CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: methyl isocyanate
Accession: CHEBI:59059
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Definition: The isocyanate that is methane modified by a single isocyanato substituent.
Synonyms: related_synonym: Formula=C2H3NO; InChI=1S/C2H3NO/c1-3-2-4/h1H3; InChIKey=HAMGRBXTJNITHG-UHFFFAOYSA-N; Iso-cyanatomethane; Isocyanate de methyle; MIC; Methyl carbonimide; Methyl isocyanide; Methylcarbylamine; SMILES=CN=C=O; isocyanatomethane
xref: Beilstein:605318; CAS:624-83-9; DrugBank:DB04337; Gmelin:100500
xref_mesh: MESH:C008461
xref: PMID:16091349; PMID:19494520; PMID:24081639; PMID:3622432; PMID:6821040; Reaxys:605318
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Aurka
aurora kinase A
affects expression
ISO
methyl isocyanate affects the expression of AURKA mRNA
CTD
PMID:22223508
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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Aurkb
aurora kinase B
increases expression
ISO
methyl isocyanate results in increased expression of AURKB protein
CTD
PMID:22223508
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Ccne1
cyclin E1
affects expression
ISO
methyl isocyanate affects the expression of CCNE1 protein
CTD
PMID:19513903
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Cdk2
cyclin dependent kinase 2
affects expression increases expression
ISO
methyl isocyanate affects the expression of CDK2 protein methyl isocyanate results in increased expression of CDK2 protein
CTD
PMID:19513903 PMID:22223508
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
affects expression
ISO
methyl isocyanate affects the expression of CDKN1A protein
CTD
PMID:19513903
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Chek1
checkpoint kinase 1
increases expression
ISO
methyl isocyanate results in increased expression of CHEK1 mRNA
CTD
PMID:22223508
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Chek2
checkpoint kinase 2
decreases expression
ISO
methyl isocyanate results in decreased expression of CHEK2 mRNA
CTD
PMID:22223508
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Ifng
interferon gamma
increases expression
ISO
methyl isocyanate results in increased expression of IFNG protein
CTD
PMID:19295137
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
increases expression
ISO
methyl isocyanate results in increased expression of IL10 protein
CTD
PMID:19295137
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il2
interleukin 2
increases expression
ISO
methyl isocyanate results in increased expression of IL2 protein
CTD
PMID:19295137
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il4
interleukin 4
increases expression
ISO
methyl isocyanate results in increased expression of IL4 protein
CTD
PMID:19295137
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Mgmt
O-6-methylguanine-DNA methyltransferase
decreases activity
ISO
methyl isocyanate results in decreased activity of MGMT protein
CTD
PMID:14685775
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Pcnt
pericentrin
increases expression
ISO
methyl isocyanate results in increased expression of PCNT protein
CTD
PMID:22223508
NCBI chr20:12,190,597...12,278,723
Ensembl chr20:12,191,648...12,278,710
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Pot1
protection of telomeres 1
decreases expression
ISO
methyl isocyanate results in decreased expression of POT1A protein
CTD
PMID:22223508
NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042
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Slc4a1
solute carrier family 4 member 1 (Diego blood group)
multiple interactions
EXP
methyl isocyanate binds to and results in increased degradation of SLC4A1 protein
CTD
PMID:8935787
NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
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Tp53
tumor protein p53
affects expression decreases expression
ISO
methyl isocyanate affects the expression of TP53 protein methyl isocyanate results in decreased expression of TRP53 protein
CTD
PMID:19513903 PMID:22223508
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ache
acetylcholinesterase
decreases activity
EXP ISO
Aldicarb results in decreased activity of ACHE protein
CTD
PMID:8134223 PMID:14644616 PMID:16256972 PMID:21251949 PMID:23962483 PMID:27132127 PMID:33844597 More...
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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App
amyloid beta precursor protein
decreases response to substance
ISO
APP protein modified form results in decreased susceptibility to Aldicarb
CTD
PMID:34902447
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
EXP
Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]
CTD
PMID:14644616
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrnb4
cholinergic receptor nicotinic beta 4 subunit
multiple interactions
EXP
Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]
CTD
PMID:14644616
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
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Esr1
estrogen receptor 1
multiple interactions
ISO
Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
CTD
PMID:9126867
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Il2
interleukin 2
decreases response to substance
ISO
Aldicarb results in decreased susceptibility to IL2 protein
CTD
PMID:8349949
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Map2
microtubule-associated protein 2
multiple interactions
ISO
Aldicarb promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA]
CTD
PMID:32949729
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Nefh
neurofilament heavy chain
increases phosphorylation
ISO
Aldicarb results in increased phosphorylation of NEFH protein
CTD
PMID:16256972
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nrxn1
neurexin 1
multiple interactions
ISO
NRXN1 protein affects the reaction [NLG-1 results in increased susceptibility to Aldicarb]; NRXN1 protein affects the reaction [NRX-1 results in decreased susceptibility to Aldicarb]
CTD
PMID:23638761
NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710
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Pax6
paired box 6
multiple interactions
ISO
Aldicarb inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]
CTD
PMID:32949729
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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Pgr
progesterone receptor
multiple interactions
ISO
Aldicarb inhibits the reaction [Progesterone results in increased activity of PGR protein]
CTD
PMID:9126867
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Pon1
paraoxonase 1
multiple interactions
ISO EXP
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb
CTD
PMID:27132127
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Vpreb1a
V-set pre-B cell surrogate light chain 1A
decreases expression
ISO
Aldicarb results in decreased expression of VPREB1 mRNA
CTD
PMID:25424538
NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846
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