CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hinokiflavone
Accession: CHEBI:5721
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Definition: A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic potential.
Synonyms: exact_synonym: 6-[4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
related_synonym: 4',6''-O-biapigenin; Formula=C30H18O10; InChI=1S/C30H18O10/c31-16-5-1-14(2-6-16)24-12-21(35)28-26(40-24)13-22(36)30(29(28)37)38-18-7-3-15(4-8-18)23-11-20(34)27-19(33)9-17(32)10-25(27)39-23/h1-13,31-33,36-37H; InChIKey=WTDHMFBJQJSTMH-UHFFFAOYSA-N; SMILES=Oc1ccc(cc1)-c1cc(=O)c2c(O)c(Oc3ccc(cc3)-c3cc(=O)c4c(O)cc(O)cc4o3)c(O)cc2o1
alt_id: CHEBI:66014
xref: CAS:19202-36-9; KEGG:C10057; KNApSAcK:C00001049; LIPID_MAPS_instance:LMPK12040004
xref_mesh: MESH:C060299
xref: PMID:10532874; PMID:17340268; PMID:2526343; PMID:5977959; Patent:EP1245230; Patent:WO9700679; Reaxys:379316
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
hinokiflavone results in increased expression of BAX protein
CTD
PMID:30575109 PMID:32252563
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
hinokiflavone results in decreased expression of BCL2 protein
CTD
PMID:30575109 PMID:32252563
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
increases expression increases cleavage
ISO
hinokiflavone results in increased expression of CASP3 protein hinokiflavone results in increased cleavage of CASP3 protein
CTD
PMID:30575109 PMID:32252563
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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F3
coagulation factor III, tissue factor
multiple interactions
ISO
hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein]
CTD
PMID:8882428
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Il1b
interleukin 1 beta
multiple interactions
ISO
hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]
CTD
PMID:8882428
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:29673161
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD
PMID:29673161
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD
PMID:29673161
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
hinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 protein
CTD
PMID:29635122 PMID:30575109
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
hinokiflavone results in decreased expression of MMP9 protein hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein
CTD
PMID:29635122 PMID:30575109
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:29673161
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Prpf40a
pre-mRNA processing factor 40 homolog A
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of PRPF40A protein
CTD
PMID:28884683
NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886
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Ptgds
prostaglandin D2 synthase
affects binding
ISO
hinokiflavone binds to PTGDS protein
CTD
PMID:26456343
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:29673161
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
CTD
PMID:29673161
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Senp1
SUMO specific peptidase 1
decreases activity
ISO
hinokiflavone results in decreased activity of SENP1 protein
CTD
PMID:28884683
NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598
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Sf3a2
splicing factor 3A subunit 2
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SF3A2 protein
CTD
PMID:28884683
NCBI chr 7:8,909,507...8,916,104
Ensembl chr 7:8,909,507...8,915,530
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Sf3b1
splicing factor 3b, subunit 1
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SF3B1 protein
CTD
PMID:28884683
NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300
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Sf3b2
splicing factor 3b, subunit 2
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SF3B2 protein
CTD
PMID:28884683
NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759
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Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SNRPD2 protein
CTD
PMID:28884683
NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351
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Sumo1
small ubiquitin-like modifier 1
increases localization
ISO
hinokiflavone results in increased localization of SUMO1 protein
CTD
PMID:28884683
NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761
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Sumo2
small ubiquitin-like modifier 2
increases localization
ISO
hinokiflavone results in increased localization of SUMO2 protein
CTD
PMID:28884683
NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513
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Sumo3
small ubiquitin-like modifier 3
increases localization
ISO
hinokiflavone results in increased localization of SUMO3 protein
CTD
PMID:28884683
NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,007,148...11,020,877 Ensembl chr20:11,007,148...11,020,877
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Timp2
TIMP metallopeptidase inhibitor 2
increases expression
ISO
hinokiflavone results in increased expression of TIMP2 mRNA; hinokiflavone results in increased expression of TIMP2 protein
CTD
PMID:30575109
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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Tnf
tumor necrosis factor
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:29673161
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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U2surp
U2 snRNP-associated SURP domain containing
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of U2SURP protein
CTD
PMID:28884683
NCBI chr 8:96,018,932...96,075,795
Ensembl chr 8:96,022,957...96,075,691
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