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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:herbimycin
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Accession:CHEBI:5674 term browser browse the term
Definition:A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.
Synonyms:exact_synonym: (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
 related_synonym: Antibiotic Tan 420F;   Formula=C30H42N2O9;   Herbimycin A;   InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1;   InChIKey=MCAHMSDENAOJFZ-BVXDHVRPSA-N;   SMILES=CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\\C(C)=C\\C=C/[C@H](OC)[C@@H](OC(N)=O)\\C(C)=C\\[C@H](C)[C@H]1OC)C2=O
 xref: CAS:70563-58-5;   KEGG:C11225
 xref_mesh: MESH:C020754
 xref: PMID:21198874;   PMID:21488197;   PMID:21505853;   PMID:21543765;   PMID:21743149;   PMID:22420214;   PMID:22526207;   Reaxys:4834067;   Wikipedia:Herbimycin


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herbimycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO herbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [herbimycin results in decreased expression of AHR protein] CTD PMID:20057149 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases activity ISO herbimycin results in increased activity of CACNA1H protein CTD PMID:18309285 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Csn2 casein beta multiple interactions ISO herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr14:21,972,274...21,979,511
Ensembl chr14:21,972,274...21,979,510
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP
ISO
herbimycin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein]
herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:14987951 PMID:20057149 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP herbimycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA] CTD PMID:9242432 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO herbimycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]
herbimycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]
CTD PMID:9722676 PMID:16171798 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions EXP herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA] CTD PMID:16294319 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein] CTD PMID:12044887 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]
herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]
CTD PMID:10825233 PMID:12044887 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP herbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]; herbimycin inhibits the reaction [IL1B protein results in increased activity of TAC1 protein]; herbimycin inhibits the reaction [IL1B protein results in increased expression of TAC1 mRNA] CTD PMID:14622206 PMID:15808840 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] CTD PMID:11035063 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO herbimycin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased phosphorylation of MAPK1 protein]
herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
CTD PMID:10653605 PMID:11035063 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:11035063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO herbimycin inhibits the reaction [Chromium results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Cobalt results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein] CTD PMID:10921504 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA] CTD PMID:10825233 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions EXP herbimycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO herbimycin results in increased cleavage of PARP1 protein CTD PMID:11035063 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prl prolactin multiple interactions ISO herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
EXP herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]]; herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
herbimycin results in decreased expression of PTGS2 mRNA
CTD PMID:11133817 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
decreases activity
EXP herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]
herbimycin results in decreased activity of STAT1 protein
CTD PMID:10825233 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP herbimycin inhibits the reaction [IL1B protein results in increased activity of TAC1 protein]; herbimycin inhibits the reaction [IL1B protein results in increased expression of TAC1 mRNA] CTD PMID:14622206 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA] CTD PMID:15878362 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO herbimycin inhibits the reaction [Chromium results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Cobalt results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:10653605 PMID:15878362 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO herbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions EXP herbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link

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  CHEBI ontology 19771
    role 19716
      biological role 19716
        antimicrobial agent 17373
          herbimycin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        carboacyl group 17416
                                          univalent carboacyl group 17416
                                            carbamoyl group 17213
                                              carboxamide 17213
                                                lactam 8049
                                                  herbimycin 29
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