The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
[Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine ABCB1 protein results in increased transport of hypaconitine ABCB1A protein affects the susceptibility to hypaconitine
[verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of hypaconitine ABCC2 protein affects the susceptibility to hypaconitine
[3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of hypaconitine ABCG2 protein results in increased transport of hypaconitine ABCG2 protein affects the susceptibility to hypaconitine
[BMAL1 protein affects the expression of CYP3A11 mRNA] which affects the susceptibility to hypaconitine; [BMAL1 protein affects the expression of CYP3A11 protein] which affects the metabolism of hypaconitine
CYP3A4 protein results in increased metabolism of hypaconitine hypaconitine results in increased expression of CYP3A4 mRNA [Aconitine co-treated with mesaconitine co-treated with hypaconitine] results in increased expression of CYP3A4 mRNA