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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imperatorin
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Accession:CHEBI:5885 term browser browse the term
Definition:A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
Synonyms:exact_synonym: 9-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
 related_synonym: 8-Isoamylenoxypsoralen;   8-Isopentenyloxypsoralene;   9-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g]-1-benzopyran-7-one;   Ammidin;   Formula=C16H14O4;   InChI=1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3;   InChIKey=OLOOJGVNMBJLLR-UHFFFAOYSA-N;   Marmelosin;   Pentosalen;   SMILES=CC(C)=CCOc1c2occc2cc2ccc(=O)oc12
 alt_id: CHEBI:66070
 xref: CAS:482-44-0;   HMDB:HMDB0034376;   KEGG:C09269;   KNApSAcK:C00002477;   LINCS:LSM-2140
 xref_mesh: MESH:C031534
 xref: PMID:12510838;   PMID:17396918;   PMID:21627108;   Patent:CN102349891;   Patent:KR20120060192;   Patent:WO2011160597;   Reaxys:249728;   Wikipedia:Imperatorin


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imperatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP imperatorin analog inhibits the reaction [AGT protein results in decreased expression of ACTA2 protein] CTD PMID:25727310 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions EXP imperatorin analog inhibits the reaction [AGT protein results in decreased expression of ACTA2 protein]; imperatorin analog inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:25727310 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression
multiple interactions
ISO imperatorin results in increased expression of BMP2 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]; SB 203580 inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]
CTD PMID:17980360 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO imperatorin results in increased expression of CYP1A1 protein CTD PMID:18692084 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO imperatorin results in increased expression of CYP1A2 protein CTD PMID:18692084 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO imperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]
imperatorin results in decreased activity of CYP1B1 protein; imperatorin results in decreased activity of CYP1B1 protein polymorphism
CTD PMID:15861043 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO imperatorin results in increased expression of CYP2B10 protein CTD PMID:18692084 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO imperatorin results in increased phosphorylation of MAPK1 protein CTD PMID:17980360 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO imperatorin results in increased phosphorylation of MAPK3 protein CTD PMID:17980360 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to imperatorin CTD PMID:19150646 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO imperatorin binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO imperatorin results in increased expression of SLC22A1 mRNA; imperatorin results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases expression
increases expression
ISO imperatorin results in decreased expression of SLC22A12 mRNA
imperatorin results in increased expression of SLC22A12 protein
CTD PMID:22173200 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression
decreases expression
ISO imperatorin results in increased expression of SLC22A2 protein
imperatorin results in decreased expression of SLC22A2 mRNA
CTD PMID:22173200 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a4 solute carrier family 22 member 4 decreases expression ISO imperatorin results in decreased expression of SLC22A4 mRNA CTD PMID:22173200 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO imperatorin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression ISO imperatorin results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression ISO imperatorin results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc2a9 solute carrier family 2 member 9 decreases expression
increases expression
ISO imperatorin results in decreased expression of SLC2A9 protein
imperatorin results in increased expression of SLC2A9 mRNA
CTD PMID:22173200 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702
JBrowse link
G Smad1 SMAD family member 1 increases phosphorylation ISO imperatorin results in increased phosphorylation of SMAD1 protein CTD PMID:17980360 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad5 SMAD family member 5 increases phosphorylation ISO imperatorin results in increased phosphorylation of SMAD5 protein CTD PMID:17980360 NCBI chr17:8,307,448...8,336,996
Ensembl chr17:8,311,796...8,331,032
JBrowse link
G Smad9 SMAD family member 9 increases phosphorylation ISO imperatorin results in increased phosphorylation of SMAD9 protein CTD PMID:17980360 NCBI chr 2:143,951,725...144,002,025
Ensembl chr 2:144,191,846...144,212,138
Ensembl chr 2:144,191,846...144,212,138
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP imperatorin analog inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:25727310 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP
ISO
imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] CTD PMID:17599282 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            imperatorin 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterotricyclic compound 14571
                                      furochromene 99
                                        furanocoumarin 99
                                          psoralens 90
                                            imperatorin 24
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