Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:polymyxin
go back to main search page
Accession:CHEBI:59062 term browser browse the term
Definition:Polymyxins are antibiotics with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins are produced by the Gram-positive bacterium Bacillus polymyxa and are selectively toxic for Gram-negative bacteria.
Synonyms:related_synonym: polymixin;   polymycin;   polymyxins


show annotations for term's descendants           Sort by:
 
colistin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP Colistin results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]
CTD PMID:28465020 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein] CTD PMID:28465020, PMID:28842171 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases phosphorylation
multiple interactions
EXP Colistin results in decreased expression of BCL2 protein
Colistin results in increased phosphorylation of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; [Colistin co-treated with Anisomycin] results in increased phosphorylation of BCL2 protein; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]
CTD PMID:28465020, PMID:28842171, PMID:30138604 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
EXP Colistin results in increased expression of BECN1 protein
Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]
CTD PMID:28842171 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; [Colistin co-treated with Anisomycin] results in increased cleavage of CASP3 protein; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Colistin results in increased activity of and results in increased cleavage of CASP3 protein; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:28465020, PMID:28842171, PMID:30138604, PMID:30273961 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions
EXP Colistin results in decreased expression of CAT protein
Colistin results in decreased activity of CAT protein
chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]
CTD PMID:30138604, PMID:30273961 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein] CTD PMID:30138604 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
EXP chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] CTD PMID:30273961 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mrgprx2 MAS related GPR family member X2 multiple interactions
increases response to substance
ISO MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein]
MRGPRX2 protein results in increased susceptibility to Colistin
CTD PMID:31132327 NCBI chr 1:103,743,746...103,760,945
Ensembl chr 1:103,741,503...103,760,913
JBrowse link
G Oga O-GlcNAcase increases secretion
multiple interactions
ISO Colistin results in increased secretion of OGA protein
MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein]
CTD PMID:31132327 NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein CTD PMID:28842171 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Sqstm1 sequestosome 1 increases degradation
multiple interactions
EXP Colistin results in increased degradation of SQSTM1 protein
Anisomycin promotes the reaction [Colistin results in increased degradation of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein]
CTD PMID:28842171 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions
EXP
ISO
Colistin results in increased expression of TNF protein
Colistin results in increased secretion of TNF protein
Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]
CTD PMID:30138604, PMID:31132327 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
EXP Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of TP53 protein] CTD PMID:28842171 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
polymyxin B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein] CTD PMID:26882889 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]] CTD PMID:26882889, PMID:28555929 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases secretion
ISO Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]]; Acetylcysteine promotes the reaction [Polymyxin B results in decreased secretion of CCL3 protein]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL3 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of CCL3 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine results in decreased secretion of CCL3 protein] CTD PMID:26882889, PMID:28555929 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL5 protein]
Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein]
CTD PMID:26882889, PMID:29348435 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein] CTD PMID:26882889 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD80 protein] CTD PMID:14977963 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions
ISO Polymyxin B results in increased expression of CD86 protein
Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein]
Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD86 protein]
CTD PMID:14977963, PMID:15671028, PMID:30944281 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases expression
ISO Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 protein]
Polymyxin B results in decreased expression of CSF2 protein
CTD PMID:31442584 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein]; Polymyxin B promotes the reaction [Cadmium Chloride results in increased expression of CSF3 protein] CTD PMID:26790433 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Polymyxin B co-treated with Particulate Matter] results in increased expression of CXCL1 protein; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CXCL1 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of CXCL1 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]] CTD PMID:26882889, PMID:28555929 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Polymyxin B promotes the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA] CTD PMID:20801209 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP2C11 protein] CTD PMID:18079364 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] CTD PMID:18079364 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Ddx58 DEXD/H-box helicase 58 multiple interactions ISO Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of DDX58 mRNA] CTD PMID:27183587 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO Polymyxin B inhibits the reaction [Alpha-Amanitin results in decreased expression of GAPDH mRNA] CTD PMID:26385100 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] CTD PMID:30891624 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]; Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Polymyxin B inhibits the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]] CTD PMID:28555929 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Polymyxin B inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein] CTD PMID:24080332, PMID:30944281 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of IL10 protein] CTD PMID:14977963 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:26882889 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:9278343, PMID:26882889 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein] CTD PMID:26882889 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL1A mRNA] CTD PMID:21703343 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Polymyxin B inhibits the reaction [Vehicle Emissions results in increased secretion of IL1B protein]
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL1B protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of IL1B mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]
CTD PMID:14993811, PMID:18406506, PMID:26882889, PMID:27393915 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein] CTD PMID:26882889 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]
Polymyxin B results in decreased expression of IL6 protein
Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL6]
Dextran Sulfate inhibits the reaction [Polymyxin B results in decreased expression of IL6 protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of IL6 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]
CTD PMID:8886760, PMID:12185005, PMID:20549640, PMID:21784459, PMID:26882889, PMID:28555929, PMID:31442584 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK1 protein
Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]]; Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]
CTD PMID:15671028, PMID:28555929 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK3 protein
Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]]; Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]
CTD PMID:15671028, PMID:28555929 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]; Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]] CTD PMID:18986645 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein] CTD PMID:30891624 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrgprx2 MAS related GPR family member X2 increases response to substance
multiple interactions
ISO MRGPRX2 protein results in increased susceptibility to Polymyxin B
MRGPRX2 protein affects the reaction [Polymyxin B results in increased secretion of OGA protein]
CTD PMID:31132327 NCBI chr 1:103,743,746...103,760,945
Ensembl chr 1:103,741,503...103,760,913
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein; [Particulate Matter co-treated with Polymyxin B] results in increased secretion of MYD88 protein; MYD88 protein affects the reaction [[Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]] CTD PMID:28555929 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Polymyxin B inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]
Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:12568917, PMID:23500011 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Oga O-GlcNAcase increases secretion
multiple interactions
ISO Polymyxin B results in increased secretion of OGA protein
MRGPRX2 protein affects the reaction [Polymyxin B results in increased secretion of OGA protein]
CTD PMID:31132327 NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Polymyxin B affects the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]] CTD PMID:23500011, PMID:27393915, PMID:28555929 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
increases secretion
ISO
EXP
Dextran Sulfate inhibits the reaction [Polymyxin B results in decreased expression of TNF protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]]; Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]
Polymyxin B results in increased secretion of TNF protein
Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF]
Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Polymyxin B inhibits the reaction [Vehicle Emissions results in increased secretion of TNF protein]
CTD PMID:8886760, PMID:12185005, PMID:18406506, PMID:26882889, PMID:28555929, PMID:29348435, PMID:31132327, PMID:31442584 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          polymyxin 48
            colistimethate 0
            colistimethate A + 0
            colistimethate B + 0
            colistimethate sodium 0
            colistin + 14
            colistin A + 14
            colistin A sodium methanesulfonate + 0
            colistin B + 14
            colistin B sodium methanesulfonate + 0
            polymyxin B1 0
            polymyxin B2 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                peptide 9396
                                                  cyclic peptide 8723
                                                    heterodetic cyclic peptide 1440
                                                      polymyxin 48
                                                        colistimethate 0
                                                        colistimethate A + 0
                                                        colistimethate B + 0
                                                        colistimethate sodium 0
                                                        colistin + 14
                                                        colistin A + 14
                                                        colistin A sodium methanesulfonate + 0
                                                        colistin B + 14
                                                        colistin B sodium methanesulfonate + 0
                                                        polymyxin B1 0
                                                        polymyxin B2 38
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.