Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ibogamine
go back to main search page
Accession:CHEBI:5853 term browser browse the term
Definition:A monoterpenoid indole alkaloid with formula C19H24N2. It is isolated from the flowering plant genus, Tabernaemontana and exhibits anti-addictive properties.
Synonyms:related_synonym: Formula=C19H24N2;   InChI=1S/C19H24N2/c1-2-13-9-12-10-16-18-15(7-8-21(11-12)19(13)16)14-5-3-4-6-17(14)20-18/h3-6,12-13,16,19-20H,2,7-11H2,1H3/t12-,13+,16+,19+/m1/s1;   InChIKey=LRLCVRYKAFDXKU-YGOSVGOTSA-N;   SMILES=[C@H]12[C@@]3([C@H](C[C@](C1)(CN3CCC=4C5=C(C=CC=C5)NC42)[H])CC)[H]
 xref: Beilstein:26631;   Beilstein:5753131;   CAS:481-87-8;   KEGG:C09215;   KNApSAcK:C00001742;   PMID:10930287;   PMID:15911323;   PMID:16959135;   PMID:17879729;   PMID:18797794;   PMID:23919354;   PMID:25633249;   PMID:26022277;   PMID:30599414;   PMID:30618175;   PMID:31095891;   PMID:621649;   Wikipedia:Ibogamine
 cyclic_relationship: is_conjugate_base_of CHEBI:146257


show annotations for term's descendants           Sort by:
 
ibogaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Ibogaine results in decreased activity of KCNH2 protein CTD PMID:23707769 PMID:24307198 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Ibogaine results in decreased activity of SCN5A protein CTD PMID:23707769 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component increases response to substance ISO SEC24D protein results in increased susceptibility to Ibogaine CTD PMID:27555326 NCBI chr 2:227,455,704...227,562,801
Ensembl chr 2:227,455,722...227,562,319
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases expression
ISO Ibogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Ibogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]
Ibogaine results in increased expression of SLC6A3 protein
CTD PMID:27555326 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      application 19413
        refrigerant 17474
          ammonia 17008
            organic amino compound 17007
              tertiary amino compound 8650
                ibogamine 4
                  ibogaine + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            inorganic hydride 17457
                              pnictogen hydride 17432
                                nitrogen hydride 17277
                                  azane 17009
                                    ammonia 17008
                                      organic amino compound 17007
                                        tertiary amino compound 8650
                                          ibogamine 4
                                            ibogaine + 4
paths to the root