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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methyl isocyanate
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Accession:CHEBI:59059 term browser browse the term
Definition:The isocyanate that is methane modified by a single isocyanato substituent.
Synonyms:related_synonym: Formula=C2H3NO;   InChI=1S/C2H3NO/c1-3-2-4/h1H3;   InChIKey=HAMGRBXTJNITHG-UHFFFAOYSA-N;   Iso-cyanatomethane;   Isocyanate de methyle;   MIC;   Methyl carbonimide;   Methyl isocyanide;   Methylcarbylamine;   SMILES=CN=C=O;   isocyanatomethane
 xref: Beilstein:605318;   CAS:624-83-9;   DrugBank:DB04337;   Gmelin:100500
 xref_mesh: MESH:C008461
 xref: PMID:16091349;   PMID:19494520;   PMID:24081639;   PMID:3622432;   PMID:6821040;   Reaxys:605318

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methyl isocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A affects expression ISO methyl isocyanate affects the expression of AURKA mRNA CTD PMID:22223508 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210 		JBrowse link
G Aurkb aurora kinase B increases expression ISO methyl isocyanate results in increased expression of AURKB protein CTD PMID:22223508 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991 		JBrowse link
G Ccne1 cyclin E1 affects expression ISO methyl isocyanate affects the expression of CCNE1 protein CTD PMID:19513903 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression
increases expression		 ISO methyl isocyanate affects the expression of CDK2 protein
methyl isocyanate results in increased expression of CDK2 protein		 CTD PMID:19513903 PMID:22223508 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO methyl isocyanate affects the expression of CDKN1A protein CTD PMID:19513903 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO methyl isocyanate results in increased expression of CHEK1 mRNA CTD PMID:22223508 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO methyl isocyanate results in decreased expression of CHEK2 mRNA CTD PMID:22223508 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Ifng interferon gamma increases expression ISO methyl isocyanate results in increased expression of IFNG protein CTD PMID:19295137 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il10 interleukin 10 increases expression ISO methyl isocyanate results in increased expression of IL10 protein CTD PMID:19295137 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il2 interleukin 2 increases expression ISO methyl isocyanate results in increased expression of IL2 protein CTD PMID:19295137 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il4 interleukin 4 increases expression ISO methyl isocyanate results in increased expression of IL4 protein CTD PMID:19295137 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO methyl isocyanate results in decreased activity of MGMT protein CTD PMID:14685775 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Pcnt pericentrin increases expression ISO methyl isocyanate results in increased expression of PCNT protein CTD PMID:22223508 NCBI chr20:12,943,523...13,038,615
Ensembl chr20:12,944,786...13,038,431 		JBrowse link
G Pot1 protection of telomeres 1 decreases expression ISO methyl isocyanate results in decreased expression of POT1A protein CTD PMID:22223508 NCBI chr 4:51,888,632...51,946,764
Ensembl chr 4:51,888,634...51,946,715 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) multiple interactions EXP methyl isocyanate binds to and results in increased degradation of SLC4A1 protein CTD PMID:8935787 NCBI chr10:90,296,144...90,312,401
Ensembl chr10:90,296,141...90,312,386 		JBrowse link
G Tp53 tumor protein p53 affects expression
decreases expression		 ISO methyl isocyanate affects the expression of TP53 protein
methyl isocyanate results in decreased expression of TRP53 protein		 CTD PMID:19513903 PMID:22223508 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
aldicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO		 Aldicarb results in decreased activity of ACHE protein CTD PMID:8134223 PMID:14644616 PMID:16256972 PMID:21251949 PMID:23962483 PMID:27132127 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Aldicarb results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Nefh neurofilament heavy increases phosphorylation ISO Aldicarb results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557 		JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO NRXN1 protein affects the reaction [NLG-1 results in increased susceptibility to Aldicarb]; NRXN1 protein affects the reaction [NRX-1 results in decreased susceptibility to Aldicarb] CTD PMID:23638761 NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Aldicarb inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP		 [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb CTD PMID:27132127 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Vpreb1 V-set pre-B cell surrogate light chain 1 decreases expression ISO Aldicarb results in decreased expression of VPREB1 mRNA CTD PMID:25424538 NCBI chr11:88,376,256...88,377,133
Ensembl chr11:88,376,256...88,377,133 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        aetiopathogenetic role 18974
          allergen 16943
            methyl isocyanate 25
              aldicarb 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            heteroorganic entity 19217
                              organochalcogen compound 18922
                                organooxygen compound 18846
                                  isocyanates 342
                                    methyl isocyanate 25
                                      aldicarb 10
paths to the root