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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexachlorophene
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Accession:CHEBI:5693 term browser browse the term
Definition:An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.
Synonyms:exact_synonym: 2,2'-methylenebis(3,4,6-trichlorophenol)
 related_synonym: 2,2',3,3',5,5'-hexachloro-6,6'-dihydroxydiphenylmethane;   2,2'-dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane;   2,2'-methanediylbis(3,4,6-trichlorophenol);   Acigena;   Almederm;   Armohex;   Distodin;   Esaclorofene;   Exofene;   Formula=C13H6Cl6O2;   Gamophen;   Gamophene;   Germa-medica;   Hexa-Germ;   Hexabalm;   Hexafen;   Hexascrub;   Hexide;   InChI=1S/C13H6Cl6O2/c14-6-2-8(16)12(20)4(10(6)18)1-5-11(19)7(15)3-9(17)13(5)21/h2-3,20-21H,1H2;   InChIKey=ACGUYXCXAPNIKK-UHFFFAOYSA-N;   Nabac;   Phiso-Scrub;   Phisodan;   SMILES=Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl;   Septi-Soft;   Septisol;   Septofen;   Solu-Heks;   Soy-Dome;   Staphene O;   Ster-Zac;   Steral;   Steraskin;   Surgi-Cen;   Surgi-cin;   Surofene;   Tersaseptic;   Turgex;   bis(2-hydroxy-3,5,6-trichlorophenyl)methane;   bis(3,5,6-trichloro-2-hydroxyphenyl)methane;   hexachlorophenum;   hexaclorofeno
 xref: CAS:70-30-4;   DrugBank:DB00756;   Drug_Central:1364;   HMDB:HMDB0014894;   KEGG:C08039;   KEGG:D00859;   LINCS:LSM-6032
 xref_mesh: MESH:D006582
 xref: PDBeChem:H3P;   PMID:1133685;   PMID:22313968;   PMID:23251633;   PMID:397166;   PMID:894425;   PMID:952574;   PPDB:381;   Patent:US2250480;   Patent:US2435593;   Patent:US2812365;   Reaxys:2064407;   Wikipedia:Hexachlorophene



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hexachlorophene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Hexachlorophene results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Hexachlorophene results in decreased expression of BCL2 mRNA CTD PMID:25497112 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Hexachlorophene results in decreased expression of CCND1 mRNA; Hexachlorophene results in decreased expression of CCND1 protein CTD PMID:16735606 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit decreases expression ISO Hexachlorophene results in decreased expression of CHRNA4 mRNA CTD PMID:25943520 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit decreases expression EXP
ISO
Hexachlorophene results in decreased expression of CHRNB2 mRNA CTD PMID:25497112 PMID:25943520 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases degradation
ISO Hexachlorophene inhibits the reaction [Lithium Chloride results in increased expression of CTNNB1 protein]; Hexachlorophene inhibits the reaction [WNT3A protein results in increased expression of CTNNB1 protein]; SIAH1 protein promotes the reaction [Hexachlorophene results in increased degradation of CTNNB1 protein] CTD PMID:16735606 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Hexachlorophene results in increased expression of DDIT3 mRNA CTD PMID:32870474 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression ISO Hexachlorophene results in decreased expression of DLG4 mRNA CTD PMID:29301063 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dlx4 distal-less homeobox 4 increases methylation ISO Hexachlorophene results in increased methylation of DLX4 promoter CTD PMID:29301063 NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456
JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 increases methylation ISO Hexachlorophene results in increased methylation of DMRT1 promoter CTD PMID:29301063 NCBI chr 1:223,142,859...223,241,333
Ensembl chr 1:223,142,859...223,241,333
JBrowse link
G Eomes eomesodermin decreases expression ISO Hexachlorophene results in decreased expression of EOMES protein CTD PMID:25943520 NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
ISO Hexachlorophene binds to ESR1 protein
Hexachlorophene inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:15081572 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Hexachlorophene results in decreased expression of GABBR1 mRNA CTD PMID:29301063 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 affects expression ISO Hexachlorophene affects the expression of GABBR2 mRNA CTD PMID:29301063 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects expression ISO Hexachlorophene affects the expression of GABRA1 mRNA CTD PMID:29301063 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 increases expression ISO Hexachlorophene results in increased expression of GABRB2 mRNA CTD PMID:29301063 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D decreases expression ISO Hexachlorophene results in decreased expression of GRIN2D mRNA CTD PMID:25943520 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression ISO Hexachlorophene results in decreased expression of GRM1 mRNA CTD PMID:25943520 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Hexachlorophene inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Homer1 homer scaffold protein 1 decreases expression ISO Hexachlorophene results in decreased expression of HOMER1 mRNA CTD PMID:29301063 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] CTD PMID:32949729 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Hexachlorophene results in decreased expression of MYC protein CTD PMID:16735606 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nanog Nanog homeobox multiple interactions ISO Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of NANOG mRNA] CTD PMID:32949729 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions ISO Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of OTX2 mRNA] CTD PMID:32949729 NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416
JBrowse link
G Pax6 paired box 6 decreases expression
multiple interactions
ISO Hexachlorophene results in decreased expression of PAX6 mRNA; Hexachlorophene results in decreased expression of PAX6 protein
Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]
CTD PMID:25943520 PMID:32949729 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 affects expression ISO Hexachlorophene affects the expression of PDK4 mRNA CTD PMID:32870474 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Plcb4 phospholipase C, beta 4 increases methylation ISO Hexachlorophene results in increased methylation of PLCB4 promoter CTD PMID:29301063 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA] CTD PMID:32949729 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 increases expression
multiple interactions
ISO Hexachlorophene results in increased expression of SIAH1 mRNA
SIAH1 protein promotes the reaction [Hexachlorophene results in increased degradation of CTNNB1 protein]
CTD PMID:16735606 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Hexachlorophene results in decreased expression of SOX2 mRNA; Hexachlorophene results in decreased expression of SOX2 protein CTD PMID:25943520 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Stx4 syntaxin 4 decreases expression ISO Hexachlorophene results in decreased expression of STX4A mRNA CTD PMID:29301063 NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979
JBrowse link
G Tardbp TAR DNA binding protein decreases expression ISO Hexachlorophene results in decreased expression of TARDBP protein CTD PMID:25987361 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO Hexachlorophene inhibits the reaction [WNT3A protein results in increased expression of CTNNB1 protein] CTD PMID:16735606 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link

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  CHEBI ontology 19823
    role 19773
      application 19486
        pesticide 17133
          acaricide 12065
            hexachlorophene 33
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                carbocyclic compound 18336
                                  benzenoid aromatic compound 17495
                                    benzenes 17282
                                      chlorobenzenes 13757
                                        trichlorobenzene 2807
                                          hexachlorophene 33
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