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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:metamizole sodium
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Accession:CHEBI:59033 term browser browse the term
Definition:An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic.
Synonyms:exact_synonym: sodium [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate
 related_synonym: Algocalmin;   Analgin;   Analgin (sodium salt);   Dipyrone;   Formula=C13H16N3NaO4S;   InChI=1S/C13H17N3O4S.Na/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;/h4-8H,9H2,1-3H3,(H,18,19,20);/q;+1/p-1;   InChIKey=DJGAAPFSPWAYTJ-UHFFFAOYSA-M;   Methampyrone;   Methylmelubrin;   Mexican aspirin;   Neomelurbrin;   Noraminophenazone methanesulfonate sodium salt;   Noraminophenazone sodium mesylate;   Novalgin;   SMILES=[Na+].CN(CS([O-])(=O)=O)c1c(C)n(C)n(-c2ccccc2)c1=O;   Sodium (antipyrinylmethylamino)methanesulfonate;   Sodium methylaminoantipyrine methanesulfonate;   Sodium noramidopyrine methanesulfonate;   Sulpyrine;   Vetalgin;   aminopyrine sodium sulfonate;   dipyrone [anhydrous];   meamizol sodico;   metamizole sodique;   metamizolum natricum
 xref: CAS:68-89-3;   DrugBank:DB04817;   KEGG:D08190
 xref_mesh: MESH:D004177
 xref: PMID:15012736;   PMID:15137974;   PMID:15595715;   PMID:15851637;   PMID:16752674;   PMID:17435797;   PMID:21446784;   PMID:25776531;   PMID:25789542;   PMID:3044874;   PMID:3425858;   Reaxys:3643594;   Wikipedia:Metamizole


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metamizole sodium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone multiple interactions ISO Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G EGFR epidermal growth factor receptor multiple interactions ISO Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP
ISO		 Dipyrone analog results in decreased activity of PTGS1 protein; Dipyrone results in decreased activity of PTGS1 protein CTD PMID:12242329 PMID:16141368 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G TGFA transforming growth factor alpha multiple interactions ISO Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:15309881 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        anti-inflammatory agent 17787
          metamizole sodium 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      chalcogen 24917
                        oxygen atom 24817
                          oxygen molecular entity 24806
                            oxide 13767
                              oxoanion 10848
                                chalcogen oxoanion 725
                                  sulfur oxoanion 723
                                    sulfonate 121
                                      organosulfonate oxoanion 121
                                        metamizole(1-) 7
                                          metamizole sodium 7
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