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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clopenthixol
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Accession:CHEBI:59115 term browser browse the term
Definition:A thioxanthene derivative having a chloro substituent at the 2-position and an alkylidene group at the 10-position with undefined double bond stereochemistry.
Synonyms:exact_synonym: 2-{4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]piperazin-1-yl}ethan-1-ol
 related_synonym: 2-{4-[3-(2-chloro-10H-dibenzo[b,e]thiopyran-10-ylidene)propyl]piperazin-1-yl}ethanol;   4-(3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol;   4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol;   Chlorpenthixol;   Formula=C22H25ClN2OS;   InChI=1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2;   InChIKey=WFPIAZLQTJBIFN-UHFFFAOYSA-N;   SMILES=[H]C(CCN1CCN(CCO)CC1)=C1c2ccccc2Sc2ccc(Cl)cc12;   clopenthixolum;   clopentixol
 xref: Beilstein:899403;   CAS:982-24-1;   Drug_Central:4397;   KEGG:D02613;   LINCS:LSM-2631
 xref_mesh: MESH:D003006
 xref: PMID:1650428;   Patent:BE585338;   Patent:US3116291;   Wikipedia:Clopenthixol



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clopenthixol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Clopenthixol results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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  CHEBI ontology 19659
    role 19634
      biological role 19633
        pharmacological role 18933
          antagonist 16594
            histamine antagonist 4860
              H1-receptor antagonist 4125
                clopenthixol 1
                  zuclopenthixol 0
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Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        tertiary amino compound 9087
                                          N-alkylpiperazine 3353
                                            clopenthixol 1
                                              zuclopenthixol 0
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