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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hemiacetal
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Accession:CHEBI:5653 term browser browse the term
Definition:A compound having the general formula RR'C(OH)OR'' (R'' =/= H).
Synonyms:related_synonym: Formula=CH2O2R2;   hemiacetals


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(-)-noscapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO Noscapine promotes the reaction [Cisplatin results in increased expression of BAX protein]
Noscapine results in increased expression of BAX protein
CTD PMID:20674069 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
ISO Noscapine results in decreased expression of BCL2 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD PMID:20674069 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance
increases expression
multiple interactions
decreases expression
ISO BIRC5 protein results in decreased susceptibility to Noscapine
Noscapine results in increased expression of BIRC5 mRNA; Noscapine results in increased expression of BIRC5 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BIRC5 protein]
Noscapine results in decreased expression of BIRC5 protein
CTD PMID:20674069 PMID:22848370 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [Noscapine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP3 protein
Noscapine results in increased activity of CASP3 protein
CTD PMID:20674069 PMID:22848370 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP9 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP9 protein CTD PMID:20674069 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
ISO Noscapine promotes the reaction [Cisplatin results in increased expression of CDKN1A protein]
Noscapine results in increased expression of CDKN1A protein
CTD PMID:20674069 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Noscapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Noscapine results in increased degradation of and results in decreased expression of and results in decreased activity of HIF1A protein CTD PMID:16596621 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Noscapine results in increased cleavage of PARP1 protein CTD PMID:22848370 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Noscapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression
ISO Noscapine promotes the reaction [Cisplatin results in increased expression of TP53 protein]; Noscapine results in increased expression of and results in increased phosphorylation of TP53 protein
Noscapine results in increased expression of TP53 protein
CTD PMID:20674069 PMID:22848370 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO Noscapine results in decreased secretion of VEGFA protein CTD PMID:16596621 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
11-dehydro-thromboxane B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E multiple interactions ISO APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; tempol inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919
JBrowse link
alborixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression ISO alborixin results in increased expression of BAX protein CTD PMID:27378626 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO alborixin results in decreased expression of BCL2 protein CTD PMID:27378626 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 increases cleavage ISO alborixin results in increased cleavage of CASP3 protein CTD PMID:27378626 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases activity ISO alborixin results in increased activity of CASP8 protein CTD PMID:27378626 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases activity ISO alborixin results in increased activity of CASP9 protein CTD PMID:27378626 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO alborixin results in increased cleavage of PARP1 protein CTD PMID:27378626 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
ascomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1a FK506 binding protein 1a multiple interactions EXP
ISO
immunomycin inhibits the reaction [Sirolimus binds to FKBP1A protein] CTD PMID:7503980 PMID:7532117 NCBI chr 2:151,542,483...151,561,691
Ensembl chr 2:151,542,483...151,561,692
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO [Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein CTD PMID:7723735 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
azadirachtin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
decreases expression
EXP azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of ACP5 mRNA]
azadirachtin results in decreased expression of ACP5 mRNA
CTD PMID:31225646 NCBI chr 9:22,126,727...22,135,746
Ensembl chr 9:22,126,727...22,135,711
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO azadirachtin results in increased expression of APAF1 protein CTD PMID:20429769 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO azadirachtin results in increased expression of BAD mRNA CTD PMID:20429769 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bax BCL2-associated X protein increases expression ISO azadirachtin results in increased expression of BAX mRNA CTD PMID:20429769 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO azadirachtin results in decreased expression of BCL2 mRNA; azadirachtin results in decreased expression of BCL2 protein CTD PMID:20429769 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO azadirachtin results in decreased expression of BCL2L1 mRNA CTD PMID:20429769 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions EXP azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of BGLAP protein] CTD PMID:31225646 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO azadirachtin results in increased expression of BID mRNA CTD PMID:20429769 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO azadirachtin results in decreased expression of BIRC5 protein CTD PMID:20429769 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression EXP azadirachtin results in increased expression of BMP2 mRNA; azadirachtin results in increased expression of BMP2 protein CTD PMID:31225646 NCBI chr 2:133,552,159...133,562,896
Ensembl chr 2:133,552,159...133,562,885
JBrowse link
G Casp3 caspase 3 increases expression ISO azadirachtin results in increased expression of CASP3 mRNA; azadirachtin results in increased expression of CASP3 protein CTD PMID:20429769 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp6 caspase 6 increases expression ISO azadirachtin results in increased expression of CASP6 protein CTD PMID:20429769 NCBI chr 3:129,901,415...129,914,112
Ensembl chr 3:129,901,425...129,914,103
JBrowse link
G Casp8 caspase 8 increases expression ISO azadirachtin results in increased expression of CASP8 protein CTD PMID:20429769 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases expression ISO azadirachtin results in increased expression of CASP9 mRNA; azadirachtin results in increased expression of CASP9 protein CTD PMID:20429769 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO azadirachtin results in decreased expression of CCND1 mRNA CTD PMID:20429769 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO azadirachtin results in increased expression of CDKN1A mRNA; azadirachtin results in increased expression of CDKN1A protein CTD PMID:20429769 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cycs cytochrome c, somatic affects localization
increases expression
ISO azadirachtin affects the localization of CYCS protein
azadirachtin results in increased expression of CYCS mRNA
CTD PMID:20429769 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Esr1 estrogen receptor 1 (alpha) affects binding
multiple interactions
increases expression
ISO
EXP
azadirachtin binds to ESR1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 protein]; azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR1 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
azadirachtin results in increased expression of ESR1 mRNA; azadirachtin results in increased expression of ESR1 protein
CTD PMID:31225646 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) affects binding
multiple interactions
increases expression
ISO
EXP
azadirachtin binds to ESR2 protein
azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR2 mRNA]
azadirachtin results in increased expression of ESR2 mRNA; azadirachtin results in increased expression of ESR2 protein
CTD PMID:31225646 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta decreases expression ISO azadirachtin results in decreased expression of IKBKB protein CTD PMID:20429769 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation EXP azadirachtin results in increased phosphorylation of MAPK1 protein CTD PMID:31225646 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation EXP azadirachtin results in increased phosphorylation of MAPK3 protein CTD PMID:31225646 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases expression ISO azadirachtin results in decreased expression of NFKB1 protein CTD PMID:20429769 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases expression ISO azadirachtin results in decreased expression of NFKBIA protein modified form CTD PMID:20429769 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO azadirachtin results in decreased expression of PCNA mRNA; azadirachtin results in decreased expression of PCNA protein CTD PMID:20429769 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases expression ISO azadirachtin results in decreased expression of RELA protein CTD PMID:20429769 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions
increases expression
EXP ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
azadirachtin results in increased expression of RUNX2 mRNA; azadirachtin results in increased expression of RUNX2 protein
CTD PMID:31225646 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G Smad1 SMAD family member 1 increases expression EXP azadirachtin results in increased expression of SMAD1 protein modified form CTD PMID:31225646 NCBI chr 8:79,338,395...79,399,428
Ensembl chr 8:79,338,395...79,399,518
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP azadirachtin results in decreased expression of TNF mRNA CTD PMID:31225646 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator decreases expression
multiple interactions
EXP azadirachtin results in decreased expression of TNFRSF11A mRNA
azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of TNFRSF11A mRNA]
CTD PMID:31225646 NCBI chr 1:105,780,673...105,849,444
Ensembl chr 1:105,780,718...105,847,981
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO azadirachtin results in increased expression of TP53 mRNA; azadirachtin results in increased expression of TP53 protein CTD PMID:20429769 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
bafilomycin A1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions ISO bafilomycin A1 inhibits the reaction [AGT protein affects the localization of Calcium] CTD PMID:21613610 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Aim2 absent in melanoma 2 multiple interactions ISO [bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of AIM2 protein CTD PMID:32645460 NCBI chr 1:173,349,547...173,466,040
Ensembl chr 1:173,350,879...173,466,040
JBrowse link
G Akt1s1 AKT1 substrate 1 (proline-rich) multiple interactions ISO bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein] CTD PMID:22689575 NCBI chr 7:44,849,224...44,855,421
Ensembl chr 7:44,848,991...44,855,421
JBrowse link
G Alb albumin decreases uptake ISO bafilomycin A1 results in decreased uptake of ALB protein CTD PMID:16313995 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO bafilomycin A1 results in increased expression of APAF1 protein CTD PMID:28483490 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 multiple interactions EXP bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr14:26,918,986...26,970,611
Ensembl chr14:26,918,988...26,971,232
JBrowse link
G Asic1 acid-sensing (proton-gated) ion channel 1 multiple interactions EXP bafilomycin A1 inhibits the reaction [Freund's Adjuvant results in increased expression of ASIC1 mRNA] CTD PMID:16769263 NCBI chr15:99,670,197...99,701,130
Ensembl chr15:99,670,368...99,701,130
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO ATG5 protein affects the reaction [bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]] CTD PMID:29938581 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO bafilomycin A1 inhibits the reaction [Hydroxychloroquine results in increased activity of BAX protein] CTD PMID:12813466 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression EXP bafilomycin A1 results in decreased expression of BCL2 mRNA CTD PMID:31310755 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression
ISO bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BECN1 protein]
bafilomycin A1 results in increased expression of BECN1 protein
[Swainsonine co-treated with bafilomycin A1] results in increased expression of BECN1 protein; bafilomycin A1 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BECN1 protein]
CTD PMID:32645460 PMID:33186601 PMID:33242459 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions ISO bafilomycin A1 inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA] CTD PMID:23111315 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage
increases expression
ISO bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein]
bafilomycin A1 results in increased cleavage of BID protein
vistusertib affects the reaction [bafilomycin A1 results in increased cleavage of BID protein]
bafilomycin A1 results in increased expression of BID protein modified form
CTD PMID:26853465 PMID:28378122 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of BNIP3 mRNA; bafilomycin A1 results in increased expression of BNIP3 protein
BNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; capivasertib affects the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; Gefitinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; Lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; vistusertib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]
CTD PMID:25981168 PMID:26853465 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G C1qtnf9 C1q and tumor necrosis factor related protein 9 multiple interactions ISO bafilomycin A1 promotes the reaction [C1QTNF9 protein results in increased expression of MAP1LC3B protein modified form] CTD PMID:32278738 NCBI chr14:60,768,134...60,780,869
Ensembl chr14:60,768,134...60,780,869
JBrowse link
G Casp3 caspase 3 decreases activity
increases cleavage
multiple interactions
increases activity
ISO
EXP
bafilomycin A1 results in decreased activity of CASP3 protein
bafilomycin A1 results in increased cleavage of CASP3 protein
bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]
bafilomycin A1 results in increased activity of CASP3 protein
[Swainsonine co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein; bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]
[bafilomycin A1 co-treated with Cannabidiol] results in increased cleavage of CASP3 protein; [bafilomycin A1 co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; [bafilomycin A1 co-treated with methanandamide] results in increased cleavage of CASP3 protein; [Cannabidiol co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein; bafilomycin A1 inhibits the reaction [Soot analog results in increased expression of CASP3 protein]; bafilomycin A1 inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [[bafilomycin A1 co-treated with Cannabidiol] results in increased cleavage of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [[bafilomycin A1 co-treated with methanandamide] results in increased cleavage of CASP3 protein]; vistusertib affects the reaction [bafilomycin A1 results in increased cleavage of CASP3 protein]
CTD PMID:20876807 PMID:23380477 PMID:24321340 PMID:24889822 PMID:25266202 PMID:25981168 PMID:26853465 PMID:28063998 PMID:28378122 PMID:29111403 PMID:30240709 PMID:32708634 PMID:33076330 PMID:33186601 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase increases activity ISO bafilomycin A1 results in increased activity of CASP4 protein CTD PMID:20371669 NCBI chr 9:5,308,849...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp7 caspase 7 increases activity
decreases activity
ISO bafilomycin A1 results in increased activity of CASP7 protein
bafilomycin A1 results in decreased activity of CASP7 protein
CTD PMID:20371669 PMID:25981168 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 multiple interactions ISO
EXP
bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]
bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]
CTD PMID:28378122 PMID:29111403 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions ISO bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]
bafilomycin A1 inhibits the reaction [Soot analog results in increased expression of CASP9 protein]
CTD PMID:28378122 PMID:30240709 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of CCND1 protein] CTD PMID:33359579 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO bafilomycin A1 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein] CTD PMID:29074359 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Ctsb cathepsin B multiple interactions ISO bafilomycin A1 inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; bafilomycin A1 inhibits the reaction [Hydroxychloroquine affects the localization of CTSB protein] CTD PMID:12813466 PMID:23380477 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 multiple interactions ISO bafilomycin A1 inhibits the reaction [CpG ODN 2216 results in increased expression of CXCL10 protein]; bafilomycin A1 inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; bafilomycin A1 inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein] CTD PMID:26682054 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of DDIT4 protein
[EGF protein co-treated with bafilomycin A1] results in increased expression of DDIT4 protein
CTD PMID:22689575 NCBI chr10:59,949,675...59,951,770
Ensembl chr10:59,949,669...59,951,834
JBrowse link
G Egf epidermal growth factor multiple interactions ISO [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine; [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Aspartic Acid; [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Taurine; [EGF protein co-treated with bafilomycin A1] results in increased expression of DDIT4 protein; bafilomycin A1 inhibits the reaction [EGF protein results in increased activity of and results in increased phosphorylation of RPS6KB1 protein]; bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine] CTD PMID:22689575 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO bafilomycin A1 inhibits the reaction [Arsenic Trioxide results in decreased expression of EGFR protein] CTD PMID:30237564 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:22689575 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674
JBrowse link
G Epor erythropoietin receptor multiple interactions ISO bafilomycin A1 inhibits the reaction [Aristolochic Acids results in increased degradation of and results in decreased expression of EPOR protein] CTD PMID:26136230 NCBI chr 9:21,958,897...21,963,576
Ensembl chr 9:21,958,897...21,963,506
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions EXP
ISO
bafilomycin A1 inhibits the reaction [FASL protein affects the localization of Calcium]
bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of FASLG protein]
CTD PMID:20200208 PMID:28378122 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of FMC1 protein] CTD PMID:29371327 NCBI chr 6:38,534,861...38,539,449
Ensembl chr 6:38,533,502...38,539,449
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]] CTD PMID:24889822 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of HIF1A protein
HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; HIF1A mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of HIF1A protein]
CTD PMID:25981168 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO [bafilomycin A1 co-treated with methanandamide] results in increased expression of HMOX1 protein; [bafilomycin A1 co-treated with tin protoporphyrin IX] promotes the reaction [Cannabidiol results in increased expression of HMOX1 protein]; bafilomycin A1 inhibits the reaction [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in increased expression of HMOX1 protein]
bafilomycin A1 results in decreased expression of HMOX1 protein
CTD PMID:29796178 PMID:33076330 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ifng interferon gamma decreases expression EXP bafilomycin A1 results in decreased expression of IFNG mRNA CTD PMID:16932910 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
EXP
ISO
bafilomycin A1 results in decreased expression of IL1B mRNA
[bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of IL1B protein; bafilomycin A1 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with aluminum sulfate] results in increased secretion of IL1B protein]
CTD PMID:16932910 PMID:24158569 PMID:32645460 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 increases expression EXP bafilomycin A1 results in increased expression of IL6 mRNA CTD PMID:16932910 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins2 insulin II multiple interactions ISO bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of EIF4EBP1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of RPS6KB1 protein]
bafilomycin A1 promotes the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]
CTD PMID:22689575 PMID:32283200 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 increases response to substance ISO LRRK2 gene mutant form results in increased susceptibility to bafilomycin A1 CTD PMID:25017139 NCBI chr15:91,672,791...91,816,124
Ensembl chr15:91,673,175...91,816,120
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions
increases expression
EXP
ISO
bafilomycin A1 promotes the reaction [Uranium results in increased expression of MAP1LC3A protein]
bafilomycin A1 results in increased expression of MAP1LC3A protein modified form
CTD PMID:30871063 PMID:31120128 NCBI chr 2:155,276,364...155,278,073
Ensembl chr 2:155,276,297...155,278,073
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation
increases expression
increases cleavage
decreases degradation
ISO
EXP
[di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone co-treated with bafilomycin A1] results in increased expression of MAP1LC3B mRNA; [TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form; Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]]; ATG5 protein affects the reaction [bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]]; bafilomycin A1 affects the reaction [Ammonium Chloride results in increased metabolism of MAP1LC3B protein]; bafilomycin A1 affects the reaction [AZD4547 affects the expression of MAP1LC3B protein modified form]; bafilomycin A1 affects the reaction [AZD8186 affects the expression of MAP1LC3B protein modified form]; bafilomycin A1 inhibits the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [capivasertib results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [metarrestin results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [Resveratrol results in increased expression of MAP1LC3B protein alternative form]; bafilomycin A1 promotes the reaction [vistusertib results in increased expression of MAP1LC3B protein modified form]; di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]; Resveratrol promotes the reaction [[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form]
bafilomycin A1 results in increased lipidation of MAP1LC3B protein
bafilomycin A1 results in increased expression of MAP1LC3B protein modified form
[Doxorubicin co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein; [Glycyrrhizic Acid co-treated with bafilomycin A1] results in increased lipidation of MAP1LC3B protein; bafilomycin A1 promotes the reaction [C1QTNF9 protein results in increased expression of MAP1LC3B protein modified form]
bafilomycin A1 promotes the reaction [Triiodothyronine results in increased lipidation of MAP1LC3B protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased lipidation of MAP1LC3B protein]
bafilomycin A1 results in increased cleavage of MAP1LC3B protein
bafilomycin A1 results in decreased degradation of MAP1LC3B protein modified form
bafilomycin A1 results in increased expression of MAP1LC3B protein; bafilomycin A1 results in increased expression of MAP1LC3B protein alternative form; bafilomycin A1 results in increased expression of MAP1LC3B protein modified form
CTD PMID:23880069 PMID:24145604 PMID:25301941 PMID:26459185 PMID:26853465 PMID:27305347 PMID:29248574 PMID:29524503 PMID:29908302 PMID:29938581 PMID:30209975 PMID:31310755 PMID:32278738 PMID:32525084 NCBI chr 8:121,590,438...121,598,760
Ensembl chr 8:121,590,361...121,598,760
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases expression
ISO bafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]; bafilomycin A1 inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]
bafilomycin A1 results in increased expression of MAPK1 protein modified form
CTD PMID:20371669 PMID:28483490 PMID:32645460 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases expression
ISO bafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK3 protein]; bafilomycin A1 inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]
bafilomycin A1 results in increased expression of MAPK3 protein modified form
CTD PMID:20371669 PMID:28483490 PMID:32645460 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP bafilomycin A1 results in increased phosphorylation of MAPK8 protein CTD PMID:31310755 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation EXP bafilomycin A1 results in decreased phosphorylation of MTOR protein CTD PMID:31310755 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 multiple interactions ISO NDRG1 protein results in decreased susceptibility to [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone co-treated with bafilomycin A1] CTD PMID:24532803 NCBI chr15:66,929,318...66,969,641
Ensembl chr15:66,929,318...66,969,640
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of NFE2L2 protein
bafilomycin A1 promotes the reaction [[Particulate Matter co-treated with Vitamin D] results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [[Silicon Dioxide co-treated with Vitamin D] results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [Particulate Matter results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [Silicon Dioxide results in increased expression of NFE2L2 protein]
CTD PMID:30698894 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of NLRP3 protein
bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein]
CTD PMID:32645460 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression ISO bafilomycin A1 results in decreased expression of NR5A1 protein CTD PMID:29524503 NCBI chr 2:38,692,656...38,714,542
Ensembl chr 2:38,692,656...38,714,542
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage
increases expression
ISO
EXP
bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; bafilomycin A1 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; BNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; HIF1A mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]
bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
bafilomycin A1 results in increased expression of PARP1 protein modified form
CTD PMID:20876807 PMID:21616090 PMID:24321340 PMID:25981168 PMID:28063998 PMID:29111403 PMID:31310755 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of PCNA mRNA] CTD PMID:33359579 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP bafilomycin A1 affects the localization of and results in increased activity of RELA protein CTD PMID:10339586 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 decreases phosphorylation
multiple interactions
EXP
ISO
bafilomycin A1 results in decreased phosphorylation of RPS6KB1 protein
bafilomycin A1 inhibits the reaction [EGF protein results in increased activity of and results in increased phosphorylation of RPS6KB1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:22689575 PMID:31310755 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions ISO bafilomycin A1 inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA] CTD PMID:23111315 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] CTD PMID:24889822 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 multiple interactions ISO bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]; bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Zinc]; bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]] CTD PMID:15860731 NCBI chr 7:45,163,921...45,176,139
Ensembl chr 7:45,163,949...45,176,142
JBrowse link
G Slc30a3 solute carrier family 30 (zinc transporter), member 3 multiple interactions ISO bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]] CTD PMID:15860731 NCBI chr 5:31,086,106...31,108,244
Ensembl chr 5:31,086,106...31,108,237
JBrowse link
G Snai1 snail family zinc finger 1 increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of SNAI1 protein
bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]
CTD PMID:32645460 NCBI chr 2:167,538,195...167,542,814
Ensembl chr 2:167,538,195...167,542,814
JBrowse link
G Snca synuclein, alpha multiple interactions
increases expression
EXP [bafilomycin A1 co-treated with Rotenone] results in increased expression of SNCA protein
bafilomycin A1 results in increased expression of SNCA protein
CTD PMID:26031332 NCBI chr 6:60,731,573...60,829,855
Ensembl chr 6:60,731,575...60,829,855
JBrowse link
G Sort1 sortilin 1 decreases expression EXP bafilomycin A1 results in decreased expression of SORT1 protein CTD PMID:25805502 NCBI chr 3:108,283,974...108,361,519
Ensembl chr 3:108,284,082...108,361,511
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO
EXP
bafilomycin A1 results in increased expression of SQSTM1 protein
bafilomycin A1 promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]
[Resveratrol co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Silicon Dioxide co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Silicon Dioxide co-treated with Vitamin D co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [TNF protein co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Vitamin D co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Sorafenib results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [metarrestin results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SQSTM1 protein]; Fingolimod Hydrochloride affects the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; sodium arsenite promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]
[bafilomycin A1 co-treated with Rotenone] results in increased expression of SQSTM1 protein; bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Streptozocin results in increased expression of SQSTM1 protein]]; bafilomycin A1 inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Streptozocin promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]
CTD PMID:21778691 PMID:21858812 PMID:23151917 PMID:24145604 PMID:24238063 PMID:24889822 PMID:25939952 PMID:25943029 PMID:26031332 PMID:27305347 PMID:28125038 PMID:29248574 PMID:29524503 PMID:30698894 PMID:32186374 PMID:32645460 PMID:33359579 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Tbk1 TANK-binding kinase 1 multiple interactions EXP bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein] CTD PMID:25780039 NCBI chr10:121,546,455...121,586,794
Ensembl chr10:121,546,455...121,586,787
JBrowse link
G Tlr8 toll-like receptor 8 multiple interactions ISO bafilomycin A1 inhibits the reaction [resiquimod results in increased activity of TLR8 protein] CTD PMID:21398612 NCBI chr  X:167,241,123...167,264,329
Ensembl chr  X:167,242,696...167,264,329
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP
ISO
bafilomycin A1 results in increased expression of TNF mRNA
[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form; [TNF protein co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; resveratrol promotes the reaction [[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form]
CTD PMID:16932910 PMID:24145604 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 multiple interactions
increases expression
EXP Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of TOMM20 protein] CTD PMID:30209975 NCBI chr 8:126,930,664...126,945,921
Ensembl chr 8:126,930,667...126,945,844
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [bafilomycin A1 co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; bafilomycin A1 inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein] CTD PMID:23380477 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Ulk1 unc-51 like kinase 1 multiple interactions ISO bafilomycin A1 affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]] CTD PMID:29128638 NCBI chr 5:110,784,489...110,810,120
Ensembl chr 5:110,784,488...110,810,097
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions
EXP bafilomycin A1 results in increased expression of VDAC1 protein
Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of VDAC1 protein]
CTD PMID:30209975 NCBI chr11:52,360,851...52,389,397
Ensembl chr11:52,360,860...52,389,397
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor multiple interactions ISO [bafilomycin A1 co-treated with Vitamin D] results in increased expression of VDR protein; [Silicon Dioxide co-treated with Vitamin D co-treated with bafilomycin A1] results in increased expression of VDR protein CTD PMID:30698894 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
G Vim vimentin multiple interactions
increases expression
ISO bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]
bafilomycin A1 results in increased expression of VIM protein
CTD PMID:32645460 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
bryostatin 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO bryostatin 1 results in increased expression of BIRC3 mRNA CTD PMID:14527959 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Cd22 CD22 antigen increases expression ISO bryostatin 1 results in increased expression of CD22 protein CTD PMID:10741703 NCBI chr 7:30,865,404...30,880,342
Ensembl chr 7:30,865,402...30,880,342
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein] CTD PMID:10516758 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G F3 coagulation factor III increases expression ISO bryostatin 1 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Il10 interleukin 10 decreases expression ISO bryostatin 1 analog results in decreased expression of IL10 mRNA; bryostatin 1 results in decreased expression of IL10 mRNA CTD PMID:15614042 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12b interleukin 12b decreases expression
increases expression
ISO bryostatin 1 analog results in decreased expression of IL12B mRNA
bryostatin 1 results in increased expression of IL12B mRNA
CTD PMID:15614042 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Itgax integrin alpha X increases expression ISO bryostatin 1 results in increased expression of ITGAX protein CTD PMID:10741703 NCBI chr 7:128,129,526...128,150,657
Ensembl chr 7:128,129,547...128,150,657
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein
bryostatin 1 results in decreased expression of PRKCA protein
CTD PMID:8892972 NCBI chr11:107,933,387...108,343,888
Ensembl chr11:107,933,387...108,343,928
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form
bryostatin 1 results in decreased expression of PRKCB protein; bryostatin 1 results in decreased expression of PRKCB protein alternative form
CTD PMID:8892972 NCBI chr 7:122,289,104...122,634,402
Ensembl chr 7:122,288,751...122,634,402
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein
bryostatin 1 results in decreased expression of PRKCG protein
CTD PMID:8892972 NCBI chr 7:3,303,532...3,331,099
Ensembl chr 7:3,289,179...3,331,099
JBrowse link
bryostatin 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III increases expression ISO bryostatin 2 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
concanamycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions EXP concanamycin A inhibits the reaction [enterotoxin C, staphylococcal results in increased expression of BAX protein] CTD PMID:27742270 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression
multiple interactions
ISO concanamycin A results in increased expression of BNIP3 mRNA
lapatinib inhibits the reaction [concanamycin A results in increased expression of BNIP3 mRNA]
CTD PMID:25981168 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G Casp3 caspase 3 multiple interactions EXP concanamycin A inhibits the reaction [enterotoxin C, staphylococcal analog results in increased activity of CASP3 protein]; concanamycin A inhibits the reaction [enterotoxin C, staphylococcal results in increased activity of CASP3 protein] CTD PMID:27742270 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions EXP concanamycin A inhibits the reaction [enterotoxin C, staphylococcal analog results in increased activity of CASP9 protein]; concanamycin A inhibits the reaction [enterotoxin C, staphylococcal results in increased activity of CASP9 protein] CTD PMID:27742270 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G F3 coagulation factor III increases expression ISO concanamycin A results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression
multiple interactions
ISO concanamycin A results in increased expression of HIF1A protein
lapatinib inhibits the reaction [concanamycin A results in increased expression of HIF1A protein]
CTD PMID:25981168 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO [lapatinib co-treated with concanamycin A] results in increased cleavage of PARP1 protein CTD PMID:25981168 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
latrunculin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta decreases response to substance ISO ACTB protein mutant form results in decreased susceptibility to latrunculin A CTD PMID:16685646 NCBI chr 5:142,903,115...142,907,976
Ensembl chr 5:142,903,115...142,906,754
JBrowse link
G Casp3 caspase 3 increases activity ISO latrunculin A results in increased activity of CASP3 protein CTD PMID:16723733 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cdh1 cadherin 1 decreases uptake ISO latrunculin A results in decreased uptake of CDH1 protein modified form CTD PMID:20547569 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Ctnna1 catenin (cadherin associated protein), alpha 1 multiple interactions ISO latrunculin A affects the reaction [FSCN1 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]]; latrunculin A affects the reaction [FSCN2 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 NCBI chr18:35,118,902...35,254,776
Ensembl chr18:35,118,859...35,254,779
JBrowse link
G Diaph1 diaphanous related formin 1 affects localization EXP latrunculin A affects the localization of DIAPH1 protein CTD PMID:22918941 NCBI chr18:37,843,601...37,935,622
Ensembl chr18:37,843,601...37,935,476
JBrowse link
G Fscn1 fascin actin-bundling protein 1 multiple interactions ISO latrunculin A affects the reaction [FSCN1 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 NCBI chr 5:142,960,355...142,973,189
Ensembl chr 5:142,960,343...142,973,185
JBrowse link
G Fscn2 fascin actin-bundling protein 2 multiple interactions ISO latrunculin A affects the reaction [FSCN2 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 NCBI chr11:120,360,165...120,368,173
Ensembl chr11:120,361,534...120,368,168
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO latrunculin A inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; latrunculin A inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases activity ISO latrunculin A results in decreased activity of ITGB1 protein CTD PMID:16723733 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Prlr prolactin receptor decreases uptake ISO latrunculin A results in decreased uptake of PRLR protein CTD PMID:20547569 NCBI chr15:10,177,238...10,349,190
Ensembl chr15:10,177,238...10,349,180
JBrowse link
latrunculin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin, alpha 2, smooth muscle, aorta decreases expression
multiple interactions
ISO latrunculin B results in decreased expression of ACTA2 mRNA
latrunculin B inhibits the reaction [RHOA protein results in increased expression of ACTA2 mRNA]
CTD PMID:11035001 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Aurkb aurora kinase B multiple interactions ISO latrunculin B inhibits the reaction [Silver results in increased phosphorylation of AURKB protein] CTD PMID:28499611 NCBI chr11:69,045,624...69,051,664
Ensembl chr11:69,045,647...69,051,664
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO latrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein] CTD PMID:11739382 NCBI chr14:63,198,914...63,271,712
Ensembl chr14:63,198,922...63,271,692
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO latrunculin B results in increased expression of GDF15 mRNA; latrunculin B results in increased expression of GDF15 protein
[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]
CTD PMID:23996089 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO latrunculin B promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO latrunculin B promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]; latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]
CTD PMID:11502570 PMID:12799187 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:11739382 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:11739382 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Myod1 myogenic differentiation 1 decreases expression EXP latrunculin B results in decreased expression of MYOD1 protein CTD PMID:15252113 NCBI chr 7:46,376,474...46,379,092
Ensembl chr 7:46,376,474...46,379,099
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO [latrunculin B results in decreased activity of SRF protein] which results in increased expression of NOS2 protein; latrunculin B promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]; latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]
CTD PMID:11502570 PMID:12799187 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A affects localization ISO latrunculin B affects the localization of PPP1R9A protein CTD PMID:12052877 NCBI chr 6:4,902,872...5,165,661
Ensembl chr 6:4,902,917...5,165,661
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO latrunculin B inhibits the reaction [RHOA protein results in increased expression of ACTA2 mRNA] CTD PMID:11035001 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
JBrowse link
G Srf serum response factor multiple interactions
decreases activity
ISO [latrunculin B results in decreased activity of SRF protein] which results in increased expression of NOS2 protein CTD PMID:11502570 NCBI chr17:46,546,838...46,558,267
Ensembl chr17:46,548,329...46,556,175
JBrowse link
G Tagln transgelin decreases expression ISO latrunculin B results in decreased expression of TAGLN mRNA CTD PMID:11035001 NCBI chr 9:45,929,628...45,936,058
Ensembl chr 9:45,929,619...45,936,058
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO latrunculin B promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
manoalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:7575673 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO manoalide inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:7575673 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
monensin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase, Cu++ transporting, alpha polypeptide multiple interactions ISO Monensin inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression ISO Monensin results in increased expression of BNIP3 protein CTD PMID:30718715 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Lithium inhibits the reaction [Monensin results in increased activity of CASP3 protein] CTD PMID:20799912 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Lithium inhibits the reaction [Monensin results in increased activity of CASP7 protein] CTD PMID:20799912 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Egf epidermal growth factor multiple interactions ISO [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Il6 interleukin 6 decreases secretion ISO Monensin results in decreased secretion of IL6 protein CTD PMID:11216681 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Monensin results in increased cleavage of PARP1 protein CTD PMID:30718715 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr 8:92,960,470...93,001,667
Ensembl chr 8:92,960,079...93,001,667
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr13:73,536,128...73,578,672
Ensembl chr13:73,536,747...73,578,672
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]] CTD PMID:29908239 NCBI chr11:76,998,597...77,032,343
Ensembl chr11:76,998,603...77,032,340
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 decreases expression
multiple interactions
increases expression
ISO Monensin results in decreased expression of TRPM2 protein alternative form
Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form]
CTD PMID:20799912 NCBI chr10:77,907,722...77,969,909
Ensembl chr10:77,907,722...77,970,563
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases response to substance ISO ZEB1 protein results in increased susceptibility to Monensin CTD PMID:30718715 NCBI chr18:5,591,327...5,775,468
Ensembl chr18:5,591,860...5,775,467
JBrowse link
oridonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO oridonin binds to and affects the folding of ALB protein CTD PMID:25816984 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; oridonin inhibits the reaction [Kainic Acid results in increased expression of BAX mRNA] CTD PMID:31430510 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
ISO oridonin analog results in decreased expression of BCL2 protein; oridonin results in decreased expression of BCL2 protein
oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 mRNA]; oridonin inhibits the reaction [Kainic Acid results in decreased expression of BCL2 mRNA]
CTD PMID:16019488 PMID:31430510 PMID:31594861 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO oridonin analog results in decreased expression of BIRC5 protein CTD PMID:31594861 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO oridonin results in increased cleavage of CASP3 protein
oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; oridonin inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]
CTD PMID:16019488 PMID:31430510 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of CAT protein]; oridonin inhibits the reaction [Kainic Acid results in decreased activity of CAT protein] CTD PMID:31430510 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO oridonin analog results in decreased expression of CCND1 protein CTD PMID:31594861 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]
oridonin results in increased expression of CDH1 mRNA; oridonin results in increased expression of CDH1 protein
CTD PMID:30243739 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions
ISO oridonin results in decreased expression of CDH2 mRNA; oridonin results in decreased expression of CDH2 protein
oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 protein]
CTD PMID:30243739 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Egf epidermal growth factor multiple interactions ISO oridonin analog inhibits the reaction [EGF protein promotes the reaction [EGFR protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGF protein promotes the reaction [SRC protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein] CTD PMID:31594861 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO oridonin analog inhibits the reaction [EGF protein promotes the reaction [EGFR protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGFR protein results in increased phosphorylation of STAT3 protein] CTD PMID:31594861 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) multiple interactions ISO oridonin inhibits the reaction [Kainic Acid results in decreased expression of GLUL mRNA] CTD PMID:31430510 NCBI chr 1:153,899,929...153,909,723
Ensembl chr 1:153,899,944...153,909,723
JBrowse link
G Gsr glutathione reductase multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of GSR protein]; oridonin inhibits the reaction [Kainic Acid results in decreased activity of GSR protein] CTD PMID:31430510 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO oridonin results in increased expression of and results in increased activity of HMOX1 protein
oridonin results in increased expression of HMOX1 mRNA; oridonin results in increased expression of HMOX1 protein
CTD PMID:18351433 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO
EXP
oridonin results in decreased expression of IFNG protein
oridonin analog inhibits the reaction [IFNG protein results in increased phosphorylation of STAT3 protein]
CTD PMID:18351433 PMID:31594861 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 increases expression ISO oridonin results in increased expression of IL10 protein CTD PMID:18351433 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of IL1B protein] CTD PMID:31430510 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 decreases expression ISO oridonin results in decreased expression of IL2 protein CTD PMID:18351433 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of IL6 protein]
oridonin analog inhibits the reaction [IL6 protein affects the localization of STAT3 protein]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [JAK1 protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT1 protein binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT3 protein binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein results in increased expression of STAT3 mRNA]; oridonin analog inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD PMID:31430510 PMID:31594861 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO oridonin analog inhibits the reaction [IL6 protein promotes the reaction [JAK1 protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [JAK1 protein results in increased phosphorylation of STAT3 protein] CTD PMID:31594861 NCBI chr 4:101,151,974...101,265,282
Ensembl chr 4:101,152,367...101,265,282
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression ISO oridonin analog results in decreased expression of MKI67 protein CTD PMID:31594861 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO oridonin analog results in decreased expression of MMP2 protein CTD PMID:31594861 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO oridonin analog results in decreased expression of MMP9 protein CTD PMID:31594861 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Myc myelocytomatosis oncogene decreases expression ISO oridonin analog results in decreased expression of MYC protein CTD PMID:31594861 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
ISO oridonin results in increased cleavage of PARP1 protein
oridonin analog results in decreased expression of and results in increased cleavage of PARP1 protein
CTD PMID:16019488 PMID:31594861 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of PTGS2 protein] CTD PMID:31430510 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rangap1 RAN GTPase activating protein 1 multiple interactions ISO oridonin results in decreased expression of and affects the localization of RANGAP1 protein CTD PMID:25746355 NCBI chr15:81,704,248...81,730,798
Ensembl chr15:81,704,248...81,745,530
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:30243739 NCBI chr18:76,241,090...76,311,748
Ensembl chr18:76,241,580...76,310,963
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:30243739 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Snai1 snail family zinc finger 1 decreases expression
multiple interactions
ISO oridonin results in decreased expression of SNAI1 mRNA; oridonin results in decreased expression of SNAI1 protein
oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 protein]
CTD PMID:30243739 NCBI chr 2:167,538,195...167,542,814
Ensembl chr 2:167,538,195...167,542,814
JBrowse link
G Snai2 snail family zinc finger 2 multiple interactions
decreases expression
ISO oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI2 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI2 protein]
oridonin results in decreased expression of SNAI2 mRNA; oridonin results in decreased expression of SNAI2 protein
CTD PMID:30243739 NCBI chr16:14,705,852...14,709,395
Ensembl chr16:14,705,852...14,709,385
JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO oridonin analog inhibits the reaction [EGF protein promotes the reaction [SRC protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [SRC protein results in increased phosphorylation of STAT3 protein] CTD PMID:31594861 NCBI chr 2:157,423,906...157,471,838
Ensembl chr 2:157,418,444...157,471,862
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT1 protein binds to STAT3 protein]] CTD PMID:31594861 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
EXP
ISO
oridonin analog inhibits the reaction [IFNG protein results in increased phosphorylation of STAT3 protein]
oridonin analog results in decreased phosphorylation of STAT3 protein
oridonin analog binds to and results in decreased stability of STAT3 protein; oridonin analog inhibits the reaction [EGF protein promotes the reaction [EGFR protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGF protein promotes the reaction [SRC protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [EGFR protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [IFNG protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [IL6 protein affects the localization of STAT3 protein]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [JAK1 protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT1 protein binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT3 protein binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein results in increased expression of STAT3 mRNA]; oridonin analog inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [JAK1 protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [SRC protein results in increased phosphorylation of STAT3 protein]
CTD PMID:31594861 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO oridonin results in increased expression of TGFB1 protein
oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 protein]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 protein]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI2 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI2 protein]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of VIM mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of VIM protein]; oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
CTD PMID:18351433 PMID:30243739 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA] CTD PMID:31430510 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of TNF protein] CTD PMID:31430510 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO oridonin results in decreased expression of VIM mRNA; oridonin results in decreased expression of VIM protein
oridonin inhibits the reaction [TGFB1 protein results in decreased expression of VIM mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of VIM protein]
CTD PMID:30243739 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
patulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of AKT1 protein] CTD PMID:29604266 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Patulin results in increased expression of ATF3 mRNA CTD PMID:21844328 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Bax BCL2-associated X protein increases expression EXP Patulin results in increased expression of BAX protein CTD PMID:19000704 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) increases expression ISO Patulin results in increased expression of BCL2L11 mRNA CTD PMID:21844328 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO Patulin results in increased expression of BID mRNA CTD PMID:21844328 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Casp3 caspase 3 increases activity ISO
EXP
Patulin results in increased activity of CASP3 protein CTD PMID:19000704 PMID:25577197 PMID:26095701 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase decreases activity
increases activity
decreases response to substance
multiple interactions
EXP
ISO
Patulin results in decreased activity of CAT protein
Patulin results in increased activity of CAT protein
CAT protein results in decreased susceptibility to Patulin
crocin inhibits the reaction [Patulin results in increased activity of CAT protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Patulin results in decreased activity of CAT protein]
CTD PMID:17090621 PMID:21964610 PMID:26095701 PMID:26584762 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression EXP Patulin results in increased expression of CDKN1A protein CTD PMID:19000704 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cldn1 claudin 1 affects localization ISO Patulin affects the localization of CLDN1 protein CTD PMID:19013514 NCBI chr16:26,356,645...26,371,839
Ensembl chr16:26,356,642...26,371,841
JBrowse link
G Cldn3 claudin 3 affects localization ISO Patulin affects the localization of CLDN3 protein CTD PMID:19013514 NCBI chr 5:134,986,214...134,987,476
Ensembl chr 5:134,986,214...134,987,472
JBrowse link
G Cldn4 claudin 4 affects localization ISO Patulin affects the localization of CLDN4 protein CTD PMID:19013514 NCBI chr 5:134,945,123...134,946,934
Ensembl chr 5:134,945,119...134,946,934
JBrowse link
G Clk1 CDC-like kinase 1 decreases expression ISO Patulin results in decreased expression of CLK1 mRNA CTD PMID:27913847 NCBI chr 1:58,411,988...58,424,088
Ensembl chr 1:58,410,189...58,424,066
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO Patulin inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein] CTD PMID:18308354 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Patulin results in increased expression of DDIT3 mRNA CTD PMID:21844328 PMID:25577197 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression EXP Patulin results in increased expression of FOS protein CTD PMID:21964610 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Gsr glutathione reductase decreases activity EXP Patulin results in decreased activity of GSR protein CTD PMID:21964610 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO Patulin results in increased expression of HSPA5 protein CTD PMID:25577197 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
decreases secretion
ISO [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IFNG protein
Patulin results in decreased expression of IFNG mRNA
Patulin results in decreased secretion of IFNG protein
CTD PMID:12112629 PMID:18214930 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL10 protein CTD PMID:18214930 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein CTD PMID:18214930 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Patulin inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein] CTD PMID:18308354 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 affects secretion
multiple interactions
increases expression
ISO Patulin affects the secretion of IL4 protein
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein
Patulin results in increased expression of IL4 mRNA
CTD PMID:12112629 PMID:18214930 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Jun jun proto-oncogene increases expression EXP Patulin results in increased expression of JUN protein CTD PMID:21964610 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
Patulin results in increased phosphorylation of MAPK1 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK1 protein]
CTD PMID:17090621 PMID:21964610 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
Patulin results in increased phosphorylation of MAPK3 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK3 protein]
CTD PMID:17090621 PMID:21964610 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions
ISO Patulin results in decreased phosphorylation of MTOR protein
Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of MTOR protein]
CTD PMID:29604266 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Ocln occludin increases degradation
multiple interactions
ISO Patulin results in increased degradation of OCLN protein
1,10-phenanthroline inhibits the reaction [Patulin results in increased degradation of OCLN protein]; Zinc Sulfate inhibits the reaction [Patulin results in increased degradation of OCLN protein]
CTD PMID:19013514 NCBI chr13:100,496,504...100,552,718
Ensembl chr13:100,496,507...100,552,718
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 increases activity EXP Patulin results in increased activity of ODC1 protein CTD PMID:19000704 NCBI chr12:17,544,808...17,551,502
Ensembl chr12:17,544,794...17,551,505
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Patulin results in increased expression of PMAIP1 mRNA CTD PMID:21844328 NCBI chr18:66,458,604...66,465,558
Ensembl chr18:66,458,533...66,465,565
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Patulin results in increased expression of PPP1R15A mRNA; Patulin results in increased expression of PPP1R15A protein CTD PMID:21844328 PMID:25577197 NCBI chr 7:45,522,917...45,526,268
Ensembl chr 7:45,522,916...45,526,268
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases response to substance ISO SOD1 protein results in decreased susceptibility to Patulin CTD PMID:17090621 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions
ISO Patulin results in decreased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [Patulin results in decreased expression of SQSTM1 protein]
CTD PMID:29604266 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO Patulin results in decreased expression of TJP1 protein CTD PMID:19013514 NCBI chr 7:65,296,165...65,527,850
Ensembl chr 7:65,296,165...65,527,781
JBrowse link
G Trp53 transformation related protein 53 increases expression EXP
ISO
Patulin results in increased expression of TRP53; Patulin results in increased expression of TRP53 protein
Patulin results in increased expression of TP53 protein
CTD PMID:19000704 PMID:19744505 PMID:26095701 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO Patulin results in increased splicing of XBP1 mRNA CTD PMID:21844328 PMID:25577197 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link
ryanodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Ryanodine inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:17079870 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase multiple interactions ISO [bastadin 12 co-treated with Ryanodine co-treated with Dizocilpine Maleate] inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein] CTD PMID:27718046 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] CTD PMID:21113126 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions EXP Ryanodine inhibits the reaction [FASL protein affects the localization of Calcium] CTD PMID:20200208 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fkbp1b FK506 binding protein 1b multiple interactions EXP Ryanodine inhibits the reaction [FKBP1B gene mutant form inhibits the reaction [Acetylcholine affects the localization of and affects the abundance of Calcium]] CTD PMID:17261647 NCBI chr12:4,833,176...4,841,573
Ensembl chr12:4,833,174...4,841,591
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 protein] CTD PMID:23183170 NCBI chr15:101,253,902...101,274,795
Ensembl chr15:101,254,269...101,274,795
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions EXP Ryanodine promotes the reaction [Mustard Gas results in increased activity of PLAU protein] CTD PMID:9101041 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Ryr1 ryanodine receptor 1, skeletal muscle multiple interactions ISO
EXP
Triclosan promotes the reaction [Ryanodine binds to RYR1 protein]
2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR1 protein]; chlorantranilipole promotes the reaction [Ryanodine binds to RYR1 protein]; flubendiamide promotes the reaction [Ryanodine binds to RYR1 protein]
CTD PMID:18795164 PMID:18954145 PMID:30329129 NCBI chr 7:29,003,340...29,125,179
Ensembl chr 7:29,003,344...29,125,179
JBrowse link
G Ryr2 ryanodine receptor 2, cardiac affects binding
multiple interactions
EXP
ISO
Ryanodine binds to RYR2 protein
2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR2 protein]
decamethrin promotes the reaction [Ryanodine binds to RYR2 protein]
CTD PMID:11278295 PMID:18954145 PMID:31166131 NCBI chr13:11,553,099...12,106,945
Ensembl chr13:11,553,102...12,106,945
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein] CTD PMID:23183170 NCBI chr 8:25,808,474...25,815,982
Ensembl chr 8:25,806,555...25,815,982
JBrowse link
thromboxane B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II increases chemical synthesis
multiple interactions
increases abundance
ISO F2 protein results in increased chemical synthesis of Thromboxane B2
Indomethacin inhibits the reaction [F2 protein results in increased abundance of Thromboxane B2]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [F2 protein results in increased abundance of Thromboxane B2]
CTD PMID:10027849 PMID:16293890 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Il1b interleukin 1 beta increases abundance
multiple interactions
ISO IL1B protein results in increased abundance of Thromboxane B2
Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased abundance of Thromboxane B2]
CTD PMID:15337628 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2] CTD PMID:23688403 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) multiple interactions
increases abundance
ISO varespladib inhibits the reaction [PLA2G2A protein results in increased abundance of Thromboxane B2] CTD PMID:10027849 NCBI chr 4:138,831,857...138,835,189
Ensembl chr 4:138,831,857...138,835,186
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO
EXP
[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2; arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2]
[N-caffeoyldopamine results in decreased activity of PTGS1 protein] which results in decreased abundance of Thromboxane B2
CTD PMID:17319684 PMID:20933508 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid inhibits the reaction [[Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2]; [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Thromboxane B2; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2; [Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2
[N-caffeoyldopamine results in decreased activity of PTGS2 protein] which results in decreased abundance of Thromboxane B2; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Thromboxane B2; PTGS2 gene mutant form inhibits the reaction [Nanotubes, Carbon inhibits the reaction [OVAL protein results in increased abundance of Thromboxane B2]]; PTGS2 gene mutant form inhibits the reaction [OVAL protein results in increased abundance of Thromboxane B2]
CTD PMID:8621535 PMID:17319684 PMID:18834901 PMID:19934399 PMID:23642096 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Tbxas1 thromboxane A synthase 1, platelet multiple interactions ISO [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2 CTD PMID:2572437 NCBI chr 6:38,864,159...39,084,590
Ensembl chr 6:38,875,404...39,084,585
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
increases secretion
ISO 1-carboxyheptylimidazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [TNF protein results in increased abundance of Thromboxane B2]; Ketoconazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; Terbinafine inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; wedelolactone inhibits the reaction [TNF protein results in increased abundance of Thromboxane B2] CTD PMID:16784723 PMID:27793764 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21727
    chemical entity 21725
      molecular entity 21712
        polyatomic entity 21602
          heteroatomic molecular entity 21534
            hydroxides 20148
              organic hydroxy compound 19171
                alcohol 15294
                  hemiacetal 179
                    1-(1-hydroxyalkyl)-sn-glycerol 0
                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-1-hydroxy-1-methoxypropan-2-yl 2,6-dichlorobenzoate 0
                    hemiketal + 147
                    lactol + 179
Path 2
Term Annotations click to browse term
  CHEBI ontology 21727
    subatomic particle 21713
      composite particle 21713
        hadron 21713
          baryon 21713
            nucleon 21713
              atomic nucleus 21713
                atom 21713
                  main group element atom 21630
                    p-block element atom 21630
                      p-block molecular entity 21629
                        chalcogen molecular entity 20755
                          oxygen molecular entity 20733
                            hydroxides 20148
                              organic hydroxy compound 19171
                                alcohol 15294
                                  hemiacetal 179
                                    1-(1-hydroxyalkyl)-sn-glycerol 0
                                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-1-hydroxy-1-methoxypropan-2-yl 2,6-dichlorobenzoate 0
                                    hemiketal + 147
                                    lactol + 179
paths to the root