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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxyzine
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Accession:CHEBI:5818 term browser browse the term
Definition:A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Synonyms:exact_synonym: 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol
 related_synonym: Formula=C21H27ClN2O2;   Hychotine;   Hydroxine;   Hydroxizine;   Hydroxizinum;   Hydroxycine;   Hydroxyzin;   InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2;   InChIKey=ZQDWXGKKHFNSQK-UHFFFAOYSA-N;   SMILES=OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1;   hidroxizina;   hydroxyzinum
 xref: Beilstein:321392;   CAS:68-88-2;   DrugBank:DB00557;   Drug_Central:1400;   HMDB:HMDB0014697;   KEGG:C07045;   KEGG:D08054;   LINCS:LSM-5103
 xref_mesh: MESH:D006919
 xref: PMID:15233966;   PMID:19057127;   PMID:19348661;   Patent:US2899436;   Reaxys:321392;   VSDB:2977;   Wikipedia:Hydroxyzine


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hydroxyzine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Hydroxyzine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases activity ISO Hydroxyzine results in increased activity of ACE2 protein CTD PMID:21859683 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Hydroxyzine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hexb hexosaminidase subunit beta affects secretion EXP Hydroxyzine affects the secretion of HEXB protein CTD PMID:7655991 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO Hydroxyzine binds to and results in decreased activity of HRH1 protein CTD PMID:2864258, PMID:19057127 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Il4 interleukin 4 decreases expression ISO Hydroxyzine results in decreased expression of IL4 protein CTD PMID:19672097 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Hydroxyzine results in decreased activity of KCNH2 protein CTD PMID:19057127 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Hydroxyzine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antiviral agent 10253
            anticoronaviral agent 8944
              hydroxyzine 8
                hydroxyzine hydrochloride 0
                hydroxyzine pamoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        tertiary amino compound 8643
                                          N-alkylpiperazine 3079
                                            hydroxyzine 8
                                              hydroxyzine hydrochloride 0
                                              hydroxyzine pamoate 0
paths to the root

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