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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Hypaconitine
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Accession:CHEBI:5831 term browser browse the term
Definition:A diterpenoid that has formula C33H45NO10.
Synonyms:related_synonym: Formula=C33H45NO10;   InChI=1S/C33H45NO10/c1-17(35)44-33-21-19(14-31(38,28(42-6)26(33)36)27(21)43-29(37)18-10-8-7-9-11-18)32-20(40-4)12-13-30(16-39-3)15-34(2)25(32)22(33)23(41-5)24(30)32/h7-11,19-28,36,38H,12-16H2,1-6H3/t19-,20+,21-,22+,23+,24-,25?,26+,27-,28+,30+,31-,32+,33-/m1/s1;   InChIKey=FIDOCHXHMJHKRW-VHQVDBNASA-N;   SMILES=COC[C@@]12CC[C@H](OC)[C@@]34[C@@H]5C[C@@]6(O)[C@H](OC(=O)c7ccccc7)[C@@H]5[C@@](OC(C)=O)([C@@H]([C@H](OC)[C@H]13)C4N(C)C2)[C@@H](O)[C@@H]6OC
 xref: CAS:6900-87-4;   KEGG:C08688;   KNApSAcK:C00001644
 xref_mesh: MESH:C058309



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Hypaconitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects response to substance
increases transport
ISO [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine
ABCB1A protein affects the susceptibility to hypaconitine
ABCB1 protein results in increased transport of hypaconitine
CTD PMID:23200901 PMID:33171190 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
affects response to substance
ISO [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of hypaconitine
ABCC2 protein affects the susceptibility to hypaconitine
CTD PMID:23200901 PMID:33171190 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
affects response to substance
increases transport
ISO [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of hypaconitine
ABCG2 protein affects the susceptibility to hypaconitine
ABCG2 protein results in increased transport of hypaconitine
CTD PMID:23200901 PMID:33171190 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like multiple interactions ISO [ARNTL protein affects the expression of CYP3A11 mRNA] which affects the susceptibility to hypaconitine; [ARNTL protein affects the expression of CYP3A11 protein] which affects the metabolism of hypaconitine CTD PMID:31150629 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of hypaconitine CTD PMID:21550385
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    chemical entity 19795
      atom 19794
        nonmetal atom 19681
          carbon atom 19604
            organic molecular entity 19604
              isoprenoid 12723
                terpenoid 12293
                  diterpenoid 11516
                    Hypaconitine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19474
                        hydrogen molecular entity 19466
                          hydrides 18830
                            organic hydride 18346
                              organic fundamental parent 18346
                                hydrocarbon 18057
                                  terpene 12723
                                    diterpene 11516
                                      diterpenoid 11516
                                        Hypaconitine 11
paths to the root