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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dimethyl sulfate
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Accession:CHEBI:59050 term browser browse the term
Definition:The dimethyl ester of sulfuric acid.
Synonyms:related_synonym: DMS;   Dimethoxysulfone;   Dimethyl monosulfate;   Dimethyl sulphate;   Formula=C2H6O4S;   InChI=1S/C2H6O4S/c1-5-7(3,4)6-2/h1-2H3;   InChIKey=VAYGXNSJCAHWJZ-UHFFFAOYSA-N;   SMILES=COS(=O)(=O)OC;   Sulfate dimethylique;   Sulfato de dimetilo;   Sulfuric acid dimethyl ester
 alt_id: CHEBI:371544
 xref: Beilstein:635994;   CAS:77-78-1;   KEGG:C19177
 xref_mesh: MESH:C007482
 xref: PMID:2299638

show annotations for term's descendants           Sort by:
dimethyl sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 decreases expression ISO dimethyl sulfate results in decreased expression of DNMT1 protein CTD PMID:11912126 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO dimethyl sulfate inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA] CTD PMID:20888885 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases alkylation ISO dimethyl sulfate results in increased alkylation of MGMT protein CTD PMID:8823159 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases response to substance ISO MPG protein results in increased susceptibility to dimethyl sulfate CTD PMID:15299078 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO dimethyl sulfate results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        immunomodulator 13689
          immunosuppressive agent 11936
            dimethyl sulfate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                chalcogen oxoacid 11479
                                  sulfur oxoacid 11082
                                    sulfuric acid 8009
                                      sulfuric acid derivative 8009
                                        sulfates 8006
                                          organic sulfate 1933
                                            alkyl sulfate 23
                                              dimethyl sulfate 5
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.