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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hinokiflavone
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Accession:CHEBI:5721 term browser browse the term
Definition:A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic potential.
Synonyms:exact_synonym: 6-[4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
 related_synonym: 4',6''-O-biapigenin;   Formula=C30H18O10;   InChI=1S/C30H18O10/c31-16-5-1-14(2-6-16)24-12-21(35)28-26(40-24)13-22(36)30(29(28)37)38-18-7-3-15(4-8-18)23-11-20(34)27-19(33)9-17(32)10-25(27)39-23/h1-13,31-33,36-37H;   InChIKey=WTDHMFBJQJSTMH-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)-c1cc(=O)c2c(O)c(Oc3ccc(cc3)-c3cc(=O)c4c(O)cc(O)cc4o3)c(O)cc2o1
 alt_id: CHEBI:66014
 xref: CAS:19202-36-9;   KEGG:C10057;   KNApSAcK:C00001049;   LIPID_MAPS_instance:LMPK12040004
 xref_mesh: MESH:C060299
 xref: PMID:10532874;   PMID:17340268;   PMID:2526343;   PMID:5977959;   Patent:EP1245230;   Patent:WO9700679;   Reaxys:379316


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hinokiflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression EXP hinokiflavone results in increased expression of BAX protein CTD PMID:30575109 PMID:32252563 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression EXP hinokiflavone results in decreased expression of BCL2 protein CTD PMID:30575109 PMID:32252563 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage		 EXP hinokiflavone results in increased expression of CASP3 protein
hinokiflavone results in increased cleavage of CASP3 protein		 CTD PMID:30575109 PMID:32252563 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL15 protein] CTD PMID:29673161 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G F3 coagulation factor III multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:29673161 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:29673161 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:29673161 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO
EXP		 hinokiflavone results in decreased expression of MMP2 protein
hinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 protein		 CTD PMID:29635122 PMID:30575109 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP
ISO		 hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein CTD PMID:29635122 PMID:30575109 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:29673161 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Prpf40a pre-mRNA processing factor 40A increases sumoylation ISO hinokiflavone results in increased sumoylation of PRPF40A protein CTD PMID:28884683 NCBI chr 2:53,024,714...53,081,450
Ensembl chr 2:53,024,716...53,081,714 		JBrowse link
G Ptgds prostaglandin D2 synthase (brain) affects binding ISO hinokiflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 2:25,356,723...25,360,080
Ensembl chr 2:25,356,721...25,360,058 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:29673161 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:29673161 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 decreases activity ISO hinokiflavone results in decreased activity of SENP1 protein CTD PMID:28884683 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625 		JBrowse link
G Sf3a2 splicing factor 3a, subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3A2 protein CTD PMID:28884683 NCBI chr10:80,634,569...80,640,756
Ensembl chr10:80,634,032...80,640,758 		JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B1 protein CTD PMID:28884683 NCBI chr 1:55,024,328...55,066,660
Ensembl chr 1:55,024,328...55,066,640 		JBrowse link
G Sf3b2 splicing factor 3b, subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B2 protein CTD PMID:28884683 NCBI chr19:5,323,949...5,345,485
Ensembl chr19:5,323,960...5,345,483 		JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SNRPD2 protein CTD PMID:28884683 NCBI chr 7:18,883,370...18,886,659
Ensembl chr 7:18,883,647...18,887,467 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases localization ISO hinokiflavone results in increased localization of SUMO1 protein CTD PMID:28884683 NCBI chr 1:59,678,593...59,709,993
Ensembl chr 1:59,625,717...59,709,993 		JBrowse link
G Sumo2 small ubiquitin-like modifier 2 increases localization ISO hinokiflavone results in increased localization of SUMO2 protein CTD PMID:28884683 NCBI chr11:115,413,935...115,427,056
Ensembl chr11:115,413,928...115,427,102 		JBrowse link
G Sumo3 small ubiquitin-like modifier 3 increases localization ISO hinokiflavone results in increased localization of SUMO3 protein CTD PMID:28884683 NCBI chr10:77,441,931...77,454,165
Ensembl chr10:77,441,931...77,454,165 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 increases expression EXP hinokiflavone results in increased expression of TIMP2 mRNA; hinokiflavone results in increased expression of TIMP2 protein CTD PMID:30575109 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:29673161 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases sumoylation ISO hinokiflavone results in increased sumoylation of U2SURP protein CTD PMID:28884683 NCBI chr 9:95,338,947...95,394,049
Ensembl chr 9:95,338,951...95,394,049 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          metabolite 21379
            hinokiflavone 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  oxacycle 18822
                                    benzopyran 12194
                                      1-benzopyran 11952
                                        flavonoid 7260
                                          anthoxanthin 4586
                                            flavones 4586
                                              hydroxyflavone 4570
                                                trihydroxyflavone 429
                                                  apigenin 293
                                                    hinokiflavone 27
paths to the root