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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cromoglycate(2-)
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Accession:CHEBI:59039 term browser browse the term
Definition:The dicarboxylate anion of cromoglycic acid.
Synonyms:exact_synonym: 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylate)
 related_synonym: 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-1-benzopyran-2-carboxylate);   Formula=C23H14O11;   InChI=1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30)/p-2;   InChIKey=IMZMKUWMOSJXDT-UHFFFAOYSA-L;   SMILES=OC(COc1cccc2oc(cc(=O)c12)C([O-])=O)COc1cccc2oc(cc(=O)c12)C([O-])=O;   cromoglycate
 xref: Beilstein:3659374
 cyclic_relationship: is_conjugate_base_of CHEBI:59774


show annotations for term's descendants           Sort by:
cromoglycate(2-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 affects binding ISO Chromoglycate binds to Nme2 protein RGD PMID:20082612 RGD:4107023 NCBI chr11:93,840,640...93,847,082
Ensembl chr11:93,840,640...93,847,085 		JBrowse link
disodium cromoglycate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions ISO [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of MRP4 protein] CTD PMID:35114312 PMID:36464070 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression
multiple interactions		 ISO Cromolyn Sodium results in increased expression of ABCG2 protein
Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of ABCG2 protein]		 CTD PMID:36464070 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein] CTD PMID:35114312 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP Cromolyn Sodium results in increased expression of ADIPOQ protein CTD PMID:23784744 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adora3 adenosine A3 receptor decreases activity ISO Cromolyn Sodium results in decreased activity of ADORA3 protein CTD PMID:15641640 NCBI chr 3:105,811,737...105,816,244
Ensembl chr 3:105,778,174...105,816,242 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of AGT protein] CTD PMID:35114312 PMID:36464070 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein] CTD PMID:28732690 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein] CTD PMID:28732690 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of CALCA protein] CTD PMID:15033348 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Cst3 cystatin C multiple interactions ISO Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein] CTD PMID:35114312 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein] CTD PMID:28732690 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP [pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein CTD PMID:8812242 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Cromolyn Sodium results in decreased expression of DNMT1 mRNA; Cromolyn Sodium results in decreased expression of DNMT1 protein CTD PMID:35961540 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Gpr35 G protein-coupled receptor 35 affects localization
multiple interactions		 ISO
EXP		 Cromolyn Sodium affects the localization of GPR35 protein
Cromolyn Sodium binds to and results in increased activity of GPR35 protein
2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]; Cromolyn Sodium binds to and results in increased activity of GPR35 protein; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]		 CTD PMID:20919992 PMID:22967846 NCBI chr 1:92,875,774...92,913,984
Ensembl chr 1:92,878,587...92,914,113 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of GPX1 protein] CTD PMID:36464070 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein] CTD PMID:28732690 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Ins1 insulin I increases expression EXP Cromolyn Sodium results in increased expression of INS1 protein CTD PMID:23784744 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Cromolyn Sodium results in decreased phosphorylation of MAPK1 protein CTD PMID:35961540 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein]
Cromolyn Sodium results in decreased phosphorylation of MAPK3 protein		 CTD PMID:28732690 PMID:35961540 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Cromolyn Sodium results in decreased expression of METTL3 mRNA; Cromolyn Sodium results in decreased expression of METTL3 protein CTD PMID:35961540 NCBI chr14:52,532,298...52,548,555
Ensembl chr14:52,532,298...52,542,585 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 ISO Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Cromolyn Sodium results in increased expression of MMP2 mRNA		 CTD PMID:14577597 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone] CTD PMID:1659878 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein] CTD PMID:28732690 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Ren1 renin 1 structural multiple interactions ISO Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of REN protein] CTD PMID:36464070 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Retn resistin decreases expression EXP Cromolyn Sodium results in decreased expression of RETN protein CTD PMID:23784744 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 multiple interactions ISO Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A12 protein] CTD PMID:36464070 NCBI chr19:6,585,884...6,593,100
Ensembl chr19:6,585,875...6,593,062 		JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 multiple interactions ISO [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A6 protein] CTD PMID:35114312 PMID:36464070 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663 		JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions ISO [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A8 protein] CTD PMID:35114312 PMID:36464070 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SOD1 protein] CTD PMID:36464070 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Tac1 tachykinin 1 multiple interactions ISO Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of TAC1 protein] CTD PMID:15033348 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases secretion		 ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein
Cromolyn Sodium results in increased secretion of TGFB1 protein
Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]		 CTD PMID:35007524 PMID:35114312 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride] CTD PMID:22414385 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      molecular entity 22169
        ion 17696
          anion 16930
            organic anion 3680
              carboxylic acid anion 2524
                dicarboxylic acid anion 250
                  dicarboxylic acid dianion 249
                    cromoglycate(2-) 33
                      disodium cromoglycate 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic ion 10063
                              organic anion 3680
                                carboxylic acid anion 2524
                                  dicarboxylic acid anion 250
                                    dicarboxylic acid dianion 249
                                      cromoglycate(2-) 33
                                        disodium cromoglycate 32
paths to the root