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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:myriocin
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Accession:CHEBI:582124 term browser browse the term
Definition:An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.
Synonyms:exact_synonym: (2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
 related_synonym: Formula=C21H39NO6;   InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1;   InChIKey=ZZIKIHCNFWXKDY-GNTQXERDSA-N;   SMILES=CCCCCCC(=O)CCCCCC\\C=C\\C[C@@H](O)[C@H](O)[C@@](N)(CO)C(O)=O;   Thermozymocidin;   antibiotic ISP-I
 xref: Beilstein:5113331;   CAS:35891-70-4
 xref_mesh: MESH:C001996
 xref: PMID:15679316;   PMID:23178537;   PMID:23659342;   PMID:23802886;   PMID:23957439;   PMID:24141140;   PMID:24395529;   PMID:24456332;   Reaxys:5113331;   Wikipedia:Myriocin

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myriocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO thermozymocidin inhibits the reaction [Dexamethasone results in increased expression of ACACA mRNA] CTD PMID:31053639 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO thermozymocidin results in increased expression of ANGPTL4 mRNA CTD PMID:31053639 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO thermozymocidin inhibits the reaction [Dronabinol results in increased activity of CASP3 protein]; thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein] CTD PMID:15596715 PMID:16818650 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in increased expression of DDIT3 protein] CTD PMID:24264887 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO thermozymocidin inhibits the reaction [[sorafenib co-treated with vorinostat] affects the localization of and results in increased activity of FAS protein] CTD PMID:18787411 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [thermozymocidin results in increased susceptibility to Dexamethasone] which results in decreased expression of FASN mRNA CTD PMID:31053639 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO
EXP		 thermozymocidin inhibits the reaction [Dronabinol results in increased expression of NUPR1 mRNA] CTD PMID:16616335 PMID:16818650 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in decreased activity of ODC1 protein] CTD PMID:17521618 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Prkcz protein kinase C, zeta decreases activity ISO thermozymocidin results in decreased activity of PRKCZ protein CTD PMID:31053639 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        antimicrobial agent 17383
          myriocin 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        monocarboxylic acid 17483
                                          fatty acid 16001
                                            nitrogen-containing fatty acid 17
                                              amino fatty acid 17
                                                alpha-amino fatty acid 10
                                                  myriocin 10
paths to the root