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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexachlorophene
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Accession:CHEBI:5693 term browser browse the term
Definition:An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.
Synonyms:exact_synonym: 2,2'-methylenebis(3,4,6-trichlorophenol)
 related_synonym: 2,2',3,3',5,5'-hexachloro-6,6'-dihydroxydiphenylmethane;   2,2'-dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane;   2,2'-methanediylbis(3,4,6-trichlorophenol);   Acigena;   Almederm;   Armohex;   Distodin;   Esaclorofene;   Exofene;   Formula=C13H6Cl6O2;   Gamophen;   Gamophene;   Germa-medica;   Hexa-Germ;   Hexabalm;   Hexafen;   Hexascrub;   Hexide;   InChI=1S/C13H6Cl6O2/c14-6-2-8(16)12(20)4(10(6)18)1-5-11(19)7(15)3-9(17)13(5)21/h2-3,20-21H,1H2;   InChIKey=ACGUYXCXAPNIKK-UHFFFAOYSA-N;   Nabac;   Phiso-Scrub;   Phisodan;   SMILES=Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl;   Septi-Soft;   Septisol;   Septofen;   Solu-Heks;   Soy-Dome;   Staphene O;   Ster-Zac;   Steral;   Steraskin;   Surgi-Cen;   Surgi-cin;   Surofene;   Tersaseptic;   Turgex;   bis(2-hydroxy-3,5,6-trichlorophenyl)methane;   bis(3,5,6-trichloro-2-hydroxyphenyl)methane;   hexachlorophenum;   hexaclorofeno
 xref: CAS:70-30-4;   DrugBank:DB00756;   Drug_Central:1364;   HMDB:HMDB0014894;   KEGG:C08039;   KEGG:D00859;   LINCS:LSM-6032
 xref_mesh: MESH:D006582
 xref: PDBeChem:H3P;   PMID:1133685;   PMID:22313968;   PMID:23251633;   PMID:397166;   PMID:894425;   PMID:952574;   PPDB:381;   Patent:US2250480;   Patent:US2435593;   Patent:US2812365;   Reaxys:2064407;   Wikipedia:Hexachlorophene


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hexachlorophene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Hexachlorophene results in decreased expression of BCL2 mRNA CTD PMID:25497112 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Hexachlorophene results in decreased expression of CCND1 mRNA; Hexachlorophene results in decreased expression of CCND1 protein CTD PMID:16735606 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit decreases expression ISO Hexachlorophene results in decreased expression of CHRNA4 mRNA CTD PMID:25943520 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit decreases expression EXP
ISO
Hexachlorophene results in decreased expression of CHRNB2 mRNA CTD PMID:25497112, PMID:25943520 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases degradation
ISO Hexachlorophene inhibits the reaction [Lithium Chloride results in increased expression of CTNNB1 protein]; Hexachlorophene inhibits the reaction [WNT3A protein results in increased expression of CTNNB1 protein]; SIAH1 protein promotes the reaction [Hexachlorophene results in increased degradation of CTNNB1 protein] CTD PMID:16735606 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression ISO Hexachlorophene results in decreased expression of DLG4 mRNA CTD PMID:29301063 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dlx4 distal-less homeobox 4 increases methylation ISO Hexachlorophene results in increased methylation of DLX4 promoter CTD PMID:29301063 NCBI chr10:82,958,525...82,963,919
Ensembl chr10:82,958,525...82,963,919
JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 increases methylation ISO Hexachlorophene results in increased methylation of DMRT1 promoter CTD PMID:29301063 NCBI chr 1:243,477,403...243,582,629
Ensembl chr 1:243,477,493...243,582,629
JBrowse link
G Eomes eomesodermin decreases expression ISO Hexachlorophene results in decreased expression of EOMES protein CTD PMID:25943520 NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
ISO Hexachlorophene binds to ESR1 protein
Hexachlorophene inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:15081572 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Hexachlorophene results in decreased expression of GABBR1 mRNA CTD PMID:29301063 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 affects expression ISO Hexachlorophene affects the expression of GABBR2 mRNA CTD PMID:29301063 NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects expression ISO Hexachlorophene affects the expression of GABRA1 mRNA CTD PMID:29301063 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 increases expression ISO Hexachlorophene results in increased expression of GABRB2 mRNA CTD PMID:29301063 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D decreases expression ISO Hexachlorophene results in decreased expression of GRIN2D mRNA CTD PMID:25943520 NCBI chr 1:101,819,068...101,859,146
Ensembl chr 1:101,820,461...101,856,881
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression ISO Hexachlorophene results in decreased expression of GRM1 mRNA CTD PMID:25943520 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Hexachlorophene inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Homer1 homer scaffold protein 1 decreases expression ISO Hexachlorophene results in decreased expression of HOMER1 mRNA CTD PMID:29301063 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Hexachlorophene results in decreased expression of MYC protein CTD PMID:16735606 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Pax6 paired box 6 decreases expression ISO Hexachlorophene results in decreased expression of PAX6 mRNA; Hexachlorophene results in decreased expression of PAX6 protein CTD PMID:25943520 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G Plcb4 phospholipase C, beta 4 increases methylation ISO Hexachlorophene results in increased methylation of PLCB4 promoter CTD PMID:29301063 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 increases expression
multiple interactions
ISO Hexachlorophene results in increased expression of SIAH1 mRNA
SIAH1 protein promotes the reaction [Hexachlorophene results in increased degradation of CTNNB1 protein]
CTD PMID:16735606 NCBI chr19:21,372,163...21,395,773
Ensembl chr19:21,372,163...21,395,767
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Hexachlorophene results in decreased expression of SOX2 mRNA; Hexachlorophene results in decreased expression of SOX2 protein CTD PMID:25943520 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Stx4 syntaxin 4 decreases expression ISO Hexachlorophene results in decreased expression of STX4A mRNA CTD PMID:29301063 NCBI chr 1:199,287,384...199,295,606
Ensembl chr 1:199,287,710...199,294,979
JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO Hexachlorophene inhibits the reaction [WNT3A protein results in increased expression of CTNNB1 protein] CTD PMID:16735606 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          acaricide 9039
            hexachlorophene 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      chlorobenzenes 12990
                                        trichlorobenzene 2763
                                          hexachlorophene 25
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.