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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indapamide
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Accession:CHEBI:5893 term browser browse the term
Definition:A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.
Synonyms:exact_synonym: 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide
 related_synonym: Formula=C16H16ClN3O3S;   InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23);   InChIKey=NDDAHWYSQHTHNT-UHFFFAOYSA-N;   SMILES=CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O;   indapamida;   indapamidum
 xref: CAS:26807-65-8;   DrugBank:DB00808;   Drug_Central:1433;   KEGG:D00345;   LINCS:LSM-1936
 xref_mesh: MESH:D007190
 xref: PMID:22567944;   PMID:22579001;   PMID:22606892;   PMID:22725706;   Patent:FR2003311;   Patent:US3565911;   Reaxys:1604026;   Wikipedia:Indapamide


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indapamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A increases expression ISO Indapamide results in increased expression of ADRA2A protein CTD PMID:2829625 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Indapamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression EXP Indapamide affects the expression of FOS mRNA CTD PMID:11779033 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK1 protein CTD PMID:11779033 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK3 protein CTD PMID:11779033 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ren renin increases expression ISO Indapamide results in increased expression of REN protein CTD PMID:6578003 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G RT1-DOa RT1 class II, locus DOa affects expression ISO Indapamide affects the expression of HLA-DOA mRNA CTD PMID:25811541 NCBI chr20:3,889,106...3,892,360
Ensembl chr20:3,889,370...3,892,449
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Indapamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        pharmaceutical 19255
          drug 19255
            diuretic 1122
              indapamide 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      carboxylic acid 18079
                                        carboacyl group 17368
                                          univalent carboacyl group 17368
                                            carbamoyl group 17154
                                              carboxamide 17154
                                                monocarboxylic acid amide 14574
                                                  arenecarboxamide 6513
                                                    benzamides 6513
                                                      benzamide 61
                                                        indapamide 8
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