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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Hexachloro-1,3-butadiene
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Accession:CHEBI:5691 term browser browse the term
Definition:An organochlorine compound that has formula C4Cl6.
Synonyms:related_synonym: Formula=C4Cl6;   HCBD;   Hexachlorobutadiene;   InChI=1S/C4Cl6/c5-1(3(7)8)2(6)4(9)10;   InChIKey=RWNKSTSCBHKHTB-UHFFFAOYSA-N;   SMILES=ClC(Cl)=C(Cl)C(Cl)=C(Cl)Cl
 xref: CAS:87-68-3;   KEGG:C11091
 xref_mesh: MESH:C001335


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Hexachloro-1,3-butadiene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP hexachlorobutadiene results in increased expression of ABCC3 mRNA CTD PMID:21905055 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Alb albumin increases expression EXP hexachlorobutadiene results in increased expression of ALB protein CTD PMID:21259293, PMID:21905055, PMID:23136149 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Anxa7 annexin A7 increases expression
affects expression
EXP hexachlorobutadiene results in increased expression of ANXA7 mRNA
hexachlorobutadiene affects the expression of ANXA7 mRNA
CTD PMID:21905055, PMID:23136149 NCBI chr15:4,254,470...4,281,296
Ensembl chr15:4,254,499...4,281,287
JBrowse link
G B2m beta-2 microglobulin increases expression EXP hexachlorobutadiene results in increased expression of B2M protein CTD PMID:2202081, PMID:21259293 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP hexachlorobutadiene results in increased expression of CCL2 mRNA CTD PMID:21905055 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Clu clusterin increases expression EXP hexachlorobutadiene results in increased expression of CLU protein CTD PMID:21259293 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col1a1 collagen type I alpha 1 chain affects expression
decreases expression
EXP hexachlorobutadiene affects the expression of COL1A1 mRNA
hexachlorobutadiene results in decreased expression of COL1A1 mRNA
CTD PMID:21905055 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cryab crystallin, alpha B affects expression
increases expression
EXP hexachlorobutadiene affects the expression of CRYAB mRNA
hexachlorobutadiene results in increased expression of CRYAB mRNA
CTD PMID:21905055 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cst3 cystatin C increases expression EXP hexachlorobutadiene results in increased expression of CST3 protein CTD PMID:21259293 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
EXP
ISO
hexachlorobutadiene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
hexachlorobutadiene results in decreased expression of CYP1A1 mRNA
CTD PMID:18493746, PMID:21905055 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of hexachlorobutadiene CTD PMID:8555406 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions
decreases activity
EXP hexachlorobutadiene affects the reaction [S-pentachlorobuta-1,3-dien-yl-cysteine results in decreased activity of DLD protein]
hexachlorobutadiene results in decreased activity of DLD protein
CTD PMID:2360207 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP hexachlorobutadiene results in increased expression of EPHX1 mRNA CTD PMID:21905055 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression
increases expression
EXP hexachlorobutadiene results in decreased expression of G6PDX mRNA
hexachlorobutadiene results in increased expression of G6PDX mRNA
CTD PMID:21905055 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
increases expression
EXP hexachlorobutadiene results in decreased expression of GCLC mRNA
hexachlorobutadiene results in increased expression of GCLC mRNA
CTD PMID:21905055 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Glul glutamate-ammonia ligase increases expression EXP hexachlorobutadiene results in increased expression of GLUL protein CTD PMID:10463391 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gpnmb glycoprotein nmb decreases expression
increases expression
EXP hexachlorobutadiene results in decreased expression of GPNMB mRNA
hexachlorobutadiene results in increased expression of GPNMB mRNA
CTD PMID:21905055 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
increases expression
EXP hexachlorobutadiene results in decreased activity of GSR protein
hexachlorobutadiene results in increased expression of GSR mRNA
CTD PMID:2360207, PMID:21905055 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gss glutathione synthetase decreases activity EXP hexachlorobutadiene results in decreased activity of GSS protein CTD PMID:15669050 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP hexachlorobutadiene results in increased expression of GSTA3 mRNA CTD PMID:21905055 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP hexachlorobutadiene results in increased expression of GSTM1 protein CTD PMID:21259293, PMID:21905055 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression EXP hexachlorobutadiene results in increased expression of GSTM4 mRNA CTD PMID:21905055 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP hexachlorobutadiene results in increased expression of HAVCR1 mRNA; hexachlorobutadiene results in increased expression of HAVCR1 protein CTD PMID:20305092, PMID:21259293, PMID:21905055, PMID:23136149 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP hexachlorobutadiene results in increased expression of HMOX1 mRNA CTD PMID:21905055, PMID:23136149 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta increases expression EXP hexachlorobutadiene results in increased expression of IL1B mRNA CTD PMID:21905055 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kng2 kininogen 2 decreases expression
increases expression
EXP hexachlorobutadiene results in decreased expression of KNG1 mRNA
hexachlorobutadiene results in increased expression of KNG1 mRNA
CTD PMID:21905055 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases expression
decreases activity
EXP hexachlorobutadiene results in increased expression of KYAT1 protein
hexachlorobutadiene results in decreased activity of KYAT1 protein
CTD PMID:9049049, PMID:9765069, PMID:15012908 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Lcn2 lipocalin 2 decreases expression
increases expression
affects expression
EXP hexachlorobutadiene results in decreased expression of LCN2 mRNA
hexachlorobutadiene results in increased expression of LCN2 protein
hexachlorobutadiene affects the expression of LCN2 mRNA
CTD PMID:21259293, PMID:21905055 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP hexachlorobutadiene results in increased expression of MMP2 mRNA CTD PMID:21905055 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP hexachlorobutadiene results in increased expression of NQO1 mRNA CTD PMID:21905055, PMID:23136149 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Rgn regucalcin decreases expression EXP hexachlorobutadiene results in decreased expression of RGN mRNA CTD PMID:18805471 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP hexachlorobutadiene results in increased expression of SPP1 protein CTD PMID:21259293, PMID:23136149 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP hexachlorobutadiene results in increased expression of STAT3 mRNA CTD PMID:21905055 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
increases expression
EXP hexachlorobutadiene results in decreased expression of TIMP1 mRNA
hexachlorobutadiene results in increased expression of TIMP1 mRNA; hexachlorobutadiene results in increased expression of TIMP1 protein
CTD PMID:21259293, PMID:21905055 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP hexachlorobutadiene results in increased expression of TXNRD1 mRNA CTD PMID:21905055 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP hexachlorobutadiene results in increased expression of UGT1A6 mRNA CTD PMID:21905055 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

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  CHEBI ontology 19787
    chemical entity 19787
      molecular entity 19784
        main group molecular entity 19672
          p-block molecular entity 19672
            halogen molecular entity 18011
              chlorine molecular entity 17793
                organochlorine compound 17466
                  Hexachloro-1,3-butadiene 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      p-block molecular entity 19672
                        carbon group molecular entity 19574
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organohalogen compound 17712
                                organochlorine compound 17466
                                  Hexachloro-1,3-butadiene 35
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