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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrochlorothiazide
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Accession:CHEBI:5778 term browser browse the term
Definition:A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Synonyms:exact_synonym: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
 related_synonym: Esidrix (TN);   Formula=C7H8ClN3O4S2;   InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13);   InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl;   hidroclorotiazida;   hydrochlorothiazidum
 xref: CAS:58-93-5 "ChemIDplus";   CAS:58-93-5 "KEGG COMPOUND";   CAS:58-93-5 "NIST Chemistry WebBook";   DrugBank:DB00999;   Drug_Central:1385 "DrugCentral";   HMDB:HMDB0001928;   KEGG:C07041;   KEGG:D00340;   LINCS:LSM-5308
 xref_mesh: MESH:D006852
 xref: PDBeChem:HCZ;   PMID:24055851 "Europe PMC";   PMID:24657333 "Europe PMC";   PMID:24849193 "Europe PMC";   Reaxys:625101 "Reaxys";   Wikipedia:Hydrochlorothiazide


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hydrochlorothiazide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCC4 ATP binding cassette subfamily C member 4 JBrowse link 13 95,019,829 95,301,451 RGD:6480464
G ACE angiotensin I converting enzyme JBrowse link 17 63,477,061 63,498,373 RGD:6480464
G ACTA1 actin alpha 1, skeletal muscle JBrowse link 1 229,431,245 229,434,094 RGD:6480464
G ADIPOQ adiponectin, C1Q and collagen domain containing JBrowse link 3 186,842,710 186,858,463 RGD:6480464
G AGTR1 angiotensin II receptor type 1 JBrowse link 3 148,697,871 148,743,003 RGD:6480464
G AQP2 aquaporin 2 JBrowse link 12 49,950,741 49,958,881 RGD:6480464
G ATP6V1B1 ATPase H+ transporting V1 subunit B1 JBrowse link 2 70,935,900 70,965,431 RGD:6480464
G AVP arginine vasopressin JBrowse link 20 3,082,556 3,093,521 RGD:6480464
G AVPR2 arginine vasopressin receptor 2 JBrowse link X 153,902,625 153,907,166 RGD:6480464
G BDKRB1 bradykinin receptor B1 JBrowse link 14 96,256,210 96,264,763 RGD:6480464
G CAT catalase JBrowse link 11 34,438,934 34,472,060 RGD:6480464
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 34,255,285 34,257,203 RGD:6480464
G CDKN1B cyclin dependent kinase inhibitor 1B JBrowse link 12 12,717,270 12,722,383 RGD:6480464
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,967,752 21,995,324 RGD:6480464
G CMA1 chymase 1 JBrowse link 14 24,505,353 24,508,265 RGD:6480464
G CYBA cytochrome b-245 alpha chain JBrowse link 16 88,643,289 88,651,079 RGD:6480464
G CYBB cytochrome b-245 beta chain JBrowse link X 37,780,059 37,813,461 RGD:6480464
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 JBrowse link 8 142,910,559 142,917,843 RGD:6480464
G EDN1 endothelin 1 JBrowse link 6 12,256,463 12,297,194 RGD:6480464
G FLT1 fms related tyrosine kinase 1 JBrowse link 13 28,300,346 28,495,128 RGD:6480464
G HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 JBrowse link 6 33,064,569 33,080,748 RGD:6480464
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 JBrowse link 6 32,578,769 32,589,836 RGD:6480464
G HLA-E major histocompatibility complex, class I, E JBrowse link 6 30,489,508 30,494,194 RGD:6480464
G HLA-F major histocompatibility complex, class I, F JBrowse link 6 29,723,340 29,740,355 RGD:6480464
G KLK1 kallikrein 1 JBrowse link 19 50,819,146 50,823,787 RGD:6480464
G LEPR leptin receptor JBrowse link 1 65,420,652 65,637,493 RGD:6480464
G MR1 major histocompatibility complex, class I-related JBrowse link 1 181,033,392 181,061,938 RGD:6480464
G MYH7 myosin heavy chain 7 JBrowse link 14 23,412,740 23,435,677 RGD:6480464
G NOS3 nitric oxide synthase 3 JBrowse link 7 150,991,017 151,014,588 RGD:6480464
G NOX1 NADPH oxidase 1 JBrowse link X 100,843,324 100,874,359 RGD:6480464
G NOX4 NADPH oxidase 4 JBrowse link 11 89,324,353 89,589,557 RGD:6480464
G NPPB natriuretic peptide B JBrowse link 1 11,857,464 11,858,945 RGD:6480464
G NR3C2 nuclear receptor subfamily 3 group C member 2 JBrowse link 4 148,078,764 148,444,698 RGD:6480464
G PCNA proliferating cell nuclear antigen JBrowse link 20 5,114,953 5,126,622 RGD:6480464
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:6480464
G RAMP2 receptor activity modifying protein 2 JBrowse link 17 42,761,227 42,763,041 RGD:6480464
G RAMP3 receptor activity modifying protein 3 JBrowse link 7 45,157,778 45,184,250 RGD:6480464
G REN renin JBrowse link 1 204,154,819 204,166,337 RGD:6480464
G SERPINE1 serpin family E member 1 JBrowse link 7 101,127,104 101,139,247 RGD:6480464
G SLC22A6 solute carrier family 22 member 6 JBrowse link 11 62,976,597 62,984,967 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23673
    role 23561
      biological role 23522
        xenobiotic 19174
          hydrochlorothiazide 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 23673
    subatomic particle 23620
      composite particle 23620
        hadron 23620
          baryon 23620
            nucleon 23620
              atomic nucleus 23620
                atom 23620
                  main group element atom 23437
                    p-block element atom 23437
                      chalcogen 22637
                        oxygen atom 22599
                          oxygen molecular entity 22599
                            hydroxides 21859
                              oxoacid 21061
                                chalcogen oxoacid 12108
                                  sulfur oxoacid 11659
                                    sulfonic acid 7578
                                      sulfonic acid derivative 7578
                                        sulfonamide 3168
                                          hydrochlorothiazide 40
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.