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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydrochlorothiazide
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Accession:CHEBI:5778 term browser browse the term
Definition:A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Synonyms:exact_synonym: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
 related_synonym: Esidrix (TN);   Formula=C7H8ClN3O4S2;   InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13);   InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl;   hidroclorotiazida;   hydrochlorothiazidum
 xref: CAS:58-93-5;   DrugBank:DB00999;   Drug_Central:1385;   HMDB:HMDB0001928;   KEGG:C07041;   KEGG:D00340;   LINCS:LSM-5308
 xref_mesh: MESH:D006852
 xref: PDBeChem:HCZ;   PMID:24055851;   PMID:24657333;   PMID:24849193;   Reaxys:625101;   Wikipedia:Hydrochlorothiazide


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hydrochlorothiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport
increases export
ISO ABCC4 protein results in increased transport of Hydrochlorothiazide
ABCC4 protein results in increased export of Hydrochlorothiazide
CTD PMID:17135398 PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Ace angiotensin I converting enzyme increases expression
multiple interactions
EXP Hydrochlorothiazide results in increased expression of ACE mRNA
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]
CTD PMID:16326922 PMID:18796534 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA] CTD PMID:16326922 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Hydrochlorothiazide results in decreased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP Hydrochlorothiazide results in decreased expression of AGTR1A mRNA CTD PMID:18796534 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Aqp2 aquaporin 2 decreases expression
multiple interactions
EXP Hydrochlorothiazide results in decreased expression of AQP2 mRNA; Hydrochlorothiazide results in decreased expression of AQP2 protein
Hydrochlorothiazide inhibits the reaction [Lithium results in decreased expression of AQP2 protein]
CTD PMID:15504936 PMID:17584643 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 increases expression EXP Hydrochlorothiazide results in increased expression of ATP6V1B1 protein CTD PMID:17311909 NCBI chr 4:115,417,100...115,435,754
Ensembl chr 4:115,416,580...115,437,206
JBrowse link
G Avp arginine vasopressin affects secretion ISO Hydrochlorothiazide affects the secretion of AVP protein CTD PMID:6635723 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Avpr2 arginine vasopressin receptor 2 decreases expression EXP Hydrochlorothiazide results in decreased expression of AVPR2 mRNA CTD PMID:17584643 NCBI chr  X:156,889,006...156,892,707
Ensembl chr  X:156,889,410...156,891,213
JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases expression EXP Hydrochlorothiazide results in decreased expression of BDKRB1 mRNA CTD PMID:18796534 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein
Hydrochlorothiazide results in decreased activity of CAT protein
CTD PMID:23707192 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Hydrochlorothiazide results in decreased expression of CCL2 mRNA CTD PMID:19627010 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein CTD PMID:11318962 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cma1 chymase 1 affects expression EXP Hydrochlorothiazide affects the expression of CMA1 mRNA CTD PMID:18796534 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA] CTD PMID:21107329 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB] CTD PMID:21107329 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression EXP Hydrochlorothiazide results in increased expression of CYP11B2 mRNA CTD PMID:18796534 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA] CTD PMID:16326922 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions EXP [Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] CTD PMID:12110003 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Klk1 kallikrein 1 increases expression EXP Hydrochlorothiazide results in increased expression of KLK1 mRNA CTD PMID:18796534 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Lepr leptin receptor increases response to substance ISO LEPR mutant form results in increased susceptibility to Hydrochlorothiazide CTD PMID:22949526 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Hydrochlorothiazide affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA] CTD PMID:16326922 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein] CTD PMID:16197366 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4] CTD PMID:21107329 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA] CTD PMID:16326922 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Hydrochlorothiazide results in increased expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein CTD PMID:11318962 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins] CTD PMID:11703585 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein] CTD PMID:16326922 NCBI chr10:89,166,170...89,168,962
Ensembl chr10:89,166,890...89,168,965
JBrowse link
G Ramp3 receptor activity modifying protein 3 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein] CTD PMID:16326922 NCBI chr14:86,922,223...86,939,722
Ensembl chr14:86,922,223...86,939,719
JBrowse link
G Ren renin increases activity
multiple interactions
increases expression
ISO
EXP
Hydrochlorothiazide results in increased activity of REN protein
Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]; Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]
CTD PMID:1930859 PMID:2920503 PMID:11135058 PMID:12569265 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Hydrochlorothiazide affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Hydrochlorothiazide affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Hydrochlorothiazide affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Hydrochlorothiazide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein CTD PMID:11318962 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases expression EXP Hydrochlorothiazide results in increased expression of SLC22A6 protein CTD PMID:12897087 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link

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  CHEBI ontology 19771
    role 19716
      biological role 19716
        xenobiotic 18392
          hydrochlorothiazide 40
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  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      chalcogen 19387
                        oxygen atom 19350
                          oxygen molecular entity 19350
                            hydroxides 19076
                              oxoacid 18275
                                chalcogen oxoacid 11503
                                  sulfur oxoacid 11110
                                    sulfonic acid 7370
                                      sulfonic acid derivative 7370
                                        sulfonamide 3193
                                          hydrochlorothiazide 40
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