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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:myriocin
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Accession:CHEBI:582124 term browser browse the term
Definition:An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.
Synonyms:exact_synonym: (2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
 related_synonym: (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic acid;   (2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid;   Formula=C21H39NO6;   ISP-1;   ISP-I;   InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1;   InChIKey=ZZIKIHCNFWXKDY-GNTQXERDSA-N;   SMILES=CCCCCCC(=O)CCCCCC\\C=C\\C[C@@H](O)[C@H](O)[C@@](N)(CO)C(O)=O;   Thermozymocidin;   antibiotic ISP-1;   antibiotic ISP-I
 xref: AGR:IND607305181;   Beilstein:5113331;   CAS:35891-70-4;   KEGG:C19914;   KNApSAcK:C00016936;   LIPID_MAPS_instance:LMFA01060203
 xref_mesh: MESH:C001996
 xref: PDBeChem:VRP;   PMID:15679316;   PMID:21456524;   PMID:23178537;   PMID:23659342;   PMID:23802886;   PMID:23957439;   PMID:24141140;   PMID:24395529;   PMID:24456332;   PMID:27621809;   PMID:28621883;   PMID:30123648;   PMID:30883241;   PMID:31447688;   PMID:31639005;   PMID:31701696;   PMID:32091078;   PMID:32212314;   PMID:32435178;   PMID:32954686;   PMID:33378044;   PMID:33441497;   PMID:33482299;   PMID:33558761;   PMID:33731109;   PMID:34324668;   PMID:4694226;   PMID:5076310;   PMID:8020136;   Reaxys:5113331;   Wikipedia:Myriocin



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myriocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO thermozymocidin inhibits the reaction [Dexamethasone results in increased expression of ACACA mRNA] CTD PMID:31053639 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO thermozymocidin results in increased expression of ANGPTL4 mRNA CTD PMID:31053639 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Casp3 caspase 3 multiple interactions ISO thermozymocidin inhibits the reaction [Dronabinol results in increased activity of CASP3 protein]; thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein] CTD PMID:15596715 PMID:16818650 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO thermozymocidin inhibits the reaction [fumonisin B1 results in increased expression of DDIT3 protein]; thermozymocidin inhibits the reaction [Resveratrol results in increased expression of DDIT3 protein] CTD PMID:24264887 PMID:31891755 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO thermozymocidin inhibits the reaction [[sorafenib co-treated with vorinostat] affects the localization of and results in increased activity of FAS protein] CTD PMID:18787411 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [thermozymocidin results in increased susceptibility to Dexamethasone] which results in decreased expression of FASN mRNA CTD PMID:31053639 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO thermozymocidin inhibits the reaction [fumonisin B1 results in increased expression of HSPA5 protein] CTD PMID:31891755 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO thermozymocidin inhibits the reaction [Dronabinol results in increased expression of and affects the localization of and affects the lipidation of MAP1LC3B protein] CTD PMID:27635674 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO
EXP
thermozymocidin inhibits the reaction [Dronabinol results in increased expression of NUPR1 mRNA] CTD PMID:16616335 PMID:16818650 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in decreased activity of ODC1 protein] CTD PMID:17521618 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prkcz protein kinase C, zeta decreases activity ISO thermozymocidin results in decreased activity of PRKCZ protein CTD PMID:31053639 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        antimicrobial agent 17818
          myriocin 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        monocarboxylic acid 17843
                                          fatty acid 16480
                                            nitrogen-containing fatty acid 19
                                              amino fatty acid 19
                                                alpha-amino fatty acid 12
                                                  myriocin 12
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