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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ceruletide
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Accession:CHEBI:59219 term browser browse the term
Definition:A decapeptide comprising 5-oxoprolyl, glutamyl, aspartyl, O-sulfotyrosyl, threonyl, glycyl, tryptopyl, methionyl, aspartyl and phenylalaninamide residues in sequence. Found in the skins of certain Australian amphibians, it is an analogue of the gastrointestinal peptide hormone cholecystokinin and stimulates gastric, biliary, and pancreatic secretion. It is used in cases of paralysis of the intestine (paralytic ileus) and as a diagnostic aid in pancreatic malfunction.
Synonyms:exact_synonym: 5-oxo-L-prolyl-L-glutaminyl-L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-threonylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
 related_synonym: Formula=C58H73N13O21S2;   InChI=1S/C58H73N13O21S2/c1-29(72)49(71-57(87)40(23-31-12-14-33(15-13-31)92-94(89,90)91)68-56(86)43(26-48(78)79)69-52(82)37(16-18-44(59)73)65-51(81)36-17-19-45(74)63-36)58(88)62-28-46(75)64-41(24-32-27-61-35-11-7-6-10-34(32)35)54(84)66-38(20-21-93-2)53(83)70-42(25-47(76)77)55(85)67-39(50(60)80)22-30-8-4-3-5-9-30/h3-15,27,29,36-43,49,61,72H,16-26,28H2,1-2H3,(H2,59,73)(H2,60,80)(H,62,88)(H,63,74)(H,64,75)(H,65,81)(H,66,84)(H,67,85)(H,68,86)(H,69,82)(H,70,83)(H,71,87)(H,76,77)(H,78,79)(H,89,90,91)/t29-,36+,37+,38+,39+,40+,41+,42+,43+,49+/m1/s1;   InChIKey=YRALAIOMGQZKOW-HYAOXDFASA-N;   SMILES=[H][C@](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)([C@@H](C)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O;   caerulein;   cerulein;   ceruletida;   ceruletidum
 xref: Beilstein:5422487;   CAS:17650-98-5;   DrugBank:DB00403;   Drug_Central:579;   KEGG:D03442
 xref_mesh: MESH:D002108
 xref: Wikipedia:Ceruletide



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ceruletide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions
increases expression
EXP PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of ACTA2 mRNA]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of ACTA2 protein]
Ceruletide results in increased expression of ACTA2 mRNA; Ceruletide results in increased expression of ACTA2 protein
CTD PMID:25035110 PMID:38113986 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase decreases expression ISO Ceruletide results in decreased expression of AHCY protein CTD PMID:18024178 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO Ceruletide results in increased expression of AKR1B1 protein CTD PMID:18024178 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein CTD PMID:26390243 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alb albumin decreases expression ISO Ceruletide results in decreased expression of ALB protein modified form CTD PMID:17169977 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression
multiple interactions
EXP Ceruletide results in increased expression of BCL2 mRNA; Ceruletide results in increased expression of BCL2 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]
CTD PMID:34423886 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 increases expression EXP Ceruletide results in increased expression of BDKRB1 mRNA CTD PMID:21484880 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 increases expression EXP Ceruletide results in increased expression of BDKRB2 mRNA CTD PMID:21484880 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions EXP (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein CTD PMID:26390243 NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Glycodeoxycholic Acid co-treated with Ceruletide] results in decreased activity of CASP3 protein; Ceruletide results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:16339139 PMID:18832452 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Ceruletide results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16339139 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ceruletide results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16339139 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
EXP coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]]; limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]; PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]; Rosiglitazone inhibits the reaction [Ceruletide results in increased expression of CCL2 mRNA] CTD PMID:17463185 PMID:21484880 PMID:34423886 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
EXP Ceruletide results in increased expression of CCND1 mRNA; Ceruletide results in increased expression of CCND1 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]
CTD PMID:34423886 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 increases expression ISO Ceruletide results in increased expression of CCT2 protein CTD PMID:18024178 NCBI chr10:116,886,902...116,899,757
Ensembl chr10:116,886,906...116,899,719
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression
multiple interactions
ISO Ceruletide results in increased expression of CEBPA mRNA
[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPA mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPA mRNA]
CTD PMID:26873426 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
increases expression
ISO [Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPB mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPB mRNA] CTD PMID:26873426 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
increases expression
ISO
EXP
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]
PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]
CTD PMID:22280800 PMID:25035110 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Ctsb cathepsin B affects localization
multiple interactions
ISO Ceruletide affects the localization of CTSB protein
sodium arsenite inhibits the reaction [Ceruletide affects the localization of CTSB protein]
CTD PMID:17941083 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
EXP Ceruletide results in increased expression of CXCL1 mRNA
AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA]
CTD PMID:17463185 PMID:17484889 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 increases expression
multiple interactions
ISO Ceruletide results in increased expression of ERN1 mRNA; Ceruletide results in increased expression of ERN1 protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 protein]
CTD PMID:26873426 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression ISO Ceruletide results in increased expression of GLUD1 protein CTD PMID:18024178 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression
multiple interactions
EXP Ceruletide results in increased expression of GPT protein
isoborneol inhibits the reaction [Ceruletide results in increased expression of GPT protein]
CTD PMID:33166053 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP Ceruletide results in increased expression of HMOX1 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]
CTD PMID:34423886 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 increases expression ISO Ceruletide results in increased expression of HNRNPH1 protein CTD PMID:18024178 NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
JBrowse link
G Hspa5 heat shock protein 5 decreases expression ISO Ceruletide results in decreased expression of HSPA5 protein CTD PMID:18024178 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspa8 heat shock protein 8 decreases expression ISO Ceruletide results in decreased expression of HSPA8 protein CTD PMID:18024178 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO Ceruletide results in increased expression of HYOU1 protein CTD PMID:18024178 NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO
EXP
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]
CTD PMID:17463185 PMID:25035110 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [resveratrol co-treated with Ceruletide] results in increased expression of IL10 protein CTD PMID:24234420 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions
ISO
EXP
Ceruletide results in increased expression of IL1B mRNA; Ceruletide results in increased expression of IL1B protein
Ceruletide results in increased secretion of IL1B protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL1B protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]]; resveratrol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]
CTD PMID:14751415 PMID:21484880 PMID:24234420 PMID:26873426 PMID:33166053 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion
ISO
EXP
Ceruletide results in increased expression of IL6 mRNA
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
Ceruletide results in increased expression of IL6 mRNA; Ceruletide results in increased expression of IL6 protein
(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of IL6 protein]
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]]
CTD PMID:17484889 PMID:22280800 PMID:25035110 PMID:26390243 PMID:26873426 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Jak2 Janus kinase 2 multiple interactions
increases expression
EXP coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of JAK2 protein] CTD PMID:34423886 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
JBrowse link
G Jun jun proto-oncogene increases expression
multiple interactions
EXP Ceruletide results in increased expression of JUN mRNA
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of JUN mRNA]
CTD PMID:17463185 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog multiple interactions EXP (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]] CTD PMID:26390243 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
JBrowse link
G Mir216a microRNA 216a increases expression ISO Ceruletide results in increased expression of MIR216A mRNA CTD PMID:27521901 NCBI chr11:28,707,012...28,707,083
Ensembl chr11:28,707,012...28,707,083
JBrowse link
G Mir216b microRNA 216b increases expression ISO Ceruletide results in increased expression of MIR216B mRNA CTD PMID:27521901 NCBI chr11:28,696,191...28,696,276
Ensembl chr11:28,696,191...28,696,276
JBrowse link
G Mir217 microRNA 217 increases expression ISO Ceruletide results in increased expression of MIR217 mRNA CTD PMID:27521901 NCBI chr11:28,713,728...28,713,835
Ensembl chr11:28,713,728...28,713,835
JBrowse link
G Mpo myeloperoxidase increases expression
multiple interactions
increases activity
EXP Ceruletide results in increased expression of MPO protein
HU 211 inhibits the reaction [Ceruletide results in increased expression of MPO protein]; isoborneol inhibits the reaction [Ceruletide results in increased activity of MPO protein]
CTD PMID:17484889 PMID:33166053 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases expression
multiple interactions
EXP Ceruletide results in decreased expression of NFE2L2 protein
isoborneol inhibits the reaction [Ceruletide results in decreased expression of NFE2L2 protein]
CTD PMID:33166053 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases degradation
multiple interactions
ISO Ceruletide results in increased degradation of NFKBIA protein
sodium arsenite inhibits the reaction [Ceruletide results in increased degradation of NFKBIA protein]
CTD PMID:17941083 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
EXP isoborneol inhibits the reaction [Ceruletide results in increased expression of NOS2 protein] CTD PMID:33166053 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Pdia4 protein disulfide isomerase associated 4 increases expression ISO Ceruletide results in increased expression of PDIA4 protein CTD PMID:18024178 NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA] CTD PMID:17463185 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO Ceruletide results in increased expression of PRDX2 protein CTD PMID:18024178 NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Ceruletide results in increased expression of PTGS2 mRNA; Ceruletide results in increased expression of PTGS2 protein CTD PMID:14751415 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Pthlh parathyroid hormone-like peptide multiple interactions
increases expression
affects response to substance
ISO
EXP
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
Ceruletide results in increased expression of PTHLH mRNA; Ceruletide results in increased expression of PTHLH protein
PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
PTHLH protein affects the susceptibility to Ceruletide
Ethanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]
CTD PMID:22280800 PMID:25035110 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases expression
decreases phosphorylation
EXP ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Ceruletide results in increased expression of RELA protein]; isoborneol inhibits the reaction [Ceruletide results in decreased phosphorylation of RELA protein] CTD PMID:22982818 PMID:33166053 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 increases cleavage ISO Ceruletide results in increased cleavage of RIPK1 protein CTD PMID:16339139 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130
JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 increases expression ISO Ceruletide results in increased expression of RUVBL1 protein CTD PMID:18024178 NCBI chr 6:88,442,391...88,474,548
Ensembl chr 6:88,442,391...88,474,554
JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 increases activity ISO cerulein increases activity of Serpinf1 protein in blood RGD PMID:10423332 RGD:1625538 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP [Shuangshen co-treated with Ceruletide] results in decreased expression of SMAD2 protein CTD PMID:38113986 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
increases expression
EXP Shuangshen inhibits the reaction [Ceruletide results in increased expression of SMAD3 protein] CTD PMID:38113986 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
decreases expression
EXP isoborneol inhibits the reaction [Ceruletide results in decreased expression of SOD1 protein] CTD PMID:33166053 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
EXP (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein] CTD PMID:26390243 PMID:34423886 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
EXP Ceruletide results in increased expression of TGFB1 protein
Shuangshen inhibits the reaction [Ceruletide results in increased expression of TGFB1 protein]
CTD PMID:38113986 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions
ISO
EXP
Ceruletide results in increased expression of TNF mRNA; Ceruletide results in increased expression of TNF protein
Ceruletide results in increased secretion of TNF protein
2-acetoxy-5-(2-4-(trifluoromethyl)phenethylamino)benzoic acid inhibits the reaction [[Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; [Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; arsenic trioxide inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Ceruletide results in increased expression of TNF protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]]
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of TNF protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of TNF protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of TNF protein]
CTD PMID:10773043 PMID:17517186 PMID:22575522 PMID:26873426 PMID:33166053 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO Ceruletide results in increased expression of TPI1 protein CTD PMID:18024178 NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259
JBrowse link
G Vcp valosin containing protein decreases expression ISO Ceruletide results in decreased expression of VCP protein CTD PMID:18024178 NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions
ISO Ceruletide results in increased expression of XBP1 mRNA alternative form; Ceruletide results in increased expression of XBP1 protein alternative form
Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]
CTD PMID:26873426 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases degradation ISO Ceruletide results in increased degradation of XIAP protein CTD PMID:16339139 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        pharmaceutical 21187
          diagnostic agent 773
            ceruletide 61
              ceruletide diethylamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      carboacyl group 18277
                                        univalent carboacyl group 18277
                                          carbamoyl group 18088
                                            carboxamide 18106
                                              peptide 11229
                                                oligopeptide 1336
                                                  ceruletide 61
                                                    ceruletide diethylamine 0
paths to the root