CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hydrochlorothiazide
Accession: CHEBI:5778
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Definition: A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Synonyms: exact_synonym: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
related_synonym: Esidrix (TN); Formula=C7H8ClN3O4S2; InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13); InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N; SMILES=NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl; hidroclorotiazida; hydrochlorothiazidum
xref: CAS:58-93-5; DrugBank:DB00999; Drug_Central:1385; HMDB:HMDB0001928; KEGG:C07041; KEGG:D00340; LINCS:LSM-5308
xref_mesh: MESH:D006852
xref: PDBeChem:HCZ; PMID:24055851; PMID:24657333; PMID:24849193; Reaxys:625101; Wikipedia:Hydrochlorothiazide
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Abcc4
ATP binding cassette subfamily C member 4
increases transport increases export
ISO
ABCC4 protein results in increased transport of Hydrochlorothiazide ABCC4 protein results in increased export of Hydrochlorothiazide
CTD
PMID:17135398 PMID:17939016
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Ace
angiotensin I converting enzyme
increases expression multiple interactions
EXP
Hydrochlorothiazide results in increased expression of ACE mRNA Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]
CTD
PMID:16326922 PMID:18796534
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Acta1
actin, alpha 1, skeletal muscle
multiple interactions
EXP
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA]
CTD
PMID:16326922
NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression
ISO
Hydrochlorothiazide results in decreased expression of ADIPOQ mRNA
CTD
PMID:19730415
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Agtr1a
angiotensin II receptor, type 1a
decreases expression
EXP
Hydrochlorothiazide results in decreased expression of AGTR1A mRNA
CTD
PMID:18796534
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Aqp2
aquaporin 2
decreases expression multiple interactions
EXP
Hydrochlorothiazide results in decreased expression of AQP2 mRNA; Hydrochlorothiazide results in decreased expression of AQP2 protein Hydrochlorothiazide inhibits the reaction [Lithium results in decreased expression of AQP2 protein]
CTD
PMID:15504936 PMID:17584643
NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
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Atp6v1b1
ATPase H+ transporting V1 subunit B1
increases expression
EXP
Hydrochlorothiazide results in increased expression of ATP6V1B1 protein
CTD
PMID:17311909
NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475
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Avp
arginine vasopressin
affects secretion
ISO
Hydrochlorothiazide affects the secretion of AVP protein
CTD
PMID:6635723
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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Avpr2
arginine vasopressin receptor 2
decreases expression
EXP
Hydrochlorothiazide results in decreased expression of AVPR2 mRNA
CTD
PMID:17584643
NCBI chr X:151,633,501...151,636,155
Ensembl chr X:151,633,522...151,635,989
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Bdkrb1
bradykinin receptor B1
decreases expression
EXP
Hydrochlorothiazide results in decreased expression of BDKRB1 mRNA
CTD
PMID:18796534
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
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Cat
catalase
multiple interactions decreases activity
EXP
[Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein Hydrochlorothiazide results in decreased activity of CAT protein
CTD
PMID:23707192
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
decreases expression
EXP
Hydrochlorothiazide results in decreased expression of CCL2 mRNA
CTD
PMID:19627010
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
EXP
[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein
CTD
PMID:11318962
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
multiple interactions
EXP
[Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA]
CTD
PMID:18504326
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Cma1
chymase 1
affects expression
EXP
Hydrochlorothiazide affects the expression of CMA1 mRNA
CTD
PMID:18796534
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
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Cyba
cytochrome b-245 alpha chain
multiple interactions
EXP
Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA]
CTD
PMID:21107329
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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Cybb
cytochrome b-245 beta chain
multiple interactions
EXP
Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB]
CTD
PMID:21107329
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
increases expression
EXP
Hydrochlorothiazide results in increased expression of CYP11B2 mRNA
CTD
PMID:18796534
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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Edn1
endothelin 1
multiple interactions
EXP
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]
CTD
PMID:16326922
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Flt1
Fms related receptor tyrosine kinase 1
multiple interactions
EXP
[Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA]
CTD
PMID:12110003
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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Klk1
kallikrein 1
increases expression
EXP
Hydrochlorothiazide results in increased expression of KLK1 mRNA
CTD
PMID:18796534
NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754
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Lepr
leptin receptor
increases response to substance
ISO
LEPR mutant form results in increased susceptibility to Hydrochlorothiazide
CTD
PMID:22949526
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Mr1
major histocompatibility complex, class I-related
affects expression
ISO
Hydrochlorothiazide affects the expression of MR1 mRNA
CTD
PMID:25811541
NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
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Myh7
myosin heavy chain 7
multiple interactions
EXP
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA]
CTD
PMID:16326922
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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Nos3
nitric oxide synthase 3
multiple interactions
EXP
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]
CTD
PMID:16197366
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nox1
NADPH oxidase 1
multiple interactions
EXP
Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1]
CTD
PMID:21107329
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Nox4
NADPH oxidase 4
multiple interactions
EXP
Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4]
CTD
PMID:21107329
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Nppb
natriuretic peptide B
multiple interactions
EXP
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
CTD
PMID:16326922
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
increases expression
EXP
Hydrochlorothiazide results in increased expression of NR3C2 mRNA
CTD
PMID:18796534
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein
CTD
PMID:11318962
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
[rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins]
CTD
PMID:11703585
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ramp2
receptor activity modifying protein 2
multiple interactions
EXP
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein]
CTD
PMID:16326922
NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
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Ramp3
receptor activity modifying protein 3
multiple interactions
EXP
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein]
CTD
PMID:16326922
NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902
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Ren
renin
increases activity increases expression multiple interactions
ISO EXP
Hydrochlorothiazide results in increased activity of REN protein Hydrochlorothiazide results in increased expression of REN protein Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]; Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]
CTD
PMID:1930859 PMID:2920503 PMID:11135058 PMID:12569265
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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RT1-A2
RT1 class Ia, locus A2
affects expression
ISO
Hydrochlorothiazide affects the expression of HLA-E mRNA
CTD
PMID:25811541
NCBI chr20:4,870,939...4,910,183
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RT1-CE5
RT1 class I, locus CE5
affects expression
ISO
Hydrochlorothiazide affects the expression of HLA-F mRNA
CTD
PMID:25811541
NCBI chr20:3,403,418...3,479,476
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RT1-Db1
RT1 class II, locus Db1
affects expression
ISO
Hydrochlorothiazide affects the expression of HLA-DRB1 mRNA
CTD
PMID:25811541
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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RT1-Ha
RT1 class II, locus Ha
affects expression
ISO
Hydrochlorothiazide affects the expression of HLA-DPA1 mRNA
CTD
PMID:25811541
NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244
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Serpine1
serpin family E member 1
multiple interactions
EXP
[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein
CTD
PMID:11318962
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slc22a6
solute carrier family 22 member 6
increases expression
EXP
Hydrochlorothiazide results in increased expression of SLC22A6 protein
CTD
PMID:12897087
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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