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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydrochlorothiazide
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Accession:CHEBI:5778 term browser browse the term
Definition:A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Synonyms:exact_synonym: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
 related_synonym: Esidrix (TN);   Formula=C7H8ClN3O4S2;   InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13);   InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl;   hidroclorotiazida;   hydrochlorothiazidum
 xref: CAS:58-93-5;   DrugBank:DB00999;   Drug_Central:1385;   HMDB:HMDB0001928;   KEGG:C07041;   KEGG:D00340;   LINCS:LSM-5308
 xref_mesh: MESH:D006852
 xref: PDBeChem:HCZ;   PMID:24055851;   PMID:24657333;   PMID:24849193;   Reaxys:625101;   Wikipedia:Hydrochlorothiazide



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hydrochlorothiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport
increases export
ISO ABCC4 protein results in increased transport of Hydrochlorothiazide
ABCC4 protein results in increased export of Hydrochlorothiazide
CTD PMID:17135398 PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Ace angiotensin I converting enzyme increases expression
multiple interactions
EXP Hydrochlorothiazide results in increased expression of ACE mRNA
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]
CTD PMID:16326922 PMID:18796534 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA] CTD PMID:16326922 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Hydrochlorothiazide results in decreased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP Hydrochlorothiazide results in decreased expression of AGTR1A mRNA CTD PMID:18796534 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Aqp2 aquaporin 2 decreases expression
multiple interactions
EXP Hydrochlorothiazide results in decreased expression of AQP2 mRNA; Hydrochlorothiazide results in decreased expression of AQP2 protein
Hydrochlorothiazide inhibits the reaction [Lithium results in decreased expression of AQP2 protein]
CTD PMID:15504936 PMID:17584643 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 increases expression EXP Hydrochlorothiazide results in increased expression of ATP6V1B1 protein CTD PMID:17311909 NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475
JBrowse link
G Avp arginine vasopressin affects secretion ISO Hydrochlorothiazide affects the secretion of AVP protein CTD PMID:6635723 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpr2 arginine vasopressin receptor 2 decreases expression EXP Hydrochlorothiazide results in decreased expression of AVPR2 mRNA CTD PMID:17584643 NCBI chr  X:151,633,501...151,636,000
Ensembl chr  X:151,633,522...151,635,989
JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases expression EXP Hydrochlorothiazide results in decreased expression of BDKRB1 mRNA CTD PMID:18796534 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein
Hydrochlorothiazide results in decreased activity of CAT protein
CTD PMID:23707192 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Hydrochlorothiazide results in decreased expression of CCL2 mRNA CTD PMID:19627010 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein CTD PMID:11318962 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cma1 chymase 1 affects expression EXP Hydrochlorothiazide affects the expression of CMA1 mRNA CTD PMID:18796534 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA] CTD PMID:21107329 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB] CTD PMID:21107329 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression EXP Hydrochlorothiazide results in increased expression of CYP11B2 mRNA CTD PMID:18796534 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA] CTD PMID:16326922 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions EXP [Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] CTD PMID:12110003 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Klk1 kallikrein 1 increases expression EXP Hydrochlorothiazide results in increased expression of KLK1 mRNA CTD PMID:18796534 NCBI chr 1:94,642,722...94,646,714
Ensembl chr 1:94,642,687...94,646,754
JBrowse link
G Lepr leptin receptor increases response to substance ISO LEPR mutant form results in increased susceptibility to Hydrochlorothiazide CTD PMID:22949526 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Hydrochlorothiazide affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA] CTD PMID:16326922 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein] CTD PMID:16197366 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4] CTD PMID:21107329 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA] CTD PMID:16326922 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Hydrochlorothiazide results in increased expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein CTD PMID:11318962 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins] CTD PMID:11703585 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein] CTD PMID:16326922 NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
JBrowse link
G Ramp3 receptor activity modifying protein 3 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein] CTD PMID:16326922 NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902
JBrowse link
G Ren renin increases activity
multiple interactions
increases expression
ISO
EXP
Hydrochlorothiazide results in increased activity of REN protein
Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]; Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]
CTD PMID:1930859 PMID:2920503 PMID:11135058 PMID:12569265 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Hydrochlorothiazide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Hydrochlorothiazide affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:3,403,418...3,479,476 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Hydrochlorothiazide affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Hydrochlorothiazide affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein CTD PMID:11318962 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases expression EXP Hydrochlorothiazide results in increased expression of SLC22A6 protein CTD PMID:12897087 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link

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    subatomic particle 20048
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                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      chalcogen 19673
                        oxygen atom 19644
                          oxygen molecular entity 19644
                            hydroxides 19375
                              oxoacid 18675
                                chalcogen oxoacid 11672
                                  sulfur oxoacid 11291
                                    sulfonic acid 7648
                                      sulfonic acid derivative 7648
                                        sulfonamide 3204
                                          hydrochlorothiazide 40
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