CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hinokiflavone
Accession: CHEBI:5721
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Definition: A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic potential.
Synonyms: exact_synonym: 6-[4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
related_synonym: 4',6''-O-biapigenin; Formula=C30H18O10; InChI=1S/C30H18O10/c31-16-5-1-14(2-6-16)24-12-21(35)28-26(40-24)13-22(36)30(29(28)37)38-18-7-3-15(4-8-18)23-11-20(34)27-19(33)9-17(32)10-25(27)39-23/h1-13,31-33,36-37H; InChIKey=WTDHMFBJQJSTMH-UHFFFAOYSA-N; SMILES=Oc1ccc(cc1)-c1cc(=O)c2c(O)c(Oc3ccc(cc3)-c3cc(=O)c4c(O)cc(O)cc4o3)c(O)cc2o1
alt_id: CHEBI:66014
xref: CAS:19202-36-9; KEGG:C10057; KNApSAcK:C00001049; LIPID_MAPS_instance:LMPK12040004
xref_mesh: MESH:C060299
xref: PMID:10532874; PMID:17340268; PMID:2526343; PMID:5977959; Patent:EP1245230; Patent:WO9700679; Reaxys:379316
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
hinokiflavone results in increased expression of BAX protein
CTD
PMID:30575109 PMID:32252563
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
hinokiflavone results in decreased expression of BCL2 protein
CTD
PMID:30575109 PMID:32252563
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Casp3
caspase 3
increases expression increases cleavage
ISO
hinokiflavone results in increased expression of CASP3 protein hinokiflavone results in increased cleavage of CASP3 protein
CTD
PMID:30575109 PMID:32252563
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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F3
coagulation factor III, tissue factor
multiple interactions
ISO
hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein]
CTD
PMID:8882428
NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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Il1b
interleukin 1 beta
multiple interactions
ISO
hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]
CTD
PMID:8882428
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il6
interleukin 6
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:29673161
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD
PMID:29673161
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD
PMID:29673161
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
hinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 protein
CTD
PMID:29635122 PMID:30575109
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
hinokiflavone results in decreased expression of MMP9 protein hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein
CTD
PMID:29635122 PMID:30575109
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:29673161
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Prpf40a
pre-mRNA processing factor 40 homolog A
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of PRPF40A protein
CTD
PMID:28884683
NCBI chr 3:38,680,583...38,741,570
Ensembl chr 3:38,682,146...38,741,113
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Ptgds
prostaglandin D2 synthase
affects binding
ISO
hinokiflavone binds to PTGDS protein
CTD
PMID:26456343
NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:29673161
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
CTD
PMID:29673161
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Senp1
SUMO specific peptidase 1
decreases activity
ISO
hinokiflavone results in decreased activity of SENP1 protein
CTD
PMID:28884683
NCBI chr 7:139,626,444...139,684,587
Ensembl chr 7:139,630,515...139,675,245 Ensembl chr 7:139,630,515...139,675,245
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Sf3a2
splicing factor 3a, subunit 2
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SF3A2 protein
CTD
PMID:28884683
NCBI chr 7:11,777,826...11,784,373
Ensembl chr 7:11,777,826...11,783,849
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Sf3b1
splicing factor 3b, subunit 1
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SF3B1 protein
CTD
PMID:28884683
NCBI chr 9:61,594,620...61,634,510
Ensembl chr 9:61,594,620...61,634,510
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Sf3b2
splicing factor 3b, subunit 2
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SF3B2 protein
CTD
PMID:28884683
NCBI chr 1:220,645,685...220,665,611
Ensembl chr 1:220,645,672...220,665,603
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Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SNRPD2 protein
CTD
PMID:28884683
NCBI chr 1:80,057,140...80,059,990
Ensembl chr 1:80,056,755...80,059,996
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Sumo1
small ubiquitin-like modifier 1
increases localization
ISO
hinokiflavone results in increased localization of SUMO1 protein
CTD
PMID:28884683
NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
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Sumo2
small ubiquitin-like modifier 2
increases localization
ISO
hinokiflavone results in increased localization of SUMO2 protein
CTD
PMID:28884683
NCBI chr10:104,085,401...104,097,983
Ensembl chr10:104,086,002...104,097,812
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Sumo3
small ubiquitin-like modifier 3
increases localization
ISO
hinokiflavone results in increased localization of SUMO3 protein
CTD
PMID:28884683
NCBI chr20:11,726,488...11,737,050
Ensembl chr20:11,726,497...11,737,050
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Timp2
TIMP metallopeptidase inhibitor 2
increases expression
ISO
hinokiflavone results in increased expression of TIMP2 mRNA; hinokiflavone results in increased expression of TIMP2 protein
CTD
PMID:30575109
NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
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Tnf
tumor necrosis factor
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:29673161
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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U2surp
U2 snRNP-associated SURP domain containing
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of U2SURP protein
CTD
PMID:28884683
NCBI chr 8:103,242,095...103,299,082
Ensembl chr 8:103,246,558...103,298,927
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