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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perazine
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Accession:CHEBI:59118 term browser browse the term
Definition:A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position.
Synonyms:exact_synonym: 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine;   Formula=C20H25N3S;   InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3;   InChIKey=WEYVCQFUGFRXOM-UHFFFAOYSA-N;   N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine;   N-Methyl-piperazinyl-N'-propyl-phenothiazin;   N-Methyl-piperazinylpropyl-phenothiazine;   Pernazine;   SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccccc23)CC1
 xref: Beilstein:39009;   CAS:84-97-9;   Drug_Central:2100;   Gmelin:298041;   KEGG:C16903
 xref_mesh: MESH:D010464
 xref: PMID:1650428;   PMID:19904008;   PMID:23479940;   PMID:24425538;   Patent:GB780193;   Reaxys:39009;   Wikipedia:Perazine


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perazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 affects metabolic processing
decreases methylation
ISO CYP2C9 gene polymorphism affects the metabolism of Perazine
CYP2C9 protein results in decreased methylation of Perazine
CTD PMID:11026737 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 affects metabolic processing
decreases methylation
ISO CYP2C9 gene polymorphism affects the metabolism of Perazine
CYP2C9 protein results in decreased methylation of Perazine
CTD PMID:11026737 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Fmo3 flavin containing monooxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of Perazine CTD PMID:11026737 NCBI chr 1:162,953,799...162,984,528
Ensembl chr 1:162,953,800...162,984,528
JBrowse link
thiethylperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions EXP [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions EXP [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21738
    role 21717
      biological role 21715
        pharmacological role 19376
          neurotransmitter agent 16906
            dopaminergic agent 5057
              dopaminergic antagonist 1191
                perazine 5
                  thiethylperazine + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 21738
    subatomic particle 21725
      composite particle 21725
        hadron 21725
          baryon 21725
            nucleon 21725
              atomic nucleus 21725
                atom 21725
                  main group element atom 21641
                    main group molecular entity 21641
                      s-block molecular entity 21172
                        hydrogen molecular entity 21107
                          hydrides 20364
                            inorganic hydride 18052
                              pnictogen hydride 18014
                                nitrogen hydride 17830
                                  azane 17724
                                    ammonia 17723
                                      organic amino compound 17722
                                        tertiary amino compound 8741
                                          N-alkylpiperazine 3089
                                            N-methylpiperazine 870
                                              perazine 5
                                                thiethylperazine + 2
paths to the root