325 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of HSP90AB1 protein CTD PMID:19800325 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of HSP90B1 protein CTD PMID:19800325 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of HSPA4 protein CTD PMID:19800325 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of HSPA8 protein CTD PMID:19800325 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of HSPH1 protein CTD PMID:19800325 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of IDH2 protein CTD PMID:19800325 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Ipo7 importin 7 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of IPO7 protein CTD PMID:19800325 NCBI chr 1:174,655,939...174,696,173
Ensembl chr 1:174,655,939...174,696,173
JBrowse link
G Ldha lactate dehydrogenase A increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of LDHA protein CTD PMID:19800325 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO prostaglandin A1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:12031542 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npepps aminopeptidase puromycin sensitive increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of NPEPPS protein CTD PMID:19800325 NCBI chr10:85,140,368...85,222,861
Ensembl chr10:85,140,370...85,222,861
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of PGK1 protein CTD PMID:19800325 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Pgm1 phosphoglucomutase 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of PGM1 protein CTD PMID:19800325 NCBI chr 5:118,743,632...118,803,055
Ensembl chr 5:118,743,632...118,803,055
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of PHGDH protein CTD PMID:19800325 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of PSAT1 protein CTD PMID:19800325 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO prostaglandin A1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:12031542 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rack1 receptor for activated C kinase 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of RACK1 protein CTD PMID:19800325 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198
JBrowse link
G Tubb5 tubulin, beta 5 class I increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of TUBB5 protein CTD PMID:19800325 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of UBA1 protein CTD PMID:19800325 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701
JBrowse link
G Vcp valosin-containing protein increases metabolic processing ISO prostaglandin A1 analog results in increased metabolism of VCP protein CTD PMID:19800325 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
prostaglandin A2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cryab crystallin, alpha B multiple interactions EXP prostaglandin A2 promotes the reaction [arsenite results in increased expression of CRYAB mRNA]; prostaglandin A2 promotes the reaction [arsenite results in increased expression of CRYAB protein] CTD PMID:9066782 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects metabolic processing ISO GSTA1 protein affects the metabolism of prostaglandin A2 CTD PMID:9084911 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects metabolic processing ISO GSTA2 protein affects the metabolism of prostaglandin A2 CTD PMID:9084911 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing ISO GSTM1 protein affects the metabolism of prostaglandin A2 CTD PMID:9084911 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Tnf tumor necrosis factor increases abundance ISO TNF protein results in increased abundance of prostaglandin A2 CTD PMID:1993070 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
prostaglandin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of prostaglandin B1 CTD PMID:15231852 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of prostaglandin B1 CTD PMID:15231852 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of prostaglandin B1 CTD PMID:15231852 NCBI chr14:22,597,103...22,619,968 JBrowse link
prostaglandin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 increases metabolic processing
increases reduction
decreases response to substance
decreases metabolic processing
multiple interactions
ISO AKR1C3 protein results in increased metabolism of Prostaglandin D2
AKR1C3 protein results in increased reduction of Prostaglandin D2
AKR1C3 protein results in decreased susceptibility to Prostaglandin D2
AKR1C3 protein results in decreased metabolism of Prostaglandin D2
[AKR1C3 protein results in decreased metabolism of Prostaglandin D2] which results in decreased chemical synthesis of 9-deoxy-delta-9-prostaglandin D2; [AKR1C3 protein results in increased reduction of Prostaglandin D2] which results in increased chemical synthesis of Dinoprost; [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]
CTD PMID:19010312, PMID:19997560, PMID:20036328 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta increases cleavage ISO Prostaglandin D2 results in increased cleavage of ARHGDIB protein CTD PMID:15843042 NCBI chr 4:170,913,920...170,932,789
Ensembl chr 4:170,913,923...170,932,618