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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hypericin
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Accession:CHEBI:5835 term browser browse the term
Definition:A carbopolycyclic compound that has formula C30H16O8.
Synonyms:exact_synonym: 1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
 related_synonym: 1:6:8:10:11:13-hexahydroxy-3:4-dimethyl-meso-naphthodianthrene-7:14-dione;   Formula=C30H16O8;   Hyperizin;   InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3;   InChIKey=BTXNYTINYBABQR-UHFFFAOYSA-N;   SMILES=Cc1cc(O)c2c3c1c1c(C)cc(O)c4c1c1c5c(c(O)cc(O)c5c4=O)c4c(O)cc(O)c(c4c31)c2=O;   hipericina;   hypericine;   hypericum red
 xref: Beilstein:1917913;   CAS:548-04-9;   Gmelin:926160;   KEGG:C07606;   KNApSAcK:C00002829;   LINCS:LSM-2650;   LIPID_MAPS_instance:LMPK13040001
 xref_mesh: MESH:C004965
 xref: Patent:US2707704


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hypericin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
hypericin results in increased expression of ABCB1
CTD PMID:15266218 PMID:16005588 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO hypericin results in increased expression of ABCC1 protein CTD PMID:24994473 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Alb albumin affects binding ISO hypericin binds to ALB protein CTD PMID:15461448 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO hypericin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]
hypericin results in decreased activity of CYP1A1 protein
CTD PMID:14633740 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression
decreases expression
ISO hypericin results in decreased activity of CYP3A4 protein
hypericin results in increased expression of CYP3A4
hypericin results in decreased expression of CYP3A4 mRNA
CTD PMID:15266218 PMID:16005588 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO hypericin binds to and results in decreased activity of GSTA1 protein CTD PMID:15461448 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO
EXP
hypericin binds to and results in decreased activity of GSTP1 protein
hypericin results in decreased activity of GSTP1 protein
CTD PMID:15461448 PMID:20637187 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO hypericin results in decreased activity of TOP2A protein CTD PMID:11597574 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link

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  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            central nervous system drug 16522
              psychotropic drug 15171
                antidepressant 3651
                  hypericin 8
                    St. John's wort extract 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  cyclic hydrocarbon 17078
                                    arene 17074
                                      polycyclic arene 16894
                                        ortho- and peri-fused polycyclic arene 16176
                                          bisanthene 8
                                            hypericin 8
                                              St. John's wort extract 0
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