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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imperatorin
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Accession:CHEBI:5885 term browser browse the term
Definition:A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
Synonyms:exact_synonym: 9-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
 related_synonym: 8-Isoamylenoxypsoralen;   8-Isopentenyloxypsoralene;   9-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g]-1-benzopyran-7-one;   Ammidin;   Formula=C16H14O4;   InChI=1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3;   InChIKey=OLOOJGVNMBJLLR-UHFFFAOYSA-N;   Marmelosin;   Pentosalen;   SMILES=CC(C)=CCOc1c2occc2cc2ccc(=O)oc12
 alt_id: CHEBI:66070
 xref: CAS:482-44-0;   HMDB:HMDB0034376;   KEGG:C09269;   KNApSAcK:C00002477;   LINCS:LSM-2140
 xref_mesh: MESH:C031534
 xref: PMID:12510838;   PMID:17396918;   PMID:21627108;   Patent:CN102349891;   Patent:KR20120060192;   Patent:WO2011160597;   Reaxys:249728;   Wikipedia:Imperatorin



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imperatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP imperatorin analog inhibits the reaction [AGT protein results in decreased expression of ACTA2 protein] CTD PMID:25727310 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions EXP imperatorin analog inhibits the reaction [AGT protein results in decreased expression of ACTA2 protein]; imperatorin analog inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:25727310 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression
multiple interactions
ISO imperatorin results in increased expression of BMP2 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]; SB 203580 inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]
CTD PMID:17980360 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO imperatorin results in increased expression of CYP1A1 protein CTD PMID:18692084 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO imperatorin results in increased expression of CYP1A2 protein CTD PMID:18692084 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO imperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]
imperatorin results in decreased activity of CYP1B1 protein; imperatorin results in decreased activity of CYP1B1 protein polymorphism
CTD PMID:15861043 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO imperatorin results in increased expression of CYP2B10 protein CTD PMID:18692084 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO imperatorin results in increased phosphorylation of MAPK1 protein CTD PMID:17980360 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO imperatorin results in increased phosphorylation of MAPK3 protein CTD PMID:17980360 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to imperatorin CTD PMID:19150646 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO imperatorin binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO imperatorin results in increased expression of SLC22A1 mRNA; imperatorin results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases expression
increases expression
ISO imperatorin results in decreased expression of SLC22A12 mRNA
imperatorin results in increased expression of SLC22A12 protein
CTD PMID:22173200 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression
decreases expression
ISO imperatorin results in increased expression of SLC22A2 protein
imperatorin results in decreased expression of SLC22A2 mRNA
CTD PMID:22173200 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a4 solute carrier family 22 member 4 decreases expression ISO imperatorin results in decreased expression of SLC22A4 mRNA CTD PMID:22173200 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO imperatorin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression ISO imperatorin results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression ISO imperatorin results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc2a9 solute carrier family 2 member 9 decreases expression
increases expression
ISO imperatorin results in decreased expression of SLC2A9 protein
imperatorin results in increased expression of SLC2A9 mRNA
CTD PMID:22173200 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
JBrowse link
G Smad1 SMAD family member 1 increases phosphorylation ISO imperatorin results in increased phosphorylation of SMAD1 protein CTD PMID:17980360 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smad5 SMAD family member 5 increases phosphorylation ISO imperatorin results in increased phosphorylation of SMAD5 protein CTD PMID:17980360 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634
JBrowse link
G Smad9 SMAD family member 9 increases phosphorylation ISO imperatorin results in increased phosphorylation of SMAD9 protein CTD PMID:17980360 NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP imperatorin analog inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:25727310 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP
ISO
imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] CTD PMID:17599282 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            imperatorin 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteropolycyclic compound 18298
                                    organic heterotricyclic compound 15598
                                      furochromene 114
                                        furanocoumarin 113
                                          psoralens 106
                                            imperatorin 24
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