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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiosalicylic acid
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Accession:CHEBI:59124 term browser browse the term
Definition:A sulfanylbenzoic acid that is the 2-sulfanyl derivative of benzoic acid.
Synonyms:related_synonym: 2-Carboxythiophenol;   2-Mercaptobenzoic acid;   2-Sulfanylbenzoic acid;   2-Thiosalicylic acid;   Formula=C7H6O2S;   InChI=1S/C7H6O2S/c8-7(9)5-3-1-2-4-6(5)10/h1-4,10H,(H,8,9);   InChIKey=NBOMNTLFRHMDEZ-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccccc1S;   Thiophenol-2-carboxylic acid;   o-Benzoic acid thiol;   o-Carboxythiophenol;   o-Mercaptobenzoesaeure;   o-Mercaptobenzoic acid;   o-Sulfhydrylbenzoic acid;   o-Thiosalicylic acid
 xref: Beilstein:508507;   CAS:147-93-3;   Drug_Central:4856;   Gmelin:3838;   KEGG:D08586
 xref_mesh: MESH:C441201
 xref: PDBeChem:JKE;   PMID:1650428;   PMID:23934301;   PMID:24369647;   PMID:24728505;   Patent:DE189200;   Patent:DE205450;   Reaxys:508507;   Wikipedia:Thiosalicylic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:59127


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thiosalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased activity of CASP3 protein CTD PMID:19427195 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased activity of CASP8 protein CTD PMID:19427195 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased expression of FAS mRNA; [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased expression of FAS protein CTD PMID:19427195 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions EXP thiosalicylic acid inhibits the reaction [Diethylnitrosamine results in decreased expression of FASL mRNA] CTD PMID:19427195 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Mt1 metallothionein 1 decreases expression ISO thiosalicylic acid results in decreased expression of MT1 mRNA CTD PMID:19386279 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        pharmacological role 18831
          analgesic 13095
            non-narcotic analgesic 12008
              thiosalicylic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic group 18613
                              organic divalent group 18604
                                organodiyl group 18604
                                  carbonyl group 18521
                                    carbonyl compound 18521
                                      carboxylic acid 18196
                                        aromatic carboxylic acid 11307
                                          benzoic acids 11278
                                            sulfanylbenzoic acid 5
                                              thiosalicylic acid 5
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