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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hypericin
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Accession:CHEBI:5835 term browser browse the term
Definition:A carbopolycyclic compound that has formula C30H16O8.
Synonyms:exact_synonym: 1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
 related_synonym: 1:6:8:10:11:13-hexahydroxy-3:4-dimethyl-meso-naphthodianthrene-7:14-dione;   Formula=C30H16O8;   Hyperizin;   InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3;   InChIKey=BTXNYTINYBABQR-UHFFFAOYSA-N;   SMILES=Cc1cc(O)c2c3c1c1c(C)cc(O)c4c1c1c5c(c(O)cc(O)c5c4=O)c4c(O)cc(O)c(c4c31)c2=O;   hipericina;   hypericine;   hypericum red
 xref: Beilstein:1917913;   CAS:548-04-9;   Gmelin:926160;   KEGG:C07606;   KNApSAcK:C00002829;   LINCS:LSM-2650;   LIPID_MAPS_instance:LMPK13040001
 xref_mesh: MESH:C004965
 xref: Patent:US2707704


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hypericin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
hypericin results in increased expression of ABCB1
CTD PMID:15266218, PMID:16005588 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO hypericin results in increased expression of ABCC1 protein CTD PMID:24994473 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Alb albumin affects binding ISO hypericin binds to ALB protein CTD PMID:15461448 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO hypericin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]
hypericin results in decreased activity of CYP1A1 protein
CTD PMID:14633740 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO hypericin binds to and results in decreased activity of GSTA1 protein CTD PMID:15461448 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO
EXP
hypericin binds to and results in decreased activity of GSTP1 protein
hypericin results in decreased activity of GSTP1 protein
CTD PMID:15461448, PMID:20637187 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO hypericin results in decreased activity of TOP2A protein CTD PMID:11597574 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            central nervous system drug 16428
              psychotropic drug 15049
                antidepressant 3122
                  hypericin 7
                    St. John's wort extract 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  cyclic hydrocarbon 17062
                                    arene 17058
                                      polycyclic arene 16879
                                        ortho- and peri-fused polycyclic arene 16152
                                          bisanthene 7
                                            hypericin 7
                                              St. John's wort extract 0
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