EC 3.4.24.* (metalloendopeptidase) inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	*EC 3.4.24. (metalloendopeptidase) inhibitor**	go back to main search page
Accession:	CHEBI:59107	browse the term
Definition:	Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a metalloendopeptidase (EC 3.4.24.*).
Synonyms:	related_synonym:	EC 3.4.24.* (metalloendopeptidase) inhibitors; EC 3.4.24.* inhibitor; EC 3.4.24.* inhibitors; inhibitor of metalloendopeptidases; inhibitor of metalloendopeptidases (EC 3.4.24.); inhibitors of metalloendopeptidases; inhibitors of metalloendopeptidases (EC 3.4.24.); metalloendopeptidase inhibitors
	alt_id:	CHEBI:76786

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Rat (849) Mouse (851) Human (861) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (7) Green Monkey (0) Naked Mole-rat (0) All
Genes (861)

brazilein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin D1

decreases expression

brazilein results in decreased expression of CCND1 mRNA; brazilein results in decreased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

catenin beta 1

decreases expression

brazilein results in decreased expression of CTNNB1 protein

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

glycogen synthase kinase 3 beta

decreases expression

brazilein results in decreased expression of GSK3B protein modified form

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

matrix metallopeptidase 2

multiple interactions
decreases expression

brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein promotes the reaction [Wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein results in decreased expression of and results in decreased activity of MMP2 protein; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; Wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]
brazilein results in decreased expression of MMP2 mRNA

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

NFKB inhibitor alpha

multiple interactions

brazilein results in decreased expression of and results in decreased phosphorylation of NFKBIA protein

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

RELA proto-oncogene, NF-kB subunit

decreases expression

brazilein results in decreased expression of RELA protein

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

candoxatrilat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

membrane metalloendopeptidase

decreases activity

candoxatrilat results in decreased activity of MME protein

NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704

G

membrane metalloendopeptidase like 1

decreases activity

candoxatrilat results in decreased activity of MMEL1 protein

NCBI chr 1:2,590,639...2,633,016
Ensembl chr 1:2,590,639...2,633,016

G

natriuretic peptide A

multiple interactions

candoxatrilat inhibits the reaction [Carbon Tetrachloride results in decreased secretion of NPPA protein]

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

fluvastatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

[ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin

NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

fluvastatin results in decreased activity of ABCB11 protein
fluvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]

PMID:15901796 PMID:20829430

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily C member 2

affects transport
multiple interactions

ABCC2 protein affects the transport of fluvastatin
ABCC2 protein binds to and results in increased uptake of fluvastatin analog; fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]

PMID:16026004 PMID:23562342 PMID:24909372

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

AKT serine/threonine kinase 1

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

apolipoprotein B

multiple interactions

[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein]

PMID:19773416 PMID:20671225

NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073

G

apolipoprotein E

multiple interactions
increases expression

[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin
fluvastatin results in increased expression of APOE protein

PMID:8017468 PMID:19773416

NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393

G

Rho GTPase activating protein 29

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGAP29 mRNA

NCBI chr 1:94,168,905...94,314,592
Ensembl chr 1:94,148,988...94,275,068

G

Rho guanine nucleotide exchange factor 12

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF12 mRNA

NCBI chr11:120,336,413...120,489,937
Ensembl chr11:120,336,413...120,489,937

G

Rho guanine nucleotide exchange factor 3

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF3 mRNA

NCBI chr 3:56,727,420...57,079,268
Ensembl chr 3:56,727,418...57,079,329

G

BCL2 associated X, apoptosis regulator

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

B cell receptor associated protein 29

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of BCAP29 mRNA

NCBI chr 7:107,580,007...107,623,317
Ensembl chr 7:107,580,246...107,629,170

G

BCL2 apoptosis regulator

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 11

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of BCL2L11 mRNA

NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444

G

beclin 1

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]]

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

basic helix-loop-helix family member e40

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of BHLHE40 mRNA

NCBI chr 3:4,979,437...4,985,323
Ensembl chr 3:4,979,437...4,985,323

G

BUB1 mitotic checkpoint serine/threonine kinase

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of BUB1 mRNA

NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063

G

caspase 1

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of CASP1 mRNA

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

multiple interactions

fluvastatin results in increased cleavage of and results in increased activity of CASP3 protein; Mevalonic Acid inhibits the reaction [fluvastatin results in increased cleavage of and results in increased activity of CASP3 protein]
Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]

PMID:24964743 PMID:35465754

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases activity
multiple interactions

fluvastatin results in increased activity of CASP8 protein
Mevalonic Acid inhibits the reaction [fluvastatin results in increased activity of CASP8 protein]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

catalase

increases expression
multiple interactions

fluvastatin results in increased expression of CAT protein
Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]

PMID:24964743 PMID:35465754

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 2

multiple interactions

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CCL2 mRNA]

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

cyclin dependent kinase 2 associated protein 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of CDK2AP2 mRNA

NCBI chr11:67,506,497...67,508,162
Ensembl chr11:67,506,497...67,508,649

G

cholesteryl ester transfer protein

multiple interactions

[ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin

NCBI chr16:56,961,950...56,983,845
Ensembl chr16:56,961,923...56,983,845

G

CDC28 protein kinase regulatory subunit 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of CKS2 mRNA

NCBI chr 9:89,311,195...89,316,703
Ensembl chr 9:89,311,195...89,316,703

G

cytochrome P450 family 2 subfamily B member 6

increases expression

fluvastatin results in increased expression of CYP2B6 mRNA

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 9

multiple interactions

fluvastatin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions
decreases activity

[fluvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam]
fluvastatin results in decreased activity of CYP3A4 protein

PMID:16029222 PMID:24204015

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

damage specific DNA binding protein 2

decreases expression
multiple interactions

fluvastatin results in decreased expression of DDB2 mRNA; fluvastatin results in decreased expression of DDB2 protein
[fluvastatin results in decreased expression of DDB2] which results in increased expression of SOD2 mRNA; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 mRNA]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 protein]

NCBI chr11:47,214,454...47,239,217
Ensembl chr11:47,214,465...47,239,217

G

endothelin receptor type A

decreases expression

fluvastatin results in decreased expression of EDNRA mRNA

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

G

epithelial membrane protein 3 (MAM blood group)

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of EMP3 mRNA

NCBI chr19:48,325,552...48,330,553
Ensembl chr19:48,321,509...48,330,553

G

ERCC excision repair 5, endonuclease

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ERCC5 mRNA

NCBI chr13:102,846,032...102,875,995
Ensembl chr13:102,845,831...102,875,995

G

ETS transcription factor ERG

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ERG mRNA

NCBI chr21:38,367,261...38,661,783
Ensembl chr21:38,380,027...38,661,780

G

coagulation factor III, tissue factor

multiple interactions
decreases expression

Fluvastatin inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to RELA protein] which binds to F3 promoter]]; geranylgeraniol inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]
Fluvastatin results in decreased expression of F3 mRNA; Fluvastatin results in decreased expression of F3 protein

NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759

G

farnesyl-diphosphate farnesyltransferase 1

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of FDFT1 mRNA

NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,395

G

farnesyltransferase, CAAX box, subunit alpha

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of FNTA mRNA

NCBI chr 8:43,056,323...43,085,785
Ensembl chr 8:43,034,194...43,085,788

G

forkhead box O1

decreases phosphorylation

Fluvastatin results in decreased phosphorylation of FOXO1 protein

NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641

G

follicle stimulating hormone subunit beta

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]

NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Fluvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA

NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438

G

glucose-6-phosphate dehydrogenase

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]]

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

growth arrest and DNA damage inducible beta

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of GADD45B mRNA

NCBI chr19:2,476,127...2,478,257
Ensembl chr19:2,476,122...2,478,259

G

glutathione-disulfide reductase

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

major histocompatibility complex, class II, DQ alpha 1

affects expression

fluvastatin affects the expression of HLA-DQA1 mRNA

NCBI chr 6:32,637,406...32,655,272
Ensembl chr 6:32,628,179...32,647,062

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
decreases activity

[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin
fluvastatin results in decreased activity of HMGCR protein

PMID:8593127 PMID:19773416

NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001

G

heme oxygenase 1

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

hydroxysteroid 17-beta dehydrogenase 1

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]]

NCBI chr17:42,552,923...42,555,214
Ensembl chr17:42,552,922...42,555,214

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]]

NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054

G

insulin like growth factor 1

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of IGF1 mRNA

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

insulin like growth factor binding protein 5

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of IGFBP5 mRNA

NCBI chr 2:216,672,105...216,695,549
Ensembl chr 2:216,672,105...216,695,549

G

interleukin 10 receptor subunit alpha

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of IL10RA mRNA

NCBI chr11:117,986,394...118,003,037
Ensembl chr11:117,986,370...118,003,037

G

interleukin 18

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]]

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 beta

decreases expression

fluvastatin results in decreased expression of IL1B mRNA

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2 receptor subunit gamma

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of IL2RG mRNA

NCBI chr X:71,107,404...71,111,577
Ensembl chr X:71,107,404...71,112,108

G

interferon regulatory factor 4

decreases expression

Fluvastatin results in decreased expression of IRF4 protein

NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443

G

lysine acetyltransferase 2B

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of KAT2B mRNA

NCBI chr 3:20,040,446...20,154,404
Ensembl chr 3:20,040,446...20,154,404

G

low density lipoprotein receptor

multiple interactions
increases activity

[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; fluvastatin promotes the reaction [Cholesterol, LDL binds to LDLR protein]; fluvastatin promotes the reaction [Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein]]
fluvastatin results in increased activity of LDLR protein

PMID:8593127 PMID:10395027 PMID:19773416

NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820

G

luteinizing hormone subunit beta

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]

NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091

G

lipase C, hepatic type

multiple interactions

[ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin

NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844

G

lamin A/C

decreases farnesylation

fluvastatin results in decreased farnesylation of LMNA protein

NCBI chr 1:156,082,573...156,140,081
Ensembl chr 1:156,082,573...156,140,081

G

lipoprotein lipase

multiple interactions

[ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

leucine zipper tumor suppressor 1

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of LZTS1 mRNA

NCBI chr 8:20,246,165...20,303,963
Ensembl chr 8:20,246,165...20,303,963

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

fluvastatin results in decreased expression of MCL1 protein

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

mediator complex subunit 23

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of MED23 mRNA

NCBI chr 6:131,573,966...131,628,313
Ensembl chr 6:131,573,966...131,628,242

G

marker of proliferation Ki-67

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]]

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

matrix metallopeptidase 2

multiple interactions
decreases expression

Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP2 mRNA]

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

decreases expression
multiple interactions

fluvastatin results in decreased expression of MMP9 mRNA
Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP9 mRNA]

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

M-phase phosphoprotein 8

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of MPHOSPH8 mRNA

NCBI chr13:19,633,659...19,673,441
Ensembl chr13:19,633,659...19,673,441

G

myostatin

increases expression

Fluvastatin results in increased expression of MSTN protein

NCBI chr 2:190,055,700...190,062,729
Ensembl chr 2:190,055,700...190,062,729

G

mechanistic target of rapamycin kinase

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]]

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

NDC80 kinetochore complex component

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of NDC80 mRNA

NCBI chr18:2,571,557...2,616,635
Ensembl chr18:2,571,557...2,616,635

G

NFE2 like bZIP transcription factor 2

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NLR family pyrin domain containing 3

multiple interactions

Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]]

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

nitric oxide synthase 2

increases expression
multiple interactions

fluvastatin results in increased expression of NOS2 mRNA; fluvastatin results in increased expression of NOS2 protein
[[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC; [fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide; [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [fluvastatin results in increased abundance of Nitric Oxide]; Mevalonic Acid inhibits the reaction [fluvastatin results in increased expression of NOS2 protein]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

nitric oxide synthase 3

multiple interactions

[fluvastatin co-treated with Valsartan] results in increased expression of NOS3 mRNA

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

NPHS1 adhesion molecule, nephrin

increases expression
multiple interactions

fluvastatin increases expression of Nphs1 protein in kidney
Fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]

CTD
RGD

PMID:16452496 PMID:19188342

NCBI chr19:35,862,915...35,869,357
Ensembl chr19:35,825,964...35,869,287

G

nuclear receptor subfamily 1 group I member 2

increases activity
multiple interactions

fluvastatin results in increased activity of NR1I2 protein
[Fluvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Fluvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA; [Fluvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA

PMID:15802384 PMID:24204015

NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487

G

nuclear receptor subfamily 1 group I member 3

increases activity

fluvastatin results in increased activity of NR1I3 protein

NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244

G

optineurin

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of OPTN mRNA

NCBI chr10:13,100,082...13,138,308
Ensembl chr10:13,099,449...13,138,308

G

protein associated with LIN7 1, MAGUK p55 family member

multiple interactions

[Zoledronic Acid co-treated with Fluvastatin] results in increased expression of PALS1 mRNA

NCBI chr14:67,241,435...67,336,061
Ensembl chr14:67,240,713...67,336,061

G

pappalysin 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of PAPPA2 mRNA

NCBI chr 1:176,463,175...176,845,601
Ensembl chr 1:176,463,171...176,845,601

G

proprotein convertase subtilisin/kexin type 9

multiple interactions

[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin

NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852

G

paraoxonase 1

multiple interactions
decreases activity

fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
fluvastatin results in decreased activity of PON1 protein

NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532

G

peroxisome proliferator activated receptor alpha

multiple interactions

fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

G

protein phosphatase 1 regulatory subunit 12A

multiple interactions

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PPP1R12A protein modified form]

NCBI chr12:79,773,563...79,935,460
Ensembl chr12:79,773,563...79,935,460

G

protein phosphatase 1 regulatory subunit 15A

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of PPP1R15A mRNA

NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059

G

peroxiredoxin 3

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of PRDX3 mRNA

NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812

G

protein C receptor

increases expression

fluvastatin results in increased expression of PROCR protein

NCBI chr20:35,171,096...35,216,259
Ensembl chr20:35,172,072...35,216,240

G

prostaglandin I2 synthase

increases expression

Fluvastatin increases expression of PTGIS mRNA in umbilical vein endothelial cells

RGD

NCBI chr20:49,503,874...49,568,137
Ensembl chr20:49,503,874...49,568,137

G

RAB27B, member RAS oncogene family

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RAB27B mRNA

NCBI chr18:54,717,857...54,895,516
Ensembl chr18:54,717,860...54,895,516

G

RAB32, member RAS oncogene family

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RAB32 mRNA

NCBI chr 6:146,543,833...146,554,953
Ensembl chr 6:146,543,833...146,554,953

G

RAB5B, member RAS oncogene family

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RAB5B mRNA

NCBI chr12:55,973,949...55,996,683
Ensembl chr12:55,973,913...55,996,683

G

RAB GTPase activating protein 1 like

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RABGAP1L mRNA

NCBI chr 1:174,159,520...174,995,308
Ensembl chr 1:174,159,410...174,995,308

G

RAP1A, member of RAS oncogene family

decreases prenylation

fluvastatin results in decreased prenylation of RAP1A protein

NCBI chr 1:111,542,009...111,716,691
Ensembl chr 1:111,542,218...111,716,691

G

RB transcriptional corepressor 1

decreases phosphorylation

fluvastatin results in decreased phosphorylation of RB1 protein

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

REL proto-oncogene, NF-kB subunit

multiple interactions

Fluvastatin inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to RELA protein] which binds to F3 promoter]]

NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Fluvastatin inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to RELA protein] which binds to F3 promoter]]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

regulator of G protein signaling 11

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RGS11 mRNA

NCBI chr16:268,307...275,944
Ensembl chr16:268,301...275,980

G

ras homolog family member A

multiple interactions

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein]

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

ras homolog family member B

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RHOB mRNA

NCBI chr 2:20,447,074...20,449,440
Ensembl chr 2:20,447,074...20,449,440

G

regulating synaptic membrane exocytosis 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RIMS2 mRNA

NCBI chr 8:103,500,610...104,256,094
Ensembl chr 8:103,500,610...104,254,430

G

Ras and Rab interactor 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RIN2 mRNA

NCBI chr20:19,757,599...20,002,456
Ensembl chr20:19,757,606...20,002,457

G

retinoid X receptor alpha

multiple interactions

fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]

NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585

G

serum/glucocorticoid regulated kinase 1

affects expression

fluvastatin affects the expression of SGK1 mRNA; fluvastatin affects the expression of SGK1 protein

NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112

G

serum/glucocorticoid regulated kinase 2

multiple interactions

[fluvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA

NCBI chr20:43,559,027...43,585,627
Ensembl chr20:43,558,968...43,588,237

G

solute carrier family 15 member 1

decreases activity

fluvastatin results in decreased activity of SLC15A1 protein

NCBI chr13:98,683,801...98,752,672
Ensembl chr13:98,683,801...98,752,672

G

solute carrier organic anion transporter family member 1B1

affects import
increases uptake
multiple interactions

SLCO1B1 protein affects the import of fluvastatin
SLCO1B1 protein results in increased uptake of Fluvastatin
[biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin; [kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin; [licochalcone A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin; [Luteolin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin; [Rifampin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin; [sinensetin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Fluvastatin; Rifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to Fluvastatin]; SLCO1B1 protein results in increased uptake of and results in increased susceptibility to Fluvastatin

PMID:16046661 PMID:23564645 PMID:32259555

NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796

G

solute carrier organic anion transporter family member 1B3

affects import

SLCO1B3 protein affects the import of fluvastatin

NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911

G

solute carrier organic anion transporter family member 2B1

affects import

SLCO2B1 protein affects the import of fluvastatin

NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549

G

superoxide dismutase 2

multiple interactions
increases expression

[fluvastatin co-treated with Doxorubicin] results in increased expression of SOD2 protein
fluvastatin results in increased expression of SOD2 mRNA; fluvastatin results in increased expression of SOD2 protein
[Fluvastatin results in decreased expression of DDB2] which results in increased expression of SOD2 mRNA; Mevalonic Acid inhibits the reaction [Fluvastatin results in increased expression of SOD2 protein]

PMID:19147586 PMID:24964743

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

SOS Ras/Rho guanine nucleotide exchange factor 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of SOS2 mRNA

NCBI chr14:50,117,130...50,231,882
Ensembl chr14:50,117,130...50,231,578

G

spindlin family member 2A

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of SPIN2A mRNA

NCBI chr X:57,134,265...57,147,180
Ensembl chr X:57,134,530...57,137,523

G

secreted phosphoprotein 1

multiple interactions

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 mRNA]

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

G

serine/threonine kinase 17a

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of STK17A mRNA

NCBI chr 7:43,583,108...43,627,379
Ensembl chr 7:43,582,758...43,650,713

G

tissue factor pathway inhibitor

increases expression

fluvastatin results in increased expression of TFPI protein

NCBI chr 2:187,464,230...187,554,435
Ensembl chr 2:187,464,230...187,565,760

G

transferrin receptor

multiple interactions
decreases expression

[[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC; [fluvastatin results in decreased expression of TFRC protein] which results in decreased uptake of Iron; Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC mRNA]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]
fluvastatin results in decreased expression of TFRC mRNA; fluvastatin results in decreased expression of TFRC protein

NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153

G

transforming growth factor beta 1

affects expression
multiple interactions

fluvastatin affects the expression of TGFB1 protein
Fluvastatin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]

PMID:16696316 PMID:35465754

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

TNF receptor superfamily member 10a

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of TNFRSF10A mRNA

NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102

G

tumor protein p53 inducible nuclear protein 1

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of TP53INP1 mRNA

NCBI chr 8:94,925,972...94,949,378
Ensembl chr 8:94,925,972...94,949,378

G

vimentin

multiple interactions

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of VIM mRNA]

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

Wnt family member 11

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of WNT11 mRNA

NCBI chr11:76,186,325...76,210,761
Ensembl chr11:76,186,325...76,210,736

ilomastat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 13

multiple interactions

ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein]

NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110

G

matrix metallopeptidase 1

multiple interactions

ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein]; ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA]

NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160

G

TIMP metallopeptidase inhibitor 1

multiple interactions

ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]; ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 protein]

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

lovastatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression
decreases expression
multiple interactions

Lovastatin results in increased expression of ABCA1 mRNA
lovastatin decreases expression of ABCA1 mRNA in HepG2 cells
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCA1 mRNA
Lovastatin results in decreased expression of ABCA1 mRNA

CTD
RGD

PMID:19260826 PMID:29852127 PMID:27765770

NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155

G

ATP binding cassette subfamily B member 1

increases transport
decreases activity
multiple interactions

ABCB1 protein results in increased transport of Lovastatin; ABCB1 protein results in increased transport of Lovastatin analog
Lovastatin analog results in decreased activity of ABCB1 protein
Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Lovastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Lovastatin results in decreased activity of ABCB11 protein

PMID:23956101 PMID:24014644

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

decreases activity
multiple interactions

Lovastatin results in decreased activity of ABCC1 protein
[Lovastatin results in decreased activity of ABCC1 protein] which results in increased susceptibility to Antimony Sodium Gluconate; Doxorubicin inhibits the reaction [Lovastatin results in increased expression of ABCC1 mRNA]

PMID:18056276 PMID:22712078

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression
decreases activity

ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Lovastatin results in increased expression of ABCC2 mRNA
Lovastatin analog results in decreased activity of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin promotes the reaction [Cisplatin results in decreased expression of ABCC2 mRNA]

PMID:15616150 PMID:23562342 PMID:26739623

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily G member 5

affects expression
multiple interactions

Lovastatin affects the expression of ABCG5 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCG5 mRNA

PMID:27208389 PMID:29852127

NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865

G

ATP binding cassette subfamily G member 8

affects expression

Lovastatin affects the expression of ABCG8 mRNA

NCBI chr 2:43,838,971...43,882,988
Ensembl chr 2:43,831,942...43,882,988

G

acetyl-CoA carboxylase alpha

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of ACACA mRNA

NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836

G

acyl-CoA oxidase 1

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of ACOX1 mRNA

NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177

G

acyl-CoA synthetase short chain family member 2

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of ACSS2 mRNA

NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962

G

actin alpha 2, smooth muscle

multiple interactions
decreases expression

Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Lovastatin results in decreased expression of ACTA2 protein

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

actin beta

decreases expression
increases expression

Lovastatin results in decreased expression of ACTB mRNA
Lovastatin results in increased expression of ACTB mRNA

NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902

G

actin related protein 3

increases expression

Lovastatin results in increased expression of ACTR3 mRNA

NCBI chr 2:113,889,934...113,962,596
Ensembl chr 2:113,890,063...113,962,596

G

ADAM metallopeptidase domain 10

increases expression
multiple interactions

Lovastatin results in increased expression of ADAM10 protein
[Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein

NCBI chr15:58,588,809...58,749,707
Ensembl chr15:58,588,809...58,749,791

G

adiponectin, C1Q and collagen domain containing

affects expression
multiple interactions

Lovastatin affects the expression of ADIPOQ mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ADIPOQ mRNA

PMID:27208389 PMID:29852127

NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463

G

adenosylhomocysteinase

decreases expression

Lovastatin results in decreased expression of AHCY mRNA

NCBI chr20:34,231,981...34,311,836
Ensembl chr20:34,280,268...34,311,802

G

A-kinase anchoring protein 7

decreases response to substance

AKAP7 SNP results in decreased susceptibility to Lovastatin

NCBI chr 6:131,125,627...131,283,532
Ensembl chr 6:131,135,467...131,283,535

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein]
Lovastatin results in decreased phosphorylation of AKT1 protein

PMID:16425225 PMID:17472962 PMID:19760159 PMID:20578043 PMID:35734936

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

arachidonate 15-lipoxygenase

multiple interactions

Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased activity of ALOX15 protein]

NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294

G

ankyrin 2

decreases response to substance

ANK2 SNP results in decreased susceptibility to Lovastatin

NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221

G

annexin A4

decreases expression

Lovastatin results in decreased expression of ANXA4 mRNA

NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112

G

annexin A5

decreases expression

Lovastatin results in decreased expression of ANXA5 mRNA

NCBI chr 4:121,667,946...121,696,980
Ensembl chr 4:121,667,946...121,696,995

G

apolipoprotein A1

multiple interactions

[Lovastatin co-treated with Niacin] results in increased expression of APOA1 protein; [Niacin co-treated with Lovastatin] results in increased expression of APOA1 protein

PMID:12633795 PMID:17319473

NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622

G

apolipoprotein B

multiple interactions
decreases secretion

[Niacin co-treated with Lovastatin] results in decreased expression of APOB protein
Lovastatin results in decreased secretion of APOB protein

PMID:11728391 PMID:12633795

NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073

G

apolipoprotein E

affects expression
multiple interactions

Lovastatin affects the expression of APOE mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of APOE mRNA

PMID:27208389 PMID:29852127

NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393

G

amyloid beta precursor protein

multiple interactions
increases cleavage
increases secretion

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; TAPI-2 inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; U 0126 inhibits the reaction [Lovastatin results in increased secretion of APP protein]
Lovastatin results in increased cleavage of APP protein
[APP protein co-treated with Lovastatin] results in increased secretion of APP protein; [Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein; [Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein; [Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein; [Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[APP protein co-treated with Lovastatin] results in increased secretion of APP protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased secretion of APP protein; Lovastatin results in increased secretion of APP protein modified form

PMID:19741129 PMID:29341888

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

Rho GDP dissociation inhibitor alpha

increases expression

Lovastatin results in increased expression of ARHGDIA mRNA

NCBI chr17:81,867,721...81,871,337
Ensembl chr17:81,867,721...81,871,378

G

ATM serine/threonine kinase

multiple interactions

Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATM protein modified form]

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102

G

ATR serine/threonine kinase

multiple interactions

Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATR protein modified form]

NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733

G

beta-secretase 1

decreases expression
multiple interactions

Lovastatin results in decreased expression of BACE1 protein
[Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein

NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,232...117,316,259

G

beta-secretase 2

multiple interactions
increases expression

[Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein
Lovastatin results in increased expression of BACE2 protein

NCBI chr21:41,168,160...41,282,530
Ensembl chr21:41,167,801...41,282,530

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
affects localization

Lovastatin results in increased expression of BAX protein
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of BAX protein]; Lovastatin promotes the reaction [Cisplatin results in increased expression of BAX mRNA]
Lovastatin affects the localization of BAX protein

PMID:10473109 PMID:15180944 PMID:26739623 PMID:35734936

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCAR1 scaffold protein, Cas family member

increases cleavage
multiple interactions

Lovastatin results in increased cleavage of BCAR1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein]

NCBI chr16:75,228,181...75,268,007
Ensembl chr16:75,228,181...75,268,053

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

Lovastatin results in decreased expression of BCL2 protein
Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of BCL2 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2 protein]

PMID:10473109 PMID:11178870 PMID:12094262 PMID:35734936

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

decreases expression
multiple interactions

Lovastatin results in decreased expression of BCL2L1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2L1 protein]

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BCL2 like 11

multiple interactions
increases expression

pyrazolanthrone inhibits the reaction [Lovastatin results in increased expression of BCL2L11 protein]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of BCL2L11 protein]

PMID:18766339 PMID:35734936

NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444

G

brain derived neurotrophic factor

multiple interactions

Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein]

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

baculoviral IAP repeat containing 5

multiple interactions
decreases expression

farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein]

PMID:17472962 PMID:18815881

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

BRCA2 DNA repair associated

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of BRCA2 mRNA]

NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268

G

complement C1q binding protein

increases expression

Lovastatin results in increased expression of C1QBP mRNA

NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830

G

calreticulin

increases expression

Lovastatin results in increased expression of CALR mRNA

NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489

G

calcium/calmodulin dependent protein kinase II beta

multiple interactions

Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein]

NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577

G

caspase 2

increases activity
multiple interactions

Lovastatin results in increased activity of CASP2 protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]

PMID:12933658 PMID:16234849

NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696

G

caspase 3

multiple interactions
increases cleavage
increases activity
decreases expression

farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
Lovastatin analog results in increased cleavage of CASP3 protein
Lovastatin results in increased activity of CASP3 protein
Lovastatin results in decreased expression of CASP3 mRNA
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 protein]; Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]

PMID:11720884 PMID:12933658 PMID:15180944 PMID:16367743 PMID:18034278 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 6

increases activity

Lovastatin results in increased activity of CASP6 protein

NCBI chr 4:109,664,388...109,709,767
Ensembl chr 4:109,688,622...109,703,583

G

caspase 8

increases activity

Lovastatin results in increased activity of CASP8 protein

PMID:15180944 PMID:15705602

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

increases activity
multiple interactions

Lovastatin results in increased activity of CASP9 protein
Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of CASP9 protein]

PMID:12933658 PMID:15180944 PMID:15705602 PMID:35734936

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions

Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cellular communication network factor 2

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]; Lovastatin inhibits the reaction [Epirubicin results in increased expression of CCN2 mRNA]

PMID:22712078 PMID:28710503

NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372

G

cyclin D1

decreases expression
increases expression

Lovastatin results in decreased expression of CCND1 protein
Lovastatin results in increased expression of CCND1 mRNA; Lovastatin results in increased expression of CCND1 protein

PMID:18034278 PMID:20578043

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin D3

decreases expression

Lovastatin results in decreased expression of CCND3 protein

NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357

G

chaperonin containing TCP1 subunit 5

increases expression

Lovastatin results in increased expression of CCT5 mRNA

NCBI chr 5:10,249,921...10,266,412
Ensembl chr 5:10,249,929...10,266,389

G

chaperonin containing TCP1 subunit 6A

increases expression

Lovastatin results in increased expression of CCT6A mRNA

NCBI chr 7:56,051,765...56,063,989
Ensembl chr 7:56,051,685...56,063,989

G

chaperonin containing TCP1 subunit 8

decreases expression

Lovastatin results in decreased expression of CCT8 mRNA

NCBI chr21:29,056,326...29,073,648
Ensembl chr21:29,055,805...29,073,797

G

CD40 molecule

multiple interactions

Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

G

CD44 molecule (IN blood group)

decreases expression

Lovastatin results in decreased expression of CD44 mRNA; Lovastatin results in decreased expression of CD44 protein

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

G

cell division cycle 42

increases expression
decreases expression

Lovastatin results in increased expression of CDC42 protein
Lovastatin results in decreased expression of CDC42 mRNA

PMID:18766339 PMID:20493250

NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,052,627...22,101,360

G

cyclin dependent kinase 2

decreases activity

Lovastatin results in decreased activity of CDK2 protein

NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789

G

cyclin dependent kinase 4

decreases expression

Lovastatin results in decreased expression of CDK4 mRNA; Lovastatin results in decreased expression of CDK4 protein

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

cyclin dependent kinase 5

decreases cleavage

Lovastatin results in decreased cleavage of CDK5 protein

NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897

G

cyclin dependent kinase inhibitor 1A

increases expression
multiple interactions

Lovastatin results in increased expression of CDKN1A protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]

PMID:18034278 PMID:22712078

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

cyclin dependent kinase inhibitor 1B

increases expression

Lovastatin results in increased expression of CDKN1B mRNA; Lovastatin results in increased expression of CDKN1B protein

PMID:9848777 PMID:10502407 PMID:15118409 PMID:18034278 PMID:20578043

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

cyclin dependent kinase inhibitor 3

multiple interactions

Lovastatin inhibits the reaction [Cisplatin results in increased expression of CDKN3 protein modified form]

NCBI chr14:54,397,007...54,420,218
Ensembl chr14:54,396,849...54,420,218

G

centromere protein F

increases expression
multiple interactions

Lovastatin results in increased expression of CENPF protein
Lovastatin promotes the reaction [Paclitaxel results in increased expression of CENPF protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of CENPF protein]

NCBI chr 1:214,603,195...214,664,571
Ensembl chr 1:214,603,185...214,664,574

G

cofilin 1

decreases phosphorylation

Lovastatin results in decreased phosphorylation of CFL1 protein

NCBI chr11:65,854,673...65,858,180
Ensembl chr11:65,823,022...65,862,026

G

checkpoint kinase 1

multiple interactions

Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form]

PMID:17088865 PMID:21356574 PMID:26739623

NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255

G

checkpoint kinase 2

multiple interactions

Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK2 protein modified form]

NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions
increases expression

[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]
U 0126 inhibits the reaction [Lovastatin results in increased expression of CHRNA7 protein]
Lovastatin results in increased expression of CHRNA7 mRNA; Lovastatin results in increased expression of CHRNA7 protein

NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018

G

chloride intracellular channel 1

decreases expression

Lovastatin results in decreased expression of CLIC1 mRNA

NCBI chr 6:31,730,581...31,737,318
Ensembl chr 6:31,730,581...31,739,763

G

cytochrome c oxidase subunit 5A

increases expression

Lovastatin results in increased expression of COX5A mRNA

NCBI chr15:74,919,791...74,938,073
Ensembl chr15:74,919,791...74,938,083

G

ceruloplasmin

multiple interactions

Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of CP protein]

NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829

G

cAMP responsive element binding protein 1

multiple interactions

Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

CRK proto-oncogene, adaptor protein

increases expression

Lovastatin results in increased expression of CRK mRNA

NCBI chr17:1,420,693...1,456,232
Ensembl chr17:1,420,689...1,463,162

G

C-reactive protein

multiple interactions

Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of CRP protein]

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

G

catenin beta 1

decreases degradation
increases expression
multiple interactions

Lovastatin results in decreased degradation of CTNNB1 protein
Lovastatin results in increased expression of CTNNB1 mRNA
Lovastatin affects the localization of and results in increased expression of CTNNB1 protein

PMID:17234346 PMID:19741129 PMID:24742230

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions
increases expression

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CYP1A1 mRNA]; Lovastatin results in increased expression of and results in increased activity of CYP1A1 protein
Lovastatin results in increased expression of CYP1A1 mRNA

PMID:1311272 PMID:22712078

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily B member 1

decreases activity

Lovastatin results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily C member 8

decreases activity

Lovastatin results in decreased activity of CYP2C8 protein

NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions
increases expression

[Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Lovastatin results in increased expression of CYP3A4 mRNA

PMID:12505310 PMID:17041008

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

dynactin subunit 2

decreases expression

Lovastatin results in decreased expression of DCTN2 mRNA

NCBI chr12:57,530,051...57,547,192
Ensembl chr12:57,529,633...57,547,224

G

D-dopachrome tautomerase

decreases expression

Lovastatin results in decreased expression of DDT mRNA

NCBI chr22:23,971,370...23,980,504
Ensembl chr22:23,970,542...23,980,525

G

discs large MAGUK scaffold protein 3

multiple interactions

Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein]

NCBI chr X:70,444,835...70,505,490
Ensembl chr X:70,444,835...70,505,490

G

dihydrolipoamide S-succinyltransferase

decreases expression

Lovastatin results in decreased expression of DLST mRNA

NCBI chr14:74,881,916...74,903,743
Ensembl chr14:74,881,891...74,903,743

G

dedicator of cytokinesis 7

increases expression

Lovastatin results in increased expression of DOCK7 mRNA

NCBI chr 1:62,454,726...62,688,386
Ensembl chr 1:62,454,298...62,688,386

G

dihydropyrimidinase like 2

increases expression

Lovastatin results in increased expression of DPYSL2 mRNA

NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178

G

destrin, actin depolymerizing factor

decreases expression

Lovastatin results in decreased expression of DSTN mRNA

NCBI chr20:17,570,075...17,609,919
Ensembl chr20:17,570,075...17,609,919

G

ELL associated factor 2

decreases response to substance

EAF2 SNP results in decreased susceptibility to Lovastatin

NCBI chr 3:121,835,209...121,886,526
Ensembl chr 3:121,835,183...121,886,526

G

eukaryotic translation elongation factor 2

decreases expression

Lovastatin results in decreased expression of EEF2 mRNA

NCBI chr19:3,976,056...3,985,463
Ensembl chr19:3,976,056...3,985,463

G

epidermal growth factor

multiple interactions

Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein]

PMID:12942316 PMID:19760159

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

epidermal growth factor receptor

multiple interactions

Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

PMID:12942316 PMID:19760159

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

eukaryotic translation initiation factor 3 subunit I

decreases expression

Lovastatin results in decreased expression of EIF3I mRNA

NCBI chr 1:32,222,407...32,236,170
Ensembl chr 1:32,221,077...32,245,397

G

ERCC excision repair 1, endonuclease non-catalytic subunit

increases expression
multiple interactions

Lovastatin results in increased expression of ERCC1 mRNA
Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC1 mRNA]

NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828

G

ERCC excision repair 5, endonuclease

multiple interactions
increases expression

Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC5 mRNA]
Lovastatin results in increased expression of ERCC5 mRNA

NCBI chr13:102,846,032...102,875,995
Ensembl chr13:102,845,831...102,875,995

G

ERCC excision repair 6, chromatin remodeling factor

increases expression

Lovastatin results in increased expression of ERCC6 mRNA

NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538

G

endoplasmic reticulum protein 29

decreases expression

Lovastatin results in decreased expression of ERP29 mRNA

NCBI chr12:112,013,426...112,023,449
Ensembl chr12:112,013,348...112,023,449

G

fatty acid desaturase 2

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of FADS2 mRNA

NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354

G

Fas cell surface death receptor

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of FAS protein]

PMID:17088865 PMID:35734936

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FASLG mRNA]

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

fatty acid synthase

increases expression

Lovastatin results in increased expression of FASN mRNA

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

F-box protein 32

multiple interactions
increases expression

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]; Lovastatin promotes the reaction [Fenofibrate results in increased expression of FBXO32 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]
Lovastatin results in increased expression of FBXO32 mRNA; Lovastatin results in increased expression of FBXO32 protein

PMID:19406843 PMID:33408297

NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206

G

farnesyl-diphosphate farnesyltransferase 1

increases activity

Lovastatin results in increased activity of FDFT1 protein

NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,395

G

farnesyl diphosphate synthase

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of FDPS mRNA

NCBI chr 1:155,308,866...155,320,665
Ensembl chr 1:155,308,748...155,320,666

G

flotillin 1

decreases expression

Lovastatin results in decreased expression of FLOT1 protein

NCBI chr 6:30,727,709...30,742,687
Ensembl chr 6:30,727,709...30,742,732

G

Fos proto-oncogene, AP-1 transcription factor subunit

affects expression
multiple interactions
decreases expression

Lovastatin affects the expression of FOS protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FOS mRNA]
Lovastatin results in decreased expression of FOS

PMID:10412747 PMID:12392621 PMID:22712078

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased expression of FOSB protein]

NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179

G

forkhead box O1

multiple interactions
decreases phosphorylation

Lovastatin promotes the reaction [Fenofibrate results in increased expression of FOXO1 protein]
Lovastatin results in decreased phosphorylation of FOXO1 protein

PMID:33034787 PMID:33408297

NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641

G

fascin actin-bundling protein 1

decreases expression

Lovastatin results in decreased expression of FSCN1 mRNA

NCBI chr 7:5,592,816...5,606,655
Ensembl chr 7:5,592,816...5,606,655

G

G3BP stress granule assembly factor 1

increases expression

Lovastatin results in increased expression of G3BP1 mRNA

NCBI chr 5:151,771,954...151,812,785
Ensembl chr 5:151,771,045...151,812,911

G

glucose-6-phosphate dehydrogenase

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of G6PD mRNA

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

UDP-galactose-4-epimerase

decreases expression

Lovastatin results in decreased expression of GALE mRNA

NCBI chr 1:23,795,599...23,800,754
Ensembl chr 1:23,795,599...23,800,781

G

growth associated protein 43

increases expression

Lovastatin results in increased expression of GAP43 protein

NCBI chr 3:115,623,510...115,721,483
Ensembl chr 3:115,623,510...115,721,490

G

GDP dissociation inhibitor 2

increases expression

Lovastatin results in increased expression of GDI2 mRNA

NCBI chr10:5,765,223...5,813,434
Ensembl chr10:5,765,223...5,842,132

G

glycerol kinase

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of GK mRNA

NCBI chr X:30,653,423...30,731,462
Ensembl chr X:30,653,359...30,731,462

G

guanine monophosphate synthase

increases expression

Lovastatin results in increased expression of GMPS mRNA

NCBI chr 3:155,869,430...155,944,020
Ensembl chr 3:155,870,650...155,944,020

G

glutamic--pyruvic transaminase

multiple interactions

[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein; Lovastatin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]

PMID:29852127 PMID:30853469

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

glutathione peroxidase 1

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA]

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]

NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002

G

glycogen synthase kinase 3 beta

decreases phosphorylation
increases phosphorylation

Lovastatin results in decreased phosphorylation of GSK3B protein
Lovastatin results in increased phosphorylation of GSK3B protein

PMID:17234346 PMID:19741129

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

H2A.X variant histone

multiple interactions

Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]

PMID:21356574 PMID:22712078 PMID:26739623 PMID:28710503

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

histone deacetylase 1

increases expression

Lovastatin results in increased expression of HDAC1 mRNA

NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635

G

histidine triad nucleotide binding protein 1

increases expression

Lovastatin results in increased expression of HINT1 mRNA

NCBI chr 5:131,159,027...131,165,256
Ensembl chr 5:131,155,383...131,224,468

G

major histocompatibility complex, class II, DR beta 3

affects expression

Lovastatin affects the expression of HLA-DRB3 mRNA

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
affects expression
decreases activity
increases expression

[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate; [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate]
[Dietary Fats co-treated with Lovastatin] affects the expression of HMGCR mRNA
Lovastatin affects the expression of HMGCR mRNA
Lovastatin results in increased expression of HMGCR mRNA

PMID:8517861 PMID:8593127 PMID:17208200 PMID:19260826 PMID:19699819 More...

NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of HMGCS1 mRNA

NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512

G

heme oxygenase 1

increases expression
multiple interactions

Lovastatin results in increased expression of HMOX1 protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]

PMID:20594940 PMID:21910007 PMID:28710503

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

heterogeneous nuclear ribonucleoprotein A/B

increases expression

Lovastatin results in increased expression of HNRNPAB mRNA

NCBI chr 5:178,204,533...178,211,163
Ensembl chr 5:178,204,533...178,211,163

G

heterogeneous nuclear ribonucleoprotein D like

decreases expression

Lovastatin results in decreased expression of HNRNPDL mRNA

NCBI chr 4:82,422,564...82,430,462
Ensembl chr 4:82,422,565...82,430,462

G

heterogeneous nuclear ribonucleoprotein F

increases expression

Lovastatin results in increased expression of HNRNPF mRNA

NCBI chr10:43,385,618...43,409,186
Ensembl chr10:43,385,617...43,409,186

G

heterogeneous nuclear ribonucleoprotein K

decreases expression
increases expression

Lovastatin results in decreased expression of HNRNPK mRNA
Lovastatin results in increased expression of HNRNPK mRNA

NCBI chr 9:83,968,083...83,980,615
Ensembl chr 9:83,968,083...83,980,631

G

HRas proto-oncogene, GTPase

decreases prenylation
multiple interactions

Lovastatin results in decreased prenylation of HRAS protein
Lovastatin results in decreased prenylation of and results in decreased localization of HRAS protein

PMID:16156861 PMID:19360310

NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321

G

heat shock protein 90 alpha family class B member 1

decreases expression

Lovastatin results in decreased expression of HSP90AB1 mRNA

NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888

G

heat shock protein family A (Hsp70) member 8

increases expression

Lovastatin results in increased expression of HSPA8 mRNA

NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230

G

heat shock protein family D (Hsp60) member 1

increases expression

Lovastatin results in increased expression of HSPD1 mRNA

NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737

G

interferon gamma

multiple interactions

Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

insulin like growth factor 1

decreases response to substance

IGF1 protein results in decreased susceptibility to Lovastatin

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

insulin like growth factor 1 receptor

multiple interactions

Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein]

NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530

G

interleukin 18

multiple interactions

[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 beta

multiple interactions

[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]

PMID:18809656 PMID:21430599

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 protein]

PMID:28710503 PMID:35734936

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

insulin

multiple interactions

Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein]; Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein]

NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221

G

insulin induced gene 1

increases expression
multiple interactions

Lovastatin results in increased expression of INSIG1 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of INSIG1 mRNA

PMID:19260826 PMID:29852127

NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235

G

insulin induced gene 2

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of INSIG2 mRNA

NCBI chr 2:118,088,471...118,110,997
Ensembl chr 2:118,088,452...118,110,997

G

insulin receptor

multiple interactions

Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein]

NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414

G

importin 5

decreases expression

Lovastatin results in decreased expression of IPO5 mRNA

NCBI chr13:97,953,675...98,024,296
Ensembl chr13:97,953,658...98,024,296

G

interferon regulatory factor 4

decreases expression

Lovastatin results in decreased expression of IRF4 protein

NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443

G

insulin receptor substrate 1

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of IRS1 mRNA

NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820

G

insulin receptor substrate 2

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of IRS2 mRNA

NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583

G

inositol-3-phosphate synthase 1

increases expression

Lovastatin results in increased expression of ISYNA1 mRNA

NCBI chr19:18,434,388...18,438,133
Ensembl chr19:18,434,388...18,438,167

G

integrin subunit beta 1

decreases expression

Lovastatin results in decreased expression of ITGB1 protein

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression
multiple interactions
decreases expression

Lovastatin affects the expression of JUN protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of JUN mRNA]
Lovastatin results in decreased expression of JUN

PMID:10412747 PMID:12392621 PMID:22712078

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

potassium voltage-gated channel subfamily H member 2

affects activity

Lovastatin affects the activity of KCNH2 protein

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

KRAS proto-oncogene, GTPase

decreases prenylation
increases expression
affects localization
increases activity

Lovastatin results in decreased prenylation of KRAS protein
Lovastatin results in increased expression of KRAS protein
Lovastatin affects the localization of KRAS protein
Lovastatin results in increased activity of KRAS protein

PMID:12106604 PMID:12907238 PMID:16156861 PMID:17005160

NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936

G

keratin 18

decreases expression

Lovastatin results in decreased expression of KRT18 mRNA

NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906

G

LIM and SH3 protein 1

decreases expression

Lovastatin results in decreased expression of LASP1 mRNA

NCBI chr17:38,870,058...38,921,770
Ensembl chr17:38,869,859...38,921,770

G

lipocalin 2

multiple interactions

[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA

NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453

G

low density lipoprotein receptor

multiple interactions
increases activity
increases expression

OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of LDLR mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA]
Lovastatin results in increased activity of LDLR protein

PMID:8593127 PMID:11728391 PMID:12524230 PMID:20578043 PMID:29852127

NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820

G

lymphoid enhancer binding factor 1

affects localization

Lovastatin affects the localization of LEF1 protein

NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956

G

lipase C, hepatic type

affects expression

Lovastatin affects the expression of LIPC mRNA

NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844

G

lamin B1

decreases farnesylation
increases degradation
affects localization

Lovastatin results in decreased farnesylation of LMNB1 protein
Lovastatin results in increased degradation of LMNB1 protein
Lovastatin affects the localization of LMNB1 protein

PMID:10203554 PMID:11720884

NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020

G

lipoprotein(a)

multiple interactions

[Lovastatin co-treated with Niacin] results in decreased expression of LPA protein; [Niacin co-treated with Lovastatin] results in decreased expression of LPA protein

PMID:12633795 PMID:17319473

NCBI chr 6:160,531,482...160,664,275
Ensembl chr 6:160,531,482...160,664,275

G

lipin 2

decreases response to substance

LPIN2 SNP results in decreased susceptibility to Lovastatin

NCBI chr18:2,916,994...3,013,144
Ensembl chr18:2,885,296...3,013,144

G

lipoprotein lipase

affects expression
multiple interactions

Lovastatin affects the expression of LPL mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of LPL mRNA

PMID:27208389 PMID:29852127

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

LDL receptor related protein 5

increases expression

Lovastatin results in increased expression of LRP5 mRNA

NCBI chr11:68,298,412...68,449,275
Ensembl chr11:68,312,591...68,449,275

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation
decreases activity
decreases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK1 protein]
Lovastatin results in decreased activity of MAPK1 protein
[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]

PMID:12213976 PMID:16952276 PMID:19360310 PMID:19760159 PMID:20578043 More...

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation
decreases activity
decreases phosphorylation

[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased phosphorylation of MAPK3 protein
Lovastatin results in decreased activity of MAPK3 protein
Lovastatin results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK3 protein]

PMID:16952276 PMID:18434508 PMID:19360310 PMID:19760159 PMID:20578043 More...

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK8 protein modified form]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

multiple interactions

Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK9 protein modified form]

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

myelin basic protein

multiple interactions
increases expression

2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]

NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683

G

mitofusin 2

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA]

NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211

G

microRNA 133b

multiple interactions

[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA

NCBI chr 6:52,148,923...52,149,041
Ensembl chr 6:52,148,923...52,149,041

G

microRNA 206

multiple interactions

[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA

NCBI chr 6:52,144,349...52,144,434
Ensembl chr 6:52,144,349...52,144,434

G

matrix metallopeptidase 2

decreases expression

Lovastatin results in decreased expression of MMP2 protein

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 3

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]

NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609

G

matrix metallopeptidase 9

decreases expression

Lovastatin results in decreased expression of MMP9 protein

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

myeloperoxidase

multiple interactions

Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of MPO protein]

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

myostatin

increases expression

Lovastatin results in increased expression of MSTN protein

NCBI chr 2:190,055,700...190,062,729
Ensembl chr 2:190,055,700...190,062,729

G

NFE2 like bZIP transcription factor 2

multiple interactions

Doxorubicin inhibits the reaction [Lovastatin results in increased expression of NFE2L2 mRNA]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA]

PMID:22712078 PMID:28710503

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NmrA like redox sensor 1

increases expression

Lovastatin results in increased expression of NMRAL1 mRNA

NCBI chr16:4,461,694...4,476,337
Ensembl chr16:4,461,691...4,495,763

G

nitric oxide synthase 2

multiple interactions

Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein]

PMID:18809656 PMID:35734936

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

natriuretic peptide A

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA]

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

NAD(P)H quinone dehydrogenase 1

increases expression

Lovastatin results in increased expression of NQO1 mRNA

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 1 group I member 2

multiple interactions

[Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487

G

NRAS proto-oncogene, GTPase

decreases prenylation

Lovastatin results in decreased prenylation of NRAS protein

NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771

G

nucleobindin 1

increases expression

Lovastatin results in increased expression of NUCB1 mRNA

NCBI chr19:48,900,312...48,923,372
Ensembl chr19:48,900,050...48,923,473

G

ornithine aminotransferase

decreases expression

Lovastatin results in decreased expression of OAT mRNA

NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976

G

oncostatin M

multiple interactions

OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA]

NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851

G

proliferation-associated 2G4

increases expression

Lovastatin results in increased expression of PA2G4 mRNA

NCBI chr12:56,104,559...56,113,910
Ensembl chr12:56,104,537...56,113,910

G

poly(ADP-ribose) polymerase 1

increases cleavage

Lovastatin analog results in increased cleavage of PARP1 protein

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

parvin beta

decreases response to substance

PARVB SNP results in decreased susceptibility to Lovastatin

NCBI chr22:43,999,211...44,172,939
Ensembl chr22:43,999,211...44,172,939

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of PCK1 mRNA

NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121

G

platelet derived growth factor receptor alpha

decreases expression

Lovastatin results in decreased expression of PDGFRA mRNA

NCBI chr 4:54,229,293...54,298,245
Ensembl chr 4:54,229,280...54,298,245

G

protein disulfide isomerase family A member 3

decreases expression
increases expression

Lovastatin results in decreased expression of PDIA3 mRNA
Lovastatin results in increased expression of PDIA3 mRNA

NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,394...43,773,279

G

protein disulfide isomerase family A member 4

decreases expression

Lovastatin results in decreased expression of PDIA4 mRNA

NCBI chr 7:149,003,051...149,028,505
Ensembl chr 7:149,003,062...149,028,662

G

phosphoglycerate mutase 1

increases expression
decreases expression

Lovastatin results in increased expression of PGAM1 mRNA
Lovastatin results in decreased expression of PGAM1 mRNA

NCBI chr10:97,426,191...97,433,444
Ensembl chr10:97,426,191...97,433,444

G

pyruvate kinase M1/2

decreases expression

Lovastatin results in decreased expression of PKM mRNA

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

phospholipase A2 group IVA

increases expression

Lovastatin results in increased expression of PLA2G4A mRNA

NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981

G

plasminogen activator, tissue type

multiple interactions
increases secretion
increases expression

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein]
Lovastatin results in increased secretion of PLAT protein

PMID:10412747 PMID:12405293

NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709

G

plasminogen activator, urokinase

decreases secretion

Lovastatin results in decreased secretion of PLAU protein

NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496

G

paraoxonase 3

increases hydrolysis
increases metabolic processing
multiple interactions

PON3 protein results in increased hydrolysis of Lovastatin
PON3 protein results in increased metabolism of Lovastatin
7-ketocholesterol inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]; Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]

PMID:12615656 PMID:15772423

NCBI chr 7:95,359,872...95,396,375
Ensembl chr 7:95,359,872...95,396,375

G

peroxisome proliferator activated receptor gamma

multiple interactions
affects localization
increases expression

2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; Lovastatin results in increased expression of and affects the localization of PPARG protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of PPARG mRNA; PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]

PMID:16425225 PMID:20578043 PMID:26863638 PMID:29852127

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

PPARG coactivator 1 alpha

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA]

NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089

G

protein phosphatase 1 catalytic subunit alpha

decreases expression

Lovastatin results in decreased expression of PPP1CA mRNA

NCBI chr11:67,398,183...67,401,858
Ensembl chr11:67,398,181...67,421,183

G

protein phosphatase 2 scaffold subunit Aalpha

increases expression

Lovastatin results in increased expression of PPP2R1A mRNA

NCBI chr19:52,190,052...52,229,518
Ensembl chr19:52,170,936...52,229,518

G

protein kinase C delta

multiple interactions
increases cleavage

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein]

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

G

proteasome 20S subunit alpha 3

decreases expression

Lovastatin results in decreased expression of PSMA3 mRNA

NCBI chr14:58,244,843...58,272,004
Ensembl chr14:58,244,843...58,272,012

G

proteasome 20S subunit alpha 6

decreases expression

Lovastatin results in decreased expression of PSMA6 mRNA

NCBI chr14:35,278,558...35,317,493
Ensembl chr14:35,278,633...35,317,493

G

proteasome 26S subunit, ATPase 2

decreases expression

Lovastatin results in decreased expression of PSMC2 mRNA

NCBI chr 7:103,347,524...103,369,395
Ensembl chr 7:103,328,570...103,370,346

G

phosphatase and tensin homolog

multiple interactions
increases expression

Cycloheximide inhibits the reaction [Lovastatin results in increased expression of PTEN protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; Lovastatin results in increased expression of and results in increased phosphorylation of PTEN protein; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]

PMID:16425225 PMID:20578043

NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions
increases expression

Lovastatin results in decreased expression of PTGS2 protein
Mevalonic Acid affects the reaction [Lovastatin analog results in increased expression of PTGS2 protein]
Lovastatin analog results in increased expression of PTGS2 mRNA; Lovastatin analog results in increased expression of PTGS2 protein
Lovastatin results in increased expression of PTGS2 mRNA; Lovastatin results in increased expression of PTGS2 protein

PMID:20578043 PMID:21910007 PMID:26863638

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RAB1A, member RAS oncogene family

decreases expression

Lovastatin results in decreased expression of RAB1A mRNA

NCBI chr 2:65,086,854...65,130,106
Ensembl chr 2:65,070,696...65,130,331

G

Rac family small GTPase 1

multiple interactions
affects localization
decreases activity
increases expression

geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RAC1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
Lovastatin results in decreased activity of RAC1 protein
Lovastatin results in increased expression of RAC1 protein

PMID:12933658 PMID:18766339 PMID:19360310 PMID:21356574

NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions
decreases activity

Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein]
Lovastatin results in decreased activity of RAF1 protein

PMID:19360310 PMID:19760159

NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201

G

RAP1A, member of RAS oncogene family

increases expression

Lovastatin results in increased expression of RAP1A protein

NCBI chr 1:111,542,009...111,716,691
Ensembl chr 1:111,542,218...111,716,691

G

RB transcriptional corepressor 1

decreases phosphorylation

Lovastatin results in decreased phosphorylation of RB1 protein

PMID:9848777 PMID:10502407 PMID:15118409

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

ras homolog family member A

multiple interactions
decreases expression
decreases prenylation
affects localization

geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]
Lovastatin results in decreased geranoylation of and affects the localization of RHOA protein
Lovastatin results in decreased expression of RHOA mRNA
Lovastatin results in decreased prenylation of RHOA protein
Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]

PMID:9398081 PMID:11178870 PMID:12405293 PMID:12933658 PMID:16156861 More...

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

ras homolog family member B

decreases prenylation
multiple interactions
increases expression

Lovastatin results in decreased prenylation of RHOB protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]
Lovastatin results in increased expression of RHOB protein

PMID:12467231 PMID:16156861 PMID:16234849

NCBI chr 2:20,447,074...20,449,440
Ensembl chr 2:20,447,074...20,449,440

G

ribosomal protein L27

increases expression

Lovastatin results in increased expression of RPL27 mRNA

NCBI chr17:42,998,273...43,002,959
Ensembl chr17:42,998,273...43,002,959

G

ribosomal protein L9

increases expression

Lovastatin results in increased expression of RPL9 mRNA

NCBI chr 4:39,454,124...39,458,922
Ensembl chr 4:39,452,587...39,458,931

G

ribosomal protein lateral stalk subunit P0

increases expression

Lovastatin results in increased expression of RPLP0 mRNA

NCBI chr12:120,196,699...120,201,111
Ensembl chr12:120,196,699...120,201,235

G

ribosomal protein SA

increases expression

Lovastatin results in increased expression of RPSA mRNA

NCBI chr 3:39,406,720...39,412,542
Ensembl chr 3:39,406,716...39,426,255

G

RuvB like AAA ATPase 2

decreases expression

Lovastatin results in decreased expression of RUVBL2 mRNA

NCBI chr19:48,993,448...49,015,995
Ensembl chr19:48,993,562...49,015,970

G

S100 calcium binding protein A8

multiple interactions

[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA

NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073

G

S100 calcium binding protein A9

multiple interactions

[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA

NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023

G

SUMO1 activating enzyme subunit 1

decreases expression

Lovastatin results in decreased expression of SAE1 mRNA

NCBI chr19:47,130,835...47,210,636
Ensembl chr19:47,113,274...47,210,636

G

SREBF chaperone

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of SCAP mRNA

NCBI chr 3:47,413,681...47,477,127
Ensembl chr 3:47,413,681...47,477,126

G

scavenger receptor class B member 1

multiple interactions
affects expression

[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]
Lovastatin affects the expression of SCARB1 mRNA

PMID:20404351 PMID:27208389

NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668

G

selenophosphate synthetase 1

increases expression

Lovastatin results in increased expression of SEPHS1 mRNA

NCBI chr10:13,317,428...13,348,293
Ensembl chr10:13,317,428...13,348,298

G

solute carrier family 31 member 1

increases expression

Lovastatin results in increased expression of SLC31A1 mRNA

NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492

G

solute carrier organic anion transporter family member 1B1

multiple interactions
decreases activity

Lovastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]
Lovastatin results in decreased activity of SLCO1B1 protein

NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796

G

SRY-box transcription factor 10

multiple interactions
increases expression

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]

NCBI chr22:37,972,312...37,984,555
Ensembl chr22:37,970,686...37,987,422

G

sterol regulatory element binding transcription factor 1

multiple interactions
increases expression

[Dietary Fats co-treated with Lovastatin] affects the expression of SREBF1 mRNA
Lovastatin results in increased expression of SREBF1 mRNA

PMID:29852127 PMID:32739440

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

sterol regulatory element binding transcription factor 2

increases localization
multiple interactions

Lovastatin results in increased localization of SREBF2 protein
[Dietary Fats co-treated with Lovastatin] affects the expression of SREBF2 mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]

PMID:11728391 PMID:20578043 PMID:29852127

NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306

G

STEAP2 metalloreductase

decreases response to substance

STEAP2 SNP results in decreased susceptibility to Lovastatin

NCBI chr 7:90,211,740...90,243,408
Ensembl chr 7:90,167,590...90,238,137

G

stress induced phosphoprotein 1

decreases expression

Lovastatin results in decreased expression of STIP1 mRNA

NCBI chr11:64,185,272...64,204,543
Ensembl chr11:64,185,272...64,204,543

G

synaptic Ras GTPase activating protein 1

multiple interactions

Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein]

NCBI chr 6:33,418,167...33,453,689
Ensembl chr 6:33,419,661...33,453,689

G

t-complex 1

increases expression

Lovastatin results in increased expression of TCP1 mRNA

NCBI chr 6:159,778,498...159,789,602
Ensembl chr 6:159,778,498...159,789,703

G

thyroglobulin

increases secretion

Lovastatin results in increased secretion of TG protein

NCBI chr 8:132,866,958...133,134,899
Ensembl chr 8:132,866,958...133,134,903

G

transforming growth factor beta 1

multiple interactions

Lovastatin inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tyrosine hydroxylase

increases expression
multiple interactions

Lovastatin results in increased expression of TH protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein]

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815

G

thimet oligopeptidase 1

increases expression

Lovastatin results in increased expression of THOP1 mRNA

NCBI chr19:2,785,503...2,815,807
Ensembl chr19:2,785,503...2,815,807

G

tumor necrosis factor

multiple interactions

[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of TNF protein]

PMID:18809656 PMID:21430599 PMID:22712078 PMID:35734936

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 11b

increases expression

Lovastatin results in increased expression of TNFRSF11B mRNA

NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885

G

TNF superfamily member 10

increases response to substance

Lovastatin results in increased susceptibility to TNFSF10 protein

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

TNF superfamily member 11

decreases expression

Lovastatin results in decreased expression of TNFSF11 mRNA

NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013

G

DNA topoisomerase II alpha

multiple interactions

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA]

NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896

G

tumor protein p53

multiple interactions
increases expression

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Lovastatin results in increased expression of and results in increased phosphorylation of TP53 protein
Lovastatin inhibits the reaction [Cisplatin results in increased expression of TP53 protein modified form]
Lovastatin results in increased expression of TP53 mRNA

PMID:17088865 PMID:21199873 PMID:26739623

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

tripartite motif containing 63

multiple interactions

Lovastatin promotes the reaction [Fenofibrate results in increased expression of TRIM63 protein]

NCBI chr 1:26,051,301...26,067,630
Ensembl chr 1:26,051,301...26,068,436

G

tetratricopeptide repeat domain 7A

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of FSN mRNA

NCBI chr 2:46,915,866...47,076,123
Ensembl chr 2:46,915,869...47,076,137

G

tubulin alpha 1a

increases expression

Lovastatin results in increased expression of TUBA1A mRNA

NCBI chr12:49,184,795...49,189,080
Ensembl chr12:49,184,686...49,189,080

G

tubulin alpha 1b

decreases expression
increases expression

Lovastatin results in decreased expression of TUBA1B mRNA
Lovastatin results in increased expression of TUBA1B mRNA

NCBI chr12:49,127,782...49,131,395
Ensembl chr12:49,127,782...49,131,397

G

tubulin beta class I

decreases expression

Lovastatin results in decreased expression of TUBB5 mRNA

NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,717,435...30,725,538

G

Tu translation elongation factor, mitochondrial

decreases expression

Lovastatin results in decreased expression of TUFM mRNA

NCBI chr16:28,842,411...28,846,348
Ensembl chr16:28,842,411...28,846,348

G

U2 small nuclear RNA auxiliary factor 2

increases expression

Lovastatin results in increased expression of U2AF2 mRNA

NCBI chr19:55,655,035...55,674,716
Ensembl chr19:55,654,146...55,674,716

G

uncoupling protein 2

multiple interactions

[Dietary Fats co-treated with Lovastatin] affects the expression of UCP2 mRNA

NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843

G

ubiquitin specific peptidase 5

decreases expression

Lovastatin results in decreased expression of USP5 mRNA

NCBI chr12:6,852,150...6,866,632
Ensembl chr12:6,852,148...6,866,632

G

valosin containing protein

decreases expression
increases expression

Lovastatin results in decreased expression of VCP mRNA
Lovastatin results in increased expression of VCP mRNA

NCBI chr 9:35,056,064...35,072,625
Ensembl chr 9:35,053,928...35,072,668

G

WEE1 G2 checkpoint kinase

multiple interactions
increases expression

Lovastatin inhibits the reaction [Doxorubicin results in increased expression of WEE1 mRNA]
Lovastatin results in increased expression of WEE1 mRNA

NCBI chr11:9,573,670...9,589,985
Ensembl chr11:9,573,670...9,593,457

G

X-linked inhibitor of apoptosis

increases expression

Lovastatin results in increased expression of XIAP mRNA

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

G

XPA, DNA damage recognition and repair factor

increases expression

Lovastatin results in increased expression of XPA mRNA

NCBI chr 9:97,654,398...97,697,340
Ensembl chr 9:97,674,909...97,697,340

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

increases expression

Lovastatin results in increased expression of YWHAE mRNA

NCBI chr17:1,344,275...1,400,222
Ensembl chr17:1,344,275...1,400,222

mevastatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

affects expression
decreases expression
multiple interactions

mevastatin affects the expression of ABCA1 mRNA
Mevastatin (compactin) decreases expression of abca1 mRNA in rat peripheral fibroblasts
Mevalonic Acid inhibits the reaction [mevastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]]

CTD
RGD

PMID:16415093 PMID:17526932 PMID:17526932

NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155

G

brain derived neurotrophic factor

multiple interactions

mevastatin inhibits the reaction [BDNF protein results in decreased activity of HU 211]

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

bone morphogenetic protein 2

increases expression

mevastatin results in increased expression of BMP2 mRNA; mevastatin results in increased expression of BMP2 protein

NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246

G

CD40 molecule

multiple interactions

mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

G

cytochrome P450 family 3 subfamily A member 4

increases expression
multiple interactions

mevastatin results in increased expression of CYP3A4 mRNA
[mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA]

PMID:12235278 PMID:15466163 PMID:17041008

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

DNA damage inducible transcript 3

multiple interactions
decreases expression

EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA]

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

mevastatin results in increased phosphorylation of EIF2AK3 protein

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA]

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

forkhead box O1

decreases phosphorylation

mevastatin results in decreased phosphorylation of FOXO1 protein

NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641

G

isopentenyl-diphosphate delta isomerase 1

multiple interactions
increases expression

EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA]

NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,119

G

interferon gamma

multiple interactions

mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interleukin 1 beta

multiple interactions

mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interferon regulatory factor 4

decreases expression

mevastatin results in decreased expression of IRF4 protein

NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443

G

methylsterol monooxygenase 1

increases expression
multiple interactions

mevastatin results in increased expression of MSMO1 mRNA
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA]

NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164

G

myostatin

increases expression

mevastatin results in increased expression of MSTN protein

NCBI chr 2:190,055,700...190,062,729
Ensembl chr 2:190,055,700...190,062,729

G

nuclear receptor subfamily 1 group H member 3

increases expression

Mevastatin increases expression of NR1H3 mRNA in mononuclear cells

RGD

NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033

G

nuclear receptor subfamily 1 group I member 2

multiple interactions

[mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA]

PMID:12235278 PMID:17041008

NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487

G

Rac family small GTPase 1

multiple interactions

mevastatin results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]

NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967

G

ras homolog family member A

decreases lipidation
multiple interactions

mevastatin results in decreased lipidation of RHOA protein
Mevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

selectin E

multiple interactions

mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein]

NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705

G

sterol regulatory element binding transcription factor 1

decreases expression
increases cleavage
multiple interactions

mevastatin results in decreased expression of SREBF1 protein
mevastatin results in increased cleavage of SREBF1 protein
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]

PMID:16330322 PMID:17526932

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

sterol regulatory element binding transcription factor 2

increases expression
increases cleavage

mevastatin results in increased expression of SREBF2 protein
mevastatin results in increased cleavage of SREBF2 protein

PMID:16330322 PMID:17526932

NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306

G

tumor necrosis factor

multiple interactions

mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

X-box binding protein 1

multiple interactions

Tunicamycin inhibits the reaction [mevastatin results in increased cleavage of XBP1 protein]

NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597

norverapamil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 3 subfamily A member 5

decreases activity

norverapamil results in decreased activity of CYP3A5 protein

NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996

phosphoramidon

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions

phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein]

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

AKT serine/threonine kinase 1

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

endothelin converting enzyme 1

multiple interactions
decreases activity

EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of ECE1 protein]
phosphoramidon decreases activity of recombinant Ece1 protein in COS cells

CTD
RGD

PMID:11145282 PMID:16280098 PMID:8034569

NCBI chr 1:21,217,250...21,345,504
Ensembl chr 1:21,217,247...21,345,572

G

endothelin 1

decreases expression
multiple interactions

phosphoramidon results in decreased expression of EDN1 protein
EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]

PMID:11145282 PMID:16280098 PMID:16391412

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

endothelin receptor type A

multiple interactions

phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein]; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

G

endothelin receptor type B

increases expression

phosphoramidon results in increased expression of EDNRB protein

NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529

G

epidermal growth factor receptor

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

intercellular adhesion molecule 1

multiple interactions

phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

Kell metallo-endopeptidase (Kell blood group)

multiple interactions

KEL protein alternative form binds to and affects the metabolism of phosphoramidon

NCBI chr 7:142,941,114...142,962,363
Ensembl chr 7:142,941,114...142,962,363

G

leptin

decreases expression

phosphoramidon results in decreased expression of LEP protein

NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629

G

mitogen-activated protein kinase 1

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

membrane metalloendopeptidase

multiple interactions

phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein]

NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704

G

neurotensin

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992

G

selectin L

multiple interactions

phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]

NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702

G

tachykinin precursor 1

multiple interactions

[TAC1 protein co-treated with phosphoramidon] results in increased uptake of Oxygen

NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472

prinomastat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

matrix metallopeptidase 13

decreases activity

prinomastat results in decreased activity of MMP13 protein

NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732

G

matrix metallopeptidase 2

decreases activity

prinomastat results in decreased activity of MMP2 protein

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 3

decreases activity

prinomastat results in decreased activity of MMP3 protein

NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609

G

matrix metallopeptidase 8

decreases activity

prinomastat results in decreased activity of MMP8 protein

NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050

G

solute carrier family 22 member 2

multiple interactions

prinomastat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

simvastatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

decreases expression

Simvastatin results in decreased expression of A2M mRNA

NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229

G

ATP binding cassette subfamily A member 1

decreases expression
increases expression

Simvastatin results in decreased expression of ABCA1; Simvastatin results in decreased expression of ABCA1 mRNA
Simvastatin results in increased expression of ABCA1 mRNA; Simvastatin results in increased expression of ABCA1 protein

PMID:16282522 PMID:18270459 PMID:19383813 PMID:19461118 PMID:21241519 More...

NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155

G

ATP binding cassette subfamily B member 1

increases transport
affects response to substance
multiple interactions
decreases activity

ABCB1 protein results in increased transport of Simvastatin
ABCB1 polymorphism affects the susceptibility to Simvastatin
ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Simvastatin]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
Simvastatin analog results in decreased activity of ABCB1 protein

PMID:15616150 PMID:16321621 PMID:19802823 PMID:19891551

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases expression
decreases activity

Simvastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Simvastatin results in decreased expression of ABCB11 mRNA
Simvastatin results in decreased activity of ABCB11 protein

PMID:20829430 PMID:23956101 PMID:24014644 PMID:27765674

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily B member 4

increases expression
decreases expression

Simvastatin results in increased expression of ABCB4 mRNA
Simvastatin results in decreased expression of ABCB4 mRNA

PMID:21241519 PMID:27765674

NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435

G

ATP binding cassette subfamily C member 2

multiple interactions
decreases expression
affects response to substance
decreases activity

ABCC2 protein binds to and results in increased uptake of Simvastatin analog; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Simvastatin results in decreased expression of ABCC2 mRNA
ABCC2 polymorphism affects the susceptibility to Simvastatin
Simvastatin analog results in decreased activity of ABCC2 protein

PMID:15616150 PMID:22186618 PMID:23562342 PMID:27765674

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 3

multiple interactions
increases nitrosation

artemisinin inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein]; parthenolide inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein]; Simvastatin promotes the reaction [Doxorubicin results in increased nitrosation of ABCC3 protein]

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

ATP binding cassette subfamily G member 1

decreases expression

Simvastatin results in decreased expression of ABCG1 mRNA

PMID:19383813 PMID:22120639

NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244

G

ATP binding cassette subfamily G member 5

increases expression

Simvastatin results in increased expression of ABCG5 mRNA

NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865

G

ATP binding cassette subfamily G member 8

decreases expression

Simvastatin results in decreased expression of ABCG8 mRNA

NCBI chr 2:43,838,971...43,882,988
Ensembl chr 2:43,831,942...43,882,988

G

acetyl-CoA acyltransferase 2

decreases expression
multiple interactions

Simvastatin results in decreased expression of ACAA2 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of ACAA2 mRNA

NCBI chr18:49,782,164...49,813,533
Ensembl chr18:49,782,164...49,813,953

G

acetyl-CoA carboxylase beta

increases expression

Simvastatin results in increased expression of ACACB mRNA

NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226

G

aggrecan

multiple interactions
increases expression

Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA]; NOG inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA]

PMID:18628692 PMID:19912653

NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,353

G

angiotensin converting enzyme 2

decreases expression

Simvastatin results in decreased expression of ACE2 mRNA

NCBI chr X:15,518,197...15,607,211
Ensembl chr X:15,494,566...15,607,236

G

actin alpha 2, smooth muscle

multiple interactions
decreases expression

Simvastatin inhibits the reaction [TGFB1 results in increased expression of ACTA2 mRNA]
Simvastatin results in decreased expression of ACTA2 protein

PMID:15677772 PMID:15855201

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

actin beta

increases expression

Simvastatin results in increased expression of ACTB mRNA

NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902

G

actinin alpha 4

increases expression

Simvastatin results in increased expression of ACTN4 mRNA

NCBI chr19:38,647,649...38,731,589
Ensembl chr19:38,647,649...38,731,589

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of ADIPOQ mRNA]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of ADIPOQ protein]
carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]

PMID:17641834 PMID:29071762

NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463

G

adenosine A2b receptor

multiple interactions

Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of ADORA2B mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of ADORA2B protein]

NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746

G

adrenoceptor beta 1

increases expression

Simvastatin results in increased expression of ADRB1 mRNA; Simvastatin results in increased expression of ADRB1 protein

NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904

G

alpha fetoprotein

increases expression

Simvastatin results in increased expression of AFP mRNA

NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174

G

advanced glycosylation end-product specific receptor

multiple interactions
decreases expression

Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]
Simvastatin results in decreased expression of AGER protein

NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322

G

angiotensinogen

multiple interactions
decreases expression

[Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Simvastatin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [AGT results in increased activity of RAC1 protein]; Simvastatin promotes the reaction [Glucose promotes the reaction [AGT protein results in increased expression of PTGS2 mRNA]]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]]; Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of PXN protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of AGT mRNA]
Simvastatin results in decreased expression of AGT mRNA

PMID:17513949 PMID:18400235 PMID:18475152 PMID:19100119 PMID:19225232 More...

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

angiotensin II receptor type 1

decreases expression

Simvastatin results in decreased expression of AGTR1 mRNA

PMID:17513949 PMID:18475152

NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008

G

aldo-keto reductase family 1 member C1

increases expression

Simvastatin results in increased expression of AKR1C1 mRNA

NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283

G

aldo-keto reductase family 1 member C3

decreases expression

Simvastatin results in decreased expression of AKR1C3 mRNA

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

aldo-keto reductase family 1 member D1

decreases expression

Simvastatin results in decreased expression of AKR1D1 mRNA

NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305

G

AKT serine/threonine kinase 1

decreases expression
decreases phosphorylation
increases phosphorylation
multiple interactions
decreases activity

Simvastatin results in decreased expression of AKT1 mRNA; Simvastatin results in decreased expression of AKT1 protein
Simvastatin results in decreased phosphorylation of AKT1 protein
Simvastatin results in increased phosphorylation of AKT1 protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of AKT1 protein]
Simvastatin results in decreased activity of AKT1 protein
Simvastatin inhibits the reaction [Glucose results in decreased expression of AKT1 protein modified form]; Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; [Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein; [Simvastatin co-treated with Metformin] results in decreased phosphorylation of AKT1 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of AKT1 mRNA]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]

PMID:12438947 PMID:17327694 PMID:17335931 PMID:18004065 PMID:18031796 More...

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

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aldehyde dehydrogenase 3 family member A1

increases expression

Simvastatin results in increased expression of ALDH3A1 mRNA

NCBI chr17:19,737,984...19,748,298
Ensembl chr17:19,737,984...19,748,943

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ALK receptor tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA

NCBI chr 2:29,192,774...29,921,586
Ensembl chr 2:29,192,774...29,921,586

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arachidonate 5-lipoxygenase activating protein

increases expression

Simvastatin results in increased expression of ALOX5AP mRNA

NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426

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alkaline phosphatase, intestinal

increases expression

Simvastatin results in increased expression of ALPI mRNA

NCBI chr 2:232,456,153...232,460,753
Ensembl chr 2:232,456,125...232,460,753

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alkaline phosphatase, biomineralization associated

increases expression
multiple interactions
affects expression

Simvastatin results in increased expression of ALPL mRNA
Hydroxychloroquine affects the reaction [Simvastatin affects the expression of ALPL mRNA]

PMID:20417880 PMID:28975700

NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410

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angiopoietin 1

increases expression

Simvastatin results in increased expression of ANGPT1; Simvastatin results in increased expression of ANGPT1 mRNA; Simvastatin results in increased expression of ANGPT1 protein

NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055

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angiopoietin 2

multiple interactions

Simvastatin inhibits the reaction [Streptozocin results in increased expression of ANGPT2 protein]

NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409

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angiopoietin like 3

decreases expression

Simvastatin results in decreased expression of ANGPTL3 mRNA

NCBI chr 1:62,597,520...62,606,313
Ensembl chr 1:62,597,520...62,606,313

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angiopoietin like 4

increases expression

Simvastatin results in increased expression of ANGPTL4 mRNA

NCBI chr19:8,364,155...8,374,370
Ensembl chr19:8,363,289...8,374,370

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ankyrin repeat family A member 2

increases expression

Simvastatin results in increased expression of ANKRA2 mRNA

NCBI chr 5:73,552,190...73,565,639
Ensembl chr 5:73,552,190...73,565,667

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alanyl aminopeptidase, membrane

increases expression

Simvastatin results in increased expression of ANPEP mRNA

NCBI chr15:89,784,895...89,814,852
Ensembl chr15:89,784,895...89,815,401

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annexin A1

increases expression

Simvastatin results in increased expression of ANXA1 protein

NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393

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annexin A3

decreases expression

Simvastatin results in decreased expression of ANXA3 mRNA
Simvastatin results in decreased expression of ANXA3 protein

PMID:14973129 PMID:17428261

NCBI chr 4:78,551,770...78,610,447
Ensembl chr 4:78,551,747...78,610,451

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amine oxidase copper containing 1

multiple interactions

Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of AOC1 mRNA]

NCBI chr 7:150,852,120...150,861,504
Ensembl chr 7:150,824,627...150,861,504

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adipocyte plasma membrane associated protein

decreases expression

Simvastatin results in decreased expression of APMAP protein

NCBI chr20:24,962,925...24,992,751
Ensembl chr20:24,962,925...24,992,751

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apolipoprotein A1

multiple interactions
decreases expression
increases expression

MTHFR gene mutant form inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]
Simvastatin results in decreased expression of APOA1 mRNA; Simvastatin results in decreased expression of APOA1 protein
[Niacin co-treated with Ezetimibe co-treated with Simvastatin] results in increased expression of APOA1 protein; [Simvastatin co-treated with Ezetimibe] results in increased expression of APOA1 protein; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]; Niacin promotes the reaction [[Simvastatin co-treated with Ezetimibe] results in increased expression of APOA1 protein]; Simvastatin results in increased expression of and results in increased secretion of APOA1 protein
Simvastatin results in increased expression of APOA1 mRNA; Simvastatin results in increased expression of APOA1 protein
Polystyrenes analog promotes the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Simvastatin promotes the reaction [Polystyrenes analog results in increased expression of APOA1 mRNA]

PMID:8289597 PMID:8461338 PMID:12048122 PMID:12633795 PMID:18270459 More...

NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622

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apolipoprotein A2

decreases expression

Simvastatin results in decreased expression of APOA2 mRNA

NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631

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apolipoprotein A4

multiple interactions
decreases expression
increases expression

Simvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]; Simvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein]
Simvastatin results in decreased expression of APOA4 mRNA; Simvastatin results in decreased expression of APOA4 protein
Polystyrenes analog promotes the reaction [Simvastatin results in decreased expression of APOA4 protein]; Simvastatin promotes the reaction [Polystyrenes analog results in decreased expression of APOA4 protein]
Simvastatin results in increased expression of APOA4 protein

PMID:8289597 PMID:8461338 PMID:18224302 PMID:25055962

NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304

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apolipoprotein B

multiple interactions
decreases expression
decreases secretion
affects response to substance

[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB; [Niacin co-treated with Simvastatin] results in decreased expression of APOB protein; HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]
Simvastatin results in decreased expression of APOB protein
Simvastatin results in decreased secretion of APOB protein
Simvastatin results in decreased expression of APOB mRNA; Simvastatin results in decreased expression of APOB protein
Simvastatin promotes the reaction [Polystyrenes analog results in decreased expression of APOB protein]
APOB polymorphism affects the susceptibility to Simvastatin

PMID:1627634 PMID:8289597 PMID:8461338 PMID:9512650 PMID:10498134 More...

NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073

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apolipoprotein C1

decreases expression

Simvastatin results in decreased expression of APOC1 mRNA

NCBI chr19:44,914,325...44,919,346
Ensembl chr19:44,914,247...44,919,349

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apolipoprotein C3

decreases expression

Simvastatin results in decreased expression of APOC3 mRNA

NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072

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apolipoprotein E

decreases expression
affects response to substance
multiple interactions

Simvastatin results in decreased expression of APOE; Simvastatin results in decreased expression of APOE mRNA
Simvastatin results in decreased expression of APOE mRNA; Simvastatin results in decreased expression of APOE protein
APOE polymorphism affects the susceptibility to Simvastatin
Polystyrenes analog inhibits the reaction [Simvastatin results in decreased expression of APOE protein]
APOE affects the susceptibility to Simvastatin

PMID:8289597 PMID:8461338 PMID:11849659 PMID:11947894 PMID:12901521 More...

NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393

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apolipoprotein F

decreases expression

Simvastatin results in decreased expression of APOF mRNA

NCBI chr12:56,360,568...56,362,857
Ensembl chr12:56,360,568...56,362,857

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apolipoprotein M

decreases expression
increases expression
multiple interactions

Simvastatin results in decreased expression of APOM mRNA
Simvastatin results in increased expression of APOM mRNA; Simvastatin results in increased expression of APOM protein
T0901317 inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]; T0901317 inhibits the reaction [Simvastatin results in increased expression of APOM protein]; Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]; Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM protein]

PMID:21729290 PMID:22160096

NCBI chr 6:31,652,404...31,658,210
Ensembl chr 6:31,652,416...31,658,210

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amyloid beta precursor protein

multiple interactions
decreases activity

oblimersen inhibits the reaction [Simvastatin results in decreased activity of APP protein alternative form]; Simvastatin inhibits the reaction [APP protein alternative form results in decreased expression of CASP3 protein]; Simvastatin inhibits the reaction [APP protein alternative form results in increased activity of CASP3 protein]
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein]

PMID:17241114 PMID:28734741

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

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Rho GTPase activating protein 29

decreases expression

Simvastatin results in decreased expression of ARHGAP29 mRNA

NCBI chr 1:94,168,905...94,314,592
Ensembl chr 1:94,148,988...94,275,068

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Rho GTPase activating protein 4

increases expression

Simvastatin results in increased expression of ARHGAP4 mRNA

NCBI chr X:153,907,378...153,926,264
Ensembl chr X:153,907,367...153,934,999

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Rho/Rac guanine nucleotide exchange factor 2

increases expression

Simvastatin results in increased expression of ARHGEF2 mRNA

NCBI chr 1:155,946,854...155,979,617
Ensembl chr 1:155,946,851...156,007,070

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argininosuccinate synthase 1

decreases expression

Simvastatin results in decreased expression of ASS1 mRNA

NCBI chr 9:130,444,707...130,501,274
Ensembl chr 9:130,444,961...130,501,274

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activating transcription factor 2

increases phosphorylation

Simvastatin results in increased phosphorylation of ATF2 protein

NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382

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activating transcription factor 3

increases expression

Simvastatin results in increased expression of ATF3 mRNA

NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777

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activating transcription factor 6

increases expression

Simvastatin results in increased expression of ATF6 mRNA; Simvastatin results in increased expression of ATF6 protein

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

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ATM serine/threonine kinase

multiple interactions

Simvastatin results in increased phosphorylation of and results in increased activity of ATM protein

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102

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ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

increases expression

Simvastatin results in increased expression of ATP2A2 mRNA; Simvastatin results in increased expression of ATP2A2 protein

NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093

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ATPase H+ transporting V1 subunit E1

increases expression

Simvastatin results in increased expression of ATP6V1E1 mRNA

NCBI chr22:17,592,136...17,628,822
Ensembl chr22:17,592,136...17,628,749

G

aurora kinase A

decreases expression

Simvastatin results in decreased expression of AURKA mRNA

NCBI chr20:56,369,390...56,392,215
Ensembl chr20:56,369,389...56,392,337

G

axin 2

affects expression

Simvastatin affects the expression of AXIN2 mRNA

NCBI chr17:65,528,563...65,561,648
Ensembl chr17:65,528,563...65,561,648

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AXL receptor tyrosine kinase

decreases expression

Simvastatin results in decreased expression of AXL mRNA

NCBI chr19:41,219,223...41,261,766
Ensembl chr19:41,219,223...41,261,766

G

BCL2 associated agonist of cell death

multiple interactions
decreases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]
IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]

PMID:12438947 PMID:27734117

NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704

G

BCL2 associated X, apoptosis regulator

affects localization
increases expression

Simvastatin affects the localization of BAX protein
Simvastatin results in increased expression of BAX protein
Simvastatin results in increased expression of BAX mRNA
Simvastatin results in increased expression of BAX mRNA; Simvastatin results in increased expression of BAX protein

PMID:12557325 PMID:17901590 PMID:20045437 PMID:25300705

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

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BCL2 binding component 3

multiple interactions
increases expression
affects localization

Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]
Simvastatin results in increased expression of BBC3 mRNA; Simvastatin results in increased expression of BBC3 protein
Simvastatin affects the localization of BBC3 protein

PMID:17428261 PMID:20045437 PMID:21199873 PMID:37956312

NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766

G

BCL2 apoptosis regulator

multiple interactions
decreases expression
increases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of BCL2 mRNA]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Simvastatin promotes the reaction [NFATC3 protein binds to BCL2 promoter]
Simvastatin results in decreased expression of BCL2 protein
Simvastatin results in increased expression of BCL2 mRNA; Simvastatin results in increased expression of BCL2 protein
Simvastatin results in decreased expression of BCL2 mRNA; Simvastatin results in decreased expression of BCL2 protein

PMID:17241114 PMID:17277159 PMID:17901590 PMID:18031796 PMID:18521906 More...

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

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BCL2 like 1

multiple interactions
decreases expression

Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]
Simvastatin results in decreased expression of BCL2L1 protein

PMID:17277159 PMID:18521906 PMID:20060890

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

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brain derived neurotrophic factor

increases expression
multiple interactions

Simvastatin results in increased expression of BDNF
Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of BDNF mRNA]

PMID:18047562 PMID:20851742

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

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bone gamma-carboxyglutamate protein

increases expression
multiple interactions
increases secretion

Simvastatin results in increased expression of BGLAP; Simvastatin results in increased expression of BGLAP mRNA
Simvastatin results in increased expression of BGLAP; Simvastatin results in increased expression of BGLAP mRNA; Simvastatin results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of BGLAP protein]; DKK1 inhibits the reaction [Simvastatin results in increased expression of BGLAP mRNA]
[Simvastatin co-treated with Dexamethasone] results in increased expression of BGLAP
Simvastatin results in increased secretion of BGLAP protein

PMID:12914771 PMID:14601315 PMID:14973129 PMID:15953866 PMID:17252541 More...

NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317

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basic helix-loop-helix family member a15

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA

NCBI chr 7:98,211,439...98,215,457
Ensembl chr 7:98,211,439...98,215,457

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baculoviral IAP repeat containing 2

multiple interactions
decreases expression

Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]
Simvastatin results in decreased expression of BIRC2 protein

PMID:17277159 PMID:18521906 PMID:19343037

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

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baculoviral IAP repeat containing 3

multiple interactions

Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]

PMID:17277159 PMID:19343037

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

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baculoviral IAP repeat containing 5

multiple interactions
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased expression of BIRC5 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 protein]
Simvastatin results in decreased expression of BIRC5 mRNA; Simvastatin results in decreased expression of BIRC5 protein

PMID:17277159 PMID:20464445

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

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bone morphogenetic protein 1

increases expression

Simvastatin results in increased expression of BMP1 mRNA

NCBI chr 8:22,165,372...22,212,326
Ensembl chr 8:22,165,140...22,212,326

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bone morphogenetic protein 2

increases secretion
increases expression
multiple interactions

Simvastatin results in increased secretion of BMP2 protein
Simvastatin results in increased expression of BMP2 mRNA; Simvastatin results in increased expression of BMP2 protein
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA]
Simvastatin results in increased expression of BMP2; Simvastatin results in increased expression of BMP2 mRNA
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; Simvastatin inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD1 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD9 protein]]; Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]

PMID:10814523 PMID:11162604 PMID:12914771 PMID:16470222 PMID:17252541 More...

NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246

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bone morphogenetic protein receptor type 2

affects expression
increases stability
increases expression

Simvastatin affects the expression of BMPR2 mRNA
Simvastatin results in increased stability of BMPR2 mRNA
Simvastatin results in increased expression of BMPR2 protein

NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751

G

BCL2 interacting protein 3

increases expression

Simvastatin results in increased expression of BNIP3 mRNA

NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967

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complement C5a receptor 1

decreases expression

Simvastatin results in decreased expression of C5AR1 mRNA

NCBI chr19:47,307,477...47,322,066
Ensembl chr19:47,290,023...47,322,066

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calcium voltage-gated channel subunit alpha1 C

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C protein]
Simvastatin results in decreased expression of CACNA1C mRNA; Simvastatin results in decreased expression of CACNA1C protein

NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950

G

calcium voltage-gated channel subunit alpha1 H

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H protein]
Simvastatin results in decreased expression of CACNA1H mRNA; Simvastatin results in decreased expression of CACNA1H protein

NCBI chr16:1,153,106...1,221,768
Ensembl chr16:1,153,103...1,224,169

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calbindin 1

multiple interactions

Simvastatin inhibits the reaction [Oxygen deficiency results in decreased expression of CALB1 mRNA]

NCBI chr 8:90,058,608...90,082,879
Ensembl chr 8:90,058,608...90,095,475

G

calbindin 2

decreases expression

Simvastatin results in decreased expression of CALB2 protein

NCBI chr16:71,358,723...71,390,433
Ensembl chr16:71,358,713...71,390,436

G

caldesmon 1

decreases expression

Simvastatin results in decreased expression of CALD1 mRNA; Simvastatin results in decreased expression of CALD1 protein

NCBI chr 7:134,745,467...134,970,729
Ensembl chr 7:134,744,252...134,970,729

G

calmodulin like 3

increases expression

Simvastatin results in increased expression of CALML3 mRNA

NCBI chr10:5,524,961...5,526,771
Ensembl chr10:5,524,961...5,526,771

G

calpain 1

increases expression

Simvastatin results in increased expression of CAPN1 mRNA

PMID:18664198 PMID:19253821

NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006

G

capping actin protein of muscle Z-line subunit alpha 1

decreases expression

Simvastatin results in decreased expression of CAPZA1 protein

NCBI chr 1:112,619,832...112,671,616
Ensembl chr 1:112,619,805...112,671,616

G

capping actin protein of muscle Z-line subunit alpha 2

decreases expression

Simvastatin results in decreased expression of CAPZA2 protein

NCBI chr 7:116,862,587...116,922,049
Ensembl chr 7:116,811,070...116,922,049

G

caspase 1

decreases activity
multiple interactions

Simvastatin results in decreased activity of CASP1 protein
Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CASP1 protein]]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CASP1 protein]

PMID:16054375 PMID:30408459 PMID:35762198

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 12 (gene/pseudogene)

multiple interactions

Simvastatin results in increased cleavage of and results in increased activity of CASP12 protein

NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670

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caspase 3

multiple interactions
increases cleavage
increases activity
decreases activity
increases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of CASP3 protein]; Simvastatin inhibits the reaction [APP protein alternative form results in decreased expression of CASP3 protein]; Simvastatin inhibits the reaction [APP protein alternative form results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Coal Ash results in increased expression of CASP3 protein modified form]; Simvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]; Simvastatin results in increased cleavage of and results in increased activity of CASP3 protein
Simvastatin results in increased cleavage of CASP3 protein
Simvastatin results in decreased activity of CASP3 protein
Simvastatin results in increased expression of CASP3 mRNA; Simvastatin results in increased expression of CASP3 protein
carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP3 protein]]; PD 150606 inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP3 protein]; Simvastatin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of CASP3 mRNA]; Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]; Simvastatin results in decreased expression of and results in decreased activity of CASP3 protein; Simvastatin results in increased cleavage of and results in increased activity of CASP3 protein; Verapamil inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]
[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein; [Lipopolysaccharides co-treated with Simvastatin] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]

PMID:11868908 PMID:12557325 PMID:12962723 PMID:14527821 PMID:15200425 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

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caspase 6

multiple interactions

Simvastatin results in increased cleavage of and results in increased activity of CASP6 protein

NCBI chr 4:109,664,388...109,709,767
Ensembl chr 4:109,688,622...109,703,583

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caspase 7

multiple interactions
increases activity

Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP7 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP7 protein]; Simvastatin results in increased cleavage of and results in increased activity of CASP7 protein

PMID:19253821 PMID:20045437 PMID:20427495

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

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caspase 8

increases activity
multiple interactions
increases cleavage

Simvastatin results in increased activity of CASP8 protein
Simvastatin results in increased cleavage of and results in increased activity of CASP8 protein
Simvastatin results in increased cleavage of CASP8 protein
Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP8 protein]

PMID:12962723 PMID:15705602 PMID:20464445 PMID:20883752 PMID:21910007

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

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caspase 9

multiple interactions
increases activity
decreases activity
increases cleavage

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased activity of CASP9 protein]; DIABLO protein promotes the reaction [Simvastatin results in increased activity of CASP9 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP9 protein]; Simvastatin results in increased cleavage of and results in increased activity of CASP9 protein

PMID:12438947 PMID:12962723 PMID:15705602 PMID:16470222 PMID:19253821 More...

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

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catalase

decreases expression
multiple interactions
increases activity

Simvastatin results in decreased expression of CAT mRNA
carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]]; Simvastatin inhibits the reaction [Diazepam results in decreased activity of CAT protein]; Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]
Simvastatin results in increased activity of CAT protein

PMID:17479860 PMID:20883752 PMID:27111380 PMID:29071762

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

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caveolin 1

multiple interactions
decreases expression

Simvastatin inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA]
Simvastatin inhibits the reaction [[Semaxinib co-treated with Oxygen deficiency] results in decreased expression of CAV1 protein]
Simvastatin results in decreased expression of CAV1 protein
Simvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein]

PMID:16698853 PMID:18224302 PMID:19816600

NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179

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caveolin 2

multiple interactions

Simvastatin inhibits the reaction [[Semaxinib co-treated with Oxygen deficiency] results in decreased expression of CAV2 protein]

NCBI chr 7:116,499,738...116,508,541
Ensembl chr 7:116,287,380...116,508,541

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cystathionine beta-synthase

multiple interactions

Simvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]; Simvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein]

NCBI chr21:43,053,191...43,076,873
Ensembl chr21:43,053,191...43,076,943

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C-C motif chemokine ligand 2

multiple interactions
decreases expression
affects expression
decreases response to substance

[Simvastatin co-treated with Ramipril] results in decreased expression of CCL2 protein; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL2 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL2 protein]; Simvastatin results in decreased expression of and results in decreased secretion of CCL2 protein
Simvastatin results in decreased expression of CCL2 mRNA; Simvastatin results in decreased expression of CCL2 protein
Simvastatin affects the expression of CCL2 mRNA
Simvastatin results in decreased susceptibility to CCL2 protein

PMID:12117737 PMID:12818400 PMID:15184351 PMID:15781755 PMID:15824212 More...

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

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C-C motif chemokine ligand 20

decreases expression

Simvastatin results in decreased expression of CCL20 mRNA

NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564

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C-C motif chemokine ligand 3

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL3 mRNA]
Simvastatin results in decreased expression of CCL3 mRNA

PMID:16321392 PMID:16414398

NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169

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C-C motif chemokine ligand 4

multiple interactions

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL4 mRNA]

NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621

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C-C motif chemokine ligand 5

increases expression
decreases expression

Simvastatin results in increased expression of CCL5 mRNA
Simvastatin results in decreased expression of CCL5 protein
Simvastatin results in decreased expression of CCL5 mRNA

PMID:17112859 PMID:17183729 PMID:17449418

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

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cellular communication network factor 1

multiple interactions
decreases expression

Simvastatin inhibits the reaction [CCN1 results in increased expression of IL1B]; Simvastatin inhibits the reaction [CCN1 results in increased expression of OSM]; Simvastatin inhibits the reaction [CCN1 results in increased expression of TNF]; Simvastatin inhibits the reaction [OSM results in increased expression of CCN1 mRNA]
Simvastatin results in decreased expression of CCN1 mRNA

PMID:17428261 PMID:20191585

NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589

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cellular communication network factor 2

multiple interactions
decreases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 protein]
Simvastatin results in decreased expression of CCN2 mRNA; Simvastatin results in decreased expression of CCN2 protein
Simvastatin inhibits the reaction [lysophosphatidic acid results in increased expression of CCN2 protein]
Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]

PMID:15200425 PMID:15298857 PMID:15677772 PMID:19080365 PMID:19099753 More...

NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372

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cyclin A2

decreases expression
multiple interactions

Simvastatin results in decreased expression of CCNA2 mRNA
Simvastatin results in decreased expression of CCNA2 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein]

PMID:17428261 PMID:26577051

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

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cyclin D1

multiple interactions
decreases expression

Simvastatin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Simvastatin results in decreased expression of CCND1 mRNA; Simvastatin results in decreased expression of CCND1 protein

PMID:17277159 PMID:17428261 PMID:20878096

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

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cyclin E1

multiple interactions
decreases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein]

NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312

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C-C motif chemokine receptor 1

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]
Simvastatin results in decreased expression of CCR1 mRNA

PMID:16321392 PMID:16414398

NCBI chr 3:46,201,711...46,208,313
Ensembl chr 3:46,201,711...46,208,313

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C-C motif chemokine receptor 2

multiple interactions
decreases expression

[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 mRNA]; [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]
Simvastatin results in decreased expression of CCR2 mRNA; Simvastatin results in decreased expression of CCR2 protein

PMID:15781755 PMID:16321392 PMID:16414398 PMID:16781696 PMID:17449418

NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940

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C-C motif chemokine receptor 4

multiple interactions

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]

NCBI chr 3:32,951,644...32,956,349
Ensembl chr 3:32,951,644...32,956,349

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C-C motif chemokine receptor 5

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]
Simvastatin results in decreased expression of CCR5 protein
Simvastatin results in decreased expression of CCR5 mRNA

PMID:16321392 PMID:17112859 PMID:17449418

NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206

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CD14 molecule

decreases expression

Simvastatin results in decreased expression of CD14 mRNA

NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700

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CD151 molecule (Raph blood group)

decreases expression

Simvastatin results in decreased expression of CD151 mRNA

NCBI chr11:832,952...838,831
Ensembl chr11:832,887...839,831

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CD24 molecule

increases expression

Simvastatin results in increased expression of CD24 mRNA

NCBI chr 6:106,969,831...106,976,855
Ensembl chr 6:106,969,831...106,975,627

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CD27 molecule

decreases expression

Simvastatin results in decreased expression of CD27 mRNA

NCBI chr12:6,443,892...6,451,713
Ensembl chr12:6,444,955...6,451,718

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CD2 associated protein

increases expression

Simvastatin results in increased expression of CD2AP mRNA

NCBI chr 6:47,477,789...47,627,263
Ensembl chr 6:47,477,789...47,627,263

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CD40 molecule

decreases expression
multiple interactions

Simvastatin results in decreased expression of CD40 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]; Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]

PMID:16387846 PMID:17169357 PMID:17507688

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

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CD40 ligand

decreases expression
multiple interactions
increases expression

Simvastatin results in decreased expression of CD40LG protein; Simvastatin results in decreased expression of CD40LG protein modified form
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]; Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]
Simvastatin results in increased expression of CD40LG protein

PMID:17169357 PMID:18269829 PMID:21330348

NCBI chr X:136,648,158...136,660,390
Ensembl chr X:136,648,158...136,660,390

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CD44 molecule (IN blood group)

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein]; Simvastatin promotes the reaction [TP53 protein binds to CD44 promoter]
Simvastatin results in decreased expression of CD44 mRNA; Simvastatin results in decreased expression of CD44 protein

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

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CD80 molecule

decreases expression

Simvastatin results in decreased expression of CD80 mRNA

NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614

G

CD83 molecule

decreases expression

Simvastatin results in decreased expression of CD83 protein

NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918

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CD86 molecule

decreases expression

Simvastatin results in decreased expression of CD86 protein

NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139

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cell division cycle 25B

affects expression

Simvastatin affects the expression of CDC25B mRNA; Simvastatin affects the expression of CDC25B protein

NCBI chr20:3,786,951...3,806,115
Ensembl chr20:3,786,772...3,806,121

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cell division cycle 42

decreases activity

Simvastatin results in decreased activity of CDC42 protein

NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,052,627...22,101,360

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cell division cycle 45

decreases expression

Simvastatin results in decreased expression of CDC45 mRNA

NCBI chr22:19,479,466...19,520,612
Ensembl chr22:19,479,457...19,520,612

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cell division cycle 6

decreases expression

Simvastatin results in decreased expression of CDC6 mRNA

NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657

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cadherin 5

increases expression

Simvastatin results in increased expression of CDH5 mRNA; Simvastatin results in increased expression of CDH5 protein

NCBI chr16:66,366,691...66,404,784
Ensembl chr16:66,366,690...66,404,784

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cyclin dependent kinase 1

decreases expression
multiple interactions

Simvastatin results in decreased expression of CDK1 mRNA; Simvastatin results in decreased expression of CDK1 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]

PMID:17428261 PMID:20878096 PMID:26577051

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

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cyclin dependent kinase 2

multiple interactions
decreases expression
decreases activity

[Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein; [Simvastatin results in decreased degradation of CDKN1B protein] which results in decreased activity of CDK2 protein
Simvastatin results in decreased expression of CDK2 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]
Simvastatin results in decreased activity of CDK2 protein

PMID:10412745 PMID:17928568 PMID:18804536 PMID:20878096 PMID:26577051

NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789

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cyclin dependent kinase 4

decreases expression
decreases activity

Simvastatin results in decreased expression of CDK4 protein
Simvastatin results in decreased activity of CDK4 protein

PMID:18804536 PMID:20878096

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

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cyclin dependent kinase 5

increases expression

Simvastatin results in increased expression of CDK5

NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897

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cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression

[Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of CDKN1A protein]; Simvastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein]
Simvastatin results in increased expression of CDKN1A mRNA; Simvastatin results in increased expression of CDKN1A protein

PMID:15625077 PMID:17428261 PMID:17928568 PMID:18337644 PMID:18625202 More...

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

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cyclin dependent kinase inhibitor 1B

multiple interactions
increases expression

[Simvastatin results in decreased degradation of CDKN1B protein] which results in decreased activity of CDK2 protein
Simvastatin results in increased expression of CDKN1B mRNA; Simvastatin results in increased expression of CDKN1B protein

PMID:12963647 PMID:17428261 PMID:17928568 PMID:18337644 PMID:18804536 More...

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

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cyclin dependent kinase inhibitor 1C

increases expression

Simvastatin results in increased expression of CDKN1C mRNA

NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775

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cyclin dependent kinase inhibitor 2A

increases expression

Simvastatin results in increased expression of CDKN2A protein

NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301

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cyclin dependent kinase inhibitor 2D

increases expression

Simvastatin results in increased expression of CDKN2D mRNA; Simvastatin results in increased expression of CDKN2D protein

NCBI chr19:10,566,460...10,568,979
Ensembl chr19:10,566,460...10,569,059

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chromatin licensing and DNA replication factor 1

decreases expression

Simvastatin results in decreased expression of CDT1 mRNA

NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258

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CCAAT enhancer binding protein zeta

multiple interactions

Simvastatin inhibits the reaction [CEBPZ binds to COL1A1 promoter]

NCBI chr 2:37,201,612...37,231,596
Ensembl chr 2:37,201,612...37,231,596

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carboxylesterase 1

multiple interactions

Simvastatin affects the reaction [Dietary Fats affects the expression of CES1 mRNA]; Simvastatin affects the reaction [Dietary Fats affects the expression of CES1 protein]
Simvastatin inhibits the reaction [CES1 protein results in increased hydrolysis of remdesivir]

PMID:33383043 PMID:34774545

NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337

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cholesteryl ester transfer protein

affects response to substance
decreases expression
multiple interactions

CETP polymorphism affects the susceptibility to Simvastatin
Simvastatin results in decreased expression of CETP protein
[CETP polymorphism affects the susceptibility to Simvastatin] which affects the abundance of Cholesterol, HDL; [CETP polymorphism affects the susceptibility to Simvastatin] which affects the abundance of Triglycerides

PMID:10519734 PMID:16038892 PMID:17931083

NCBI chr16:56,961,950...56,983,845
Ensembl chr16:56,961,923...56,983,845

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CASP8 and FADD like apoptosis regulator

multiple interactions
increases expression
decreases expression

Simvastatin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]
Simvastatin results in increased expression of CFLAR mRNA; Simvastatin results in increased expression of CFLAR protein
Simvastatin results in decreased expression of CFLAR protein; Simvastatin results in decreased expression of CFLAR protein alternative form

PMID:17277159 PMID:18521906 PMID:19262002 PMID:21910007

NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687

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CF transmembrane conductance regulator

multiple interactions

Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CFTR mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CFTR protein]

NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971

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choline O-acetyltransferase

multiple interactions

Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA]

NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942

G

cholinergic receptor muscarinic 5

multiple interactions

Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHRM5 mRNA]

NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458

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component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions
increases expression
increases phosphorylation

artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein]; Simvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of CHUK protein]
Simvastatin results in increased expression of CHUK mRNA

PMID:18463201 PMID:19262002

NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596

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class II major histocompatibility complex transactivator

multiple interactions

Simvastatin inhibits the reaction [IFNG results in increased expression of CIITA protein]

NCBI chr16:10,866,206...10,943,021
Ensembl chr16:10,866,222...10,943,021

G

creatine kinase, M-type

multiple interactions
increases secretion
decreases expression

[Clarithromycin co-treated with Simvastatin] results in increased expression of CKM protein
carvacrol inhibits the reaction [Simvastatin results in increased secretion of CKM protein]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CKM protein]]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CKM protein]
Simvastatin results in decreased expression of CKM protein

PMID:8611662 PMID:19252767 PMID:29071762 PMID:35762198

NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875

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chloride voltage-gated channel 3

multiple interactions
decreases expression

Simvastatin inhibits the reaction [EDN1 protein results in increased expression of CLCN3 protein]
Simvastatin results in decreased expression of CLCN3 protein

NCBI chr 4:169,620,578...169,723,673
Ensembl chr 4:169,612,633...169,723,673

G

claudin 18

multiple interactions

Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CLDN18 mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CLDN18 protein]

NCBI chr 3:137,998,816...138,033,649
Ensembl chr 3:137,998,735...138,033,655

G

claudin 4

multiple interactions

Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CLDN4 mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CLDN4 protein]

NCBI chr 7:73,830,996...73,832,690
Ensembl chr 7:73,799,542...73,832,690

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collagen type XI alpha 1 chain

increases expression

Simvastatin results in increased expression of COL11A1 mRNA

NCBI chr 1:102,876,473...103,108,522
Ensembl chr 1:102,876,467...103,108,872

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collagen type XII alpha 1 chain

increases expression

Simvastatin results in increased expression of COL12A1 mRNA

NCBI chr 6:75,084,326...75,206,053
Ensembl chr 6:75,084,326...75,206,267

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collagen type XIII alpha 1 chain

decreases response to substance

COL13A1 SNP results in decreased susceptibility to Simvastatin

NCBI chr10:69,801,906...69,959,144
Ensembl chr10:69,801,880...69,964,275

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collagen type I alpha 1 chain

multiple interactions
increases expression
decreases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA]; Simvastatin inhibits the reaction [CEBPZ binds to COL1A1 promoter]; Simvastatin inhibits the reaction [SP1 binds to COL1A1 promoter]
Simvastatin results in increased expression of COL1A1 mRNA

PMID:10412775 PMID:14973129 PMID:16274305 PMID:16575855 PMID:17252541 More...

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

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collagen type II alpha 1 chain

multiple interactions
increases expression

Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA]; NOG inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA]

PMID:18628692 PMID:19912653

NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554

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collagen type III alpha 1 chain

increases expression
decreases expression

Simvastatin results in increased expression of COL3A1 mRNA
Simvastatin results in decreased expression of COL3A1 mRNA

PMID:10412775 PMID:16274305 PMID:16414398 PMID:17183729

NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746

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collagen type IV alpha 1 chain

decreases expression

Simvastatin results in decreased expression of COL4A1 mRNA

NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157

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collagen type V alpha 1 chain

increases expression

Simvastatin results in increased expression of COL5A1 mRNA

NCBI chr 9:134,641,803...134,844,843
Ensembl chr 9:134,641,803...134,844,843

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collagen type VI alpha 2 chain

increases expression

Simvastatin results in increased expression of COL6A2 mRNA

NCBI chr21:46,098,112...46,132,848
Ensembl chr21:46,098,112...46,132,848

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collagen type VII alpha 1 chain

increases expression

Simvastatin results in increased expression of COL7A1 mRNA

NCBI chr 3:48,564,073...48,595,329
Ensembl chr 3:48,564,073...48,595,329

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coronin 1A

decreases expression

Simvastatin results in decreased expression of CORO1A protein

NCBI chr16:30,183,602...30,189,076
Ensembl chr16:30,182,827...30,189,076

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cAMP responsive element binding protein 1

multiple interactions

Simvastatin inhibits the reaction [OSM results in increased phosphorylation of CREB1 protein]

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

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C-reactive protein

decreases expression
multiple interactions

Simvastatin results in decreased expression of CRP protein
[Ezetimibe co-treated with Simvastatin] results in decreased expression of CRP protein; [Simvastatin co-treated with Ezetimibe] promotes the reaction [Niacin results in decreased expression of CRP protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Simvastatin inhibits the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in increased expression of CRP protein]; Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]; Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]; Simvastatin inhibits the reaction [ethinyl estradiol-desogestrel combination results in increased expression of CRP protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein]

PMID:15184351 PMID:15824212 PMID:17105841 PMID:18023360 PMID:18420099 More...

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

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casein alpha s2 like A, pseudogene

increases expression

Simvastatin results in increased expression of CSN1S2A mRNA

NCBI chr 4:70,067,386...70,085,273
Ensembl chr 4:70,067,386...70,085,290
Ensembl chr 4:70,067,386...70,085,290

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chondroitin sulfate proteoglycan 4

increases expression

Simvastatin results in increased expression of CSPG4 mRNA

NCBI chr15:75,674,322...75,713,466
Ensembl chr15:75,674,322...75,712,848

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cardiotrophin 1

multiple interactions

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of AGT mRNA]; Simvastatin inhibits the reaction [CTF1 results in increased expression of FOS mRNA]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of JAK2 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of STAT3 protein]

PMID:16534557 PMID:18400235 PMID:19100119

NCBI chr16:30,895,846...30,903,560
Ensembl chr16:30,896,614...30,903,547

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cytotoxic T-lymphocyte associated protein 4

decreases expression

Simvastatin results in decreased expression of CTLA4 mRNA

NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965

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catenin alpha like 1

decreases expression

Simvastatin results in decreased expression of CTNNAL1 mRNA

NCBI chr 9:108,942,577...109,013,499
Ensembl chr 9:108,942,569...109,013,522

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catenin beta 1

multiple interactions
increases expression

CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of SP7 protein]
Simvastatin results in increased expression of CTNNB1 protein
Simvastatin inhibits the reaction [Glucose results in decreased expression of CTNNB1 protein]

PMID:18004065 PMID:22058016

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

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cathepsin L

increases expression

Simvastatin results in increased expression of CTSL mRNA

NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469

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cathepsin S

multiple interactions

Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of CTSS mRNA]; Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of CTSS protein]

NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957

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cortactin

affects localization
multiple interactions

Simvastatin affects the localization of CTTN protein
Simvastatin affects the reaction [F2 affects the localization of CTTN protein]

NCBI chr11:70,398,529...70,436,575
Ensembl chr11:70,398,404...70,436,584

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C-X3-C motif chemokine receptor 1

decreases expression

Simvastatin results in decreased expression of CX3CR1 mRNA

NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735

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C-X-C motif chemokine ligand 1

decreases expression

Simvastatin results in decreased expression of CXCL1 mRNA; Simvastatin results in decreased expression of CXCL1 protein

PMID:21330348 PMID:21441352

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

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C-X-C motif chemokine ligand 10

multiple interactions
decreases expression

Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL10 mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL10 protein]
Simvastatin results in decreased expression of CXCL10 mRNA; Simvastatin results in decreased expression of CXCL10 protein

PMID:15187114 PMID:16414398 PMID:17449418 PMID:22305382

NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497

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C-X-C motif chemokine ligand 12

increases expression

Simvastatin results in increased expression of CXCL12

NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493

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C-X-C motif chemokine ligand 16

decreases expression

Simvastatin results in decreased expression of CXCL16 mRNA

NCBI chr17:4,733,533...4,739,928
Ensembl chr17:4,733,533...4,739,928

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C-X-C motif chemokine ligand 2

decreases expression

Simvastatin results in decreased expression of CXCL2 mRNA; Simvastatin results in decreased expression of CXCL2 protein

PMID:21330348 PMID:21441352

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

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C-X-C motif chemokine ligand 8

multiple interactions
decreases expression
decreases secretion

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CXCL8 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CXCL8 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; Simvastatin results in decreased expression of and results in decreased secretion of CXCL8 protein
Simvastatin results in decreased expression of CXCL8 mRNA; Simvastatin results in decreased expression of CXCL8 protein
Simvastatin inhibits the reaction [TNF results in increased expression of CXCL15 mRNA]
Simvastatin results in decreased secretion of CXCL8 protein

PMID:12117737 PMID:16387846 PMID:16511915 PMID:17178392 PMID:18203325 More...

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

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C-X-C motif chemokine receptor 2

decreases expression

Simvastatin results in decreased expression of CXCR2 mRNA

NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251

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C-X-C motif chemokine receptor 4

decreases expression
increases expression

Simvastatin results in decreased expression of CXCR4 mRNA
Simvastatin results in increased expression of CXCR4

PMID:16414398 PMID:19591934

NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177

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cytochrome b-245 alpha chain

affects response to substance

CYBA gene SNP affects the susceptibility to Simvastatin

NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083

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cytochrome b-245 beta chain

multiple interactions

Simvastatin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]

NCBI chr X:37,780,059...37,813,461
Ensembl chr X:37,780,018...37,813,461

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cytochrome P450 family 11 subfamily A member 1

multiple interactions

[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11A1 mRNA; [Simvastatin co-treated with resveratrol] results in decreased expression of CYP11A1 mRNA

PMID:24524197 PMID:25055962

NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646

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cytochrome P450 family 11 subfamily B member 1

multiple interactions

[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B1 mRNA

NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846

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cytochrome P450 family 11 subfamily B member 2

multiple interactions

[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B2 mRNA

NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843

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cytochrome P450 family 17 subfamily A member 1

decreases expression
multiple interactions

Simvastatin results in decreased expression of CYP17A1 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP17A1 mRNA; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]; resveratrol promotes the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]; Simvastatin promotes the reaction [resveratrol results in decreased expression of CYP17A1 mRNA]

PMID:21918126 PMID:24524197 PMID:25055962

NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472

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cytochrome P450 family 1 subfamily A member 1

decreases activity

Simvastatin results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

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cytochrome P450 family 1 subfamily B member 1

decreases activity

Simvastatin results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

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cytochrome P450 family 27 subfamily A member 1

multiple interactions

Simvastatin promotes the reaction [Dietary Fats results in increased expression of CYP27A1 mRNA]

NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293

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cytochrome P450 family 2 subfamily B member 6

increases expression

Simvastatin results in increased expression of CYP2B6 mRNA

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

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cytochrome P450 family 2 subfamily C member 8

decreases activity

Simvastatin results in decreased activity of CYP2C8 protein

NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497

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cytochrome P450 family 2 subfamily C member 9

multiple interactions

Simvastatin affects the reaction [CYP2C9 polymorphism affects the susceptibility to Warfarin]

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

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cytochrome P450 family 2 subfamily D member 6

affects response to substance

CYP2D6 polymorphism affects the susceptibility to Simvastatin

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

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cytochrome P450 family 39 subfamily A member 1

decreases expression

Simvastatin results in decreased expression of CYP39A1 mRNA

NCBI chr 6:46,549,580...46,652,818
Ensembl chr 6:46,549,580...46,652,830

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cytochrome P450 family 3 subfamily A member 4

affects metabolic processing
decreases expression
multiple interactions
decreases activity
increases metabolic processing
affects response to substance
increases expression

CYP3A4 protein affects the metabolism of Simvastatin
Simvastatin results in decreased expression of CYP3A4 mRNA; Simvastatin results in decreased expression of CYP3A4 protein
Berberine promotes the reaction [Simvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased expression of CYP3A4 protein]; Simvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]
CYP3A4 protein results in increased metabolism of Simvastatin
CYP3A4 polymorphism affects the susceptibility to Simvastatin
Simvastatin results in increased expression of CYP3A4 mRNA
[Simvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Simvastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Simvastatin]; telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin]

PMID:12505310 PMID:15650881 PMID:16011971 PMID:17041008 PMID:19802823 More...

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

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cytochrome P450 family 3 subfamily A member 5

affects response to substance

CYP3A5 polymorphism affects the susceptibility to Simvastatin

NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996

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cytochrome P450 family 3 subfamily A member 51, pseudogene

affects response to substance

CYP3A51P gene polymorphism affects the susceptibility to Simvastatin

NCBI chr 7:99,685,024...99,700,120
Ensembl chr 7:99,685,145...99,700,034

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cytochrome P450 family 46 subfamily A member 1

decreases expression

Simvastatin results in decreased expression of CYP46A1 mRNA

NCBI chr14:99,684,298...99,727,301
Ensembl chr14:99,684,298...99,727,301

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cytochrome P450 family 51 subfamily A member 1

increases expression

Simvastatin results in increased expression of CYP51 mRNA

NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803

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cytochrome P450 family 7 subfamily A member 1

multiple interactions

Simvastatin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Simvastatin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 protein]

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

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DBF4-CDC7 kinase regulatory subunit

decreases expression

Simvastatin results in decreased expression of DBF4 mRNA

NCBI chr 7:87,876,493...87,909,553
Ensembl chr 7:87,876,216...87,909,553

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D-box binding PAR bZIP transcription factor

multiple interactions

Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of DBP mRNA]

NCBI chr19:48,630,030...48,637,379
Ensembl chr19:48,630,030...48,637,379

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doublecortin

increases expression

Simvastatin results in increased expression of DCX

NCBI chr X:111,293,779...111,412,192
Ensembl chr X:111,293,779...111,412,429

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dimethylarginine dimethylaminohydrolase 1

decreases expression

Simvastatin results in decreased expression of DDAH1 mRNA

NCBI chr 1:85,318,485...85,578,200
Ensembl chr 1:85,318,481...85,578,363

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diacylglycerol O-acyltransferase 1

increases expression
increases activity

Simvastatin results in increased expression of DGAT1 mRNA
Simvastatin results in increased activity of DGAT1 protein

NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910

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24-dehydrocholesterol reductase

increases expression

Simvastatin results in increased expression of DHCR24
Simvastatin results in increased expression of DHCR24 mRNA
Simvastatin results in increased expression of DHCR24 mRNA; Simvastatin results in increased expression of DHCR24 protein

PMID:21987590 PMID:25055962

NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195

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7-dehydrocholesterol reductase

affects response to substance
affects expression
multiple interactions

DHCR7 mutant form affects the susceptibility to Simvastatin
Simvastatin affects the expression of DHCR7 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of DHCR7 mRNA
Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]
Hydroxychloroquine affects the reaction [Simvastatin affects the expression of DHCR7 mRNA]; Simvastatin promotes the reaction [DHCR7 results in increased chemical synthesis of Cholesterol]

PMID:15896653 PMID:16446309 PMID:19365639 PMID:25055962 PMID:28975700

NCBI chr11:71,434,411...71,448,393
Ensembl chr11:71,428,193...71,452,868

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diablo IAP-binding mitochondrial protein

affects localization
multiple interactions

Simvastatin affects the localization of DIABLO protein
DIABLO protein promotes the reaction [Simvastatin results in increased activity of CASP9 protein]

NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,668...122,226,062

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dickkopf WNT signaling pathway inhibitor 1

multiple interactions

DKK1 inhibits the reaction [Simvastatin results in increased expression of BGLAP mRNA]; DKK1 inhibits the reaction [Simvastatin results in increased expression of RUNX2 mRNA]; DKK1 inhibits the reaction [Simvastatin results in increased expression of SP7 mRNA]

NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042

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delta like canonical Notch ligand 4

increases expression

Simvastatin results in increased expression of DLL4 mRNA

NCBI chr15:40,929,340...40,939,073
Ensembl chr15:40,929,340...40,939,073

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dynamin 1 like

affects localization
increases expression

Simvastatin affects the localization of DNM1L protein
Simvastatin results in increased expression of DNM1L protein

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

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dopamine receptor D1

multiple interactions
increases expression

SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]]; SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]]; Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]; Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]
Simvastatin results in increased expression of DRD1 mRNA; Simvastatin results in increased expression of DRD1 protein

NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182

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dopamine receptor D2

increases expression

Simvastatin results in increased expression of DRD2 mRNA; Simvastatin results in increased expression of DRD2 protein

NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691

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dentin sialophosphoprotein

increases expression

Simvastatin results in increased expression of DSPP mRNA

NCBI chr 4:87,608,529...87,616,873
Ensembl chr 4:87,608,529...87,616,873

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dual specificity phosphatase 1

decreases expression

Simvastatin results in decreased expression of DUSP1 mRNA; Simvastatin results in decreased expression of DUSP1 protein

NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195

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E2F transcription factor 1

decreases expression

Simvastatin results in decreased expression of E2F1 mRNA

NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385

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ELL associated factor 2

decreases response to substance

EAF2 SNP results in decreased susceptibility to Simvastatin

NCBI chr 3:121,835,209...121,886,526
Ensembl chr 3:121,835,183...121,886,526

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endothelin 1

decreases secretion
decreases expression
multiple interactions

Simvastatin results in decreased secretion of EDN1 protein
Simvastatin results in decreased expression of EDN1 mRNA
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein]; Simvastatin results in increased expression of and results in increased secretion of EDN1 protein
Simvastatin results in decreased expression of EDN1 mRNA; Simvastatin results in decreased expression of EDN1 protein
Simvastatin inhibits the reaction [EDN1 protein results in increased expression of CLCN3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]

PMID:16375908 PMID:18390205 PMID:19099753 PMID:20369390 PMID:20644009 More...

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

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endothelin receptor type A

multiple interactions

Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA]

PMID:19505368 PMID:22022327

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

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epidermal growth factor receptor

multiple interactions

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

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early growth response 1

decreases expression

Simvastatin results in decreased expression of EGR1 protein

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

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eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation
multiple interactions

Simvastatin results in decreased phosphorylation of EIF4EBP1 protein
IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of EIF4EBP1 protein]

PMID:22144680 PMID:27734117

NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365

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enolase 1

decreases expression

Simvastatin results in decreased expression of ENO1 protein

NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190

G

ectonucleoside triphosphate diphosphohydrolase 1

multiple interactions

Simvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein]

NCBI chr10:95,694,186...95,877,266
Ensembl chr10:95,711,779...95,877,266

G

EPH receptor A3

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA

NCBI chr 3:89,107,621...89,482,134
Ensembl chr 3:89,107,621...89,482,134

G

EPH receptor A8

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA

NCBI chr 1:22,563,489...22,603,595
Ensembl chr 1:22,563,489...22,603,595

G

erythropoietin

multiple interactions

Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPO protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]

NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700

G

erythropoietin receptor

multiple interactions

Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPOR protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]

NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342

G

coagulation factor II, thrombin

multiple interactions
decreases activity

Cycloheximide inhibits the reaction [Simvastatin results in decreased activity of F2 protein]; Simvastatin affects the reaction [F2 affects the localization of CTTN protein]; Simvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein]

PMID:12067895 PMID:14630613

NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506

G

coagulation factor III, tissue factor

multiple interactions
decreases activity
decreases expression
affects response to substance
increases expression

geranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]
Simvastatin results in decreased activity of F3 protein
F3 polymorphism affects the susceptibility to Simvastatin
Simvastatin results in increased expression of F3 mRNA; Simvastatin results in increased expression of F3 protein
Simvastatin results in decreased expression of F3; Simvastatin results in decreased expression of F3 mRNA; Simvastatin results in decreased expression of F3 protein

PMID:9081680 PMID:10830219 PMID:12753293 PMID:12818400 PMID:15824212 More...

NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759

G

fatty acid synthase

increases expression

Simvastatin results in increased expression of FASN mRNA

PMID:11728391 PMID:12056585

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

F-box protein 32

increases expression
multiple interactions

Simvastatin results in increased expression of FBXO32 mRNA; Simvastatin results in increased expression of FBXO32 protein
FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]

PMID:19001041 PMID:25300705 PMID:27734117 PMID:33034787

NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206

G

farnesyl-diphosphate farnesyltransferase 1

increases expression
multiple interactions
increases activity

Simvastatin results in increased expression of FDFT1 protein
Simvastatin results in increased expression of FDFT1 mRNA
resveratrol inhibits the reaction [Simvastatin results in increased expression of FDFT1 mRNA]
Simvastatin results in increased activity of FDFT1 protein

PMID:8517861 PMID:12518039 PMID:23386644

NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,395

G

farnesyl diphosphate synthase

increases expression
multiple interactions

Simvastatin results in increased expression of FDPS mRNA
resveratrol inhibits the reaction [Simvastatin results in increased expression of FDPS mRNA]

NCBI chr 1:155,308,866...155,320,665
Ensembl chr 1:155,308,748...155,320,666

G

fibroblast growth factor 19

multiple interactions

Simvastatin inhibits the reaction [Dietary Fats results in increased expression of FGF19 mRNA]

NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022

G

fibroblast growth factor 2

increases expression

Simvastatin results in increased expression of FGF2

NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236

G

FKBP prolyl isomerase 1A

decreases expression

Simvastatin results in decreased expression of FKBP1A mRNA

NCBI chr20:1,368,978...1,393,054
Ensembl chr20:1,368,977...1,393,164

G

FKBP prolyl isomerase 4

increases expression

Simvastatin results in increased expression of FKBP4 mRNA

NCBI chr12:2,794,970...2,805,423
Ensembl chr12:2,794,970...2,805,423

G

flotillin 1

decreases expression

Simvastatin results in decreased expression of FLOT1 protein

NCBI chr 6:30,727,709...30,742,687
Ensembl chr 6:30,727,709...30,742,732

G

fms related receptor tyrosine kinase 1

multiple interactions
increases expression

Simvastatin inhibits the reaction [Streptozocin results in increased expression of FLT1 mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein]
Simvastatin results in increased expression of FLT1 mRNA

PMID:19109527 PMID:20821229

NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145

G

fibronectin 1

decreases expression
increases expression

Simvastatin results in decreased expression of FN1 mRNA
Simvastatin results in increased expression of FN1 mRNA

PMID:10412775 PMID:15855201 PMID:16274305 PMID:16414398

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
decreases localization

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA]
Simvastatin inhibits the reaction [CTF1 results in increased expression of FOS mRNA]
FOS inhibits the reaction [Simvastatin results in increased expression of IL12B mRNA]; Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FOS protein]
Simvastatin results in decreased localization of FOS protein

PMID:12753293 PMID:12963647 PMID:15187114 PMID:16005304 PMID:19100119

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]

NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Simvastatin results in increased expression of FOSL1 protein

NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions

Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]

NCBI chr 2:28,392,858...28,417,317
Ensembl chr 2:28,392,448...28,417,317

G

forkhead box O1

affects localization
decreases phosphorylation
multiple interactions
decreases localization
increases phosphorylation

Simvastatin affects the localization of FOXO1 protein
Simvastatin results in decreased phosphorylation of FOXO1 protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein]
Simvastatin results in decreased localization of FOXO1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased localization of FOXO1 protein]
Simvastatin results in increased phosphorylation of FOXO1 protein

PMID:12438947 PMID:18826357 PMID:19001041 PMID:33034787

NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641

G

forkhead box O3

multiple interactions
affects localization
decreases phosphorylation
decreases expression
increases phosphorylation

Acetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein]; IGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein]
Simvastatin results in decreased phosphorylation of FOXO3 protein
Simvastatin results in decreased expression of FOXO3 protein

PMID:19001041 PMID:20883752 PMID:27734117

NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774

G

forkhead box P3

increases expression
decreases expression
affects methylation
multiple interactions

Simvastatin results in increased expression of FOXP3
Simvastatin results in decreased expression of FOXP3 mRNA
Simvastatin affects the methylation of FOXP3 promoter
IL2 affects the reaction [Simvastatin results in increased expression of FOXP3]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of FOXP3]

PMID:20408897 PMID:20491794 PMID:22305382

NCBI chr X:49,250,438...49,264,710
Ensembl chr X:49,250,438...49,264,800

G

follistatin

multiple interactions

FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of MTOR protein]; FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 protein]; FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 protein]; FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD2 protein]; FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD3 protein]

NCBI chr 5:53,480,629...53,487,134
Ensembl chr 5:53,480,626...53,487,134

G

frizzled class receptor 2

increases expression

Simvastatin results in increased expression of FZD2 mRNA

NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Simvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA

NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

Simvastatin results in decreased expression of GAPDH mRNA

NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374

G

GATA binding protein 6

increases expression

Simvastatin results in increased expression of GATA6 mRNA; Simvastatin results in increased expression of GATA6 protein

NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528

G

GDP dissociation inhibitor 2

decreases expression

Simvastatin results in decreased expression of GDI2 protein

NCBI chr10:5,765,223...5,813,434
Ensembl chr10:5,765,223...5,842,132

G

glial cell derived neurotrophic factor

increases expression

Simvastatin results in increased expression of GDNF

NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041

G

GDNF family receptor alpha 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA

NCBI chr10:116,056,925...116,274,705
Ensembl chr10:116,056,925...116,276,803

G

gap junction protein alpha 1

multiple interactions

GJA1 protein affects the reaction [Simvastatin results in increased susceptibility to Etoposide]; Simvastatin affects the localization of and results in decreased phosphorylation of GJA1 protein

NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727

G

gap junction protein beta 2

increases expression

Simvastatin results in increased expression of GJB2 mRNA

NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938

G

galactosidase beta 1

multiple interactions

Simvastatin inhibits the reaction [Coal Ash results in increased expression of GLB1 protein]

NCBI chr 3:32,961,108...33,097,146
Ensembl chr 3:32,996,609...33,097,202

G

glutathione peroxidase 1

decreases expression
multiple interactions

Simvastatin results in decreased expression of GPX1 mRNA
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]

PMID:20883752 PMID:28734741

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutathione peroxidase 2

increases expression

Simvastatin results in increased expression of GPX2 mRNA

NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746

G

glycogen synthase kinase 3 beta

increases expression
multiple interactions

Simvastatin results in increased expression of GSK3B
Simvastatin results in increased expression of GSK3B protein modified form
Simvastatin inhibits the reaction [Glucose results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of GSK3B protein]

PMID:18004065 PMID:18047562 PMID:19461118

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

glutathione S-transferase pi 1

multiple interactions

Simvastatin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

H2A.X variant histone

increases phosphorylation

Simvastatin results in increased phosphorylation of H2AX protein

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

hes family bHLH transcription factor 5

increases expression

Simvastatin results in increased expression of HES5 mRNA

NCBI chr 1:2,528,745...2,530,263
Ensembl chr 1:2,528,745...2,530,263

G

hypoxia inducible factor 1 subunit alpha

increases expression
decreases expression
multiple interactions

Simvastatin results in increased expression of HIF1A protein
Simvastatin results in decreased expression of HIF1A mRNA
HIF1A mutant form inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]

PMID:18356691 PMID:21844074

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

major histocompatibility complex, class II, DM alpha

decreases expression

Simvastatin results in decreased expression of RT1-DMA mRNA

NCBI chr 6:32,948,618...32,953,097
Ensembl chr 6:32,948,613...32,969,094

G

major histocompatibility complex, class II, DQ beta 1

affects expression

Simvastatin affects the expression of HLA-DQB1 mRNA

NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383

G

major histocompatibility complex, class II, DR alpha

multiple interactions

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]

NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046

G

major histocompatibility complex, class I, E

affects expression

Simvastatin affects the expression of HLA-E mRNA

NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194

G

major histocompatibility complex, class I, F

affects expression

Simvastatin affects the expression of HLA-F mRNA

NCBI chr 6:29,723,434...29,738,532
Ensembl chr 6:29,722,775...29,738,528

G

high mobility group box 1

multiple interactions

Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA]
[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein]

PMID:20519084 PMID:25412314

NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases response to substance
decreases activity
increases expression
increases activity
multiple interactions
affects response to substance

HMGCR exon alternative form results in decreased susceptibility to Simvastatin
Simvastatin results in decreased activity of HMGCR protein
Simvastatin results in increased expression of HMGCR mRNA; Simvastatin results in increased expression of HMGCR protein
Simvastatin results in increased activity of HMGCR protein
Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]; resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]; resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]; resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; Simvastatin results in increased expression of and results in decreased activity of HMGCR protein; Simvastatin results in increased expression of and results in increased activity of HMGCR protein
Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]
[HMGCR intron polymorphism affects the expression of HMGCR exon alternative form] which results in decreased susceptibility to Simvastatin; [MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to Simvastatin; [Simvastatin co-treated with Ezetimibe] results in increased expression of HMGCR mRNA; HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; Resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]; Resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]; Resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; Simvastatin affects the reaction [Hydroxychloroquine affects the expression of HMGCR mRNA]; Simvastatin results in increased expression of and results in increased activity of HMGCR protein
HMGCR intron polymorphism affects the susceptibility to Simvastatin; HMGCR polymorphism affects the susceptibility to Simvastatin

PMID:1627634 PMID:8517861 PMID:8593127 PMID:9512650 PMID:10357840 More...

NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001

G

heme oxygenase 1

multiple interactions
increases response to substance
increases expression
increases activity
decreases expression
increases stability

[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; [Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]
HMOX1 gene mutant form results in increased susceptibility to Simvastatin
Simvastatin results in increased expression of HMOX1 mRNA; Simvastatin results in increased expression of HMOX1 protein
Simvastatin results in increased activity of HMOX1 protein
Simvastatin results in decreased expression of HMOX1 mRNA
Simvastatin results in increased stability of HMOX1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased stability of HMOX1 mRNA]; MAPK1 promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; [Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; tin protoporphyrin IX inhibits the reaction [Simvastatin results in increased expression of HMOX1 protein]

PMID:16375908 PMID:16414398 PMID:16628357 PMID:17928392 PMID:18073186 More...

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

HNF1 homeobox A

increases expression

Simvastatin results in increased expression of HNF1A mRNA

NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512

G

HRas proto-oncogene, GTPase

multiple interactions
decreases activity

Farnesol inhibits the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased prenylation of HRAS protein]; Simvastatin results in decreased prenylation of and results in decreased localization of HRAS protein
Simvastatin results in decreased activity of HRAS

PMID:11914545 PMID:12477733 PMID:18625914 PMID:19360310

NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

[Simvastatin co-treated with resveratrol] results in decreased expression of HSD3B1 mRNA

NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054

G

heat shock transcription factor 1

affects localization

Simvastatin affects the localization of HSF1 protein

NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720

G

heat shock protein 90 alpha family class A member 1

increases expression

Simvastatin results in increased expression of HSP90AA1 protein

NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699

G

heat shock protein family A (Hsp70) member 4

increases expression

Simvastatin results in increased expression of HSPA4 protein

NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449

G

heat shock protein family A (Hsp70) member 5

increases expression

Simvastatin results in increased expression of HSPA5 mRNA; Simvastatin results in increased expression of HSPA5 protein

PMID:18664198 PMID:19253821

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

heat shock protein family A (Hsp70) member 8

decreases expression

Simvastatin results in decreased expression of HSPA8 protein

NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230

G

HtrA serine peptidase 2

affects localization

Simvastatin affects the localization of HTRA2 protein

NCBI chr 2:74,529,405...74,533,556
Ensembl chr 2:74,529,596...74,533,350

G

integrin binding sialoprotein

increases expression

Simvastatin results in increased expression of IBSP mRNA

NCBI chr 4:87,799,554...87,812,435
Ensembl chr 4:87,799,554...87,812,435

G

intercellular adhesion molecule 1

multiple interactions
decreases expression

farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Simvastatin affects the expression of and affects the secretion of ICAM1 protein; Simvastatin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1]; Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]; Vitamin E inhibits the reaction [Simvastatin results in decreased expression of ICAM1 protein modified form]
Simvastatin results in decreased expression of ICAM1 mRNA; Simvastatin results in decreased expression of ICAM1 protein
Simvastatin results in decreased expression of ICAM1 mRNA; Simvastatin results in decreased expression of ICAM1 protein; Simvastatin results in decreased expression of ICAM1 protein modified form

PMID:10946302 PMID:12615677 PMID:14602771 PMID:15234187 PMID:16054375 More...

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

inhibitor of DNA binding 1

increases expression

Simvastatin results in increased expression of ID1 mRNA

NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,605,283...31,606,515

G

isopentenyl-diphosphate delta isomerase 1

increases expression

Simvastatin results in increased expression of IDI1 mRNA

NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,119

G

indoleamine 2,3-dioxygenase 1

increases expression

Simvastatin results in increased expression of IDO1

NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790

G

interferon gamma

multiple interactions
increases secretion
increases expression

IFNG affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IFNG affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IFNG affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CIITA protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of PTGS2]; Simvastatin inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL2 protein]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL3 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL4 mRNA]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of IRF1 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein]; Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]; Simvastatin promotes the reaction [IFNG results in increased expression of PTGS2]
Simvastatin results in increased secretion of IFNG protein
Simvastatin results in increased expression of IFNG mRNA

PMID:11219190 PMID:16321392 PMID:17507688 PMID:18453621 PMID:19589242 More...

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

insulin like growth factor 1

multiple interactions

[Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; IGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of EIF4EBP1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of CASP3 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK3 protein]

PMID:17327694 PMID:27734117

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

insulin like growth factor 1 receptor

decreases expression
multiple interactions
increases expression

Simvastatin results in decreased expression of IGF1R; Simvastatin results in decreased expression of IGF1R mRNA; Simvastatin results in decreased expression of IGF1R protein
[Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]
Simvastatin results in increased expression of IGF1R protein alternative form

PMID:17158816 PMID:17327694 PMID:18489904 PMID:27734117

NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530

G

insulin like growth factor binding protein 6

increases expression

Simvastatin results in increased expression of IGFBP6 mRNA

NCBI chr12:53,097,667...53,102,340
Ensembl chr12:53,097,436...53,102,345

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions
increases phosphorylation
decreases expression

artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]; Simvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of IKBKB protein]
Simvastatin results in decreased expression of IKBKB mRNA

PMID:17277159 PMID:18463201

NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460

G

interleukin 10

increases expression
multiple interactions

Simvastatin results in increased expression of IL10
1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of IL10 protein]]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of IL10 protein]
Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
Simvastatin results in increased expression of IL10 mRNA; Simvastatin results in increased expression of IL10 protein

PMID:15883752 PMID:20491794 PMID:21925249 PMID:33774062

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 12B

multiple interactions
increases expression

FOS inhibits the reaction [Simvastatin results in increased expression of IL12B mRNA]; JUN promotes the reaction [Simvastatin results in increased expression of IL12B mRNA]; Simvastatin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]; Simvastatin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein]; Simvastatin promotes the reaction [Pam(3)CSK(4) peptide results in increased expression of IL12B protein]; Simvastatin promotes the reaction [resiquimod results in increased expression of IL12B protein]

NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863

G

interleukin 13

decreases expression

Simvastatin results in decreased expression of IL13 mRNA; Simvastatin results in decreased expression of IL13 protein

NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110

G

interleukin 16

multiple interactions

[Lipopolysaccharides co-treated with Simvastatin] results in increased expression of IL16 mRNA

NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058

G

interleukin 17A

multiple interactions
decreases secretion
decreases expression

IFNG affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IFNG affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; IL27 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL27 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; IL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL4 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL17A mRNA]

PMID:18453621 PMID:21856936

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 17F

decreases secretion

Simvastatin results in decreased secretion of IL17F protein

NCBI chr 6:52,236,681...52,245,689
Ensembl chr 6:52,236,681...52,245,689

G

interleukin 18

multiple interactions

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]; Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]
Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]

PMID:18660453 PMID:27377765

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 alpha

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]]; Simvastatin inhibits the reaction [IL1A results in decreased expression of NFKBIA protein modified form]; Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]; Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]; Simvastatin inhibits the reaction [IL1A results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]

PMID:15705589 PMID:15728660

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 beta

multiple interactions
decreases secretion
decreases expression

1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]]; Simvastatin affects the reaction [Doxorubicin results in increased expression of IL1B mRNA]; Simvastatin affects the reaction [Doxorubicin results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]
Simvastatin results in decreased secretion of IL1B protein
Simvastatin results in decreased expression of IL1B mRNA; Simvastatin results in decreased expression of IL1B protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Simvastatin affects the reaction [IL1B protein results in increased activity of MMP2 protein]; Simvastatin inhibits the reaction [CCN1 results in increased expression of IL1B]; Simvastatin inhibits the reaction [IL1B protein results in increased activity of MMP9 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [TNF results in increased localization of IL1B protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE mRNA]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of VCAM1 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:10946302 PMID:12829860 PMID:15883752 PMID:16054375 PMID:17075836 More...

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 1 receptor type 2

decreases expression

Simvastatin results in decreased expression of IL1R2 mRNA

NCBI chr 2:101,991,960...102,028,544
Ensembl chr 2:101,991,960...102,028,544

G

interleukin 1 receptor like 1

decreases expression

Simvastatin results in decreased expression of IL1RL1 mRNA

NCBI chr 2:102,311,563...102,352,356
Ensembl chr 2:102,311,502...102,352,037

G

interleukin 2

multiple interactions

IL2 affects the reaction [Simvastatin results in increased expression of FOXP3]

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 20 receptor subunit beta

increases expression

Simvastatin results in increased expression of IL20RB mRNA

NCBI chr 3:136,957,983...137,011,085
Ensembl chr 3:136,946,230...137,011,085

G

interleukin 21

decreases expression
decreases secretion

Simvastatin results in decreased expression of IL21 mRNA
Simvastatin results in decreased secretion of IL21 protein

PMID:18453621 PMID:21856936

NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066

G

interleukin 22

decreases secretion

Simvastatin results in decreased secretion of IL22 protein

NCBI chr12:68,248,242...68,253,604
Ensembl chr12:68,248,242...68,253,604

G

interleukin 23 subunit alpha

decreases expression

Simvastatin results in decreased expression of IL23A mRNA

PMID:18453621 PMID:22305382

NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410

G

interleukin 25

decreases expression

Simvastatin results in decreased expression of IL25 mRNA

NCBI chr14:23,372,809...23,376,403
Ensembl chr14:23,372,809...23,376,403

G

interleukin 27

increases expression
increases secretion
multiple interactions

Simvastatin results in increased expression of IL27 mRNA
Simvastatin results in increased secretion of IL27 protein
IL27 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL27 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL27 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]

NCBI chr16:28,499,362...28,506,834
Ensembl chr16:28,499,362...28,512,051

G

interleukin 2 receptor subunit alpha

affects expression
decreases expression

Simvastatin affects the expression of IL2RA protein
Simvastatin results in decreased expression of IL2RA mRNA

PMID:16387846 PMID:18453621

NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370

G

interleukin 4

multiple interactions
decreases expression
increases secretion
increases expression

IL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL4 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL4 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]
Simvastatin results in decreased expression of IL4 mRNA; Simvastatin results in decreased expression of IL4 protein
Simvastatin results in increased secretion of IL4 protein
Simvastatin results in increased expression of IL4 mRNA

PMID:17169357 PMID:18453621

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 4 receptor

decreases expression

Simvastatin results in decreased expression of IL4R mRNA
Simvastatin results in decreased expression of IL4RA mRNA

PMID:16414398 PMID:18453621

NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778

G

interleukin 6

multiple interactions
affects secretion
decreases secretion
decreases expression
increases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL6 mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]; Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; Simvastatin inhibits the reaction [TNF results in increased localization of IL6 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Simvastatin results in decreased expression of and results in decreased secretion of IL6 protein
Simvastatin affects the secretion of IL6 protein
Simvastatin results in decreased secretion of IL6 protein
Simvastatin results in decreased expression of IL6 mRNA; Simvastatin results in decreased expression of IL6 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]
Simvastatin results in increased expression of IL6 mRNA
Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]

PMID:12117737 PMID:15665042 PMID:15883752 PMID:16387846 PMID:16424782 More...

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

inhibin subunit alpha

multiple interactions

[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INHA mRNA

NCBI chr 2:219,572,310...219,575,711
Ensembl chr 2:219,569,162...219,575,711

G

insulin induced gene 2

decreases expression

Simvastatin results in decreased expression of INSIG2 mRNA

NCBI chr 2:118,088,471...118,110,997
Ensembl chr 2:118,088,452...118,110,997

G

insulin like 3

multiple interactions

[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INSL3 mRNA

NCBI chr19:17,816,512...17,821,519
Ensembl chr19:17,816,512...17,821,574

G

interferon regulatory factor 1

multiple interactions

Simvastatin inhibits the reaction [IFNG results in increased expression of IRF1 mRNA]

NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719

G

interferon regulatory factor 4

decreases expression
multiple interactions

Simvastatin results in decreased expression of IRF4 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein]
Simvastatin results in decreased expression of IRF4 mRNA; Simvastatin results in decreased expression of IRF4 protein

PMID:21856936 PMID:33034787

NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443

G

insulin receptor substrate 1

multiple interactions

Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]

NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820

G

integrin subunit alpha L

affects binding
decreases expression
multiple interactions

Simvastatin binds to [ITGAL protein binds to ITGB2 protein]
Simvastatin results in decreased expression of ITGAL mRNA
Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHRM5 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ITGAL]

PMID:12615677 PMID:15041742 PMID:16828882

NCBI chr16:30,472,742...30,523,185
Ensembl chr16:30,472,658...30,523,567

G

integrin subunit alpha M

multiple interactions
decreases expression

Simvastatin results in decreased expression of [ITGAM protein binds to ITGB2 protein]
Simvastatin results in decreased expression of ITGAM mRNA
Simvastatin results in decreased expression of ITGAM mRNA; Simvastatin results in decreased expression of ITGAM protein

PMID:16414398 PMID:21330348 PMID:21441352

NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892

G

integrin subunit beta 1

decreases expression

Simvastatin results in decreased expression of ITGB1 mRNA; Simvastatin results in decreased expression of ITGB1 protein

PMID:17428261 PMID:21874229

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

integrin subunit beta 2

affects binding
decreases expression
multiple interactions

Simvastatin binds to [ITGAL protein binds to ITGB2 protein]
Simvastatin results in decreased expression of ITGB2 mRNA
Simvastatin inhibits the reaction [TNF results in increased expression of ITGB2]
Simvastatin results in decreased expression of [ITGAM protein binds to ITGB2 protein]

PMID:12615677 PMID:15041742 PMID:21330348

NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989

G

integrin subunit beta 3 binding protein

decreases expression

Simvastatin results in decreased expression of ITGB3BP mRNA

NCBI chr 1:63,440,770...63,529,187
Ensembl chr 1:63,440,770...63,593,721

G

integrin subunit beta 4

affects expression
increases expression

Simvastatin affects the expression of ITGB4 mRNA; Simvastatin affects the expression of ITGB4 protein
Simvastatin results in increased expression of ITGB4 mRNA; Simvastatin results in increased expression of ITGB4 protein

PMID:14630613 PMID:19110722

NCBI chr17:75,721,459...75,757,818
Ensembl chr17:75,721,328...75,757,818

G

integrin subunit beta like 1

decreases expression

Simvastatin results in decreased expression of ITGBL1 mRNA

NCBI chr13:101,452,675...101,720,856
Ensembl chr13:101,452,593...101,720,856

G

Janus kinase 1

multiple interactions

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]

NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754

G

Janus kinase 2

multiple interactions
decreases phosphorylation
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of JAK2 protein]
Simvastatin results in decreased phosphorylation of JAK2 protein
Simvastatin results in decreased expression of JAK2 mRNA

PMID:16414398 PMID:16534557 PMID:18400235 PMID:19100119

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases phosphorylation
decreases localization

pyrazolanthrone inhibits the reaction [Simvastatin results in increased phosphorylation of JUN protein]
Simvastatin results in decreased expression of JUN mRNA
Simvastatin results in decreased localization of JUN protein
JUN promotes the reaction [Simvastatin results in increased expression of IL12B mRNA]; Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]; Simvastatin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JUN protein]

PMID:12753293 PMID:12963647 PMID:15187114 PMID:15488325 PMID:17125918

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]

NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315

G

potassium voltage-gated channel subfamily H member 2

decreases localization
multiple interactions
decreases activity

Simvastatin results in decreased localization of KCNH2 protein
Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]

PMID:21525004 PMID:30086269

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

kinase insert domain receptor

increases expression
multiple interactions

Simvastatin results in increased expression of KDR mRNA; Simvastatin results in increased expression of KDR protein
Simvastatin inhibits the reaction [Streptozocin results in increased expression of KDR mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of KDR protein]

PMID:15572054 PMID:19109527 PMID:20821229

NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595

G

killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2

decreases expression

Simvastatin results in decreased expression of KIR2DS2 mRNA

G

KIT proto-oncogene, receptor tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA

NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783

G

KLF transcription factor 10

multiple interactions

[Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]

NCBI chr 8:102,648,784...102,655,725
Ensembl chr 8:102,648,784...102,655,725

G

KLF transcription factor 16

increases expression

Simvastatin results in increased expression of KLF16 mRNA

NCBI chr19:1,852,399...1,876,536
Ensembl chr19:1,852,399...1,863,579

G

KLF transcription factor 2

increases expression
decreases expression
multiple interactions

Simvastatin results in increased expression of KLF2 mRNA
Simvastatin results in decreased expression of KLF2 mRNA
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of KLF2 mRNA]

PMID:17428261 PMID:20493886 PMID:20737288 PMID:22305382

NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,826...16,328,685

G

KLF transcription factor 6

increases expression

Simvastatin results in increased expression of KLF6 mRNA

NCBI chr10:3,775,996...3,785,209
Ensembl chr10:3,775,996...3,785,281

G

killer cell lectin like receptor F1

decreases expression

Simvastatin results in decreased expression of KLRF1 mRNA

NCBI chr12:9,800,052...9,845,005
Ensembl chr12:9,827,481...9,845,007

G

KRAS proto-oncogene, GTPase

decreases prenylation

Simvastatin results in decreased prenylation of KRAS protein

NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936

G

keratin 13

increases expression

Simvastatin results in increased expression of KRT13 mRNA

NCBI chr17:41,500,981...41,505,612
Ensembl chr17:41,500,981...41,505,705

G

keratin 15

increases expression

Simvastatin results in increased expression of KRT15 mRNA

NCBI chr17:41,513,745...41,518,890
Ensembl chr17:41,513,745...41,522,529

G

keratin 17

increases expression

Simvastatin results in increased expression of KRT17 mRNA

NCBI chr17:41,619,442...41,624,575
Ensembl chr17:41,619,442...41,624,842

G

LBH regulator of WNT signaling pathway

increases expression

Simvastatin results in increased expression of LBH mRNA

NCBI chr 2:30,231,534...30,260,028
Ensembl chr 2:30,231,534...30,323,730

G

lipopolysaccharide binding protein

decreases expression

Simvastatin results in decreased expression of LBP mRNA

NCBI chr20:38,346,482...38,377,013
Ensembl chr20:38,346,482...38,377,013

G

lecithin-cholesterol acyltransferase

increases activity
decreases expression

Simvastatin results in increased activity of LCAT protein
Simvastatin results in decreased expression of LCAT mRNA

PMID:21241519 PMID:25055962

NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131

G

low density lipoprotein receptor

multiple interactions
increases expression
increases activity
affects response to substance

[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB; [Simvastatin co-treated with Ezetimibe] results in increased expression of LDLR mRNA; HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]
Simvastatin results in increased expression of LDLR mRNA; Simvastatin results in increased expression of LDLR protein
Simvastatin results in increased activity of LDLR protein
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]
LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin; LDLR mutant form affects the susceptibility to Simvastatin

PMID:1627634 PMID:8457250 PMID:8593127 PMID:9633944 PMID:10208479 More...

NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820

G

lymphoid enhancer binding factor 1

increases expression

Simvastatin results in increased expression of LEF1 mRNA

NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956

G

leptin

multiple interactions
decreases secretion
decreases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]; GGTI 298 inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; GGTI 298 inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]
Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein]
Simvastatin results in decreased expression of LEP mRNA; Simvastatin results in decreased expression of LEP mRNA alternative form

PMID:19254925 PMID:29071762

NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629

G

leptin receptor

affects response to substance

LEPR polymorphism affects the susceptibility to Simvastatin

PMID:14625131 PMID:18854995

NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559

G

luteinizing hormone subunit beta

multiple interactions

Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein]; Simvastatin promotes the reaction [ethinyl estradiol-desogestrel combination results in decreased expression of LHB protein]

NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091

G

LIF interleukin 6 family cytokine

multiple interactions

[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]

NCBI chr22:30,240,453...30,246,759
Ensembl chr22:30,240,453...30,246,759

G

lipopolysaccharide induced TNF factor

decreases expression

Simvastatin results in decreased expression of LITAF mRNA

NCBI chr16:11,547,722...11,640,317
Ensembl chr16:11,547,722...11,636,381

G

lysyl oxidase

decreases expression

Simvastatin results in decreased expression of LOX mRNA

NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,413

G

lipoprotein(a)

multiple interactions

[Niacin co-treated with Simvastatin] results in decreased expression of LPA protein

NCBI chr 6:160,531,482...160,664,275
Ensembl chr 6:160,531,482...160,664,275

G

lipoprotein lipase

decreases expression
increases expression

Simvastatin results in decreased expression of LPL
Simvastatin results in increased expression of LPL protein

PMID:2009092 PMID:19216230

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

LDL receptor related protein 6

decreases expression

Simvastatin results in decreased expression of LRP6 mRNA

NCBI chr12:12,116,025...12,267,044
Ensembl chr12:12,116,025...12,267,044

G

leucine rich repeat containing 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA

NCBI chr 3:46,515,385...46,566,302
Ensembl chr 3:46,515,385...46,606,948

G

lymphotoxin beta

decreases expression

Simvastatin results in decreased expression of LTB mRNA

NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522

G

mitotic arrest deficient 2 like 1

decreases expression

Simvastatin results in decreased expression of MAD2L1 mRNA

NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858

G

microtubule associated protein 1 light chain 3 beta

increases expression
multiple interactions

Simvastatin results in increased expression of MAP1LC3B protein
[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form]

PMID:23817226 PMID:25412314

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

G

mitogen-activated protein kinase kinase kinase 14

decreases expression

Simvastatin results in decreased expression of MAP3K14 mRNA

NCBI chr17:45,263,119...45,317,020
Ensembl chr17:45,263,119...45,317,029

G

mitogen-activated protein kinase kinase kinase 7

multiple interactions

Simvastatin results in decreased activity of [MAP3K7 protein co-treated with TAB1 protein]

NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086

G

mitogen-activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation
decreases activity

[tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK1 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; MAPK1 promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; MAPK1 promotes the reaction [Simvastatin results in increased expression of NFE2L2 mRNA]; MAPK1 promotes the reaction [Simvastatin results in increased expression of NQO1 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
Simvastatin results in decreased phosphorylation of MAPK1 protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK1 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK1 protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of MAPK1 protein
Simvastatin results in increased phosphorylation of MAPK1 protein
Simvastatin results in decreased activity of MAPK1 protein

PMID:17169357 PMID:17327694 PMID:17428261 PMID:17928392 PMID:18047562 More...

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 14

multiple interactions
decreases expression

Simvastatin results in increased phosphorylation of and results in increased activity of MAPK14 protein
Simvastatin results in decreased expression of MAPK14 mRNA

PMID:16414398 PMID:17928392

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation
decreases activity

[tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK3 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Simvastatin results in decreased phosphorylation of MAPK3 protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK3 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK3 protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of MAPK3 protein
Simvastatin results in increased phosphorylation of MAPK3 protein
Simvastatin results in decreased activity of MAPK3 protein

PMID:17169357 PMID:17327694 PMID:17428261 PMID:17928392 PMID:18047562 More...

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions
increases activity

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]
Simvastatin results in increased activity of MAPK8 protein
Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]

PMID:15187114 PMID:18047562 PMID:18310456

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

increases activity

Simvastatin results in increased activity of MAPK9 protein

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

microtubule associated protein tau

affects expression

Simvastatin affects the expression of MAPT

NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334

G

myoglobin

multiple interactions

Simvastatin inhibits the reaction [Poloxamer results in increased secretion of MB protein]

NCBI chr22:35,606,764...35,623,354
Ensembl chr22:35,606,764...35,637,951

G

minichromosome maintenance complex component 4

decreases expression

Simvastatin results in decreased expression of MCM4 mRNA

NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160

G

malate dehydrogenase 1

decreases expression

Simvastatin results in decreased expression of MDH1 protein

NCBI chr 2:63,588,963...63,607,197
Ensembl chr 2:63,588,609...63,607,197

G

MDM2 proto-oncogene

increases phosphorylation
multiple interactions

Simvastatin results in increased phosphorylation of MDM2 protein
Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]]

NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544

G

MER proto-oncogene, tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA

NCBI chr 2:111,898,607...112,029,561
Ensembl chr 2:111,898,607...112,029,561

G

microRNA 221

decreases expression

Simvastatin results in decreased expression of MIR221

NCBI chr X:45,746,157...45,746,266
Ensembl chr X:45,746,157...45,746,266

G

marker of proliferation Ki-67

decreases expression

Simvastatin results in decreased expression of MKI67 protein

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

matrix metallopeptidase 1

multiple interactions
increases expression
decreases secretion
decreases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]
Simvastatin results in increased expression of MMP1 mRNA
Simvastatin results in decreased secretion of MMP1 mRNA; Simvastatin results in decreased secretion of MMP1 protein

PMID:17303772 PMID:17428261 PMID:18625914 PMID:31260663

NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160

G

matrix metallopeptidase 10

increases expression

Simvastatin results in increased expression of MMP10 mRNA

NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628

G

matrix metallopeptidase 12

increases expression

Simvastatin results in increased expression of MMP12 mRNA

NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982

G

matrix metallopeptidase 13

increases expression
multiple interactions

Simvastatin results in increased expression of MMP13 mRNA
Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]

PMID:16274305 PMID:17428261 PMID:31260663

NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732

G

matrix metallopeptidase 2

decreases activity
increases activity
decreases expression
multiple interactions

Simvastatin results in decreased activity of MMP2 protein
Simvastatin results in increased activity of MMP2 protein
Simvastatin results in decreased expression of MMP2 protein
Simvastatin results in decreased expression of MMP2 mRNA
Simvastatin affects the reaction [IL1B protein results in increased activity of MMP2 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]
Simvastatin inhibits the reaction [Monocrotaline results in increased expression of MMP2 mRNA]; Simvastatin results in decreased expression of and results in decreased activity of MMP2 protein

PMID:15210533 PMID:17038636 PMID:17158816 PMID:17169357 PMID:18309148 More...

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 28

increases expression

Simvastatin results in increased expression of MMP28 mRNA

NCBI chr17:35,756,249...35,795,641
Ensembl chr17:35,756,249...35,795,707

G

matrix metallopeptidase 3

decreases expression
multiple interactions

Simvastatin results in decreased expression of MMP3 mRNA
Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]

PMID:16414398 PMID:31260663

NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609

G

matrix metallopeptidase 8

multiple interactions

Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP8 mRNA]

NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050

G

matrix metallopeptidase 9

multiple interactions
increases activity
decreases expression
decreases activity

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased activity of MMP9 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of MMP9 protein]; Simvastatin promotes the reaction [TNF results in increased expression of MMP9 mRNA]
Simvastatin results in increased activity of MMP9 protein
Simvastatin results in decreased expression of MMP9 mRNA; Simvastatin results in decreased expression of MMP9 protein
Simvastatin results in decreased activity of MMP9 protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of MMP9 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased activity of MMP9 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of MMP9 mRNA]; Simvastatin results in decreased expression of and results in decreased activity of MMP9 protein
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of MMP9 protein]

PMID:15107580 PMID:15210533 PMID:15537504 PMID:15728660 PMID:16002570 More...

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

myeloperoxidase

multiple interactions
decreases activity
decreases expression

Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]
1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of MPO protein]]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of MPO protein]
Simvastatin results in decreased activity of MPO protein
Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
Simvastatin results in decreased expression of MPO protein

PMID:15665042 PMID:17038636 PMID:21764683 PMID:33774062

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

muscle RAS oncogene homolog

multiple interactions

Simvastatin inhibits the reaction [Glucose results in increased activity of MRAS protein]; Simvastatin inhibits the reaction [Smoke analog results in increased activity of MRAS protein]

PMID:18569938 PMID:19299917

NCBI chr 3:138,347,648...138,405,535
Ensembl chr 3:138,347,648...138,405,534

G

mitochondrial ribosomal protein S31

decreases response to substance

MRPS31 SNP results in decreased susceptibility to Simvastatin

NCBI chr13:40,729,128...40,771,190
Ensembl chr13:40,729,128...40,771,190

G

myostatin

multiple interactions
increases expression

5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; Simvastatin results in increased expression of and results in increased secretion of MSTN protein
Simvastatin results in increased expression of MSTN mRNA; Simvastatin results in increased expression of MSTN protein

NCBI chr 2:190,055,700...190,062,729
Ensembl chr 2:190,055,700...190,062,729

G

metallothionein 1A

increases expression

Simvastatin results in increased expression of MT1A mRNA

NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087

G

methylenetetrahydrofolate reductase

multiple interactions
increases expression
affects response to substance

Homocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]; Simvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein]
MTHFR gene mutant form inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 mRNA]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 protein]
MTHFR affects the susceptibility to Simvastatin

NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions

Simvastatin results in decreased phosphorylation of MTOR protein
FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of MTOR protein]

PMID:22144680 PMID:33034787

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]; Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]]; Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]

PMID:19024099 PMID:20359552

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

mevalonate diphosphate decarboxylase

increases expression

Simvastatin results in increased expression of MVD mRNA

NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161

G

mevalonate kinase

increases expression
multiple interactions

Simvastatin results in increased expression of MVK mRNA
[MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to Simvastatin; MVK gene mutant form promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]

PMID:12477733 PMID:25055962

NCBI chr12:109,573,272...109,598,125
Ensembl chr12:109,573,255...109,598,125

G

myosin binding protein H

increases expression

Simvastatin results in increased expression of MYBPH mRNA

NCBI chr 1:203,167,811...203,179,214
Ensembl chr 1:203,167,811...203,175,826

G

myosin heavy chain 10

decreases expression

Simvastatin results in decreased expression of MYH10 protein

NCBI chr17:8,474,212...8,630,725
Ensembl chr17:8,474,207...8,631,376

G

myosin heavy chain 6

increases expression

Simvastatin results in increased expression of MYH6 mRNA

NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273

G

myosin light chain 5

increases expression

Simvastatin results in increased expression of MYL5 mRNA

NCBI chr 4:674,542...682,028
Ensembl chr 4:673,580...682,028

G

N-myc downstream regulated 1

decreases expression

Simvastatin results in decreased expression of NDRG1 protein

NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022

G

nuclear paraspeckle assembly transcript 1

increases expression

Simvastatin results in increased expression of NEAT1 mRNA; Simvastatin results in increased expression of NEAT1 mRNA alternative form

NCBI chr11:65,422,798...65,445,540
Ensembl chr11:65,422,774...65,445,540

G

nuclear factor of activated T cells 3

multiple interactions
increases localization
decreases localization

Simvastatin promotes the reaction [NFATC3 protein binds to BCL2 promoter]
Simvastatin results in increased localization of NFATC3 protein
Simvastatin results in decreased localization of NFATC3 protein alternative form

NCBI chr16:68,085,370...68,229,259
Ensembl chr16:68,084,751...68,229,259

G

NFE2 like bZIP transcription factor 2

increases localization
increases expression
multiple interactions

Simvastatin results in increased localization of NFE2L2 protein
Simvastatin results in increased expression of NFE2L2 mRNA
MAPK1 promotes the reaction [Simvastatin results in increased expression of NFE2L2 mRNA]; Simvastatin results in increased expression of and affects the localization of NFE2L2 protein
Mevalonic Acid affects the reaction [Simvastatin results in increased localization of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]]

PMID:17928392 PMID:18787804 PMID:30513525

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear factor kappa B subunit 1

multiple interactions
decreases expression
decreases activity
decreases localization
increases localization

artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of and results in increased activity of NFKB1 protein]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of NFKB1 protein]; Simvastatin results in increased localization of and results in increased activity of NFKB1 protein
Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]]
Simvastatin results in decreased expression of NFKB1 mRNA
Simvastatin results in decreased activity of NFKB1 protein
Simvastatin results in decreased localization of NFKB1 protein

PMID:12753293 PMID:17038636 PMID:17277159 PMID:18463201 PMID:21465237 More...

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

multiple interactions
increases phosphorylation

artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Simvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of NFKBIA protein]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; Simvastatin inhibits the reaction [IL1A results in decreased expression of NFKBIA protein modified form]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of NFKBIA protein]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]]

PMID:15705589 PMID:17075836 PMID:17178392 PMID:17277159 PMID:18073186 More...

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

neuroligin 3

multiple interactions

Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of NLGN3 mRNA]

NCBI chr X:71,144,841...71,175,307
Ensembl chr X:71,144,821...71,175,255

G

NLR family pyrin domain containing 3

multiple interactions

Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of NLRP3 protein]]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of NLRP3 protein]

PMID:30408459 PMID:35762198

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

noggin

multiple interactions

NOG inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA]; NOG inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA]

NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611

G

nitric oxide synthase 2

multiple interactions
decreases expression
increases expression

Simvastatin promotes the reaction [Doxorubicin results in increased expression of NOS2 protein]
Simvastatin results in decreased expression of NOS2 mRNA; Simvastatin results in decreased expression of NOS2 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein]; Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]; Simvastatin inhibits the reaction [IL1A results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of NOS2 mRNA]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]
Simvastatin results in increased expression of NOS2 mRNA; Simvastatin results in increased expression of NOS2 protein
Homocysteine affects the reaction [Simvastatin results in increased expression of NOS2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 mRNA]; MTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]; Simvastatin promotes the reaction [Homocysteine results in increased expression of NOS2 mRNA]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]

PMID:10188333 PMID:11470468 PMID:15705589 PMID:16414398 PMID:17729120 More...

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

nitric oxide synthase 3

increases expression
decreases expression
multiple interactions
increases phosphorylation

Simvastatin results in increased expression of NOS3; Simvastatin results in increased expression of NOS3 mRNA; Simvastatin results in increased expression of NOS3 protein
Simvastatin results in decreased expression of NOS3 mRNA; Simvastatin results in decreased expression of NOS3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; [Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of NOS3 mRNA]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Nifedipine promotes the reaction [Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Simvastatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]
Simvastatin results in increased phosphorylation of NOS3 protein
Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in decreased expression of NOS3 protein]]; Simvastatin inhibits the reaction [Cyclophosphamide results in decreased expression of NOS3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Smoke analog affects the expression of NOS3 mRNA]; Simvastatin results in increased expression of and results in increased phosphorylation of and results in increased activity of NOS3 protein

PMID:10188333 PMID:11470468 PMID:11947894 PMID:12379581 PMID:12406854 More...

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

notch receptor 1

increases cleavage
increases expression

Simvastatin results in increased cleavage of NOTCH1 protein
Simvastatin results in increased expression of NOTCH1 mRNA

NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048

G

notch receptor 4

increases expression

Simvastatin results in increased expression of NOTCH4 mRNA

NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067

G

NPC1 like intracellular cholesterol transporter 1

decreases expression

Simvastatin results in decreased expression of NPC1L1 mRNA

NCBI chr 7:44,512,535...44,541,330
Ensembl chr 7:44,512,535...44,541,330

G

NPHS1 adhesion molecule, nephrin

increases expression

Simvastatin results in increased expression of NPHS1 mRNA

NCBI chr19:35,825,372...35,852,504
Ensembl chr19:35,825,372...35,869,287

G

NPHS2 stomatin family member, podocin

increases expression

Simvastatin results in increased expression of NPHS2 mRNA

NCBI chr 1:179,550,539...179,575,948
Ensembl chr 1:179,550,539...179,575,952

G

natriuretic peptide A

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]
Simvastatin results in decreased expression of NPPA mRNA

PMID:16029635 PMID:16534557

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

natriuretic peptide B

decreases expression

Simvastatin results in decreased expression of NPPB; Simvastatin results in decreased expression of NPPB protein

PMID:16628357 PMID:21124329

NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Simvastatin results in increased expression of NQO1 mRNA; Simvastatin results in increased expression of NQO1 protein
MAPK1 promotes the reaction [Simvastatin results in increased expression of NQO1 mRNA]

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 0 group B member 1

multiple interactions

[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of NR0B1 mRNA

NCBI chr X:30,304,206...30,309,390
Ensembl chr X:30,304,206...30,309,390

G

nuclear receptor subfamily 1 group D member 1

multiple interactions

Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of NR1D1 mRNA]

NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589

G

nuclear receptor subfamily 1 group H member 3

decreases expression

Simvastatin results in decreased expression of NR1H3 mRNA

NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033

G

nuclear receptor subfamily 1 group H member 4

multiple interactions

Simvastatin affects the reaction [Dietary Fats affects the expression of NR1H4 mRNA]; Simvastatin affects the reaction [Dietary Fats affects the expression of NR1H4 protein]

NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414

G

nuclear receptor subfamily 1 group I member 2

increases activity
multiple interactions

Simvastatin results in increased activity of NR1I2 protein
[Simvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Simvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA; [Simvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA; [Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose; [Simvastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; SGK2 mutant form inhibits the reaction [[Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose]; Simvastatin promotes the reaction [NR1I2 protein binds to SGK2 promoter]

PMID:15802384 PMID:17041008 PMID:24204015

NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487

G

nuclear receptor subfamily 1 group I member 3

increases activity

Simvastatin results in increased activity of NR1I3 protein

NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244

G

nuclear receptor subfamily 4 group A member 3

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA]

NCBI chr 9:99,821,885...99,866,891
Ensembl chr 9:99,821,855...99,866,891

G

neuropilin 1

decreases response to substance

NRP1 SNP results in decreased susceptibility to Simvastatin

NCBI chr10:33,177,493...33,334,667
Ensembl chr10:33,177,492...33,336,262

G

NAD(P) dependent steroid dehydrogenase-like

decreases expression

Simvastatin results in decreased expression of NSDHL mRNA

NCBI chr X:152,831,063...152,869,729
Ensembl chr X:152,830,967...152,869,729

G

neurotrophic receptor tyrosine kinase 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA

NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,636...156,881,850

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA

NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751

G

occludin

increases expression

Simvastatin results in increased expression of OCLN

NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104

G

oxidized low density lipoprotein receptor 1

decreases expression

Simvastatin results in decreased expression of OLR1 mRNA

NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138

G

oxysterol binding protein like 1A

decreases expression

Simvastatin results in decreased expression of OSBPL1A mRNA

NCBI chr18:24,162,045...24,397,824
Ensembl chr18:24,162,045...24,397,880

G

oncostatin M

multiple interactions

Simvastatin inhibits the reaction [CCN1 results in increased expression of OSM]; Simvastatin inhibits the reaction [OSM results in increased expression of CCN1 mRNA]; Simvastatin inhibits the reaction [OSM results in increased phosphorylation of CREB1 protein]

NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851

G

prolyl 4-hydroxylase subunit beta

decreases expression

Simvastatin results in decreased expression of P4HB mRNA

NCBI chr17:81,843,166...81,860,535
Ensembl chr17:81,843,159...81,860,856

G

poly(ADP-ribose) polymerase 1

multiple interactions
increases cleavage
decreases cleavage

[Simvastatin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]]; pifithrin inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; Simvastatin inhibits the reaction [Coal Ash results in increased expression of PARP1 protein modified form]; Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]
IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]
Simvastatin inhibits the reaction [Glucose results in increased activity of PARP1 protein]
Simvastatin results in decreased cleavage of PARP1 mRNA

PMID:16054375 PMID:18004065 PMID:20045437 PMID:20464445 PMID:21910007 More...

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

proliferating cell nuclear antigen

decreases expression

Simvastatin results in decreased expression of PCNA mRNA; Simvastatin results in decreased expression of PCNA protein

PMID:17428261 PMID:18824851

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

proprotein convertase subtilisin/kexin type 9

multiple interactions

[Simvastatin co-treated with Ezetimibe] results in increased expression of PCSK9 mRNA

NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852

G

phosphodiesterase 4B

multiple interactions

Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of PDE4B mRNA]

NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579

G

platelet derived growth factor subunit A

decreases expression

Simvastatin results in decreased expression of PDGFA mRNA

NCBI chr 7:497,258...520,700
Ensembl chr 7:497,258...520,296

G

platelet derived growth factor subunit B

decreases expression
decreases activity
multiple interactions

Simvastatin results in decreased expression of PDGFB protein
Simvastatin results in decreased expression of PDGFB mRNA
Simvastatin results in decreased activity of PDGFB protein
Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of PDGFB protein]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]

PMID:8231022 PMID:10412745 PMID:10412775 PMID:15728660 PMID:16373842

NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982

G

platelet derived growth factor receptor alpha

decreases expression

Simvastatin results in decreased expression of PDGFRA mRNA

NCBI chr 4:54,229,293...54,298,245
Ensembl chr 4:54,229,280...54,298,245

G

platelet derived growth factor receptor beta

decreases expression
multiple interactions

Simvastatin results in decreased expression of PDGFRB mRNA
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA

PMID:10412775 PMID:28263720

NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872

G

pyruvate dehydrogenase kinase 2

increases expression

Simvastatin results in increased expression of PDK2 mRNA

NCBI chr17:50,094,737...50,112,152
Ensembl chr17:50,094,737...50,112,152

G

pyruvate dehydrogenase kinase 4

increases expression

Simvastatin results in increased expression of PDK4 mRNA

PMID:19001041 PMID:19262002

NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516

G

platelet and endothelial cell adhesion molecule 1

increases expression

Simvastatin results in increased expression of PECAM1 mRNA

NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776

G

prohibitin 2

decreases expression

Simvastatin results in decreased expression of PHB2 protein

NCBI chr12:6,965,327...6,970,753
Ensembl chr12:6,965,327...6,970,780

G

phosphatidylinositol glycan anchor biosynthesis class C

decreases expression

Simvastatin results in decreased expression of PIGC mRNA

NCBI chr 1:172,441,457...172,444,069
Ensembl chr 1:172,370,189...172,444,086

G

paired like homeodomain 2

decreases expression

Simvastatin results in decreased expression of PITX2 mRNA

NCBI chr 4:110,617,423...110,642,123
Ensembl chr 4:110,617,423...110,642,123

G

protein kinase, membrane associated tyrosine/threonine 1

decreases expression

Simvastatin results in decreased expression of PKMYT1 mRNA

NCBI chr16:2,972,808...2,980,446
Ensembl chr16:2,968,024...2,980,479

G

phospholipase A2 group IIA

multiple interactions

Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of PLA2G2A protein]

NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416

G

phospholipase A2 group VII

multiple interactions

Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G7 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G7 mRNA]

NCBI chr 6:46,704,201...46,735,721
Ensembl chr 6:46,704,201...46,735,693

G

plasminogen activator, tissue type

multiple interactions
decreases expression
increases activity
increases expression

geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT]; Simvastatin inhibits the reaction [TNF results in decreased expression of PLAT]
Simvastatin results in decreased expression of PLAT mRNA
Simvastatin results in increased activity of PLAT protein
Simvastatin results in increased expression of PLAT; Simvastatin results in increased expression of PLAT mRNA; Simvastatin results in increased expression of PLAT protein

PMID:12371961 PMID:12753293 PMID:16414398

NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709

G

plasminogen activator, urokinase

decreases expression

Simvastatin results in decreased expression of PLAU mRNA

NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496

G

phospholipase C gamma 2

increases expression

Simvastatin results in increased expression of PLCG2 mRNA

NCBI chr16:81,779,291...81,962,685
Ensembl chr16:81,779,279...81,962,685

G

polo like kinase 2

decreases expression

Simvastatin results in decreased expression of PLK2 mRNA

NCBI chr 5:58,453,982...58,460,086
Ensembl chr 5:58,453,982...58,460,139

G

procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

decreases expression

Simvastatin results in decreased expression of PLOD3 mRNA

NCBI chr 7:101,205,984...101,217,581
Ensembl chr 7:101,205,977...101,218,420

G

plexin D1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA

NCBI chr 3:129,555,214...129,606,676
Ensembl chr 3:129,555,214...129,606,676

G

phorbol-12-myristate-13-acetate-induced protein 1

affects localization
increases expression
multiple interactions

Simvastatin affects the localization of PMAIP1 protein
Simvastatin results in increased expression of PMAIP1 mRNA; Simvastatin results in increased expression of PMAIP1 protein
pifithrin inhibits the reaction [Simvastatin results in increased expression of PMAIP1 mRNA]

NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305

G

phosphomevalonate kinase

increases expression

Simvastatin results in increased expression of PMVK mRNA

NCBI chr 1:154,924,740...154,942,658
Ensembl chr 1:154,924,740...154,936,719

G

protein O-mannosyltransferase 1

increases expression

Simvastatin results in increased expression of POMT1 mRNA

NCBI chr 9:131,502,918...131,523,799
Ensembl chr 9:131,502,789...131,523,806

G

paraoxonase 1

multiple interactions
increases expression

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA]; PON1 gene polymorphism affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL]; PON1 gene SNP affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL]; PON1 protein affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL]; Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]; Simvastatin results in increased expression of and results in increased activity of PON1 protein; Squalene inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA]

PMID:14500290 PMID:15690306 PMID:16238680

NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532

G

peroxisome proliferator activated receptor alpha

increases expression
multiple interactions

Simvastatin results in increased expression of PPARA mRNA
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of PPARA mRNA]; Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of PPARA protein]; Simvastatin promotes the reaction [Zymosan results in increased expression of PPARA]
PPARA mutant form inhibits the reaction [Simvastatin results in increased expression of SCARB1]; Simvastatin promotes the reaction [TNF results in increased expression of PPARA]

PMID:15234187 PMID:18981156 PMID:19001041 PMID:20835264 PMID:21323892

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

G

peroxisome proliferator activated receptor gamma

multiple interactions
decreases expression

[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 mRNA]; [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 protein]
Simvastatin results in decreased expression of PPARG
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of PPARG mRNA]; Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of PPARG protein]

PMID:15781755 PMID:19216230 PMID:20835264

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

protein phosphatase 1 regulatory subunit 12A

multiple interactions

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]

NCBI chr12:79,773,563...79,935,460
Ensembl chr12:79,773,563...79,935,460

G

protein phosphatase 1 regulatory inhibitor subunit 14A

multiple interactions

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]

NCBI chr19:38,251,237...38,256,374
Ensembl chr19:38,251,237...38,256,532

G

DNA primase subunit 1

decreases expression

Simvastatin results in decreased expression of PRIM1 mRNA

NCBI chr12:56,731,580...56,752,323
Ensembl chr12:56,730,438...56,752,374

G

protein kinase AMP-activated catalytic subunit alpha 1

increases expression

Simvastatin results in increased expression of PRKAA1 mRNA

NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374

G

presenilin 1

increases expression

Simvastatin results in increased expression of PSEN1 mRNA

NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691

G

platelet activating factor receptor

decreases expression

Simvastatin results in decreased expression of PTAFR mRNA

NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936

G

phosphatase and tensin homolog

increases expression

Simvastatin results in increased expression of PTEN mRNA; Simvastatin results in increased expression of PTEN protein

NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930

G

prostaglandin E synthase

multiple interactions
decreases expression

Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES protein]
Simvastatin results in decreased expression of PTGES protein

NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression
increases expression

JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of PTGS2]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Simvastatin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Simvastatin promotes the reaction [Glucose promotes the reaction [AGT protein results in increased expression of PTGS2 mRNA]]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
Simvastatin inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]
Simvastatin results in decreased expression of PTGS2 protein
Simvastatin results in increased expression of PTGS2 mRNA
Simvastatin promotes the reaction [IFNG results in increased expression of PTGS2]

PMID:17038636 PMID:17277159 PMID:17901590 PMID:18612546 PMID:19225232 More...

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

protein tyrosine kinase 2

decreases activity

Simvastatin results in decreased activity of PTK2 protein

NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216

G

paxillin

multiple interactions
decreases phosphorylation
affects localization

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]]; Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of PXN protein]
Simvastatin results in decreased phosphorylation of PXN protein
Simvastatin affects the localization of PXN protein

NCBI chr12:120,210,447...120,265,730
Ensembl chr12:120,210,439...120,265,771

G

Rac family small GTPase 1

multiple interactions
decreases activity
increases activity
decreases expression
increases expression
affects localization

Cholesterol inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RAC1 protein]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]]; Simvastatin affects the localization of and results in decreased activity of RAC1 protein; Simvastatin inhibits the reaction [AGT results in increased activity of RAC1 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased prenylation of RAC1 protein]
Simvastatin results in decreased activity of RAC1 protein
Simvastatin results in increased activity of RAC1 protein
Simvastatin results in decreased expression of RAC1
Simvastatin results in increased expression of RAC1 protein
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of RAC1 protein]
Simvastatin affects the localization of RAC1 protein

PMID:16698853 PMID:17169357 PMID:17303772 PMID:17513949 PMID:18625914 More...

NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967

G

Rac family small GTPase 2

affects localization
decreases activity

Simvastatin affects the localization of RAC2 protein
Simvastatin results in decreased activity of RAC2 protein

PMID:17169357 PMID:20045437

NCBI chr22:37,225,270...37,244,269
Ensembl chr22:37,225,270...37,259,594

G

Rac family small GTPase 3

affects localization

Simvastatin affects the localization of RAC3 protein

NCBI chr17:82,031,678...82,034,204
Ensembl chr17:82,031,678...82,034,204

G

Rac GTPase activating protein 1

decreases expression

Simvastatin results in decreased expression of RACGAP1 mRNA

NCBI chr12:49,989,162...50,033,440
Ensembl chr12:49,976,923...50,033,136

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases activity
multiple interactions

Simvastatin results in decreased activity of RAF1 protein
Simvastatin inhibits the reaction [Streptozocin results in increased expression of RAF1 protein]

PMID:18569938 PMID:19360310

NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201

G

RAP1A, member of RAS oncogene family

decreases prenylation
decreases expression
decreases geranoylation
multiple interactions

Simvastatin results in decreased prenylation of RAP1A protein
Simvastatin results in decreased expression of RAP1A protein alternative form
Simvastatin results in decreased geranoylation of RAP1A protein
Simvastatin results in decreased geranoylation of and results in decreased prenylation of RAP1A protein
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of RAP1A protein]; Simvastatin results in decreased geranoylation of and results in decreased prenylation of RAP1A protein

PMID:20018177 PMID:22120639 PMID:25578243 PMID:37956312

NCBI chr 1:111,542,009...111,716,691
Ensembl chr 1:111,542,218...111,716,691

G

Ras protein specific guanine nucleotide releasing factor 1

affects localization
affects phosphorylation

Simvastatin affects the localization of RASGRF1 protein
Simvastatin affects the phosphorylation of RASGRF1 protein

NCBI chr15:78,959,906...79,090,780
Ensembl chr15:78,959,906...79,090,780

G

RB transcriptional corepressor 1

decreases phosphorylation

Simvastatin results in decreased phosphorylation of RB1 protein

PMID:17928568 PMID:18804536

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression
decreases localization
increases localization

artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of RELA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of RELA protein]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Simvastatin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Simvastatin inhibits the reaction [TNF results in increased localization of RELA protein]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of and results in increased activity of RELA protein]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of RELA protein]; Simvastatin results in increased localization of and results in increased activity of RELA protein
Simvastatin results in decreased expression of RELA protein
Simvastatin results in decreased expression of RELA mRNA; Simvastatin results in decreased expression of RELA protein
Simvastatin results in decreased localization of RELA protein
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; Homocysteine inhibits the reaction [Simvastatin results in decreased expression of RELA protein]; Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]; Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein modified form]; Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein modified form]]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]]; Simvastatin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of RELA protein]

PMID:12753293 PMID:15705589 PMID:16414398 PMID:17038636 PMID:17075836 More...

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

ret proto-oncogene

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA

NCBI chr10:43,077,069...43,130,351
Ensembl chr10:43,077,064...43,130,351

G

resistin

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]; Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]

NCBI chr19:7,669,049...7,670,455
Ensembl chr19:7,669,049...7,670,455

G

replication factor C subunit 5

decreases expression

Simvastatin results in decreased expression of RFC5 mRNA

NCBI chr12:118,016,703...118,041,448
Ensembl chr12:118,013,588...118,033,130

G

regulator of G protein signaling 2

increases expression

Simvastatin results in increased expression of RGS2 mRNA

NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275

G

ras homolog family member A

multiple interactions
decreases prenylation
affects localization
increases expression
increases localization
decreases expression
decreases activity

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]; geranylgeraniol inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased localization of RHOA protein]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; RHOA inhibits the reaction [Simvastatin results in increased expression of SCARB1]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; Simvastatin affects the localization of and results in decreased activity of RHOA protein; Simvastatin inhibits the reaction [geranylgeranyl pyrophosphate affects the localization of RHOA protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]; Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]; Simvastatin results in decreased localization of and results in decreased activity of RHOA protein; Simvastatin results in increased localization of and results in decreased prenylation of RHOA protein
Simvastatin results in decreased prenylation of RHOA protein
Simvastatin affects the localization of RHOA protein
Simvastatin results in increased expression of RHOA protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]
Simvastatin results in increased expression of RHOA mRNA
Simvastatin results in decreased expression of RHOA; Simvastatin results in decreased expression of RHOA protein
geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RHOA protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of RHOA]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]; Simvastatin results in decreased geranoylation of and results in decreased prenylation of RHOA protein

PMID:12477733 PMID:14630613 PMID:15200425 PMID:16005304 PMID:16470222 More...

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

ras homolog family member C

increases expression

Simvastatin results in increased expression of RHOC mRNA

NCBI chr 1:112,701,131...112,707,408
Ensembl chr 1:112,701,127...112,707,434

G

receptor interacting serine/threonine kinase 1

multiple interactions

[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; [Simvastatin co-treated with Metformin] results in increased expression of RIPK1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]]

NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187

G

receptor interacting serine/threonine kinase 3

multiple interactions

[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]]

NCBI chr14:24,336,025...24,339,991
Ensembl chr14:24,336,025...24,340,022

G

RAR related orphan receptor C

multiple interactions
decreases expression

IFNG affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL27 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL4 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RORC mRNA]

NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845

G

ribosomal protein L39

increases expression

Simvastatin results in increased expression of RPL39 mRNA

NCBI chr X:119,786,504...119,791,630
Ensembl chr X:119,786,504...119,791,630

G

ribosomal protein S10

increases expression

Simvastatin results in increased expression of RPS10 mRNA

NCBI chr 6:34,417,454...34,426,069
Ensembl chr 6:34,417,454...34,426,069

G

ribosomal protein S6

multiple interactions
decreases phosphorylation

IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6 protein]

NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions

Simvastatin results in decreased phosphorylation of RPS6KB1 protein
FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]

PMID:27734117 PMID:33034787

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

RUNX family transcription factor 2

increases expression
multiple interactions

Simvastatin results in increased expression of RUNX2
Simvastatin results in increased expression of RUNX2 mRNA
DKK1 inhibits the reaction [Simvastatin results in increased expression of RUNX2 mRNA]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; Simvastatin inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]; Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]

PMID:18310456 PMID:20381859 PMID:20417880 PMID:22058016

NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349

G

ryanodine receptor 2

increases expression

Simvastatin results in increased expression of RYR2 mRNA; Simvastatin results in increased expression of RYR2 protein

NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988

G

S100 calcium binding protein A6

increases expression
multiple interactions

Simvastatin results in increased expression of S100A6 mRNA
Simvastatin results in increased expression of S100A6 mRNA; Simvastatin results in increased expression of S100A6 protein
Simvastatin results in increased expression of and results in increased localization of S100A6 protein

PMID:14973129 PMID:17428261

NCBI chr 1:153,534,599...153,535,991
Ensembl chr 1:153,534,599...153,536,244

G

S100 calcium binding protein A8

increases expression

Simvastatin results in increased expression of S100A8 mRNA

NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073

G

S100 calcium binding protein A9

increases expression

Simvastatin results in increased expression of S100A9 mRNA

NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023

G

sphingosine-1-phosphate receptor 1

increases expression

Simvastatin results in increased expression of S1PR1 mRNA

NCBI chr 1:101,236,899...101,242,313
Ensembl chr 1:101,236,865...101,243,713

G

sphingosine-1-phosphate receptor 3

increases expression
decreases expression

Simvastatin results in increased expression of S1PR3 mRNA
Simvastatin results in decreased expression of S1PR3 mRNA

PMID:18612546 PMID:18981156

NCBI chr 9:88,990,863...89,005,155
Ensembl chr 9:88,990,863...89,005,155

G

SREBF chaperone

affects response to substance

SCAP polymorphism affects the susceptibility to Simvastatin

NCBI chr 3:47,413,681...47,477,127
Ensembl chr 3:47,413,681...47,477,126

G

scavenger receptor class B member 1

multiple interactions
increases expression

PPARA mutant form inhibits the reaction [Simvastatin results in increased expression of SCARB1]; RHOA inhibits the reaction [Simvastatin results in increased expression of SCARB1]
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SCARB1 mRNA; Simvastatin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 mRNA]; Simvastatin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 protein]
Simvastatin results in increased expression of SCARB1; Simvastatin results in increased expression of SCARB1 mRNA; Simvastatin results in increased expression of SCARB1 protein

PMID:18981156 PMID:20025956 PMID:21241519 PMID:25055962 PMID:33383043

NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668

G

syndecan 1

decreases expression

Simvastatin results in decreased expression of SDC1 mRNA

NCBI chr 2:20,200,797...20,225,475
Ensembl chr 2:20,200,797...20,225,433

G

syndecan 4

decreases expression

Simvastatin results in decreased expression of SDC4 mRNA

NCBI chr20:45,325,288...45,348,424
Ensembl chr20:45,325,288...45,348,424

G

selectin E

multiple interactions
affects expression
decreases expression

farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE mRNA]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]; Vitamin E inhibits the reaction [Simvastatin results in decreased expression of SELE protein modified form]
Simvastatin affects the expression of SELE protein

PMID:10946302 PMID:14602771 PMID:16740276 PMID:21994025

NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705

G

selectin P

multiple interactions
decreases expression

Simvastatin inhibits the reaction [staphylococcal alpha-toxin results in increased expression of SELP protein]
Simvastatin results in decreased expression of SELP mRNA

PMID:12379581 PMID:16414398

NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193

G

serpin family E member 1

decreases expression
decreases secretion
decreases activity
multiple interactions

Simvastatin results in decreased expression of SERPINE1 mRNA; Simvastatin results in decreased expression of SERPINE1 protein
Simvastatin results in decreased secretion of SERPINE1 protein
Simvastatin results in decreased activity of SERPINE1 protein
[Simvastatin co-treated with Dexamethasone] results in increased secretion of SERPINE1 protein

PMID:16375908 PMID:16414398 PMID:17513194 PMID:21524281

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

sestrin 2

increases expression

Simvastatin results in increased expression of SESN2 mRNA

NCBI chr 1:28,259,518...28,282,491
Ensembl chr 1:28,259,518...28,282,491

G

sestrin 3

decreases expression

Simvastatin results in decreased expression of SESN3 mRNA

NCBI chr11:95,165,513...95,232,475
Ensembl chr11:95,165,513...95,232,541

G

serum/glucocorticoid regulated kinase 2

multiple interactions

[Simvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA; SGK2 mutant form inhibits the reaction [[Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose]; Simvastatin promotes the reaction [NR1I2 protein binds to SGK2 promoter]

NCBI chr20:43,559,027...43,585,627
Ensembl chr20:43,558,968...43,588,237

G

solute carrier family 10 member 1

decreases expression

Simvastatin results in decreased expression of SLC10A1 mRNA

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

solute carrier family 38 member 4

increases expression

Simvastatin results in increased expression of SLC38A4 mRNA

NCBI chr12:46,764,761...46,832,431
Ensembl chr12:46,764,761...46,832,408

G

solute carrier family 6 member 4

increases activity

Simvastatin results in increased activity of SLC6A4 protein

NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002

G

solute carrier organic anion transporter family member 1B1

multiple interactions
increases response to substance
affects response to substance
decreases activity

[SLCO1B1 SNP results in increased abundance of Lithocholic Acid] which results in increased susceptibility to Simvastatin; [SLCO1B1 SNP results in increased abundance of Taurolithocholic Acid] which results in increased susceptibility to Simvastatin; Simvastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]
SLCO1B1 gene SNP results in increased susceptibility to Simvastatin
SLCO1B1 affects the susceptibility to Simvastatin; SLCO1B1 mutant form affects the susceptibility to Simvastatin; SLCO1B1 polymorphism affects the susceptibility to Simvastatin analog
Simvastatin results in decreased activity of SLCO1B1 protein

PMID:15616150 PMID:17108811 PMID:18650507 PMID:19833260 PMID:21243006 More...

NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796

G

SMAD family member 1

multiple interactions
increases phosphorylation
increases expression

Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD1 protein]]
Simvastatin results in increased phosphorylation of SMAD1 protein
Simvastatin results in increased expression of SMAD1 mRNA

PMID:18310456 PMID:20417880

NCBI chr 4:145,480,770...145,559,176
Ensembl chr 4:145,481,194...145,559,176

G

SMAD family member 2

decreases phosphorylation
increases phosphorylation
multiple interactions
increases expression

Simvastatin results in decreased phosphorylation of SMAD2 protein
Simvastatin results in increased phosphorylation of SMAD2 protein
FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD2 protein]
Simvastatin results in increased expression of SMAD2 mRNA

PMID:18310456 PMID:19659652 PMID:33034787

NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146

G

SMAD family member 3

increases expression
multiple interactions
increases phosphorylation
decreases phosphorylation

Simvastatin results in increased expression of SMAD3 mRNA
FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD3 protein]
Simvastatin results in decreased phosphorylation of SMAD3 protein

PMID:18310456 PMID:19659652 PMID:33034787

NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173

G

SMAD family member 5

multiple interactions

Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]]

NCBI chr 5:136,132,845...136,182,733
Ensembl chr 5:136,132,845...136,188,747

G

SMAD family member 9

multiple interactions

Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD9 protein]]

NCBI chr13:36,844,831...36,920,854
Ensembl chr13:36,844,831...36,920,887

G

sorting nexin 17

decreases expression
multiple interactions

Simvastatin results in decreased expression of SNX17 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SNX17 mRNA

NCBI chr 2:27,370,616...27,377,535
Ensembl chr 2:27,370,496...27,377,535

G

sterol O-acyltransferase 1

increases expression

Simvastatin results in increased expression of SOAT1 mRNA

NCBI chr 1:179,293,797...179,358,680
Ensembl chr 1:179,293,714...179,358,680

G

suppressor of cytokine signaling 3

increases expression

Simvastatin results in increased expression of SOCS3 mRNA

NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077

G

suppressor of cytokine signaling 4

increases expression

Simvastatin results in increased expression of SOCS4 mRNA; Simvastatin results in increased expression of SOCS4 protein

NCBI chr14:55,027,236...55,049,489
Ensembl chr14:55,027,230...55,049,489

G

suppressor of cytokine signaling 7

increases expression

Simvastatin results in increased expression of SOCS7 mRNA

NCBI chr17:38,351,844...38,405,593
Ensembl chr17:38,351,844...38,405,593

G

superoxide dismutase 2

decreases expression

Simvastatin results in decreased expression of SOD2 mRNA

PMID:16414398 PMID:20883752

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

superoxide dismutase 3

multiple interactions

Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]

NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842

G

Sp1 transcription factor

multiple interactions

Simvastatin inhibits the reaction [SP1 binds to COL1A1 promoter]

NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446

G

Sp7 transcription factor

multiple interactions
increases expression

CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of SP7 protein]; DKK1 inhibits the reaction [Simvastatin results in increased expression of SP7 mRNA]
Simvastatin results in increased expression of SP7; Simvastatin results in increased expression of SP7 mRNA; Simvastatin results in increased expression of SP7 protein

PMID:20564244 PMID:22058016

NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315

G

spondin 2

increases expression

Simvastatin results in increased expression of SPON2 mRNA

NCBI chr 4:1,166,932...1,208,844
Ensembl chr 4:1,166,932...1,208,962

G

secreted phosphoprotein 1

decreases expression
increases expression

Simvastatin results in decreased expression of SPP1 mRNA
Simvastatin results in increased expression of SPP1 protein

PMID:12914771 PMID:14601315 PMID:21076490 PMID:21109955 PMID:22058016

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

G

sequestosome 1

multiple interactions

[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein; Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein]

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

sterol regulatory element binding transcription factor 1

increases localization
decreases expression

Simvastatin results in increased localization of SREBF1 protein
Simvastatin results in decreased expression of SREBF1 mRNA

PMID:17655842 PMID:25055962

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

sterol regulatory element binding transcription factor 2

multiple interactions
increases expression

Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]; Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]
Simvastatin results in increased expression of SREBF2 mRNA
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA]; Simvastatin results in increased activity of and results in increased localization of SREBF2 protein
Simvastatin results in increased expression of SREBF2 protein modified form

PMID:12056585 PMID:14500290 PMID:20018177

NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306

G

steroidogenic acute regulatory protein

increases expression
multiple interactions

Simvastatin results in increased expression of STAR mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of STAR mRNA

PMID:24524197 PMID:25055962

NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992

G

signal transducer and activator of transcription 1

multiple interactions
decreases activity
decreases expression
decreases phosphorylation

Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT1 protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]
Simvastatin results in decreased activity of STAT1 protein
Simvastatin results in decreased expression of STAT1 mRNA; Simvastatin results in decreased expression of STAT1 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]; Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]; Simvastatin inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein]

PMID:16534557 PMID:17507688 PMID:18453621 PMID:19886038 PMID:21268089

NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960

G

signal transducer and activator of transcription 3

decreases activity
decreases phosphorylation
multiple interactions
affects expression

Simvastatin results in decreased activity of STAT3 protein
Simvastatin results in decreased phosphorylation of STAT3 protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of STAT3 protein]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein]
Simvastatin affects the expression of STAT3 protein
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT3 protein]

PMID:16534557 PMID:17507688 PMID:18400235 PMID:18453621 PMID:19100119 More...

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

signal transducer and activator of transcription 5A

affects expression

Simvastatin affects the expression of STAT5A protein

NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943

G

signal transducer and activator of transcription 6

affects expression

Simvastatin affects the expression of STAT6 protein

NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139

G

serine/threonine kinase 11

increases phosphorylation

Simvastatin results in increased phosphorylation of STK11 protein

NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431

G

TGF-beta activated kinase 1 (MAP3K7) binding protein 1

multiple interactions

Simvastatin results in decreased activity of [MAP3K7 protein co-treated with TAB1 protein]

NCBI chr22:39,399,780...39,437,132
Ensembl chr22:39,399,778...39,437,060

G

TRAF family member associated NFKB activator

multiple interactions

[Lipopolysaccharides co-treated with Simvastatin] results in increased expression of TANK mRNA

NCBI chr 2:161,136,963...161,236,230
Ensembl chr 2:161,136,908...161,236,230

G

thromboxane A synthase 1

decreases expression
increases expression

Simvastatin results in decreased expression of TBXAS1 mRNA
Simvastatin results in increased expression of TBXAS1 mRNA

PMID:16414398 PMID:20659230

NCBI chr 7:139,778,242...140,020,293
Ensembl chr 7:139,777,051...140,020,325

G

TEK receptor tyrosine kinase

multiple interactions
increases expression

Simvastatin inhibits the reaction [Streptozocin results in increased expression of TEK mRNA]; Simvastatin results in increased expression of and results in increased activity of TEK protein
Simvastatin results in increased expression of TEK; Simvastatin results in increased expression of TEK mRNA

PMID:18544044 PMID:20821229

NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174

G

transferrin

multiple interactions

Simvastatin inhibits the reaction [TNF results in increased expression of TF]

NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641

G

transferrin receptor

affects expression

Simvastatin affects the expression of TFRC protein

NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153

G

transforming growth factor beta 1

multiple interactions
decreases expression
increases activity
increases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of ACTA2 mRNA]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 protein]
Simvastatin results in decreased expression of TGFB1 mRNA; Simvastatin results in decreased expression of TGFB1 protein
Simvastatin results in increased activity of TGFB1 protein
Simvastatin results in increased expression of TGFB1 mRNA
Simvastatin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]

PMID:15298857 PMID:15677772 PMID:15855201 PMID:16320597 PMID:19080365 More...

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

transforming growth factor beta receptor 2

multiple interactions
decreases expression

Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of TGFBR2 mRNA]
Simvastatin results in decreased expression of TGFBR2 mRNA

PMID:16320597 PMID:16373842

NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142

G

thrombomodulin

increases expression
multiple interactions

Simvastatin results in increased expression of THBD mRNA; Simvastatin results in increased expression of THBD protein
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of THBD mRNA]

PMID:14630613 PMID:16375908 PMID:20493886 PMID:20737288

NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672

G

thrombospondin 1

decreases expression

Simvastatin results in decreased expression of THBS1 mRNA

NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of TIMP1 mRNA]

PMID:16414398 PMID:20137537 PMID:22022327

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

TIMP metallopeptidase inhibitor 2

multiple interactions
decreases expression

Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]

NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387

G

toll like receptor 2

increases expression
multiple interactions

Simvastatin results in increased expression of TLR2 protein
Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]

PMID:16387846 PMID:16443229

NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,070...153,706,260

G

toll like receptor 4

increases expression
multiple interactions
decreases expression

Simvastatin results in increased expression of TLR4 protein
Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
Simvastatin results in decreased expression of TLR4 mRNA; Simvastatin results in decreased expression of TLR4 protein

PMID:16387846 PMID:16443229 PMID:19166837

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

transmembrane 7 superfamily member 2

increases expression

Simvastatin results in increased expression of TM7SF2 mRNA

NCBI chr11:65,111,872...65,116,230
Ensembl chr11:65,111,845...65,116,384

G

transmembrane serine protease 2

increases expression

Simvastatin results in increased expression of TMPRSS2 mRNA

NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116

G

tenascin C

decreases expression

Simvastatin results in decreased expression of TNC mRNA

NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207

G

tumor necrosis factor

multiple interactions
affects secretion
decreases secretion
decreases expression
increases expression
increases secretion
decreases activity

geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Simvastatin inhibits the reaction [CCN1 results in increased expression of TNF]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Simvastatin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Simvastatin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Simvastatin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Simvastatin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in decreased expression of PLAT]; Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]; Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1]; Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ITGAL]; Simvastatin inhibits the reaction [TNF results in increased expression of ITGB2]; Simvastatin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of TF]; Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased localization of IL1B protein]; Simvastatin inhibits the reaction [TNF results in increased localization of IL6 protein]; Simvastatin inhibits the reaction [TNF results in increased localization of RELA protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL2 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CXCL8 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of MMP9 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]; Simvastatin promotes the reaction [TNF results in increased expression of MMP9 mRNA]; Simvastatin promotes the reaction [TNF results in increased expression of PPARA]
Simvastatin affects the secretion of TNF protein
Simvastatin results in decreased secretion of TNF protein
Simvastatin results in decreased expression of TNF mRNA; Simvastatin results in decreased expression of TNF protein
Simvastatin results in increased expression of TNF mRNA
Simvastatin results in increased secretion of TNF protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Guanidines inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD1 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD9 protein]]; Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]; Simvastatin inhibits the reaction [TNF results in increased expression of CXCL15 mRNA]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Simvastatin results in decreased activity of TNF; Simvastatin results in decreased activity of TNF protein
1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased secretion of TNF protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Simvastatin inhibits the reaction [Acrolein results in increased secretion of TNF protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]; Simvastatin inhibits the reaction [TNF results in decreased expression of NOS2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of NOS2 mRNA]

PMID:10946302 PMID:12117737 PMID:12615677 PMID:12753293 PMID:12829860 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 11b

increases expression

Simvastatin results in increased expression of TNFRSF11B mRNA

NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885

G

TNF receptor superfamily member 1A

decreases expression

Simvastatin results in decreased expression of TNFRSF1A mRNA

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

G

TNF receptor superfamily member 1B

decreases expression

Simvastatin results in decreased expression of TNFRSF1B mRNA

NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228

G

TNF receptor superfamily member 4

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]
Simvastatin results in decreased expression of TNFRSF4 mRNA; Simvastatin results in decreased expression of TNFRSF4 protein

NCBI chr 1:1,211,340...1,214,153
Ensembl chr 1:1,211,326...1,214,153

G

TNF superfamily member 10

multiple interactions
increases response to substance

[Simvastatin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]]; Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]
TNFSF10 protein results in increased susceptibility to Simvastatin

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

TNF superfamily member 4

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]
Simvastatin results in decreased expression of TNFSF4 mRNA; Simvastatin results in decreased expression of TNFSF4 protein

NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,183,731...173,207,331

G

troponin I3, cardiac type

multiple interactions

Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNNI3 protein]]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNNI3 protein]

NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773

G

tumor protein p53

multiple interactions
increases expression
increases phosphorylation

pifithrin inhibits the reaction [Simvastatin results in increased expression of TP53 protein]; Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]]; Simvastatin promotes the reaction [TP53 protein binds to CD44 promoter]; Simvastatin results in increased expression of and results in increased phosphorylation of TP53 protein
Simvastatin results in increased expression of TP53 mRNA; Simvastatin results in increased expression of TP53 mutant form; Simvastatin results in increased expression of TP53 protein
Simvastatin results in increased phosphorylation of TP53 protein

PMID:15625077 PMID:18804536 PMID:20045437 PMID:21199873

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

tumor protein, translationally-controlled 1

decreases expression

Simvastatin results in decreased expression of TPT1 protein

NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,284

G

T cell receptor alpha locus

decreases expression

Simvastatin results in decreased expression of TRA mRNA

NCBI chr14:21,621,904...22,552,132

G

TNFRSF1A associated via death domain

decreases expression

Simvastatin results in decreased expression of TRADD mRNA

NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909

G

TNF receptor associated factor 2

decreases expression

Simvastatin results in decreased expression of TRAF2 mRNA

NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607

G

tripartite motif containing 63

increases expression
multiple interactions

Simvastatin results in increased expression of TRIM63 mRNA
FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]
Simvastatin results in increased expression of TRIM63 mRNA; Simvastatin results in increased expression of TRIM63 protein

PMID:19001041 PMID:27734117 PMID:33034787

NCBI chr 1:26,051,301...26,067,630
Ensembl chr 1:26,051,301...26,068,436

G

thioredoxin reductase 1

decreases expression

Simvastatin results in decreased expression of TXNRD1 mRNA

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

thymidylate synthetase

decreases expression

Simvastatin results in decreased expression of TYMS mRNA; Simvastatin results in decreased expression of TYMS protein

NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578

G

vasodilator stimulated phosphoprotein

decreases phosphorylation

Simvastatin results in decreased phosphorylation of VASP protein

NCBI chr19:45,507,479...45,526,983
Ensembl chr19:45,506,579...45,526,989

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]]; Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]; Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of VCAM1 protein]; Simvastatin promotes the reaction [ethinyl estradiol-desogestrel combination results in decreased expression of VCAM1 protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of VCAM1 protein]; Vitamin E inhibits the reaction [Simvastatin results in decreased expression of VCAM1 protein modified form]
Simvastatin results in decreased expression of VCAM1 mRNA; Simvastatin results in decreased expression of VCAM1 protein
Simvastatin results in decreased expression of VCAM1 mRNA; Simvastatin results in decreased expression of VCAM1 protein; Simvastatin results in decreased expression of VCAM1 protein modified form

PMID:10946302 PMID:14602771 PMID:15234187 PMID:17105841 PMID:17169357 More...

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

G

vinculin

affects localization

Simvastatin affects the localization of VCL protein

NCBI chr10:73,998,116...74,121,363
Ensembl chr10:73,995,193...74,121,363

G

voltage dependent anion channel 1

decreases expression

Simvastatin results in decreased expression of VDAC1 protein

NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975

G

vitamin D receptor

increases expression

Simvastatin results in increased expression of VDR mRNA

NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048

G

vascular endothelial growth factor A

multiple interactions
increases expression
increases secretion
decreases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]; HIF1A mutant form inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]
Simvastatin inhibits the reaction [Glucose results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
Simvastatin results in increased expression of VEGFA mRNA; Simvastatin results in increased expression of VEGFA protein
Simvastatin results in increased secretion of VEGFA protein
Simvastatin results in increased expression of VEGFA; Simvastatin results in increased expression of VEGFA mRNA
Simvastatin results in decreased expression of VEGFA protein

PMID:15572054 PMID:16424782 PMID:17277159 PMID:18316203 PMID:18356691 More...

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

vimentin

decreases expression

Simvastatin results in decreased expression of VIM protein

PMID:14973129 PMID:15855201

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

von Willebrand factor

increases expression

Simvastatin results in increased expression of VWF mRNA; Simvastatin results in increased expression of VWF protein

NCBI chr12:5,948,877...6,124,670
Ensembl chr12:5,948,877...6,124,770

G

Wnt family member 4

multiple interactions
increases expression

Simvastatin inhibits the reaction [Glucose results in decreased expression of WNT4 mRNA]
Simvastatin results in increased expression of WNT4 protein

NCBI chr 1:22,117,313...22,143,097
Ensembl chr 1:22,117,313...22,143,969

G

Wnt family member 5A

multiple interactions
increases expression

Simvastatin inhibits the reaction [Glucose results in decreased expression of WNT5A mRNA]
Simvastatin results in increased expression of WNT5A mRNA; Simvastatin results in increased expression of WNT5A protein

PMID:18004065 PMID:19968183

NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539

G

X-box binding protein 1

decreases expression

Simvastatin results in decreased expression of XBP1 protein

NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597

G

X-linked inhibitor of apoptosis

decreases expression

Simvastatin results in decreased expression of XIAP mRNA; Simvastatin results in decreased expression of XIAP protein

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

G

zinc finger protein 700

decreases expression

Simvastatin results in decreased expression of CXCL5 mRNA

NCBI chr19:11,925,107...11,950,763
Ensembl chr19:11,925,068...11,950,773

verapamil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 8

multiple interactions

Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr17:68,867,289...68,955,392
Ensembl chr17:68,867,289...68,955,392

G

ATP binding cassette subfamily B member 1

multiple interactions
decreases expression
decreases activity
increases activity
increases transport
affects response to substance
increases expression

[Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] results in decreased activity of ABCB1 protein; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] results in decreased activity of ABCB1 protein; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased transport of N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide; [Verapamil co-treated with kaempferol] results in decreased expression of ABCB1 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of ABCB1 protein; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased export of Topotecan; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylhypaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of mesaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to Doxorubicin; [Verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Cyclosporine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Demecolcine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil results in decreased activity of ABCB1 protein]; Glycyrrhetinic Acid inhibits the reaction [Verapamil results in increased activity of ABCB1 protein]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil results in decreased activity of ABCB1 protein]; Verapamil affects the reaction [ABCB1 protein results in increased export of Tacrolimus]; Verapamil binds to and affects the activity of ABCB1 protein; Verapamil binds to and results in decreased activity of ABCB1 protein; Verapamil inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [ABCB1 protein affects the uptake of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in decreased abundance of Quercetin]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Fluorescent Dyes]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of cyazofamid]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Sulpiride]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Verapamil inhibits the reaction [Acetaminophen results in increased activity of ABCB1 protein]; Verapamil inhibits the reaction [Doxorubicin results in increased activity of ABCB1 protein]; Verapamil inhibits the reaction [Methoxsalen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [tangeretin results in increased activity of ABCB1 protein]; Verapamil inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Verapamil promotes the reaction [ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate]; Verapamil promotes the reaction [galangin results in increased activity of ABCB1 protein]; Verapamil promotes the reaction [kaempferol results in increased activity of ABCB1 protein]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Verapamil promotes the reaction [propiconazole results in decreased activity of ABCB1 protein]; Verapamil promotes the reaction [Quercetin results in increased activity of ABCB1 protein]; Vinblastine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]
Verapamil results in decreased expression of ABCB1A mRNA
Verapamil results in decreased activity of ABCB1 protein; Verapamil results in decreased activity of ABCB1A protein
[Verapamil results in decreased activity of ABCB1 protein] inhibits the reaction [P-glycoprotein inducer and activator TX5 results in increased export of Rhodamine 123]; Verapamil inhibits the reaction [ABCB1 results in decreased susceptibility to Cadmium Chloride]
ABCB1 protein results in increased transport of Verapamil
ABCB1A protein affects the susceptibility to Verapamil
Verapamil results in decreased expression of ABCB1 protein
Verapamil results in increased expression of ABCB1 mRNA
Verapamil analog results in increased activity of ABCB1 protein mutant form; Verapamil results in increased activity of ABCB1 protein
[Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; [Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP7 protein]; Verapamil promotes the reaction [Vanadates results in decreased activity of ABCB1A protein]

PMID:2900677 PMID:7083125 PMID:7476894 PMID:8917702 PMID:10527640 More...

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 4

decreases activity
decreases expression

Verapamil results in decreased activity of ABCB4 protein
Verapamil results in decreased expression of ABCB4 mRNA

PMID:12202523 PMID:28437613 PMID:28552422

NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

affects activity
multiple interactions
decreases activity

Verapamil affects the activity of ABCC1 protein
Verapamil inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]; Verapamil inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]; Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the transport of Glutathione]; Verapamil promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]
Verapamil results in decreased activity of ABCC1 protein
Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]

PMID:7954421 PMID:9334814 PMID:10856430 PMID:11278867 PMID:12485947 More...

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

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ATP binding cassette subfamily C member 2

multiple interactions

Verapamil inhibits the reaction [ABCC2 protein affects the export of 5-carboxyfluorescein diacetate]

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

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ATP binding cassette subfamily C member 3

multiple interactions

Verapamil inhibits the reaction [ABCC3 protein affects the export of 5-carboxyfluorescein diacetate]

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

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ATP binding cassette subfamily C member 6

decreases activity

Verapamil results in decreased activity of ABCC6 protein

NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522

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actin alpha 2, smooth muscle

multiple interactions

Verapamil inhibits the reaction [[Carbon Tetrachloride co-treated with lard co-treated with Ethanol] results in increased expression of ACTA2 protein]

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

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adrenoceptor alpha 1A

multiple interactions
affects binding

[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
Verapamil binds to ADRA1A protein

NCBI chr 8:26,748,150...26,867,379
Ensembl chr 8:26,748,150...26,867,278

G

adrenoceptor alpha 1B

affects binding
multiple interactions

Verapamil binds to ADRA1B protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]

NCBI chr 5:159,865,086...159,989,205
Ensembl chr 5:159,865,080...159,973,012

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adrenoceptor alpha 1D

multiple interactions
affects binding

[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
Verapamil binds to ADRA1D protein

NCBI chr20:4,220,630...4,249,287
Ensembl chr20:4,220,630...4,249,287

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adrenoceptor beta 1

affects response to substance

ADRB1 protein polymorphism affects the susceptibility to Verapamil

NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904

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AKT serine/threonine kinase 1

multiple interactions

Verapamil inhibits the reaction [Thioacetamide results in decreased expression of AKT1 mRNA]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

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aquaporin 1 (Colton blood group)

multiple interactions

Verapamil inhibits the reaction [cobaltous chloride results in increased expression of AQP1 protein]

NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517

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BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Verapamil co-treated with Temozolomide] results in increased expression of BAX mRNA; Temozolomide promotes the reaction [Verapamil results in increased expression of BAX protein]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

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BCL2 apoptosis regulator

multiple interactions
decreases expression

[Temozolomide co-treated with Verapamil] results in decreased expression of BCL2 mRNA; [Temozolomide co-treated with Verapamil] results in decreased expression of BCL2 protein; [Verapamil co-treated with gambogic acid] results in decreased expression of BCL2 protein
Verapamil results in decreased expression of BCL2 mRNA; Verapamil results in decreased expression of BCL2 protein

PMID:24373880 PMID:30003979

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

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calcium voltage-gated channel subunit alpha1 C

increases response to substance
multiple interactions
decreases expression

CACNA1C gene polymorphism results in increased susceptibility to Verapamil
Verapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]
Verapamil results in decreased expression of CACNA1C mRNA; Verapamil results in decreased expression of CACNA1C protein
Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein]

PMID:19791473 PMID:20031608 PMID:27095094

NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950

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calcium voltage-gated channel subunit alpha1 F

multiple interactions

Verapamil inhibits the reaction [CACNA1F protein results in increased transport of Barium]

NCBI chr X:49,205,063...49,233,340
Ensembl chr X:49,205,063...49,233,371

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calcium voltage-gated channel subunit alpha1 H

multiple interactions
decreases expression

Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H protein]
Verapamil results in decreased expression of CACNA1H mRNA; Verapamil results in decreased expression of CACNA1H protein

NCBI chr16:1,153,106...1,221,768
Ensembl chr16:1,153,103...1,224,169

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calcitonin related polypeptide alpha

multiple interactions

Verapamil inhibits the reaction [[Ionomycin co-treated with Lipopolysaccharides] results in increased expression of CALCA protein]; Verapamil inhibits the reaction [Lipopolysaccharides results in increased expression of CALCA mRNA]

NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354

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calcium/calmodulin dependent protein kinase II alpha

multiple interactions

Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]

NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093

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calcium/calmodulin dependent protein kinase IV

multiple interactions

Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]

NCBI chr 5:111,223,583...111,494,886
Ensembl chr 5:111,223,653...111,494,886

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caspase 1

multiple interactions

Verapamil inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Verapamil inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 12 (gene/pseudogene)

multiple interactions

[Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]

NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670

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caspase 3

multiple interactions
increases expression

[Doxorubicin co-treated with Verapamil] results in increased activity of CASP3 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP3 protein; [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
Verapamil results in increased expression of CASP3 mRNA
Verapamil inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]
[Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]

PMID:14527821 PMID:15861398 PMID:18358092 PMID:19631781 PMID:19815060 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

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caspase 7

multiple interactions

[Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP7 protein]

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

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caspase 8

multiple interactions

[Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

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caspase 9

multiple interactions

[Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

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CD44 molecule (IN blood group)

multiple interactions

Verapamil inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CD44 protein binds to Hyaluronic Acid]]; Verapamil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of CD44 protein]
[Verapamil co-treated with kaempferol] results in decreased expression of CD44 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of CD44 protein

PMID:9929743 PMID:35063459

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

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cadherin 1

multiple interactions

Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]

NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537

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class II major histocompatibility complex transactivator

affects expression

Verapamil affects the expression of CIITA mRNA

NCBI chr16:10,866,206...10,943,021
Ensembl chr16:10,866,222...10,943,021

G

clusterin

affects expression

Verapamil affects the expression of CLU protein

NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700

G

collagen type I alpha 1 chain

multiple interactions

Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]
Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]

PMID:27095094 PMID:34217686

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

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collagen type III alpha 1 chain

multiple interactions

Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]

NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746

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cysteine and glycine rich protein 3

decreases localization

Verapamil results in decreased localization of CSRP3 protein

NCBI chr11:19,182,030...19,201,983
Ensembl chr11:19,182,030...19,210,571

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cytochrome P450 family 1 subfamily A member 1

decreases activity

Verapamil results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

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cytochrome P450 family 1 subfamily A member 2

decreases activity

Verapamil results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

decreases activity

Verapamil results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily A member 7

decreases activity

Verapamil results in decreased activity of CYP2A4 protein

NCBI chr19:40,875,439...40,882,231
Ensembl chr19:40,875,439...40,882,752

G

cytochrome P450 family 2 subfamily B member 6

decreases activity

Verapamil results in decreased activity of CYP2B10 protein

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 18

multiple interactions

Verapamil inhibits the reaction [Cyclosporine results in increased expression of CYP2C11 protein]

NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190

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cytochrome P450 family 2 subfamily C member 8

multiple interactions
decreases activity

torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]
Verapamil results in decreased activity of CYP2C29 protein

PMID:15304522 PMID:18420780

NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

Verapamil results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily D member 6

decreases activity

Verapamil results in decreased activity of CYP2D22 protein; Verapamil results in decreased activity of CYP2D6 protein

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions
affects metabolic processing
decreases activity

[Verapamil results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Verapamil inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; Verapamil inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
Verapamil results in decreased activity of CYP3A4 protein

PMID:15286053 PMID:15689501 PMID:15692829 PMID:15860655 PMID:16013069 More...

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

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cytochrome P450 family 3 subfamily A member 43

decreases expression

Verapamil results in decreased expression of CYP3A18 mRNA

NCBI chr 7:99,828,013...99,866,093
Ensembl chr 7:99,828,013...99,866,093

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cytochrome P450 family 3 subfamily A member 5

decreases activity
decreases expression

Verapamil results in decreased activity of CYP3A5 protein
Verapamil results in decreased expression of CYP3A9 mRNA

PMID:15689501 PMID:17973928

NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996

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DNA damage inducible transcript 3

multiple interactions

[Verapamil co-treated with gambogic acid] results in increased expression of DDIT3 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

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dynamin 1 like

multiple interactions
increases phosphorylation

Verapamil inhibits the reaction [bisphenol A affects the localization of DNM1L protein]
Verapamil results in increased phosphorylation of DNM1L protein

PMID:31830493 PMID:34023961

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

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dopamine receptor D1

multiple interactions

Verapamil inhibits the reaction [SCH 23390 binds to DRD1 protein]

NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182

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dopamine receptor D2

multiple interactions

Verapamil inhibits the reaction [Raclopride binds to DRD2 protein]

NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691

G

endothelin 1

multiple interactions

Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB protein]

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

fibronectin 1

multiple interactions

Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

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Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Verapamil results in increased expression of FOS mRNA

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

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ferritin heavy chain 1

multiple interactions

Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]

NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634

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galanin and GMAP prepropeptide

affects expression

Verapamil affects the expression of GAL protein

NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175

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growth associated protein 43

affects expression

Verapamil affects the expression of GAP43 protein

NCBI chr 3:115,623,510...115,721,483
Ensembl chr 3:115,623,510...115,721,490

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GC vitamin D binding protein

affects expression

Verapamil affects the expression of GC protein

NCBI chr 4:71,741,693...71,805,520
Ensembl chr 4:71,741,696...71,804,041

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glial fibrillary acidic protein

multiple interactions
increases expression

Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein]
Verapamil results in increased expression of GFAP mRNA

PMID:21863293 PMID:21879721 PMID:22954530

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

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glutamic--pyruvic transaminase

multiple interactions

Verapamil inhibits the reaction [Thioacetamide results in increased expression of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

gelsolin

affects expression

Verapamil affects the expression of GSN protein

NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843

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hepcidin antimicrobial peptide

multiple interactions

Verapamil promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]

NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143

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heme oxygenase 1

increases expression
multiple interactions

Verapamil results in increased expression of HMOX1 protein
Verapamil inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]

PMID:21525764 PMID:30526075

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

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islet amyloid polypeptide

multiple interactions

Verapamil inhibits the reaction [Glucose results in increased expression of IAPP mRNA]

NCBI chr12:21,354,959...21,379,980
Ensembl chr12:21,354,959...21,379,980

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interleukin 1 alpha

multiple interactions

Verapamil inhibits the reaction [Particulate Matter results in increased expression of IL1A mRNA]

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

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interleukin 6

multiple interactions

Verapamil inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of IL6 protein]

PMID:20682585 PMID:35460826

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

insulin receptor

multiple interactions

Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSR mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSR protein]

NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414

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potassium voltage-gated channel subfamily A member 10

multiple interactions

Verapamil inhibits the reaction [KCNA10 protein results in increased transport of Potassium]

NCBI chr 1:110,517,217...110,519,175
Ensembl chr 1:110,517,217...110,519,175

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potassium voltage-gated channel subfamily A member 3

decreases activity
multiple interactions

Verapamil results in decreased activity of KCNA3 protein
[Verapamil results in decreased activity of KCNA3 protein] which results in decreased import of Thallium

NCBI chr 1:110,653,560...110,674,940
Ensembl chr 1:110,653,560...110,674,940

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potassium voltage-gated channel subfamily D member 3

decreases activity

Verapamil results in decreased activity of KCND3 protein

NCBI chr 1:111,770,662...111,989,668
Ensembl chr 1:111,770,662...111,989,668

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

[Verapamil results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Verapamil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

PMID:15671647 PMID:19583963 PMID:21158687 PMID:21362439 PMID:24052561 More...

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

potassium calcium-activated channel subfamily M regulatory beta subunit 1

affects response to substance

KCNMB1 gene SNP affects the susceptibility to Verapamil

NCBI chr 5:170,374,671...170,389,367
Ensembl chr 5:170,374,671...170,389,634

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LIF interleukin 6 family cytokine

multiple interactions

Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]; Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]

NCBI chr22:30,240,453...30,246,759
Ensembl chr22:30,240,453...30,246,759

G

mitogen-activated protein kinase 1

multiple interactions

Verapamil inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

Verapamil inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

Verapamil inhibits the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK8 protein]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

matrix metallopeptidase 13

multiple interactions

Verapamil promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]

NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732

G

myeloperoxidase

multiple interactions

Verapamil promotes the reaction [Paraquat results in increased activity of MPO protein]

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

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mechanistic target of rapamycin kinase

multiple interactions

Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MTOR mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MTOR protein]

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

myosin binding protein C3

affects response to substance

MYBPC3 protein affects the susceptibility to Verapamil

NCBI chr11:47,331,406...47,352,702
Ensembl chr11:47,331,406...47,352,702

G

myosin heavy chain 7

multiple interactions
decreases expression

Dexamethasone inhibits the reaction [Verapamil results in decreased expression of MYH7 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Verapamil results in decreased expression of MYH7 mRNA]]

NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660

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myosin light chain 2

multiple interactions
decreases expression

[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA; Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]]
Verapamil results in decreased expression of MYL2 mRNA

NCBI chr12:110,910,845...110,921,449
Ensembl chr12:110,910,819...110,921,443

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Nanog homeobox

multiple interactions

[Verapamil co-treated with kaempferol] results in decreased expression of NANOG mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of NANOG protein

NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146

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neurofilament light chain

multiple interactions

Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein]

PMID:21863293 PMID:21879721

NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721

G

neurofilament medium chain

multiple interactions

Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein]

PMID:21863293 PMID:21879721

NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098

G

NFE2 like bZIP transcription factor 2

affects localization
multiple interactions

Verapamil affects the localization of NFE2L2 protein
Verapamil inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]; Verapamil inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]]

PMID:21525764 PMID:30295103 PMID:30526075

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NLR family pyrin domain containing 3

multiple interactions

Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NLRP3 mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NLRP3 protein]

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

natriuretic peptide A

multiple interactions
increases expression
affects secretion

[Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein
Verapamil results in increased expression of NPPA protein
Verapamil affects the secretion of NPPA protein

PMID:1457087 PMID:11996326

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

natriuretic peptide B

multiple interactions

Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB protein]

NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Verapamil inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]]

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 0 group B member 1

multiple interactions
decreases expression

Verapamil promotes the reaction [Cyclic AMP results in decreased expression of NR0B1 mRNA]
Verapamil results in decreased expression of NR0B1 mRNA

NCBI chr X:30,304,206...30,309,390
Ensembl chr X:30,304,206...30,309,390

G

nuclear receptor subfamily 1 group I member 2

increases activity
multiple interactions

Verapamil results in increased activity of NR1I2 protein
[Verapamil results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487

G

nuclear receptor subfamily 3 group C member 1

multiple interactions

Verapamil promotes the reaction [Dexamethasone results in increased activity of NR3C1 protein]

NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512

G

poly(ADP-ribose) polymerase 1

multiple interactions

Verapamil inhibits the reaction [PARP1 gene mutant form results in decreased uptake of Doxorubicin]
[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]

PMID:15861398 PMID:24373880

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

platelet factor 4

decreases expression

Verapamil results in decreased expression of PF4 protein

NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027

G

RNA polymerase I subunit H

multiple interactions

Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [POLR1H protein results in increased secretion of Doxorubicin]

NCBI chr 6:30,060,062...30,064,907
Ensembl chr 6:30,058,899...30,064,909

G

POU class 5 homeobox 1

multiple interactions

[Verapamil co-treated with kaempferol] results in decreased expression of POU5F1 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of POU5F1 protein

NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731

G

pro-platelet basic protein

decreases expression

Verapamil results in decreased expression of PPBP protein

NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190

G

protein phosphatase 3 catalytic subunit beta

multiple interactions

Verapamil inhibits the reaction [bisphenol F results in increased expression of PPP3CB protein]

NCBI chr10:73,436,433...73,496,024
Ensembl chr10:73,436,433...73,496,024

G

prolactin

multiple interactions
increases secretion
increases expression

Verapamil inhibits the reaction [Sulpiride results in increased secretion of PRL protein]; Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein]
Verapamil results in increased secretion of PRL protein
Verapamil results in increased expression of PRL protein

PMID:7851873 PMID:8845563 PMID:8977754 PMID:20595935

NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826

G

ret proto-oncogene

affects expression

Verapamil affects the expression of RET protein

NCBI chr10:43,077,069...43,130,351
Ensembl chr10:43,077,064...43,130,351

G

solute carrier family 11 member 2

multiple interactions

Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]

NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566

G

solute carrier family 19 member 3

multiple interactions

Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]

NCBI chr 2:227,683,763...227,718,028
Ensembl chr 2:227,683,763...227,718,028

G

solute carrier family 22 member 1

multiple interactions

Verapamil inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium]

PMID:21641380 PMID:25466967 PMID:25862123 PMID:27450509 PMID:27989701

NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718

G

solute carrier family 22 member 2

multiple interactions

Verapamil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
Verapamil inhibits the reaction [SLC22A2 protein results in increased uptake of mepiquat]

PMID:21599003 PMID:33639197

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

G

solute carrier family 22 member 3

multiple interactions

Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]

PMID:21641380 PMID:21697722

NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577

G

solute carrier family 22 member 4

multiple interactions

Verapamil inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190

G

solute carrier family 22 member 5

decreases activity

Verapamil results in decreased activity of SLC22A5 protein

NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613

G

solute carrier family 2 member 4

multiple interactions

Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC2A4 mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC2A4 protein]

NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257

G

solute carrier family 47 member 1

multiple interactions
decreases activity

Verapamil inhibits the reaction [SLC47A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium]
Verapamil results in decreased activity of SLC47A1 protein

PMID:22419765 PMID:27450509 PMID:27989701 PMID:31364238

NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034

G

solute carrier family 47 member 2

multiple interactions
decreases activity

Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium]
Verapamil results in decreased activity of SLC47A2 protein

PMID:22419765 PMID:27989701 PMID:28629854 PMID:31364238

NCBI chr17:19,678,317...19,718,979
Ensembl chr17:19,678,288...19,718,979

G

solute carrier organic anion transporter family member 1A2

multiple interactions

Verapamil inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]

NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594

G

SMAD family member 2

multiple interactions

Verapamil inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]

NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146

G

superoxide dismutase 1

multiple interactions

[Verapamil co-treated with Cilostazol] inhibits the reaction [Thioacetamide results in decreased activity of SOD1 protein]; Verapamil inhibits the reaction [Dexamethasone inhibits the reaction [Paraquat results in increased activity of SOD1 protein]]; Verapamil inhibits the reaction [Thioacetamide results in decreased activity of SOD1 protein]

PMID:17015168 PMID:30295103

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

multiple interactions

Verapamil inhibits the reaction [Dexamethasone inhibits the reaction [Paraquat results in increased activity of SOD2 protein]]

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

SRY-box transcription factor 2

multiple interactions

[Verapamil co-treated with kaempferol] results in decreased expression of SOX2 mRNA

NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436

G

steroidogenic acute regulatory protein

multiple interactions

[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein]; N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein]; Verapamil promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA]; Verapamil promotes the reaction [Cyclic AMP results in increased expression of STAR protein]

NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992

G

signal transducer and activator of transcription 3

multiple interactions

Verapamil inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased expression of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

transforming growth factor beta 1

multiple interactions

Verapamil inhibits the reaction [[Carbon Tetrachloride co-treated with lard co-treated with Ethanol] results in increased expression of TGFB1 protein]
Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]

PMID:17223571 PMID:34217686

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

TIMP metallopeptidase inhibitor 1

affects expression
multiple interactions

Verapamil affects the expression of TIMP1 protein
Verapamil inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]

PMID:12388792 PMID:27095094

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

tumor necrosis factor

multiple interactions

Verapamil affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Verapamil inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]
Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of TNF protein]
Verapamil inhibits the reaction [tert-Butylhydroperoxide results in increased secretion of TNF protein]

PMID:15613243 PMID:17092623 PMID:17129690 PMID:17369293 PMID:35460826

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

thyrotropin releasing hormone

multiple interactions

Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein]; Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein]

NCBI chr 3:129,974,720...129,977,935
Ensembl chr 3:129,974,688...129,977,935

G

thyroid stimulating hormone subunit beta

multiple interactions

Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein]

NCBI chr 1:115,029,826...115,034,309
Ensembl chr 1:115,029,826...115,034,302

G

thioredoxin interacting protein

multiple interactions

Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TXNIP mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TXNIP protein]

NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579

G

vimentin

multiple interactions

Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein]
Verapamil inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]

PMID:21863293 PMID:21879721 PMID:34217686

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26034
role	25961
biological role	25929
inhibitor	22521
enzyme inhibitor	22343
EC 3.* (hydrolase) inhibitor	21553
EC 3.4.* (hydrolases acting on peptide bond) inhibitor	4541
EC 3.4.24.* (metalloendopeptidase) inhibitor	861
EC 3.4.24.11 (neprilysin) inhibitor +	16
EC 3.4.24.18 (meprin A) inhibitor +	125
EC 3.4.24.24 (gelatinase A) inhibitor +	9
EC 3.4.24.3 (microbial collagenase) inhibitor +	0
EC 3.4.24.35 (gelatinase B) inhibitor +	5
EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor +	16
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor +	854
GI254023X	0
N-[(benzyloxy)carbonyl]-L-tyrosyl-N-hydroxy-L-leucinamide	0
candoxatril	0
candoxatrilat +	3
Path 2
Term	Annotations
CHEBI ontology	26034
role	25961
biological role	25929
inhibitor	22521
enzyme inhibitor	22343
EC 3.* (hydrolase) inhibitor	21553
EC 3.4.* (hydrolases acting on peptide bond) inhibitor	4541
protease inhibitor	2314
EC 3.4.24.* (metalloendopeptidase) inhibitor	861
EC 3.4.24.11 (neprilysin) inhibitor +	16
EC 3.4.24.18 (meprin A) inhibitor +	125
EC 3.4.24.24 (gelatinase A) inhibitor +	9
EC 3.4.24.3 (microbial collagenase) inhibitor +	0
EC 3.4.24.35 (gelatinase B) inhibitor +	5
EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor +	16
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor +	854
GI254023X	0
N-[(benzyloxy)carbonyl]-L-tyrosyl-N-hydroxy-L-leucinamide	0
candoxatril	0
candoxatrilat +	3

paths to the root