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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indapamide
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Accession:CHEBI:5893 term browser browse the term
Definition:A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.
Synonyms:exact_synonym: 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide
 related_synonym: Formula=C16H16ClN3O3S;   InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23);   InChIKey=NDDAHWYSQHTHNT-UHFFFAOYSA-N;   SMILES=CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O;   indapamida;   indapamidum
 xref: CAS:26807-65-8;   DrugBank:DB00808;   Drug_Central:1433;   KEGG:D00345;   LINCS:LSM-1936
 xref_mesh: MESH:D007190
 xref: PMID:22567944;   PMID:22579001;   PMID:22606892;   PMID:22725706;   Patent:FR2003311;   Patent:US3565911;   Reaxys:1604026;   Wikipedia:Indapamide



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indapamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A increases expression ISO Indapamide results in increased expression of ADRA2A protein CTD PMID:2829625 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Indapamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression EXP Indapamide affects the expression of FOS mRNA CTD PMID:11779033 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK1 protein CTD PMID:11779033 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK3 protein CTD PMID:11779033 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ren renin increases expression ISO Indapamide results in increased expression of REN protein CTD PMID:6578003 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G RT1-DOa RT1 class II, locus DOa affects expression ISO Indapamide affects the expression of HLA-DOA mRNA CTD PMID:25811541 NCBI chr20:4,753,587...4,756,590
Ensembl chr20:4,753,598...4,756,577
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Indapamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      application 19773
        pharmaceutical 19647
          drug 19647
            diuretic 1135
              indapamide 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      carbon group element atom 19903
                        carbon atom 19896
                          organic molecular entity 19896
                            organic group 18994
                              organic divalent group 18980
                                organodiyl group 18980
                                  carbonyl group 18933
                                    carbonyl compound 18933
                                      carboxylic acid 18629
                                        carboacyl group 17761
                                          univalent carboacyl group 17761
                                            carbamoyl group 17602
                                              carboxamide 17602
                                                monocarboxylic acid amide 15592
                                                  arenecarboxamide 7315
                                                    benzamides 7315
                                                      benzamide 62
                                                        indapamide 8
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