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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:felodipine
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Accession:CHEBI:585948 term browser browse the term
Definition:The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Synonyms:exact_synonym: ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: (+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate;   3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate;   4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester;   Formula=C18H19Cl2NO4;   InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3;   InChIKey=RZTAMFZIAATZDJ-UHFFFAOYSA-N;   SMILES=CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC;   felodipina;   felodipinum
 alt_id: CHEBI:49383;   CHEBI:4996
 xref: CAS:72509-76-3;   DrugBank:DB01023;   Drug_Central:1142;   KEGG:D00319;   LINCS:LSM-1447
 xref_mesh: MESH:D015736
 xref: PDBeChem:225;   PMID:18457386;   Patent:EP7293;   Patent:US4264611;   Reaxys:4331472;   Wikipedia:Felodipine


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felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Felodipine results in decreased activity of ABCB11 protein
Felodipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Felodipine results in increased activity of AHR protein CTD PMID:27732883 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of NFKB1 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of RELA protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 protein] CTD PMID:18287887 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Ar androgen receptor increases activity ISO Felodipine results in increased activity of AR protein CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 protein] CTD PMID:18287887 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Felodipine results in increased expression of CYP1A1 mRNA CTD PMID:27732883 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Felodipine results in increased expression of CYP1A2 mRNA CTD PMID:27732883 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Felodipine results in increased expression of CYP2B6 mRNA; Felodipine results in increased expression of CYP2B6 protein CTD PMID:27732883 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions
ISO Felodipine results in decreased activity of CYP2C8 protein
Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine]
CTD PMID:15601807 PMID:28119166
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions
decreases activity
ISO NADP promotes the reaction [Felodipine results in decreased activity of CYP2J2 protein] CTD PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
increases expression
ISO deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine]; Felodipine results in increased expression of and results in decreased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine]
Felodipine results in increased expression of CYP3A4 mRNA
CTD PMID:23876819 PMID:27732883 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Felodipine results in increased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 protein] CTD PMID:18504504 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 protein] CTD PMID:18287887 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Felodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of NFKB1 protein] CTD PMID:18287887 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nppa natriuretic peptide A affects expression ISO Felodipine affects the expression of NPPA protein CTD PMID:9264493 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
ISO Felodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; Felodipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
Felodipine results in increased activity of NR1H4 protein
CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity EXP
ISO
Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 PMID:27732883 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases activity ISO Felodipine results in increased activity of PPARD protein CTD PMID:25257666 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 protein] CTD PMID:18287887 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of RELA protein] CTD PMID:18287887 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF protein] CTD PMID:18287887 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 protein] CTD PMID:18287887 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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