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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ibuprofen
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Accession:CHEBI:5855 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Synonyms:exact_synonym: 2-[4-(2-methylpropyl)phenyl]propanoic acid
 related_synonym: (+-)-2-(p-isobutylphenyl)propionic acid;   (+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid;   (4-isobutylphenyl)-alpha-methylacetic acid;   (RS)-ibuprofen;   2-(4-isobutylphenyl)propanoic acid;   4-isobutylhydratropic acid;   Adran;   Advil;   Amibufen;   Anco;   Anflagen;   Apsifen;   Bluton;   Brufen;   Brufort;   Buburone;   Butylenin;   Dolgin;   Dolgirid;   Dolgit;   Dolo-Dolgit;   Ebufac;   Epobron;   Femadon;   Formula=C13H18O2;   Haltran;   Ibu-Attritin;   Ibumetin;   Ibuprocin;   Ibutid;   InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15);   InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N;   Inabrin;   Inoven;   Lamidon;   Lebrufen;   Liptan;   Medipren;   Motrin;   Mynosedin;   Nobfen;   Nobgen;   Nuprin;   Nurofen;   Pediaprofen;   Roidenin;   Rufen;   SMILES=CC(C)Cc1ccc(cc1)C(C)C(O)=O;   Seclodin;   Suspren;   Tabalon;   Trendar;   Urem;   alpha-(4-isobutylphenyl)propionic acid;   alpha-(p-isobutylphenyl)propionic acid;   p-Isobutylhydratropic acid
 xref: Beilstein:2049713;   CAS:15687-27-1;   DrugBank:DB01050;   Drug_Central:1407;   HMDB:HMDB0001925;   KEGG:C01588;   KEGG:D00126;   LINCS:LSM-1354
 xref_mesh: MESH:D007052
 xref: PMID:11433218;   PMID:12723739;   PMID:14562167;   PMID:15506544;   PMID:16176022;   PMID:18335846;   PMID:18697608;   PMID:21368281;   PMID:24168233;   PMID:25708941;   PMID:25915907;   PMID:29756342;   Patent:GB971700;   Patent:US3228831;   Patent:US3385886;   Patent:US5215755;   Patent:US6727286;   Reaxys:2049713;   Wikipedia:Ibuprofen
 cyclic_relationship: is_conjugate_acid_of CHEBI:132922


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ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of ABCB11 mRNA CTD PMID:29222744 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression EXP Ibuprofen results in increased expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:37,923,974...37,956,678
Ensembl chr12:37,923,528...37,958,363
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Ibuprofen results in increased expression of ABCG1 mRNA CTD PMID:25596134 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Ibuprofen results in increased expression of ABHD4 mRNA CTD PMID:25596134 NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases expression
ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of ACOX1 mRNA
Ibuprofen results in increased expression of ACOX1 mRNA
CTD PMID:29222744 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases metabolic processing
increases expression
EXP
ISO
ACSL1 protein results in increased metabolism of Ibuprofen
Ibuprofen results in increased expression of ACSL1 mRNA
CTD PMID:10725307, PMID:25596134 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 increases metabolic processing EXP ACSL6 protein results in increased metabolism of Ibuprofen CTD PMID:10725307 NCBI chr10:39,654,771...39,717,592
Ensembl chr10:39,655,455...39,719,312
JBrowse link
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 increases expression ISO Ibuprofen results in increased expression of ADAMTS8 mRNA CTD PMID:17070997 NCBI chr 8:32,017,684...32,037,529
Ensembl chr 8:32,018,560...32,037,531
JBrowse link
G Adcy1 adenylate cyclase 1 decreases expression ISO Ibuprofen results in decreased expression of ADCY1 mRNA CTD PMID:25596134 NCBI chr14:87,311,970...87,429,880
Ensembl chr14:87,312,203...87,421,659
JBrowse link
G Agt angiotensinogen increases expression EXP Ibuprofen results in increased expression of AGT protein CTD PMID:18096423 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor affects activity EXP Ibuprofen affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 increases expression ISO
EXP
Ibuprofen results in increased expression of AIFM2 mRNA CTD PMID:25596134 NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906
JBrowse link
G Ak4 adenylate kinase 4 decreases expression ISO Ibuprofen results in decreased expression of AK4 mRNA CTD PMID:25596134 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Ibuprofen results in decreased activity of AKR1C2 protein CTD PMID:8573067, PMID:19010312 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Ibuprofen results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Alb albumin multiple interactions ISO Ibuprofen inhibits the reaction [Fenoprofen binds to ALB protein] CTD PMID:9470966 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO Ibuprofen results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type affects expression ISO Ibuprofen affects the expression of ALOX12B mRNA CTD PMID:17070997 NCBI chr10:55,744,646...55,756,524
Ensembl chr10:55,744,588...55,756,566
JBrowse link
G Aloxe3 arachidonate lipoxygenase 3 affects expression ISO Ibuprofen affects the expression of ALOXE3 mRNA CTD PMID:17070997 NCBI chr10:55,711,996...55,735,915
Ensembl chr10:55,712,043...55,735,911
JBrowse link
G Amacr alpha-methylacyl-CoA racemase affects response to substance
increases metabolic processing
multiple interactions
ISO AMACR gene SNP affects the susceptibility to Ibuprofen
AMACR protein results in increased metabolism of Ibuprofen
AMACR protein results in increased metabolism of and results in increased activity of Ibuprofen
CTD PMID:17680641, PMID:17684125 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression ISO Ibuprofen results in decreased expression of AMBP mRNA CTD PMID:25596134 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Ibuprofen results in increased expression of ANGPTL4 mRNA CTD PMID:25596134 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Anxa1 annexin A1 affects expression ISO Ibuprofen affects the expression of ANXA1 mRNA CTD PMID:17070997 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 affects expression ISO Ibuprofen affects the expression of ANXA2 protein CTD PMID:18351690 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa3 annexin A3 affects expression ISO Ibuprofen affects the expression of ANXA3 mRNA CTD PMID:17070997 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa9 annexin A9 decreases expression ISO Ibuprofen results in decreased expression of ANXA9 mRNA CTD PMID:17070997 NCBI chr 2:196,470,318...196,481,568
Ensembl chr 2:196,470,858...196,479,770
JBrowse link
G App amyloid beta precursor protein affects cleavage
multiple interactions
decreases expression
ISO
EXP
Ibuprofen affects the cleavage of APP protein
Ibuprofen inhibits the reaction [APP protein results in increased uptake of Calcium]
Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]
Ibuprofen results in decreased expression of APP protein mutant form
Ibuprofen inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]
CTD PMID:11080519, PMID:11700559, PMID:12777371, PMID:14586007, PMID:15817521, PMID:18648507 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 increases expression ISO Ibuprofen results in increased expression of ARFGEF2 mRNA CTD PMID:25596134 NCBI chr 3:163,570,435...163,656,612
Ensembl chr 3:163,570,532...163,656,626
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression
decreases activity
EXP Ibuprofen results in decreased expression of ASIC1 mRNA
Ibuprofen results in decreased activity of ASIC1 protein
CTD PMID:11588175 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Ibuprofen results in decreased expression of ASIC2 mRNA CTD PMID:11588175 NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
JBrowse link
G Asic3 acid sensing ion channel subunit 3 decreases expression EXP Ibuprofen results in decreased expression of ASIC3 mRNA CTD PMID:11588175 NCBI chr 4:7,287,868...7,293,295
Ensembl chr 4:7,288,855...7,292,901
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Ibuprofen results in increased expression of ASNS mRNA CTD PMID:25596134 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf4 activating transcription factor 4 affects activity ISO Ibuprofen affects the activity of ATF4 protein CTD PMID:25596134 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atxn1 ataxin 1 increases expression ISO Ibuprofen results in increased expression of ATXN1 mRNA CTD PMID:25596134 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
JBrowse link
G Bace1 beta-secretase 1 multiple interactions
decreases expression
decreases activity
ISO
EXP
GW0072 inhibits the reaction [Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]
Ibuprofen results in decreased expression of BACE1 mRNA
GW0072 inhibits the reaction [Ibuprofen results in decreased expression of BACE1 mRNA]
Ibuprofen results in decreased activity of BACE1 protein
CTD PMID:14586007, PMID:16407166 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bcat2 branched chain amino acid transaminase 2 increases expression ISO Ibuprofen results in increased expression of BCAT2 mRNA CTD PMID:25596134 NCBI chr 1:101,553,900...101,572,103
Ensembl chr 1:101,554,642...101,572,080
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of BCL2L1 mRNA alternative form; [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of BCL2L1 mRNA alternative form; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of BCL2L1 mRNA alternative form]; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of BCL2L1 mRNA alternative form]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of BCL2L1 mRNA alternative form]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of BCL2L1 mRNA alternative form] CTD PMID:18348186 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Ibuprofen results in increased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G C3 complement C3 affects expression ISO Ibuprofen affects the expression of C3 mRNA CTD PMID:17070997 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 affects expression ISO Ibuprofen affects the expression of CACNA2D3 mRNA CTD PMID:17070997 NCBI chr16:4,871,348...5,795,825
Ensembl chr16:4,871,650...5,795,825
JBrowse link
G Calca calcitonin-related polypeptide alpha decreases expression EXP Ibuprofen results in decreased expression of CALCA mRNA CTD PMID:11588175 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein] CTD PMID:24333387 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Ibuprofen inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA] CTD PMID:11296547, PMID:24333387 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO Ibuprofen inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]
Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]
Ibuprofen results in increased expression of CCL2 mRNA
CTD PMID:11230753, PMID:17070997, PMID:18799549 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein] CTD PMID:15263833 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15489888 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne2 cyclin E2 increases expression ISO Ibuprofen results in increased expression of CCNE2 mRNA CTD PMID:25596134 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd36 CD36 molecule increases expression ISO Ibuprofen results in increased expression of CD36 protein CTD PMID:12664607 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdh3 cadherin 3 affects expression ISO Ibuprofen affects the expression of CDH3 mRNA CTD PMID:17070997 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Ibuprofen results in decreased expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Ibuprofen results in increased expression of CDKN1A mRNA; Ibuprofen results in increased expression of CDKN1A protein CTD PMID:15099639 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdsn corneodesmosin affects expression ISO Ibuprofen affects the expression of CDSN mRNA CTD PMID:17070997 NCBI chr20:3,704,626...3,707,266 JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 affects expression ISO Ibuprofen affects the expression of CEACAM1 mRNA CTD PMID:17070997 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cers5 ceramide synthase 5 decreases expression EXP Ibuprofen results in decreased expression of CERS5 mRNA CTD PMID:25596134 NCBI chr 7:141,386,391...141,424,375
Ensembl chr 7:141,386,391...141,424,343
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases activity
multiple interactions
ISO Ibuprofen results in decreased activity of CHUK protein
Ibuprofen inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Ibuprofen results in decreased activity of [TNF protein results in increased activity of CHUK protein]
CTD PMID:10602496, PMID:15489888 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Clu clusterin affects expression ISO Ibuprofen affects the expression of CLU mRNA CTD PMID:17070997 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog increases expression
decreases expression
EXP
ISO
Ibuprofen results in increased expression of CMBL mRNA
Ibuprofen results in decreased expression of CMBL mRNA
CTD PMID:25596134 NCBI chr 2:84,645,084...84,666,836
Ensembl chr 2:84,645,084...84,666,835
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein] CTD PMID:17397826 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein] CTD PMID:17397826 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Coch cochlin decreases expression ISO Ibuprofen results in decreased expression of COCH mRNA CTD PMID:25596134 NCBI chr 6:72,359,702...72,373,710
Ensembl chr 6:72,359,791...72,373,695
JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects expression ISO Ibuprofen affects the expression of COL11A1 mRNA CTD PMID:17070997 NCBI chr 2:216,863,423...217,056,523
Ensembl chr 2:216,863,428...217,056,523
JBrowse link
G Cth cystathionine gamma-lyase multiple interactions ISO Ibuprofen promotes the reaction [Dexamethasone results in decreased activity of CTH protein]; Ibuprofen promotes the reaction [Dexamethasone results in decreased expression of CTH mRNA]; NR3C1 protein affects the reaction [Ibuprofen promotes the reaction [Dexamethasone results in decreased expression of CTH mRNA]] CTD PMID:29222744 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctsc cathepsin C decreases expression ISO
EXP
Ibuprofen results in decreased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects expression ISO Ibuprofen affects the expression of CX3CL1 mRNA CTD PMID:17070997 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 protein] CTD PMID:19020770 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression
EXP
ISO
Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]
Ibuprofen results in increased expression of CXCL2 mRNA
CTD PMID:11545620, PMID:24747151 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
decreases expression
ISO Ibuprofen results in decreased activity of CYP19A1 protein
Ibuprofen results in decreased expression of CYP19A1 mRNA
CTD PMID:15964185 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO Ibuprofen results in decreased expression of CYP1A2 mRNA CTD PMID:25596134 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing
increases metabolic processing
decreases metabolic processing
ISO CYP2C8 gene polymorphism affects the metabolism of Ibuprofen
CYP2C8 gene polymorphism results in increased metabolism of Ibuprofen
CYP2C8 gene polymorphism results in decreased metabolism of Ibuprofen
CTD PMID:15289789, PMID:15606441, PMID:18694831 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Ddx1 DEAD-box helicase 1 affects expression ISO Ibuprofen affects the expression of DDX1 protein CTD PMID:18351690 NCBI chr 6:38,422,892...38,453,762
Ensembl chr 6:38,422,888...38,453,797
JBrowse link
G Defb4 defensin beta 4 affects expression ISO Ibuprofen affects the expression of DEFB4 mRNA CTD PMID:17070997 NCBI chr16:75,634,598...75,637,789
Ensembl chr16:75,634,598...75,637,789
JBrowse link
G Dhx37 DEAH-box helicase 37 increases expression ISO Ibuprofen results in increased expression of DHX37 mRNA CTD PMID:25596134 NCBI chr12:36,594,058...36,614,165
Ensembl chr12:36,594,047...36,614,210
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein] CTD PMID:24333387 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dlgap2 DLG associated protein 2 multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA] CTD PMID:24333387 NCBI chr16:79,872,238...80,596,977
Ensembl chr16:79,872,323...79,973,877
JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 increases expression ISO Ibuprofen results in increased expression of DNAJB2 mRNA CTD PMID:25596134 NCBI chr 9:82,436,453...82,444,669
Ensembl chr 9:82,436,458...82,444,668
JBrowse link
G Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta increases expression EXP Ibuprofen results in increased expression of DNAJC5B mRNA CTD PMID:25596134 NCBI chr 2:104,290,726...104,382,846
Ensembl chr 2:104,290,726...104,382,878
JBrowse link
G Dnmbp dynamin binding protein increases expression EXP Ibuprofen results in increased expression of DNMBP mRNA CTD PMID:25596134 NCBI chr 1:263,625,503...263,718,784
Ensembl chr 1:263,625,501...263,718,745
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO Ibuprofen results in decreased expression of DNMT3A mRNA CTD PMID:29665328 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dpp9 dipeptidyl peptidase 9 increases expression EXP
ISO
Ibuprofen results in increased expression of DPP9 mRNA CTD PMID:25596134 NCBI chr 9:10,846,493...10,882,560
Ensembl chr 9:10,846,596...10,882,649
JBrowse link
G Dsc1 desmocollin 1 affects expression ISO Ibuprofen affects the expression of DSC1 mRNA CTD PMID:17070997 NCBI chr18:11,877,918...11,906,828
Ensembl chr18:11,877,561...11,906,827
JBrowse link
G Dusp22 dual specificity phosphatase 22 increases expression ISO Ibuprofen results in increased expression of DUSP22 mRNA CTD PMID:25596134 NCBI chr17:34,986,589...35,037,297
Ensembl chr17:34,986,591...35,037,076
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Ibuprofen results in increased expression of DUSP5 mRNA CTD PMID:25596134 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Ibuprofen inhibits the reaction [EGF protein results in increased activity of MMP9 protein]; Ibuprofen inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; Ibuprofen inhibits the reaction [EGF protein results in increased expression of PLAU mRNA] CTD PMID:16340751 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression EXP Ibuprofen results in decreased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions
increases phosphorylation
ISO MAPK14 protein promotes the reaction [Ibuprofen results in increased phosphorylation of EIF4E protein] CTD PMID:18056468 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
increases expression
ISO ELAVL1 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; Ibuprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]
Ibuprofen results in increased expression of ELAVL1 protein
CTD PMID:18056468 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Elf4 E74 like ETS transcription factor 4 increases expression ISO Ibuprofen results in increased expression of ELF4 mRNA CTD PMID:25596134 NCBI chr  X:135,239,626...135,284,330
Ensembl chr  X:135,240,451...135,250,519
JBrowse link
G Elk4 ETS transcription factor ELK4 increases expression ISO Ibuprofen results in increased expression of ELK4 mRNA CTD PMID:25596134 NCBI chr13:48,788,262...48,813,267
Ensembl chr13:48,790,509...48,813,260
JBrowse link
G Eno1 enolase 1 affects expression
increases expression
ISO Ibuprofen affects the expression of ENO1 protein
Ibuprofen results in increased expression of ENO1 mRNA
CTD PMID:18351690, PMID:25596134 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO Ibuprofen results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Ephb6 Eph receptor B6 affects expression ISO Ibuprofen affects the expression of EPHB6 mRNA CTD PMID:17070997 NCBI chr 4:70,903,253...70,918,514
Ensembl chr 4:70,903,253...70,918,514
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase increases expression ISO Ibuprofen results in increased expression of EPRS1 mRNA CTD PMID:25596134 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 affects cleavage ISO Ibuprofen affects the cleavage of ERBB4 protein CTD PMID:12777371 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit increases expression EXP Ibuprofen results in increased expression of EZH2 mRNA CTD PMID:29665328 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Ibuprofen results in increased expression of F3 mRNA CTD PMID:17070997 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Faah fatty acid amide hydrolase decreases activity EXP Ibuprofen analog results in decreased activity of FAAH protein CTD PMID:17397826 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression
increases expression
ISO Ibuprofen results in decreased expression of FABP4 mRNA
Ibuprofen results in increased expression of FABP4 mRNA
CTD PMID:17070997, PMID:25596134 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fam210b family with sequence similarity 210, member B decreases expression ISO Ibuprofen results in decreased expression of FAM210B mRNA CTD PMID:25596134 NCBI chr 3:170,354,109...170,364,265
Ensembl chr 3:170,354,141...170,362,513
JBrowse link
G Fam89a family with sequence similarity 89, member A increases expression ISO Ibuprofen results in increased expression of FAM89A mRNA CTD PMID:25596134 NCBI chr19:57,502,308...57,514,896
Ensembl chr19:57,502,308...57,514,896
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Ibuprofen results in decreased expression of FAS mRNA CTD PMID:25596134 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase affects expression
decreases expression
ISO Ibuprofen affects the expression of FASN protein
Ibuprofen results in decreased expression of FASN mRNA
CTD PMID:18351690 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression
multiple interactions
ISO
EXP
Ibuprofen results in decreased expression of FGF15 mRNA; Ibuprofen results in decreased expression of FGF15 protein
[Dexamethasone co-treated with Ibuprofen] results in decreased expression of FGF15 mRNA; [Dexamethasone co-treated with Ibuprofen] results in decreased expression of FGF15 protein
[Ibuprofen co-treated with Dexamethasone] results in decreased expression of FGF15 mRNA
CTD PMID:29222744 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Ibuprofen results in increased expression of FOSB mRNA CTD PMID:17070997 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Frzb frizzled-related protein affects expression ISO Ibuprofen affects the expression of FRZB mRNA CTD PMID:17070997 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO Ibuprofen results in decreased expression of GATA3 mRNA CTD PMID:17630191 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 increases expression ISO Ibuprofen results in increased expression of GBE1 mRNA CTD PMID:25596134 NCBI chr11:7,210,169...7,485,895
Ensembl chr11:7,210,209...7,485,890
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Ibuprofen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Ibuprofen results in increased expression of GCLM mRNA CTD PMID:11909699, PMID:25596134 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO Ibuprofen results in increased expression of GCNT3 mRNA CTD PMID:25596134 NCBI chr 8:76,449,078...76,459,431
Ensembl chr 8:76,449,081...76,452,554
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO Ibuprofen results in increased expression of GDF15 mRNA; Ibuprofen results in increased expression of GDF15 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]; NGFR protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]
CTD PMID:15555568, PMID:21097678, PMID:25596134 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP protein] CTD PMID:24333387 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Ibuprofen results in increased expression of GOT1 mRNA CTD PMID:25596134 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Ibuprofen results in increased expression of GPAT3 mRNA CTD PMID:25596134 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Ibuprofen results in increased expression of GSTT1 protein CTD PMID:9729437 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression EXP Ibuprofen results in increased expression of GSTT2 protein CTD PMID:9729437 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G H1f2 H1.2 linker histone, cluster member decreases expression ISO Ibuprofen results in decreased expression of H1-2 mRNA CTD PMID:25596134 NCBI chr17:43,638,938...43,640,445
Ensembl chr17:43,639,749...43,640,387
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
affects activity
ISO Ibuprofen results in decreased expression of HIF1A protein
Ibuprofen affects the activity of HIF1A protein
CTD PMID:12912967, PMID:25596134 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO Ibuprofen results in increased expression of HMGB1 protein CTD PMID:24747151 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase affects expression
increases activity
increases expression
ISO Ibuprofen affects the expression of HPGD mRNA
Ibuprofen results in increased activity of HPGD protein
Ibuprofen results in increased expression of HPGD mRNA
CTD PMID:17070997, PMID:19501039 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Ibuprofen results in increased activity of HSF1 protein CTD PMID:10328874 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects localization
increases expression
ISO Ibuprofen affects the localization of HSPA1A protein
Ibuprofen results in increased expression of HSPA1A protein
CTD PMID:16239242 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO
EXP
Ibuprofen results in decreased expression of HSPA5 mRNA CTD PMID:25596134 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects localization ISO Ibuprofen affects the localization of HSPA8 protein CTD PMID:14706622, PMID:16239242 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression EXP Ibuprofen results in decreased expression of HTATIP2 mRNA CTD PMID:25596134 NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 increases expression
decreases expression
ISO
EXP
Ibuprofen results in increased expression of IARS1 mRNA
Ibuprofen results in decreased expression of IARS1 mRNA
CTD PMID:25596134 NCBI chr17:15,356,016...15,402,680
Ensembl chr17:15,355,529...15,402,649
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Ibuprofen results in decreased expression of ICAM1 mRNA
CTD PMID:16769766, PMID:17931847 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ids iduronate 2-sulfatase increases expression ISO Ibuprofen results in increased expression of IDS mRNA CTD PMID:25596134 NCBI chr 8:69,447,971...69,466,708
Ensembl chr 8:69,449,801...69,466,618
JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion
ISO GW0072 inhibits the reaction [Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]
Ibuprofen analog results in decreased secretion of IFNG protein; Ibuprofen results in decreased secretion of IFNG protein
Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Ibuprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA]
CTD PMID:11080519, PMID:14586007, PMID:16407166, PMID:17630191 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP Ibuprofen results in increased expression of IGF1 protein CTD PMID:16799050 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igkc immunoglobulin kappa constant affects expression ISO Ibuprofen affects the expression of IGKC mRNA CTD PMID:17070997
G Il10 interleukin 10 multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:19020770 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il17rb interleukin 17 receptor B decreases expression EXP Ibuprofen results in decreased expression of IL17RB mRNA CTD PMID:25596134 NCBI chr16:6,064,287...6,077,978
Ensembl chr16:6,064,288...6,077,978
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression
ISO Ibuprofen inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]
Ibuprofen results in increased expression of IL1A mRNA
CTD PMID:11230753, PMID:17070997 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
affects expression
ISO
EXP
Ibuprofen inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Ibuprofen inhibits the reaction [IL1B protein results in increased abundance of Cyclic AMP]; Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; tert-Butylhydroperoxide inhibits the reaction [Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
Ibuprofen results in increased expression of IL1B mRNA
Ibuprofen affects the expression of IL1B protein
Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]
CTD PMID:9890559, PMID:14586007, PMID:15705740, PMID:17709599, PMID:18799549, PMID:21121909, PMID:24747151 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases secretion
increases expression
multiple interactions
ISO
EXP
Ibuprofen results in decreased secretion of IL1RN protein
Ibuprofen results in increased expression of IL1RN mRNA
Ibuprofen results in increased expression of and results in increased secretion of IL1RN protein
CTD PMID:12169827, PMID:15837124 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Ibuprofen co-treated with Lipopolysaccharides] results in increased expression of IL4 protein CTD PMID:19020770 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Ibuprofen results in increased expression of IL6 mRNA; Ibuprofen results in increased expression of IL6 protein
Ibuprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD PMID:10903797, PMID:17070997 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Ibuprofen results in increased expression of INSIG1 mRNA CTD PMID:25596134 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insm1 INSM transcriptional repressor 1 decreases expression ISO Ibuprofen results in decreased expression of INSM1 mRNA CTD PMID:17070997 NCBI chr 3:140,427,961...140,430,467 JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in increased expression of ITGAM mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of ITGAM protein] CTD PMID:24333387 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgbl1 integrin subunit beta like 1 affects expression ISO Ibuprofen affects the expression of ITGBL1 mRNA CTD PMID:17070997 NCBI chr15:110,114,148...110,378,970
Ensembl chr15:110,114,148...110,378,969
JBrowse link
G Lama3 laminin subunit alpha 3 decreases expression ISO Ibuprofen results in decreased expression of LAMA3 mRNA CTD PMID:25596134 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 increases expression ISO Ibuprofen results in increased expression of LARS1 mRNA CTD PMID:25596134 NCBI chr18:36,524,013...36,579,471
Ensembl chr18:36,524,007...36,579,403
JBrowse link
G Ldhb lactate dehydrogenase B affects expression ISO Ibuprofen affects the expression of LDHB protein CTD PMID:18351690 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO Ibuprofen promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Ibuprofen promotes the reaction [Cholesterol, LDL binds to LDLR protein] CTD PMID:10395027 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lgals1 galectin 1 affects expression ISO Ibuprofen affects the expression of LGALS1 protein CTD PMID:18351690 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289
JBrowse link
G Lta lymphotoxin alpha affects response to substance ISO LTA gene SNP affects the susceptibility to Ibuprofen CTD PMID:16931544 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Ltbr lymphotoxin beta receptor decreases expression ISO Ibuprofen results in decreased expression of LTBR mRNA CTD PMID:17070997 NCBI chr 4:157,822,838...157,829,291
Ensembl chr 4:157,822,840...157,829,241
JBrowse link
G Ly9 lymphocyte antigen 9 decreases expression ISO Ibuprofen results in decreased expression of LY9 mRNA CTD PMID:17070997 NCBI chr13:90,002,779...90,022,346
Ensembl chr13:90,002,783...90,022,269
JBrowse link
G Mafg MAF bZIP transcription factor G decreases expression EXP Ibuprofen results in decreased expression of MAFG mRNA CTD PMID:25596134 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO Ibuprofen results in increased expression of MAL mRNA CTD PMID:17070997 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO MAPK11 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Ibuprofen results in increased phosphorylation of EIF4E protein] CTD PMID:18056468, PMID:21097678 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO Ibuprofen results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein; MAPKAPK2 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 multiple interactions ISO MAPKAPK3 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 8:116,012,126...116,046,012
Ensembl chr 8:116,012,121...116,045,954
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 affects expression ISO Ibuprofen affects the expression of MAPRE2 mRNA CTD PMID:17070997 NCBI chr18:14,814,149...15,780,290 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of MCL1 mRNA alternative form; [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of MCL1 mRNA alternative form; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of MCL1 mRNA alternative form]; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of MCL1 mRNA alternative form]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of MCL1 mRNA alternative form]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of MCL1 mRNA alternative form] CTD PMID:18348186 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Me1 malic enzyme 1 increases expression EXP Ibuprofen results in increased expression of ME1 mRNA CTD PMID:25596134 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO Ibuprofen results in increased expression of MMP1 mRNA CTD PMID:16580899 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP [Ibuprofen co-treated with Carbon Tetrachloride] results in increased expression of and results in increased cleavage of MMP13 protein CTD PMID:21360558 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Ibuprofen co-treated with Carbon Tetrachloride] results in increased expression of MMP2 protein CTD PMID:21360558 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Ibuprofen results in increased expression of MMP3 mRNA CTD PMID:16580899 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP
Ibuprofen inhibits the reaction [EGF protein results in increased activity of MMP9 protein]; Ibuprofen inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]
[Ibuprofen co-treated with Carbon Tetrachloride] results in increased expression of MMP9 protein
CTD PMID:16340751, PMID:21360558 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Ibuprofen inhibits the reaction [Carrageenan results in increased expression of MPO protein] CTD PMID:25451575 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mta2 metastasis associated 1 family, member 2 increases expression ISO Ibuprofen results in increased expression of MTA2 mRNA CTD PMID:17070997 NCBI chr 1:225,140,863...225,149,584
Ensembl chr 1:225,140,863...225,149,583
JBrowse link
G Mtfp1 mitochondrial fission process 1 increases expression ISO Ibuprofen results in increased expression of MTFP1 mRNA CTD PMID:25596134 NCBI chr14:84,330,223...84,334,063
Ensembl chr14:84,330,218...84,334,066
JBrowse link
G Mxd1 max dimerization protein 1 increases expression ISO Ibuprofen results in increased expression of MXD1 mRNA CTD PMID:17070997 NCBI chr 4:118,451,752...118,472,150
Ensembl chr 4:118,449,882...118,472,179
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Ibuprofen results in increased expression of NAMPT mRNA CTD PMID:25596134 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression EXP
ISO
Ibuprofen results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
affects activity
ISO Ibuprofen results in increased expression of NFE2L2 mRNA
Ibuprofen affects the activity of NFE2L2 protein
CTD PMID:25596134 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]
Ibuprofen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Ibuprofen results in decreased activity of [NFKB1 protein binds to RELA protein]
CTD PMID:9281604, PMID:9890559, PMID:10602496, PMID:15489888 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Ibuprofen inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] CTD PMID:9890559, PMID:15489888 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions
increases expression
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of NGFR mRNA]; ELAVL1 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; Ibuprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]; Ibuprofen results in increased stability of and results in increased expression of NGFR mRNA; MAPK11 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; MAPKAPK2 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; MAPKAPK3 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; NGFR protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]
Ibuprofen results in increased expression of NGFR mRNA; Ibuprofen results in increased expression of NGFR protein
CTD PMID:17409433, PMID:17447067, PMID:18056468, PMID:21097678 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO Ibuprofen affects the expression of NOS1 mRNA CTD PMID:17070997 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
increases activity
multiple interactions
EXP
ISO
Ibuprofen results in increased expression of NOS2 mRNA
Ibuprofen results in increased activity of NOS2 protein
Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]
CTD PMID:11080519, PMID:11545620, PMID:11837731 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression ISO Ibuprofen affects the expression of NQO1 mRNA CTD PMID:17070997 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 mRNA; [Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 protein CTD PMID:29222744 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR1H4 mRNA; [Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR1H4 protein CTD PMID:29222744 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity
multiple interactions
decreases expression
EXP
ISO
Ibuprofen results in increased activity of NR3C1 protein
NR3C1 protein affects the reaction [Ibuprofen promotes the reaction [Dexamethasone results in decreased expression of CTH mRNA]]
Ibuprofen results in decreased expression of NR3C1 mRNA
CTD PMID:15700047, PMID:25596134, PMID:29222744 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nuak1 NUAK family kinase 1 decreases expression ISO Ibuprofen results in decreased expression of NUAK1 mRNA CTD PMID:25596134 NCBI chr 7:25,039,336...25,111,118
Ensembl chr 7:25,039,335...25,113,664
JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions ISO Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G Pabpn1 poly(A) binding protein, nuclear 1 multiple interactions ISO Ibuprofen inhibits the reaction [PABPN1 protein mutant form binds to PABPN1 protein mutant form] CTD PMID:16239242 NCBI chr15:33,555,640...33,560,251
Ensembl chr15:33,555,640...33,560,242
JBrowse link
G Pank1 pantothenate kinase 1 increases expression ISO
EXP
Ibuprofen results in increased expression of PANK1 mRNA CTD PMID:25596134 NCBI chr 1:253,115,400...253,189,643
Ensembl chr 1:253,119,112...253,185,533
JBrowse link
G Pclo piccolo (presynaptic cytomatrix protein) increases expression ISO Ibuprofen results in increased expression of PCLO mRNA CTD PMID:25596134 NCBI chr 4:16,454,904...17,058,921
Ensembl chr 4:16,454,904...17,058,921
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO Ibuprofen inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; Ibuprofen inhibits the reaction [PDGFA results in increased abundance of Epoprostenol] CTD PMID:19201774 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 decreases expression EXP Ibuprofen results in decreased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:68,493,035...68,578,999
Ensembl chr11:68,493,035...68,578,995
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP
ISO
Ibuprofen results in increased expression of PDK4 mRNA CTD PMID:25596134 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression ISO
EXP
Ibuprofen results in decreased expression of PDLIM1 mRNA CTD PMID:25596134 NCBI chr 1:259,308,326...259,357,006
Ensembl chr 1:259,308,296...259,357,056
JBrowse link
G Pgam1 phosphoglycerate mutase 1 affects expression
increases expression
ISO Ibuprofen affects the expression of PGAM1 protein
Ibuprofen results in increased expression of PGAM1 mRNA
CTD PMID:18351690 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
JBrowse link
G Pla2g2a phospholipase A2 group IIA affects expression ISO Ibuprofen affects the expression of PLA2G2A mRNA CTD PMID:17070997 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO Ibuprofen inhibits the reaction [EGF protein results in increased expression of PLAU mRNA] CTD PMID:16340751 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plec plectin increases expression
affects expression
ISO Ibuprofen results in increased expression of PLEC mRNA
Ibuprofen affects the expression of PLEC protein
CTD PMID:18351690 NCBI chr 7:117,230,319...117,291,859
Ensembl chr 7:117,230,319...117,289,961
JBrowse link
G Plin2 perilipin 2 increases expression EXP
ISO
Ibuprofen results in increased expression of PLIN2 mRNA CTD PMID:25596134 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression EXP Ibuprofen results in decreased expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646
JBrowse link
G Pml PML nuclear body scaffold affects expression ISO Ibuprofen affects the expression of PML mRNA CTD PMID:17070997 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Podxl podocalyxin-like decreases expression EXP Ibuprofen results in decreased expression of PODXL mRNA CTD PMID:25596134 NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Ibuprofen results in decreased expression of POU5F1 mRNA CTD PMID:29665328 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
increases activity
ISO
EXP
Ibuprofen binds to and results in increased activity of PPARA protein
[Dexamethasone co-treated with Ibuprofen] results in increased expression of PPARA mRNA
Ibuprofen results in increased expression of PPARA mRNA; Ibuprofen results in increased expression of PPARA protein
[Dexamethasone co-treated with Ibuprofen] results in increased expression of PPARA mRNA; [Dexamethasone co-treated with Ibuprofen] results in increased expression of PPARA protein
Ibuprofen analog results in increased activity of PPARA protein
CTD PMID:9013583, PMID:11755111, PMID:29222744 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
affects activity
increases expression
increases activity
ISO
EXP
Ibuprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA]; Ibuprofen inhibits the reaction [Methamphetamine results in decreased expression of PPARG protein]
Ibuprofen affects the activity of PPARG protein
Ibuprofen results in increased expression of PPARG mRNA
Ibuprofen analog results in increased activity of PPARG protein
Ibuprofen binds to and results in increased activity of PPARG protein
CTD PMID:9013583, PMID:11755111, PMID:16407166, PMID:18946735, PMID:25596134 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppia peptidylprolyl isomerase A affects expression ISO Ibuprofen affects the expression of PPIA protein CTD PMID:18351690 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha multiple interactions ISO [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of PPP1CA protein CTD PMID:18348186 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Ibuprofen results in increased expression of PPP1R15A mRNA CTD PMID:25596134 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prdx2 peroxiredoxin 2 affects expression
increases expression
ISO Ibuprofen affects the expression of PRDX2 protein
Ibuprofen results in increased expression of PRDX2 mRNA
CTD PMID:18351690 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prdx6 peroxiredoxin 6 affects expression ISO Ibuprofen affects the expression of PRDX6 protein CTD PMID:18351690 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 decreases expression ISO Ibuprofen results in decreased expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:199,831,990...199,847,623
Ensembl chr 2:199,831,990...199,847,629
JBrowse link
G Ptger3 prostaglandin E receptor 3 affects expression ISO Ibuprofen affects the expression of PTGER3 mRNA CTD PMID:17070997 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Ptgr1 prostaglandin reductase 1 affects activity ISO Ibuprofen affects the activity of PTGR1 protein CTD PMID:25619643 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression
ISO
EXP
Ibuprofen results in decreased activity of PTGS1 protein
Ibuprofen analog results in decreased activity of PTGS1 protein; Ibuprofen results in decreased activity of PTGS1 protein
Ibuprofen results in decreased expression of PTGS1 mRNA
CTD PMID:10697514, PMID:12242329, PMID:16141368, PMID:17164136, PMID:18848576 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases degradation
decreases activity
decreases expression
increases expression
increases response to substance
ISO
EXP
Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Ibuprofen inhibits the reaction [PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of glyceryl 2-arachidonate]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
[Dexamethasone co-treated with Ibuprofen] results in decreased expression of PTGS2 mRNA; [Ibuprofen binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2
Ibuprofen results in decreased degradation of PTGS2 protein
Ibuprofen results in decreased activity of PTGS2 protein; Ibuprofen results in decreased activity of PTGS2 protein mutant form
Ibuprofen results in decreased expression of PTGS2 mRNA
Ibuprofen results in increased expression of PTGS2 mRNA
Ibuprofen inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [endotoxin, Escherichia coli promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Ibuprofen inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Ibuprofen inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
PTGS2 gene SNP results in increased susceptibility to Ibuprofen
CTD PMID:10697514, PMID:12242329, PMID:15489888, PMID:15705740, PMID:15817521, PMID:16249722, PMID:16678543, PMID:16997862, PMID:17164136, PMID:18096423, PMID:18297109, PMID:18848576, PMID:19758985, PMID:21360558, PMID:22245433, PMID:26359731, PMID:29222744 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pxn paxillin decreases expression EXP Ibuprofen results in decreased expression of PXN mRNA; Ibuprofen results in decreased expression of PXN protein CTD PMID:16463375 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Pygl glycogen phosphorylase L increases expression EXP Ibuprofen results in increased expression of PYGL mRNA CTD PMID:25596134 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Pyy peptide YY decreases expression ISO Ibuprofen results in decreased expression of PYY mRNA CTD PMID:17070997 NCBI chr10:90,047,989...90,049,155
Ensembl chr10:90,047,993...90,049,112
JBrowse link
G Ran RAN, member RAS oncogene family affects expression ISO Ibuprofen affects the expression of RAN protein CTD PMID:18351690 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO Ibuprofen results in decreased expression of RARA mRNA CTD PMID:25596134 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation EXP Ibuprofen results in decreased phosphorylation of RB1 protein CTD PMID:15099639 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]; Ibuprofen results in decreased activity of [NFKB1 protein binds to RELA protein]
Ibuprofen inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]
CTD PMID:9281604, PMID:9890559, PMID:10328874, PMID:10602496, PMID:15489888 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rrp12 ribosomal RNA processing 12 homolog increases expression ISO Ibuprofen results in increased expression of RRP12 mRNA CTD PMID:25596134 NCBI chr 1:261,106,768...261,140,416
Ensembl chr 1:261,106,760...261,140,389
JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 increases expression ISO Ibuprofen results in increased expression of RSL1D1 mRNA CTD PMID:25596134 NCBI chr10:4,375,329...4,387,195
Ensembl chr10:4,356,915...4,390,030
JBrowse link
G Rsrc2 arginine and serine rich coiled-coil 2 increases expression ISO Ibuprofen results in increased expression of RSRC2 mRNA CTD PMID:25596134 NCBI chr12:38,274,290...38,294,294
Ensembl chr12:38,274,297...38,294,292
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Ibuprofen results in decreased expression of RXRA mRNA CTD PMID:25596134 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Ibuprofen results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sars1 seryl-tRNA synthetase 1 decreases expression EXP Ibuprofen results in decreased expression of SARS1 mRNA CTD PMID:25596134 NCBI chr 2:211,219,743...211,235,475
Ensembl chr 2:211,219,750...211,235,467
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO
EXP
Ibuprofen results in increased expression of SAT1 mRNA CTD PMID:16262603, PMID:25596134 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Sele selectin E multiple interactions ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16769766 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sesn1 sestrin 1 decreases expression EXP Ibuprofen results in decreased expression of SESN1 mRNA CTD PMID:25596134 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sfn stratifin increases expression ISO Ibuprofen results in increased expression of SFN mRNA CTD PMID:25596134 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Sh3tc1 SH3 domain and tetratricopeptide repeats 1 increases expression ISO Ibuprofen results in increased expression of SH3TC1 mRNA CTD PMID:25596134 NCBI chr14:80,184,814...80,229,207
Ensembl chr14:80,195,715...80,229,214
JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression
increases expression
EXP
ISO
Ibuprofen results in decreased expression of SIK1 mRNA
Ibuprofen results in increased expression of SIK1 mRNA
CTD PMID:25596134 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of SLC10A1 mRNA CTD PMID:29222744 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc10a2 solute carrier family 10 member 2 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of SLC10A2 mRNA CTD PMID:29222744 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc15a1 solute carrier family 15 member 1 affects binding ISO Ibuprofen analog binds to SLC15A1 protein CTD PMID:21147219 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression ISO Ibuprofen results in increased expression of SLC16A6 mRNA CTD PMID:25596134 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521
JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO Ibuprofen results in increased expression of SLC1A4 mRNA CTD PMID:25596134 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597
JBrowse link
G Slc1a7 solute carrier family 1 member 7 increases expression ISO Ibuprofen results in increased expression of SLC1A7 mRNA CTD PMID:25596134 NCBI chr 5:127,571,114...127,616,033
Ensembl chr 5:127,571,114...127,616,033
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Ibuprofen results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity
increases uptake
ISO Ibuprofen results in decreased activity of SLC22A9 protein
SLC22A9 protein results in increased uptake of Ibuprofen
CTD PMID:12388633 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases uptake
ISO Ibuprofen results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased uptake of Ibuprofen
CTD PMID:12388633 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
decreases activity
ISO Ibuprofen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
Ibuprofen results in decreased activity of SLC22A7 protein
CTD PMID:12388633, PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Ibuprofen inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
Ibuprofen inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
CTD PMID:11306713, PMID:15100168 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression EXP Ibuprofen results in increased expression of SLC25A20 mRNA CTD PMID:25596134 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression
increases expression
ISO Ibuprofen results in decreased expression of SLC2A1 protein
Ibuprofen results in increased expression of SLC2A1 mRNA
CTD PMID:12912967, PMID:25596134 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Ibuprofen results in increased expression of SLC3A2 mRNA CTD PMID:25596134 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc5a8 solute carrier family 5 member 8 decreases activity ISO Ibuprofen results in decreased activity of SLC5A8 protein CTD PMID:15090606, PMID:16670197 NCBI chr 7:29,434,175...29,476,807
Ensembl chr 7:29,435,444...29,477,947
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Ibuprofen inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] CTD PMID:18946735 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression ISO Ibuprofen results in increased expression of SLC6A9 mRNA CTD PMID:25596134 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Slc7a1 solute carrier family 7 member 1 increases expression ISO Ibuprofen results in increased expression of SLC7A1 mRNA CTD PMID:25596134 NCBI chr12:8,032,775...8,108,972
Ensembl chr12:8,032,809...8,108,972
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Ibuprofen results in increased expression of SLC7A11 mRNA CTD PMID:25596134 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Ibuprofen results in increased expression of SLC7A5 mRNA CTD PMID:25596134 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of SLCO1B2 mRNA CTD PMID:29222744 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression ISO Ibuprofen results in decreased expression of SLCO2B1 mRNA CTD PMID:25596134 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Socs3 suppressor of cytokine signaling 3 affects expression ISO Ibuprofen affects the expression of SOCS3 mRNA CTD PMID:17070997 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Ibuprofen results in increased expression of SOD2 mRNA CTD PMID:17070997 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression ISO Ibuprofen results in decreased expression of SORL1 mRNA CTD PMID:25596134 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Ibuprofen results in increased expression of SRXN1 mRNA CTD PMID:25596134 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression ISO Ibuprofen results in increased expression of STRBP mRNA CTD PMID:25596134 NCBI chr 3:21,817,680...21,956,988
Ensembl chr 3:21,828,298...21,904,270
JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO Ibuprofen results in decreased expression of SULF2 mRNA CTD PMID:25596134 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Ibuprofen results in decreased activity of SULT1E1 protein CTD PMID:17073578 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Taldo1 transaldolase 1 decreases expression EXP Ibuprofen results in decreased expression of TALDO1 mRNA CTD PMID:25596134 NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885
JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO Ibuprofen analog results in decreased expression of TBX21 mRNA; Ibuprofen results in decreased expression of TBX21 mRNA CTD PMID:17630191 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 increases expression EXP
ISO
Ibuprofen results in increased expression of TET1 mRNA CTD PMID:29665328 NCBI chr20:27,359,122...27,438,039
Ensembl chr20:27,366,213...27,437,427
JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases expression
increases expression
EXP
ISO
Ibuprofen results in decreased expression of TFE3 mRNA
Ibuprofen results in increased expression of TFE3 mRNA
CTD PMID:25596134 NCBI chr  X:15,574,579...15,587,826
Ensembl chr  X:15,575,934...15,587,419
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Ibuprofen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:21360558 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Ibuprofen results in increased expression of THBS1 protein CTD PMID:18261746 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP Ibuprofen results in increased expression of TIPARP mRNA CTD PMID:25596134 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link
G Tmprss4 transmembrane serine protease 4 affects expression ISO Ibuprofen affects the expression of TMPRSS4 mRNA CTD PMID:17070997 NCBI chr 8:49,469,804...49,503,304
Ensembl chr 8:49,469,503...49,502,647
JBrowse link
G Tnc tenascin C increases expression ISO Ibuprofen results in increased expression of TNC mRNA CTD PMID:17070997 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases secretion
ISO
EXP
[Oxygen deficiency co-treated with Lipopolysaccharides] promotes the reaction [Ibuprofen results in increased expression of TNF protein]; GW0072 inhibits the reaction [Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]; Ibuprofen inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of SELE protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Ibuprofen results in decreased activity of [TNF protein results in increased activity of CHUK protein]
Ibuprofen inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Ibuprofen analog results in decreased secretion of TNF protein; Ibuprofen results in decreased secretion of TNF protein
Ibuprofen affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Ibuprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ibuprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA]; Ibuprofen inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ibuprofen promotes the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; Ibuprofen promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
CTD PMID:9281604, PMID:9890559, PMID:10328874, PMID:10602496, PMID:10903797, PMID:11545620, PMID:11753679, PMID:14586007, PMID:15060681, PMID:15263833, PMID:15489888, PMID:16407166, PMID:16769766, PMID:17630191, PMID:21121909, PMID:24333387, PMID:32289289 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip8 TNF alpha induced protein 8 decreases expression ISO Ibuprofen results in decreased expression of TNFAIP8 mRNA CTD PMID:25596134 NCBI chr18:44,664,310...44,779,914
Ensembl chr18:44,716,226...44,779,914
JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 multiple interactions
decreases expression
ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein]
Ibuprofen results in decreased expression of TNFRSF21 mRNA; Ibuprofen results in decreased expression of TNFRSF21 protein
CTD PMID:11753679 NCBI chr 9:20,546,159...20,621,051
Ensembl chr 9:20,546,159...20,621,051
JBrowse link
G Tp53 tumor protein p53 affects activity ISO Ibuprofen affects the activity of TP53 protein CTD PMID:25596134 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 decreases expression ISO Ibuprofen results in decreased expression of TP53INP1 mRNA CTD PMID:25596134 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Tpd52l1 TPD52 like 1 increases expression ISO Ibuprofen results in increased expression of TPD52L1 mRNA CTD PMID:25596134 NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression
affects expression
ISO Ibuprofen results in increased expression of TPI1 mRNA
Ibuprofen affects the expression of TPI1 protein
CTD PMID:18351690 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
increases expression
multiple interactions
ISO UGT1A1 protein results in increased glucuronidation of Ibuprofen
Ibuprofen results in increased expression of UGT1A1 mRNA
[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A1 mRNA
CTD PMID:15843492, PMID:29222744 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Ibuprofen CTD PMID:15117964, PMID:15843492 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions
ISO Ibuprofen results in increased expression of UGT1A6 mRNA
[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A6 mRNA
CTD PMID:29222744 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Ibuprofen CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ibuprofen CTD PMID:15843492 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Ibuprofen CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases expression
increases glucuronidation
ISO Ibuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ibuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT2B34 mRNA
Ibuprofen results in increased expression of UGT2B34 mRNA
UGT2B7 protein alternative form results in increased glucuronidation of Ibuprofen; UGT2B7 protein results in increased glucuronidation of Ibuprofen
CTD PMID:8423545, PMID:8517101, PMID:15843492, PMID:19740398, PMID:29222744 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vars1 valyl-tRNA synthetase 1 increases expression
decreases expression
ISO
EXP
Ibuprofen results in increased expression of VARS1 mRNA
Ibuprofen results in decreased expression of VARS1 mRNA
CTD PMID:25596134 NCBI chr20:4,993,539...5,008,259
Ensembl chr20:4,993,560...5,008,262
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:16769766 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion
decreases expression
ISO
EXP
Ibuprofen results in decreased secretion of VEGFA protein
Ibuprofen results in decreased expression of VEGFA mRNA alternative form; Ibuprofen results in decreased expression of VEGFA protein
CTD PMID:12912967, PMID:16799050 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vwce von Willebrand factor C and EGF domains decreases expression ISO Ibuprofen results in decreased expression of VWCE mRNA CTD PMID:25596134 NCBI chr 1:226,687,258...226,717,989
Ensembl chr 1:226,687,258...226,710,897
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 decreases expression EXP Ibuprofen results in decreased expression of WARS1 mRNA CTD PMID:25596134 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Wdr81 WD repeat domain 81 increases expression ISO Ibuprofen results in increased expression of WDR81 mRNA CTD PMID:25596134 NCBI chr10:62,273,817...62,287,213
Ensembl chr10:62,273,800...62,287,189
JBrowse link
G Xbp1 X-box binding protein 1 affects activity ISO Ibuprofen affects the activity of XBP1 protein CTD PMID:25596134 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 increases expression ISO Ibuprofen results in increased expression of YARS1 mRNA CTD PMID:25596134 NCBI chr 5:147,375,350...147,403,578
Ensembl chr 5:147,375,350...147,403,571
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO Ibuprofen results in increased expression of ZMAT3 mRNA CTD PMID:25596134 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      biological role 19717
        xenobiotic 18379
          ibuprofen 289
            carboxyibuprofen 0
            dexibuprofen 0
            ibuproxam 0
            levibuprofen 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic group 18488
                              organic divalent group 18481
                                organodiyl group 18481
                                  carbonyl group 18384
                                    carbonyl compound 18384
                                      carboxylic acid 18054
                                        monocarboxylic acid 17396
                                          fatty acid 15810
                                            saturated fatty acid 15775
                                              propionic acid 3666
                                                ibuprofen 289
                                                  carboxyibuprofen 0
                                                  dexibuprofen 0
                                                  ibuproxam 0
                                                  levibuprofen 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.