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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxyzine
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Accession:CHEBI:5818 term browser browse the term
Definition:A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Synonyms:exact_synonym: 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol
 related_synonym: Formula=C21H27ClN2O2;   Hychotine;   Hydroxine;   Hydroxizine;   Hydroxizinum;   Hydroxycine;   Hydroxyzin;   InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2;   InChIKey=ZQDWXGKKHFNSQK-UHFFFAOYSA-N;   SMILES=OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1;   hidroxizina;   hydroxyzinum
 xref: Beilstein:321392;   CAS:68-88-2;   DrugBank:DB00557;   Drug_Central:1400;   HMDB:HMDB0014697;   KEGG:C07045;   KEGG:D08054;   LINCS:LSM-5103
 xref_mesh: MESH:D006919
 xref: PMID:15233966;   PMID:19057127;   PMID:19348661;   Patent:US2899436;   Reaxys:321392;   VSDB:2977;   Wikipedia:Hydroxyzine



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hydroxyzine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Hydroxyzine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases activity
decreases expression
ISO Hydroxyzine results in increased activity of ACE2 protein
Hydroxyzine results in decreased expression of ACE2 mRNA
CTD PMID:21859683 PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Hydroxyzine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hexb hexosaminidase subunit beta affects secretion EXP Hydroxyzine affects the secretion of HEXB protein CTD PMID:7655991 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO Hydroxyzine binds to and results in decreased activity of HRH1 protein CTD PMID:2864258 PMID:19057127 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Hydroxyzine results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression ISO Hydroxyzine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il4 interleukin 4 decreases expression ISO Hydroxyzine results in decreased expression of IL4 protein CTD PMID:19672097 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Hydroxyzine results in decreased activity of KCNH2 protein CTD PMID:19057127 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Hydroxyzine results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Hydroxyzine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Hydroxyzine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Hydroxyzine results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        antimicrobial agent 17472
          antiviral agent 10459
            anticoronaviral agent 9054
              hydroxyzine 13
                hydroxyzine hydrochloride 0
                hydroxyzine pamoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            inorganic hydride 17691
                              pnictogen hydride 17671
                                nitrogen hydride 17543
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        tertiary amino compound 8697
                                          N-alkylpiperazine 3131
                                            hydroxyzine 13
                                              hydroxyzine hydrochloride 0
                                              hydroxyzine pamoate 0
paths to the root