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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perazine
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Accession:CHEBI:59118 term browser browse the term
Definition:A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position.
Synonyms:exact_synonym: 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine;   Formula=C20H25N3S;   InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3;   InChIKey=WEYVCQFUGFRXOM-UHFFFAOYSA-N;   N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine;   N-Methyl-piperazinyl-N'-propyl-phenothiazin;   N-Methyl-piperazinylpropyl-phenothiazine;   Pernazine;   SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccccc23)CC1
 xref: Beilstein:39009;   CAS:84-97-9;   Drug_Central:2100;   Gmelin:298041;   KEGG:C16903
 xref_mesh: MESH:D010464
 xref: PMID:1650428;   PMID:19904008;   PMID:23479940;   PMID:24425538;   Patent:GB780193;   Reaxys:39009;   Wikipedia:Perazine


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perazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 affects metabolic processing
decreases methylation
EXP CYP2C9 gene polymorphism affects the metabolism of Perazine
CYP2C9 protein results in decreased methylation of Perazine
CTD PMID:11026737 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases methylation EXP CYP3A4 protein results in decreased methylation of Perazine CTD PMID:11026737 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 increases oxidation EXP FMO3 protein results in increased oxidation of Perazine CTD PMID:11026737 NCBI chr 1:171,090,873...171,117,819
Ensembl chr 1:171,090,901...171,117,819
JBrowse link
thiethylperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24513
    role 24426
      biological role 24393
        pharmacological role 21188
          neurotransmitter agent 18692
            dopaminergic agent 5065
              dopaminergic antagonist 1200
                perazine 5
                  thiethylperazine + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 24513
    subatomic particle 24471
      composite particle 24471
        hadron 24471
          baryon 24471
            nucleon 24471
              atomic nucleus 24471
                atom 24471
                  main group element atom 24329
                    main group molecular entity 24329
                      s-block molecular entity 23606
                        hydrogen molecular entity 23438
                          hydrides 21956
                            inorganic hydride 19159
                              pnictogen hydride 19131
                                nitrogen hydride 18810
                                  azane 18696
                                    ammonia 18695
                                      organic amino compound 18694
                                        tertiary amino compound 8840
                                          N-alkylpiperazine 3113
                                            N-methylpiperazine 896
                                              perazine 5
                                                thiethylperazine + 2
paths to the root