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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexachlorobenzene
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Accession:CHEBI:5692 term browser browse the term
Definition:A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Synonyms:related_synonym: 1,2,3,4,5,6-hexachlorobenzene;   Formula=C6Cl6;   HCB;   Hexachlorbenzol;   InChI=1S/C6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9;   InChIKey=CKAPSXZOOQJIBF-UHFFFAOYSA-N;   SMILES=Clc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl;   perchlorobenzene;   phenyl perchloryl
 xref: Beilstein:1912585;   CAS:118-74-1;   Gmelin:27278;   HMDB:HMDB0032566;   KEGG:C11042
 xref_mesh: MESH:D006581
 xref: PMID:10641019;   PMID:12117784;   PMID:17150971;   PMID:23336922;   PMID:23462309;   PMID:23627767;   PMID:23747559;   PMID:23923419;   PMID:23973543;   PMID:24148401;   PMID:24311623;   PMID:24365113;   PPDB:380;   Reaxys:1912585;   Wikipedia:Hexachlorobenzene



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hexachlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Hexachlorobenzene results in increased expression of ABCC3 mRNA CTD PMID:23153324 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Ackr2 atypical chemokine receptor 2 increases expression EXP Hexachlorobenzene results in increased expression of ACKR2 mRNA CTD PMID:15159207 NCBI chr 8:121,559,563...121,573,633
Ensembl chr 8:121,561,211...121,573,582
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Hexachlorobenzene results in increased expression of ACTA2 protein CTD PMID:28923513 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Hexachlorobenzene results in increased expression of AGTR1 protein CTD PMID:29277037 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
decreases expression
affects expression
increases expression
affects binding
increases localization
ISO
EXP
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Hexachlorobenzene results in decreased expression of AHR mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene binds to and results in increased activity of AHR protein; Hexachlorobenzene results in decreased expression of and affects the localization of AHR protein
Hexachlorobenzene affects the localization of AHR protein
Hexachlorobenzene results in decreased expression of AHR protein
Hexachlorobenzene affects the expression of AHR mRNA
Hexachlorobenzene affects the reaction [AHR protein affects the expression of CYP1A1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of EGFR mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of IGF1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFB1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFBR2 mRNA]
Hexachlorobenzene results in increased expression of AHR protein
Hexachlorobenzene binds to AHR protein
[Diethylnitrosamine co-treated with Hexachlorobenzene] results in increased expression of AHR protein; Hexachlorobenzene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
Hexachlorobenzene results in increased localization of AHR protein
CTD PMID:2539049 PMID:9407059 PMID:15515957 PMID:16705413 PMID:18295415 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1 allograft inflammatory factor 1 affects expression EXP Hexachlorobenzene affects the expression of AIF1 mRNA CTD PMID:15159207 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
affects localization
EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Hexachlorobenzene affects the localization of AIFM1 protein]; Reactive Oxygen Species promotes the reaction [Hexachlorobenzene affects the localization of AIFM1 protein] CTD PMID:23708402 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 mRNA]; AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 protein]; Hexachlorobenzene results in increased activity of and results in increased localization of AKT1 protein CTD PMID:16679308 PMID:17150971 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP [Hexachlorobenzene co-treated with Methylnitrosourea] results in increased phosphorylation of AKT2 protein CTD PMID:22245120 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alad aminolevulinate dehydratase affects expression EXP Hexachlorobenzene affects the expression of ALAD mRNA CTD PMID:15159207 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression EXP Hexachlorobenzene results in increased expression of ALAS2 mRNA CTD PMID:15159207 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP Hexachlorobenzene results in increased expression of ALOX15 mRNA CTD PMID:15159207 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein affects expression EXP Hexachlorobenzene affects the expression of ALOX5AP mRNA CTD PMID:15159207 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Anxa1 annexin A1 increases expression EXP Hexachlorobenzene results in increased expression of ANXA1 mRNA CTD PMID:15159207 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression EXP Hexachlorobenzene results in decreased expression of BID protein CTD PMID:21787832 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G C1qb complement C1q B chain increases expression EXP Hexachlorobenzene results in increased expression of C1QB mRNA CTD PMID:15159207 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G C1s complement C1s increases expression EXP Hexachlorobenzene results in increased expression of C1S mRNA CTD PMID:15159207 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
JBrowse link
G C4bpa complement component 4 binding protein, alpha increases expression EXP Hexachlorobenzene results in increased expression of C4BPA mRNA CTD PMID:15159207 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G Capg capping actin protein, gelsolin like increases expression EXP Hexachlorobenzene results in increased expression of CAPG mRNA CTD PMID:15159207 NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856
JBrowse link
G Casp1 caspase 1 affects expression EXP Hexachlorobenzene affects the expression of CASP1 mRNA CTD PMID:15159207 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
EXP Hexachlorobenzene results in increased expression of CASP3 mRNA
Hexachlorobenzene results in increased activity of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased activity of CASP3 protein]
CTD PMID:19815060 PMID:21787832 PMID:23708402 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity EXP Hexachlorobenzene results in increased activity of CASP8 protein CTD PMID:21787832 PMID:23708402 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
EXP Hexachlorobenzene results in increased cleavage of and results in increased activity of CASP9 protein
Hexachlorobenzene results in increased activity of CASP9 protein
CTD PMID:19182106 PMID:21787832 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases expression EXP Hexachlorobenzene results in increased expression of CAT mRNA CTD PMID:15159207 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression EXP Hexachlorobenzene results in increased expression of CCL20 mRNA CTD PMID:15159207 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased expression of CCND1 protein] CTD PMID:26219504 PMID:28215542 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Hexachlorobenzene promotes the reaction [CDK2 protein binds to CCNE1 protein]; Hexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein] CTD PMID:28215542 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd14 CD14 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD14 mRNA CTD PMID:15159207 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd24 CD24 molecule affects expression EXP Hexachlorobenzene affects the expression of CD24 mRNA CTD PMID:15159207 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
JBrowse link
G Cd247 Cd247 molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD3Z mRNA CTD PMID:15159207 NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263
JBrowse link
G Cd36 CD36 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD36 mRNA CTD PMID:15159207 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd37 CD37 molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD37 mRNA CTD PMID:15159207 NCBI chr 1:95,719,171...95,724,662
Ensembl chr 1:95,719,190...95,724,648
JBrowse link
G Cd3d CD3d molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD3D mRNA CTD PMID:15159207 NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
JBrowse link
G Cd48 Cd48 molecule affects expression EXP Hexachlorobenzene affects the expression of CD48 mRNA CTD PMID:15159207 NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142
JBrowse link
G Cd5 Cd5 molecule affects expression EXP Hexachlorobenzene affects the expression of CD5 mRNA CTD PMID:15159207 NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
JBrowse link
G Cd52 CD52 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD52 mRNA CTD PMID:15159207 NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348
JBrowse link
G Cd59 CD59 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD59 mRNA CTD PMID:15159207 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cd63 Cd63 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD63 mRNA CTD PMID:15159207 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
JBrowse link
G Cd74 CD74 molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD74 mRNA CTD PMID:15159207 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Cd9 CD9 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD9 mRNA CTD PMID:15159207 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP [Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein CTD PMID:16679308 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO Hexachlorobenzene promotes the reaction [CDK2 protein binds to CCNE1 protein] CTD PMID:28215542 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
EXP
ISO
Hexachlorobenzene results in increased expression of CDKN1B protein
Hexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein]
CTD PMID:25093615 PMID:28215542 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases methylation EXP Hexachlorobenzene results in increased methylation of CDKN2A promoter alternative form CTD PMID:26431795 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cish cytokine inducible SH2-containing protein increases expression EXP Hexachlorobenzene results in increased expression of CISH mRNA CTD PMID:15159207 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Clec4f C-type lectin domain family 4, member F increases expression EXP Hexachlorobenzene results in increased expression of CLEC4F mRNA CTD PMID:15159207 NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775
JBrowse link
G Cma1 chymase 1 increases expression EXP Hexachlorobenzene results in increased expression of CMA1 mRNA CTD PMID:15159207 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Hexachlorobenzene results in increased expression of COMT protein CTD PMID:24365113 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cp ceruloplasmin increases expression EXP Hexachlorobenzene results in increased expression of CP mRNA CTD PMID:15159207 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cpa3 carboxypeptidase A3 increases expression EXP Hexachlorobenzene results in increased expression of CPA3 mRNA CTD PMID:15159207 NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression EXP Hexachlorobenzene results in increased expression of CSF2RB mRNA CTD PMID:15159207 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Hexachlorobenzene results in increased expression of CXCL1 mRNA CTD PMID:15159207 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 affects expression EXP Hexachlorobenzene affects the expression of CXCL10 mRNA CTD PMID:15159207 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression EXP Hexachlorobenzene results in increased expression of CXCL5 mRNA CTD PMID:15159207 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression EXP Hexachlorobenzene results in increased expression of CXCR4 mRNA CTD PMID:15159207 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO Hexachlorobenzene results in increased expression of CYP11A1 protein CTD PMID:24365113 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
EXP
ISO
Hexachlorobenzene results in increased expression of CYP1A1 mRNA; Hexachlorobenzene results in increased expression of CYP1A1 protein
Hexachlorobenzene affects the reaction [AHR protein affects the expression of CYP1A1 mRNA]
Hexachlorobenzene results in increased expression of and results in increased activity of CYP1A1 protein
CTD PMID:2539049 PMID:2845946 PMID:2856071 PMID:15159207 PMID:17202759 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Hexachlorobenzene results in increased expression of CYP1A2 mRNA; Hexachlorobenzene results in increased expression of CYP1A2 protein CTD PMID:2539049 PMID:2845946 PMID:2856071 PMID:9630449 PMID:10696772 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP1B1 mRNA CTD PMID:15159207 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression EXP Hexachlorobenzene results in increased expression of CYP2A3 mRNA CTD PMID:15159207 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP2B1 protein CTD PMID:10696772 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
increases expression
EXP Hexachlorobenzene results in decreased expression of CYP2E1 mRNA
Hexachlorobenzene results in increased expression of CYP2E1 protein
CTD PMID:10696772 PMID:15159207 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP Hexachlorobenzene results in increased expression of CYP3A2 mRNA CTD PMID:15159207 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression EXP Hexachlorobenzene affects the expression of CYP3A23-3A1 mRNA CTD PMID:15159207 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 increases expression EXP Hexachlorobenzene results in increased expression of CYP4A8 mRNA CTD PMID:15159207 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP7B1 mRNA CTD PMID:15159207 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity
increases activity
EXP Hexachlorobenzene results in decreased activity of DIO1 protein
Hexachlorobenzene results in increased activity of DIO1 protein
CTD PMID:15664263 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases expression EXP Hexachlorobenzene results in decreased expression of DIO2 mRNA CTD PMID:29277037 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases expression
increases phosphorylation
ISO
EXP
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene results in increased phosphorylation of and results in increased expression of EGFR protein
Hexachlorobenzene results in increased expression of EGFR mRNA
Hexachlorobenzene affects the reaction [AHR protein affects the expression of EGFR mRNA]
AG 1879 inhibits the reaction [SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]]; Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of EGFR protein]; Hexachlorobenzene results in increased phosphorylation of and results in decreased expression of EGFR protein; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]
CTD PMID:18295415 PMID:21205633 PMID:22245120 PMID:23462309 PMID:28923513 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Emb embigin increases expression EXP Hexachlorobenzene results in increased expression of EMB mRNA CTD PMID:15159207 NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP Hexachlorobenzene results in increased expression of EPHX1 mRNA CTD PMID:15159207 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP Hexachlorobenzene results in decreased expression of EPHX2 mRNA CTD PMID:15159207 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
increases expression
increases phosphorylation
ISO
EXP
ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; Fulvestrant promotes the reaction [Hexachlorobenzene results in decreased expression of ESR1 protein]
Hexachlorobenzene results in increased expression of ESR1 protein
Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in decreased phosphorylation of ESR1 protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]
Hexachlorobenzene results in increased phosphorylation of ESR1 protein
CTD PMID:19879930 PMID:22245120 PMID:28923513 PMID:29277037 PMID:31923581 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Hexachlorobenzene results in increased expression of FAS protein CTD PMID:21787832 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression EXP Hexachlorobenzene results in increased expression of FASLG protein CTD PMID:21787832 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fcer1a Fc epsilon receptor Ia increases expression EXP Hexachlorobenzene results in increased expression of FCER1A mRNA CTD PMID:15159207 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
JBrowse link
G Fcer2 Fc epsilon receptor II decreases expression EXP Hexachlorobenzene results in decreased expression of FCER2A mRNA CTD PMID:15159207 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
JBrowse link
G Fcgr2a Fc gamma receptor IIa increases expression EXP Hexachlorobenzene results in increased expression of FCGR3 mRNA CTD PMID:15159207 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
JBrowse link
G Fcgrt Fc gamma receptor and transporter increases expression EXP Hexachlorobenzene results in increased expression of FCGRT mRNA CTD PMID:15159207 NCBI chr 1:95,574,436...95,584,171
Ensembl chr 1:95,567,175...95,584,084
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Hexachlorobenzene results in increased expression of FN1 mRNA CTD PMID:15159207 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Hexachlorobenzene results in increased expression of FOS protein CTD PMID:9630449 PMID:10696772 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression
EXP Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in decreased expression of FSHB protein]
Hexachlorobenzene results in decreased expression of FSHB protein
CTD PMID:22245120 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP Hexachlorobenzene results in increased expression of GCLM mRNA CTD PMID:15159207 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gjb1 gap junction protein, beta 1 multiple interactions
decreases expression
EXP AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 mRNA]; AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 protein]; Estradiol affects the reaction [Hexachlorobenzene results in increased expression of GJB1 mRNA]
Hexachlorobenzene results in decreased expression of GJB1 mRNA; Hexachlorobenzene results in decreased expression of GJB1 protein
CTD PMID:12117784 PMID:17150971 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression EXP Hexachlorobenzene results in decreased expression of GJB2 mRNA; Hexachlorobenzene results in decreased expression of GJB2 protein CTD PMID:12117784 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
JBrowse link
G Glg1 golgi glycoprotein 1 affects expression EXP Hexachlorobenzene affects the expression of GLG1 mRNA CTD PMID:15159207 NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
JBrowse link
G Gpx3 glutathione peroxidase 3 affects expression EXP Hexachlorobenzene affects the expression of GPX3 mRNA CTD PMID:15159207 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity
multiple interactions
EXP Hexachlorobenzene results in decreased activity of GSK3B protein
[Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein
CTD PMID:16679308 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects expression EXP Hexachlorobenzene affects the expression of GSTA2 mRNA CTD PMID:15159207 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP Hexachlorobenzene results in increased expression of GSTA3 mRNA CTD PMID:15159207 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP Hexachlorobenzene results in decreased expression of GSTM1 mRNA CTD PMID:15159207 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Hexachlorobenzene results in increased expression of GSTM2 mRNA CTD PMID:15159207 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Hexachlorobenzene results in increased expression of GSTP1 protein CTD PMID:9630449 PMID:10696772 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Hexachlorobenzene results in increased expression of H2AX protein CTD PMID:32156659 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hdc histidine decarboxylase increases expression EXP Hexachlorobenzene results in increased expression of HDC mRNA CTD PMID:15159207 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Hmbs hydroxymethylbilane synthase increases expression
increases activity
EXP Hexachlorobenzene results in increased expression of HMBS mRNA
Hexachlorobenzene increases activity of Hmbs protein in liver
CTD
RGD
PMID:15159207 PMID:1781034 RGD:25440495 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
affects expression
EXP Hexachlorobenzene results in increased expression of HMOX1 mRNA
Hexachlorobenzene affects the expression of HMOX1 mRNA
CTD PMID:15159207 PMID:22954530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hp haptoglobin increases expression EXP Hexachlorobenzene results in increased expression of HP mRNA CTD PMID:15159207 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression EXP Hexachlorobenzene results in decreased expression of HSD17B2 mRNA CTD PMID:15159207 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of HSP90AB1 mRNA CTD PMID:15159207 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Hexachlorobenzene results in increased expression of HSPE1 mRNA CTD PMID:15159207 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Hexachlorobenzene results in increased expression of ICAM1 mRNA CTD PMID:15159207 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma affects expression
decreases expression
increases expression
EXP
ISO
Hexachlorobenzene affects the expression of IFNG mRNA
Hexachlorobenzene results in decreased expression of IFNG protein
Hexachlorobenzene results in increased expression of IFNG mRNA
CTD PMID:9465272 PMID:11119253 PMID:11266329 PMID:15319175 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression
increases secretion
multiple interactions
ISO Hexachlorobenzene affects the expression of IGF1 mRNA
Hexachlorobenzene results in increased secretion of IGF1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of and results in increased secretion of IGF1 protein; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA; ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]
Hexachlorobenzene affects the reaction [AHR protein affects the expression of IGF1 mRNA]
CTD PMID:28923513 PMID:31923581 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression
multiple interactions
EXP
ISO
Hexachlorobenzene results in increased expression of IGF1R protein
[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased phosphorylation of IGF1R protein; Fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of IGF1R protein]
Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein]
CTD PMID:16237195 PMID:19879930 PMID:33571556 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 multiple interactions ISO [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] affects the expression of IGFBP2 mRNA CTD PMID:31923581 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] affects the expression of IGFBP3 mRNA CTD PMID:31923581 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain increases expression EXP Hexachlorobenzene results in increased expression of IGG-2A mRNA CTD PMID:15159207
G Igsf6 immunoglobulin superfamily, member 6 affects expression EXP Hexachlorobenzene affects the expression of IGSF6 mRNA CTD PMID:15159207 NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722
JBrowse link
G Il10 interleukin 10 affects expression
decreases expression
EXP
ISO
Hexachlorobenzene affects the expression of IL10 mRNA; Hexachlorobenzene affects the expression of IL10 protein
Hexachlorobenzene results in decreased expression of IL10 protein
CTD PMID:11119253 PMID:15319175 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il15 interleukin 15 decreases expression EXP Hexachlorobenzene results in decreased expression of IL15 mRNA CTD PMID:15159207 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il18 interleukin 18 increases expression EXP Hexachlorobenzene results in increased expression of IL18 mRNA CTD PMID:15159207 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta affects expression EXP Hexachlorobenzene affects the expression of IL1B mRNA CTD PMID:15159207 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 increases expression EXP Hexachlorobenzene results in increased expression of IL2 mRNA CTD PMID:9465272 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP Hexachlorobenzene results in increased expression of IL2RA mRNA CTD PMID:9465272 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il2rb interleukin 2 receptor subunit beta affects expression EXP Hexachlorobenzene affects the expression of IL2RB mRNA CTD PMID:15159207 NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054
JBrowse link
G Il4 interleukin 4 affects expression EXP Hexachlorobenzene affects the expression of IL4 protein CTD PMID:11119253 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases expression ISO Hexachlorobenzene results in decreased expression of IL5 protein CTD PMID:15319175 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 increases expression EXP Hexachlorobenzene results in increased expression of IL6 mRNA CTD PMID:15159207 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression EXP Hexachlorobenzene results in increased expression of IL6ST mRNA CTD PMID:15159207 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Insr insulin receptor increases expression EXP
ISO
Hexachlorobenzene results in increased expression of INSR protein CTD PMID:16237195 PMID:19879930 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irf1 interferon regulatory factor 1 decreases expression EXP Hexachlorobenzene results in decreased expression of IRF1 mRNA CTD PMID:15159207 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
increases phosphorylation
increases expression
EXP
ISO
Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein]
Hexachlorobenzene results in increased phosphorylation of IRS1 protein
[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein; fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; fulvestrant inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of IRS1 protein]
Hexachlorobenzene results in increased expression of IRS1 protein
CTD PMID:16237195 PMID:19879930 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Hexachlorobenzene results in increased expression of JUN protein CTD PMID:9630449 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Hexachlorobenzene results in increased expression of KDR protein CTD PMID:26358519 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Hexachlorobenzene results in increased expression of LCN2 mRNA CTD PMID:15159207 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Hexachlorobenzene results in decreased expression of LHB protein CTD PMID:22245120 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression EXP Hexachlorobenzene results in increased expression of LMAN1 mRNA CTD PMID:15159207 NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 affects expression EXP Hexachlorobenzene affects the expression of MAP3K1 mRNA CTD PMID:15159207 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects localization
ISO
EXP
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]; Protein Kinase Inhibitors inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]
[Hexachlorobenzene results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein
Hexachlorobenzene affects the localization of MAPK1 protein
CTD PMID:21205633 PMID:21787832 PMID:22245120 PMID:23708402 PMID:26219504 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression EXP Hexachlorobenzene affects the expression of MAPK14 mRNA CTD PMID:15159207 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
affects localization
ISO
EXP
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Protein Kinase Inhibitors inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]
[Hexachlorobenzene results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein
Hexachlorobenzene affects the localization of MAPK3 protein
CTD PMID:21205633 PMID:22245120 PMID:23708402 PMID:26219504 PMID:26358519 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Hexachlorobenzene results in increased phosphorylation of MAPK8 protein CTD PMID:23708402 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mcpt10 mast cell protease 10 increases expression EXP Hexachlorobenzene results in increased expression of MCPT10 mRNA CTD PMID:15159207 NCBI chr15:29,915,483...29,918,540
Ensembl chr15:29,915,483...29,918,511
JBrowse link
G Med16 mediator complex subunit 16 decreases expression EXP Hexachlorobenzene results in decreased expression of MED16 mRNA CTD PMID:23153324 NCBI chr 7:9,798,641...9,811,172
Ensembl chr 7:9,798,668...9,811,172
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
ISO Hexachlorobenzene results in increased expression of MMP2 mRNA; Hexachlorobenzene results in increased expression of MMP2 protein
[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of and results in increased activity of MMP2 protein; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of MMP2 mRNA; AG 1879 inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein]; picropodophyllin inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased activity of MMP2 protein]; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein]
CTD PMID:23462309 PMID:33571556 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
EXP
ISO
Hexachlorobenzene results in increased expression of MMP9 mRNA
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]; Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]
CTD PMID:15159207 PMID:23462309 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase increases expression EXP Hexachlorobenzene results in increased expression of MPST mRNA CTD PMID:15159207 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
JBrowse link
G Mt1 metallothionein 1 increases expression EXP Hexachlorobenzene results in increased expression of MT1A mRNA CTD PMID:15159207 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression EXP Hexachlorobenzene results in decreased expression of MTOR mRNA CTD PMID:15159207 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 protein CTD PMID:28634113 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO Hexachlorobenzene affects the expression of NOS1 protein CTD PMID:32526215 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 affects expression ISO Hexachlorobenzene affects the expression of NOS2 protein CTD PMID:32526215 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
affects expression
EXP
ISO
Hexachlorobenzene results in decreased expression of NOS3 protein
Hexachlorobenzene affects the expression of NOS3 protein
CTD PMID:29277037 PMID:32526215 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Hexachlorobenzene results in increased expression of NQO1 mRNA CTD PMID:23153324 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of NR1D1 mRNA CTD PMID:23153324 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Hexachlorobenzene results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Hexachlorobenzene results in increased expression of ORM1 mRNA CTD PMID:15159207 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased expression of PCNA protein]
Hexachlorobenzene results in decreased expression of PCNA protein
CTD PMID:26219504 PMID:29277037 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pglyrp1 peptidoglycan recognition protein 1 increases expression EXP Hexachlorobenzene results in increased expression of PGLYRP1 mRNA CTD PMID:15159207 NCBI chr 1:78,531,815...78,537,001
Ensembl chr 1:78,531,815...78,537,001
JBrowse link
G Plpp2 phospholipid phosphatase 2 increases expression EXP Hexachlorobenzene results in increased expression of PLPP2 mRNA CTD PMID:15159207 NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071
JBrowse link
G Por cytochrome p450 oxidoreductase decreases expression EXP Hexachlorobenzene results in decreased expression of POR mRNA CTD PMID:15159207 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppox protoporphyrinogen oxidase affects expression EXP Hexachlorobenzene affects the expression of PPOX mRNA CTD PMID:15159207 NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP Hexachlorobenzene results in increased expression of PRDX2 mRNA CTD PMID:15159207 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prl prolactin increases expression EXP Hexachlorobenzene results in increased expression of PRL protein CTD PMID:22245120 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Hexachlorobenzene results in increased expression of PTGS2 protein
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]
CTD PMID:26358519 PMID:32526215 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G RatNP-3b defensin RatNP-3 precursor increases expression EXP Hexachlorobenzene results in increased expression of RATNP-3B mRNA CTD PMID:15159207 NCBI chr16:70,544,364...70,546,533
Ensembl chr16:70,513,888...70,546,522
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of RELA protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of RELA protein] CTD PMID:28634113 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgcc regulator of cell cycle affects expression EXP Hexachlorobenzene affects the expression of RGCC mRNA CTD PMID:15159207 NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression
increases expression
EXP Hexachlorobenzene affects the expression of RT1-BB mRNA
Hexachlorobenzene results in increased expression of RT1-BB mRNA
CTD PMID:15159207 PMID:17202759 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression EXP Hexachlorobenzene results in decreased expression of RT1-DA mRNA CTD PMID:15159207 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression EXP Hexachlorobenzene affects the expression of RT1-DB1 mRNA CTD PMID:15159207 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-DMa RT1 class II, locus DMa decreases expression EXP Hexachlorobenzene results in decreased expression of HLA-DMA mRNA CTD PMID:15159207 NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432
JBrowse link
G RT1-DMb RT1 class II, locus DMb decreases expression EXP Hexachlorobenzene results in decreased expression of HLA-DMB mRNA CTD PMID:15159207 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression EXP Hexachlorobenzene results in increased expression of RT1-S3 mRNA CTD PMID:15159207 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Rxrb retinoid X receptor beta increases activity ISO Hexachlorobenzene results in increased activity of RXRB protein CTD PMID:18207673 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Hexachlorobenzene results in increased expression of S100A8 mRNA CTD PMID:15159207 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Hexachlorobenzene results in increased expression of S100A9 mRNA CTD PMID:15159207 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha increases expression EXP Hexachlorobenzene results in increased expression of SCNN1A mRNA CTD PMID:23153324 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO Hexachlorobenzene results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040
JBrowse link
G Sh2b3 SH2B adaptor protein 3 decreases expression EXP Hexachlorobenzene results in decreased expression of LNK mRNA CTD PMID:15159207 NCBI chr12:34,749,849...34,753,616
Ensembl chr12:34,731,911...34,753,616
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Hexachlorobenzene results in decreased expression of SLC2A4 protein CTD PMID:31923579 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; Hexachlorobenzene results in increased phosphorylation of and affects the localization of SMAD3 protein CTD PMID:27519288 PMID:28923513 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Socs2 suppressor of cytokine signaling 2 affects expression EXP Hexachlorobenzene affects the expression of SOCS2 mRNA CTD PMID:15159207 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Hexachlorobenzene results in increased expression of SOCS3 mRNA CTD PMID:15159207 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Hexachlorobenzene results in increased expression of SOD1 mRNA CTD PMID:15159207 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP Hexachlorobenzene affects the expression of SOD2 mRNA CTD PMID:15159207 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 affects expression EXP Hexachlorobenzene affects the expression of SOD3 mRNA CTD PMID:15159207 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
affects localization
increases phosphorylation
ISO
EXP
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]; [AG 1879 results in decreased activity of SRC protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene affects the phosphorylation of and affects the activity of SRC protein; Hexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein]
Hexachlorobenzene affects the localization of SRC protein
Hexachlorobenzene results in increased phosphorylation of SRC protein
AG 1879 inhibits the reaction [SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]]; Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of SRC protein]; Hexachlorobenzene results in increased expression of and results in increased phosphorylation of and results in increased activity of SRC protein; Hexachlorobenzene results in increased phosphorylation of and results in increased expression of SRC protein; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of SRC protein]; SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]
CTD PMID:18295415 PMID:19879930 PMID:21205633 PMID:22245120 PMID:23462309 More... NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression EXP Hexachlorobenzene results in increased expression of STAT1 mRNA CTD PMID:15159207 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO
EXP
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein
Hexachlorobenzene affects the expression of and affects the phosphorylation of STAT5B protein
CTD PMID:21205633 PMID:22245120 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Hexachlorobenzene results in increased expression of SULT1A1 mRNA CTD PMID:15159207 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases expression EXP Hexachlorobenzene results in increased expression of SULT1E1 mRNA CTD PMID:15159207 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Tf transferrin increases expression EXP Hexachlorobenzene results in increased expression of TF mRNA CTD PMID:15159207 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor affects expression EXP Hexachlorobenzene affects the expression of TFRC mRNA CTD PMID:15159207 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine co-treated with Cholecalciferol] results in increased expression of TGFA protein; [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of TGFA protein CTD PMID:28634113 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
affects expression
EXP
ISO
Hexachlorobenzene results in increased expression of TGFB1 mRNA; Hexachlorobenzene results in increased expression of TGFB1 protein
Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFB1 mRNA]
Hexachlorobenzene affects the expression of TGFB1 mRNA
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of TGFB1 mRNA]; Hexachlorobenzene results in increased expression of and results in increased cleavage of TGFB1 protein
CTD PMID:19182106 PMID:21787832 PMID:25093615 PMID:27519288 PMID:28923513 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Hexachlorobenzene results in decreased expression of TGFB3 mRNA CTD PMID:15159207 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO Hexachlorobenzene results in increased expression of TGFBR1 mRNA CTD PMID:28923513 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions
affects expression
ISO Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFBR2 mRNA]
Hexachlorobenzene affects the expression of TGFBR2 mRNA
CTD PMID:28923513 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Hexachlorobenzene results in increased expression of TIMP1 mRNA CTD PMID:15159207 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Hexachlorobenzene results in increased expression of TIMP2 mRNA CTD PMID:15159207 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Hexachlorobenzene results in increased expression of TNFRSF1A mRNA CTD PMID:15159207 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of TSC22D1 mRNA CTD PMID:15159207 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO Hexachlorobenzene affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Ttr transthyretin affects binding EXP Hexachlorobenzene binds to TTR protein CTD PMID:2043046 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
decreases expression
EXP Hexachlorobenzene results in increased expression of TXNRD1 mRNA
Hexachlorobenzene results in decreased expression of TXNRD1 mRNA
CTD PMID:23153324 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Hexachlorobenzene results in increased expression of UGT2B1 mRNA CTD PMID:15159207 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt8 UDP glycosyltransferase 8 increases expression EXP Hexachlorobenzene results in increased expression of UGT8 mRNA CTD PMID:15159207 NCBI chr 2:214,264,483...214,332,769
Ensembl chr 2:214,264,483...214,332,660
JBrowse link
G Urod uroporphyrinogen decarboxylase affects expression
multiple interactions
EXP
ISO
Hexachlorobenzene affects the expression of UROD mRNA
Hexachlorobenzene promotes the reaction [Aminolevulinic Acid results in decreased activity of UROD protein]
CTD PMID:8937451 PMID:15159207 NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Hexachlorobenzene results in increased expression of VCAM1 mRNA CTD PMID:15159207 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine] results in decreased expression of VDR protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of VDR protein] CTD PMID:28634113 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
increases expression
multiple interactions
ISO Hexachlorobenzene results in increased secretion of VEGFA protein
Hexachlorobenzene results in increased expression of VEGFA protein
alpha-naphthoflavone affects the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; Hexachlorobenzene results in increased expression of and results in increased secretion of VEGFA protein; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]
CTD PMID:26358519 PMID:32526215 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        aetiopathogenetic role 19027
          carcinogenic agent 18362
            hexachlorobenzene 203
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                carbocyclic compound 18316
                                  benzenoid aromatic compound 17484
                                    benzenes 17274
                                      chlorobenzenes 13837
                                        hexachlorobenzene 203
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