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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hypericin
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Accession:CHEBI:5835 term browser browse the term
Definition:A carbopolycyclic compound that has formula C30H16O8.
Synonyms:exact_synonym: 1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
 related_synonym: 1:6:8:10:11:13-hexahydroxy-3:4-dimethyl-meso-naphthodianthrene-7:14-dione;   Formula=C30H16O8;   Hyperizin;   InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3;   InChIKey=BTXNYTINYBABQR-UHFFFAOYSA-N;   SMILES=Cc1cc(O)c2c3c1c1c(C)cc(O)c4c1c1c5c(c(O)cc(O)c5c4=O)c4c(O)cc(O)c(c4c31)c2=O;   hipericina;   hypericine;   hypericum red
 xref: Beilstein:1917913;   CAS:548-04-9;   Gmelin:926160;   KEGG:C07606;   KNApSAcK:C00002829;   LINCS:LSM-2650;   LIPID_MAPS_instance:LMPK13040001
 xref_mesh: MESH:C004965
 xref: Patent:US2707704


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hypericin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 ISO hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
hypericin results in increased expression of ABCB1		 CTD PMID:15266218 PMID:16005588 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO hypericin results in increased expression of ABCC1 protein CTD PMID:24994473 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Alb albumin affects binding ISO hypericin binds to ALB protein CTD PMID:15461448 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity		 ISO hypericin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]
hypericin results in decreased activity of CYP1A1 protein		 CTD PMID:14633740 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression
decreases expression		 ISO hypericin results in decreased activity of CYP3A4 protein
hypericin results in increased expression of CYP3A4
hypericin results in decreased expression of CYP3A4 mRNA		 CTD PMID:15266218 PMID:16005588 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO hypericin binds to and results in decreased activity of GSTA1 protein CTD PMID:15461448 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity		 ISO
EXP		 hypericin binds to and results in decreased activity of GSTP1 protein
hypericin results in decreased activity of GSTP1 protein		 CTD PMID:15461448 PMID:20637187 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO hypericin results in decreased activity of TOP2A protein CTD PMID:11597574 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        pharmaceutical 19579
          drug 19579
            central nervous system drug 16785
              psychotropic drug 15559
                antidepressant 3760
                  hypericin 8
                    St. John's wort extract 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    main group molecular entity 19876
                      s-block molecular entity 19705
                        hydrogen molecular entity 19686
                          hydrides 19179
                            organic hydride 18717
                              organic fundamental parent 18717
                                hydrocarbon 18457
                                  cyclic hydrocarbon 17244
                                    arene 17225
                                      polycyclic arene 17050
                                        ortho- and peri-fused polycyclic arene 16291
                                          bisanthene 8
                                            hypericin 8
                                              St. John's wort extract 0
paths to the root