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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Hypaconitine
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Accession:CHEBI:5831 term browser browse the term
Definition:A diterpenoid that has formula C33H45NO10.
Synonyms:related_synonym: Formula=C33H45NO10;   InChI=1S/C33H45NO10/c1-17(35)44-33-21-19(14-31(38,28(42-6)26(33)36)27(21)43-29(37)18-10-8-7-9-11-18)32-20(40-4)12-13-30(16-39-3)15-34(2)25(32)22(33)23(41-5)24(30)32/h7-11,19-28,36,38H,12-16H2,1-6H3/t19-,20+,21-,22+,23+,24-,25?,26+,27-,28+,30+,31-,32+,33-/m1/s1;   InChIKey=FIDOCHXHMJHKRW-VHQVDBNASA-N;   SMILES=COC[C@@]12CC[C@H](OC)[C@@]34[C@@H]5C[C@@]6(O)[C@H](OC(=O)c7ccccc7)[C@@H]5[C@@](OC(C)=O)([C@@H]([C@H](OC)[C@H]13)C4N(C)C2)[C@@H](O)[C@@H]6OC
 xref: CAS:6900-87-4;   KEGG:C08688;   KNApSAcK:C00001644
 xref_mesh: MESH:C058309



show annotations for term's descendants           Sort by:
Hypaconitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
affects response to substance
ISO [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine
ABCB1 protein results in increased transport of hypaconitine
ABCB1A protein affects the susceptibility to hypaconitine
CTD PMID:23200901 PMID:33171190 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
affects response to substance
ISO [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of hypaconitine
ABCC2 protein affects the susceptibility to hypaconitine
CTD PMID:23200901 PMID:33171190 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport
affects response to substance
ISO [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of hypaconitine
ABCG2 protein results in increased transport of hypaconitine
ABCG2 protein affects the susceptibility to hypaconitine
CTD PMID:23200901 PMID:33171190 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 multiple interactions ISO [BMAL1 protein affects the expression of CYP3A11 mRNA] which affects the susceptibility to hypaconitine; [BMAL1 protein affects the expression of CYP3A11 protein] which affects the metabolism of hypaconitine CTD PMID:31150629 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of hypaconitine CTD PMID:21550385
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
increases expression
multiple interactions
ISO CYP3A4 protein results in increased metabolism of hypaconitine
hypaconitine results in increased expression of CYP3A4 mRNA
[Aconitine co-treated with mesaconitine co-treated with hypaconitine] results in increased expression of CYP3A4 mRNA
CTD PMID:21550385 PMID:30303438 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of hypaconitine CTD PMID:21550385 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO hypaconitine results in increased expression of NR1I2 mRNA CTD PMID:30303438 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      atom 19916
        nonmetal atom 19852
          carbon atom 19806
            organic molecular entity 19806
              isoprenoid 13849
                terpenoid 13543
                  diterpenoid 12815
                    Hypaconitine 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    main group molecular entity 19866
                      s-block molecular entity 19698
                        hydrogen molecular entity 19684
                          hydrides 19159
                            organic hydride 18714
                              organic fundamental parent 18714
                                hydrocarbon 18440
                                  terpene 13849
                                    diterpene 12815
                                      diterpenoid 12815
                                        Hypaconitine 12
paths to the root