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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiosalicylic acid
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Accession:CHEBI:59124 term browser browse the term
Definition:A sulfanylbenzoic acid that is the 2-sulfanyl derivative of benzoic acid.
Synonyms:related_synonym: 2-Carboxythiophenol;   2-Mercaptobenzoic acid;   2-Sulfanylbenzoic acid;   2-Thiosalicylic acid;   Formula=C7H6O2S;   InChI=1S/C7H6O2S/c8-7(9)5-3-1-2-4-6(5)10/h1-4,10H,(H,8,9);   InChIKey=NBOMNTLFRHMDEZ-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccccc1S;   Thiophenol-2-carboxylic acid;   o-Benzoic acid thiol;   o-Carboxythiophenol;   o-Mercaptobenzoesaeure;   o-Mercaptobenzoic acid;   o-Sulfhydrylbenzoic acid;   o-Thiosalicylic acid
 xref: Beilstein:508507;   CAS:147-93-3;   Drug_Central:4856;   Gmelin:3838;   KEGG:D08586
 xref_mesh: MESH:C441201
 xref: PDBeChem:JKE;   PMID:1650428;   PMID:23934301;   PMID:24369647;   PMID:24728505;   Patent:DE189200;   Patent:DE205450;   Reaxys:508507;   Wikipedia:Thiosalicylic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:59127



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thiosalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased activity of CASP3 protein CTD PMID:19427195 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions EXP [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased activity of CASP8 protein CTD PMID:19427195 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased expression of FAS mRNA; [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased expression of FAS protein CTD PMID:19427195 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions EXP thiosalicylic acid inhibits the reaction [Diethylnitrosamine results in decreased expression of FASL mRNA] CTD PMID:19427195 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Mt1 metallothionein 1 decreases expression ISO thiosalicylic acid results in decreased expression of MT1 mRNA CTD PMID:19386279 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        pharmacological role 19087
          analgesic 14627
            non-narcotic analgesic 13782
              thiosalicylic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        aromatic carboxylic acid 11788
                                          benzoic acids 11763
                                            sulfanylbenzoic acid 5
                                              thiosalicylic acid 5
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