CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: methyl isocyanate
Accession: CHEBI:59059
browse the term
Definition: The isocyanate that is methane modified by a single isocyanato substituent.
Synonyms: related_synonym: Formula=C2H3NO; InChI=1S/C2H3NO/c1-3-2-4/h1H3; InChIKey=HAMGRBXTJNITHG-UHFFFAOYSA-N; Iso-cyanatomethane; Isocyanate de methyle; MIC; Methyl carbonimide; Methyl isocyanide; Methylcarbylamine; SMILES=CN=C=O; isocyanatomethane
xref: Beilstein:605318; CAS:624-83-9; DrugBank:DB04337; Gmelin:100500
xref_mesh: MESH:C008461
xref: PMID:16091349; PMID:19494520; PMID:24081639; PMID:3622432; PMID:6821040; Reaxys:605318
G
Aurka
aurora kinase A
affects expression
ISO
methyl isocyanate affects the expression of AURKA mRNA
CTD
PMID:22223508
NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
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Aurkb
aurora kinase B
increases expression
ISO
methyl isocyanate results in increased expression of AURKB protein
CTD
PMID:22223508
NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
G
Ccne1
cyclin E1
affects expression
ISO
methyl isocyanate affects the expression of CCNE1 protein
CTD
PMID:19513903
NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
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Cdk2
cyclin dependent kinase 2
affects expression increases expression
ISO
methyl isocyanate affects the expression of CDK2 protein methyl isocyanate results in increased expression of CDK2 protein
CTD
PMID:19513903 PMID:22223508
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
affects expression
ISO
methyl isocyanate affects the expression of CDKN1A protein
CTD
PMID:19513903
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Chek1
checkpoint kinase 1
increases expression
ISO
methyl isocyanate results in increased expression of CHEK1 mRNA
CTD
PMID:22223508
NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
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Chek2
checkpoint kinase 2
decreases expression
ISO
methyl isocyanate results in decreased expression of CHEK2 mRNA
CTD
PMID:22223508
NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
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Ifng
interferon gamma
increases expression
ISO
methyl isocyanate results in increased expression of IFNG protein
CTD
PMID:19295137
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Il10
interleukin 10
increases expression
ISO
methyl isocyanate results in increased expression of IL10 protein
CTD
PMID:19295137
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il2
interleukin 2
increases expression
ISO
methyl isocyanate results in increased expression of IL2 protein
CTD
PMID:19295137
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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Il4
interleukin 4
increases expression
ISO
methyl isocyanate results in increased expression of IL4 protein
CTD
PMID:19295137
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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Mgmt
O-6-methylguanine-DNA methyltransferase
decreases activity
ISO
methyl isocyanate results in decreased activity of MGMT protein
CTD
PMID:14685775
NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
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Pcnt
pericentrin
increases expression
ISO
methyl isocyanate results in increased expression of PCNT protein
CTD
PMID:22223508
NCBI chr20:12,943,523...13,038,615
Ensembl chr20:12,944,786...13,038,431
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Pot1
protection of telomeres 1
decreases expression
ISO
methyl isocyanate results in decreased expression of POT1A protein
CTD
PMID:22223508
NCBI chr 4:51,888,632...51,946,764
Ensembl chr 4:51,888,634...51,946,715
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Slc4a1
solute carrier family 4 member 1 (Diego blood group)
multiple interactions
EXP
methyl isocyanate binds to and results in increased degradation of SLC4A1 protein
CTD
PMID:8935787
NCBI chr10:90,296,144...90,312,401
Ensembl chr10:90,296,141...90,312,386
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Tp53
tumor protein p53
affects expression decreases expression
ISO
methyl isocyanate affects the expression of TP53 protein methyl isocyanate results in decreased expression of TRP53 protein
CTD
PMID:19513903 PMID:22223508
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Ache
acetylcholinesterase
decreases activity
EXP ISO
Aldicarb results in decreased activity of ACHE protein
CTD
PMID:8134223 PMID:14644616 PMID:16256972 PMID:21251949 PMID:23962483 PMID:27132127
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
EXP
Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]
CTD
PMID:14644616
NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
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Chrnb4
cholinergic receptor nicotinic beta 4 subunit
multiple interactions
EXP
Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]
CTD
PMID:14644616
NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
G
Esr1
estrogen receptor 1
multiple interactions
ISO
Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
CTD
PMID:9126867
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
G
Il2
interleukin 2
decreases response to substance
ISO
Aldicarb results in decreased susceptibility to IL2 protein
CTD
PMID:8349949
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
G
Nefh
neurofilament heavy
increases phosphorylation
ISO
Aldicarb results in increased phosphorylation of NEFH protein
CTD
PMID:16256972
NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
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Nrxn1
neurexin 1
multiple interactions
ISO
NRXN1 protein affects the reaction [NLG-1 results in increased susceptibility to Aldicarb]; NRXN1 protein affects the reaction [NRX-1 results in decreased susceptibility to Aldicarb]
CTD
PMID:23638761
NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
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Pgr
progesterone receptor
multiple interactions
ISO
Aldicarb inhibits the reaction [Progesterone results in increased activity of PGR protein]
CTD
PMID:9126867
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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Pon1
paraoxonase 1
multiple interactions
ISO EXP
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb
CTD
PMID:27132127
NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
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Vpreb1
V-set pre-B cell surrogate light chain 1
decreases expression
ISO
Aldicarb results in decreased expression of VPREB1 mRNA
CTD
PMID:25424538
NCBI chr11:88,376,256...88,377,133
Ensembl chr11:88,376,256...88,377,133
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