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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hemiacetal
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Accession:CHEBI:5653 term browser browse the term
Definition:A compound having the general formula RR'C(OH)OR'' (R'' =/= H).
Synonyms:related_synonym: Formula=CH2O2R2;   hemiacetals


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(-)-noscapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP Noscapine promotes the reaction [Cisplatin results in increased expression of BAX protein]
Noscapine results in increased expression of BAX protein
CTD PMID:20674069 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP Noscapine results in decreased expression of BCL2 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD PMID:20674069 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases response to substance
increases expression
multiple interactions
decreases expression
EXP BIRC5 protein results in decreased susceptibility to Noscapine
Noscapine results in increased expression of BIRC5 mRNA; Noscapine results in increased expression of BIRC5 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BIRC5 protein]
Noscapine results in decreased expression of BIRC5 protein
CTD PMID:20674069 PMID:22848370 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP [Noscapine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP3 protein
Noscapine results in increased activity of CASP3 protein
CTD PMID:20674069 PMID:22848370 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP9 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP9 protein CTD PMID:20674069 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
EXP Noscapine promotes the reaction [Cisplatin results in increased expression of CDKN1A protein]
Noscapine results in increased expression of CDKN1A protein
CTD PMID:20674069 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP Noscapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Noscapine results in increased degradation of and results in decreased expression of and results in decreased activity of HIF1A protein CTD PMID:16596621 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Noscapine results in increased cleavage of PARP1 protein CTD PMID:22848370 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Noscapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
EXP Noscapine promotes the reaction [Cisplatin results in increased expression of TP53 protein]; Noscapine results in increased expression of and results in increased phosphorylation of TP53 protein
Noscapine results in increased expression of TP53 protein
CTD PMID:20674069 PMID:22848370 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G VEGFA vascular endothelial growth factor A decreases secretion EXP Noscapine results in decreased secretion of VEGFA protein CTD PMID:16596621 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
11-dehydro-thromboxane B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E multiple interactions EXP APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; tempol inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions EXP Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
alborixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP alborixin results in increased expression of BAX protein CTD PMID:27378626 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP alborixin results in decreased expression of BCL2 protein CTD PMID:27378626 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 increases cleavage EXP alborixin results in increased cleavage of CASP3 protein CTD PMID:27378626 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity EXP alborixin results in increased activity of CASP8 protein CTD PMID:27378626 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases activity EXP alborixin results in increased activity of CASP9 protein CTD PMID:27378626 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP alborixin results in increased cleavage of PARP1 protein CTD PMID:27378626 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
ascomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FKBP1A FKBP prolyl isomerase 1A multiple interactions ISO immunomycin inhibits the reaction [Sirolimus binds to FKBP1A protein] CTD PMID:7503980 PMID:7532117 NCBI chr20:1,368,977...1,393,172
Ensembl chr20:1,368,978...1,393,172
Ensembl chr20:1,368,978...1,393,172
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO
EXP
[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein CTD PMID:7723735 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
azadirachtin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP5 acid phosphatase 5, tartrate resistant multiple interactions
decreases expression
ISO azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of ACP5 mRNA]
azadirachtin results in decreased expression of ACP5 mRNA
CTD PMID:31225646 NCBI chr19:11,574,660...11,578,983
Ensembl chr19:11,574,660...11,579,008
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression EXP azadirachtin results in increased expression of APAF1 protein CTD PMID:20429769 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G BAD BCL2 associated agonist of cell death increases expression EXP azadirachtin results in increased expression of BAD mRNA CTD PMID:20429769 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP azadirachtin results in increased expression of BAX mRNA CTD PMID:20429769 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP azadirachtin results in decreased expression of BCL2 mRNA; azadirachtin results in decreased expression of BCL2 protein CTD PMID:20429769 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP azadirachtin results in decreased expression of BCL2L1 mRNA CTD PMID:20429769 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein multiple interactions ISO azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of BGLAP protein] CTD PMID:31225646 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BID BH3 interacting domain death agonist increases expression EXP azadirachtin results in increased expression of BID mRNA CTD PMID:20429769 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP azadirachtin results in decreased expression of BIRC5 protein CTD PMID:20429769 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BMP2 bone morphogenetic protein 2 increases expression ISO azadirachtin results in increased expression of BMP2 mRNA; azadirachtin results in increased expression of BMP2 protein CTD PMID:31225646 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G CASP3 caspase 3 increases expression EXP azadirachtin results in increased expression of CASP3 mRNA; azadirachtin results in increased expression of CASP3 protein CTD PMID:20429769 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP6 caspase 6 increases expression EXP azadirachtin results in increased expression of CASP6 protein CTD PMID:20429769 NCBI chr 4:109,688,628...109,703,445
Ensembl chr 4:109,688,622...109,703,583
JBrowse link
G CASP8 caspase 8 increases expression EXP azadirachtin results in increased expression of CASP8 protein CTD PMID:20429769 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases expression EXP azadirachtin results in increased expression of CASP9 mRNA; azadirachtin results in increased expression of CASP9 protein CTD PMID:20429769 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCND1 cyclin D1 decreases expression EXP azadirachtin results in decreased expression of CCND1 mRNA CTD PMID:20429769 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP azadirachtin results in increased expression of CDKN1A mRNA; azadirachtin results in increased expression of CDKN1A protein CTD PMID:20429769 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CYCS cytochrome c, somatic affects localization
increases expression
EXP azadirachtin affects the localization of CYCS protein
azadirachtin results in increased expression of CYCS mRNA
CTD PMID:20429769 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
affects binding
increases expression
ISO
EXP
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 protein]; azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR1 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
azadirachtin binds to ESR1 protein
azadirachtin results in increased expression of ESR1 mRNA; azadirachtin results in increased expression of ESR1 protein
CTD PMID:31225646 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 increases expression
multiple interactions
affects binding
ISO
EXP
azadirachtin results in increased expression of ESR2 mRNA; azadirachtin results in increased expression of ESR2 protein
azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR2 mRNA]
azadirachtin binds to ESR2 protein
CTD PMID:31225646 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta decreases expression EXP azadirachtin results in decreased expression of IKBKB protein CTD PMID:20429769 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO azadirachtin results in increased phosphorylation of MAPK1 protein CTD PMID:31225646 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO azadirachtin results in increased phosphorylation of MAPK3 protein CTD PMID:31225646 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases expression EXP azadirachtin results in decreased expression of NFKB1 protein CTD PMID:20429769 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha decreases expression EXP azadirachtin results in decreased expression of NFKBIA protein modified form CTD PMID:20429769 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP azadirachtin results in decreased expression of PCNA mRNA; azadirachtin results in decreased expression of PCNA protein CTD PMID:20429769 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases expression EXP azadirachtin results in decreased expression of RELA protein CTD PMID:20429769 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions
increases expression
ISO ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
azadirachtin results in increased expression of RUNX2 mRNA; azadirachtin results in increased expression of RUNX2 protein
CTD PMID:31225646 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SMAD1 SMAD family member 1 increases expression ISO azadirachtin results in increased expression of SMAD1 protein modified form CTD PMID:31225646 NCBI chr 4:145,481,306...145,559,176
Ensembl chr 4:145,481,194...145,559,176
JBrowse link
G TNF tumor necrosis factor decreases expression ISO azadirachtin results in decreased expression of TNF mRNA CTD PMID:31225646 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a decreases expression
multiple interactions
ISO azadirachtin results in decreased expression of TNFRSF11A mRNA
azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of TNFRSF11A mRNA]
CTD PMID:31225646 NCBI chr18:62,325,310...62,391,288
Ensembl chr18:62,325,287...62,391,288
JBrowse link
G TP53 tumor protein p53 increases expression EXP azadirachtin results in increased expression of TP53 mRNA; azadirachtin results in increased expression of TP53 protein CTD PMID:20429769 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
bafilomycin A1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions ISO bafilomycin A1 inhibits the reaction [AGT protein affects the localization of Calcium] CTD PMID:21613610 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AIM2 absent in melanoma 2 multiple interactions EXP [bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of AIM2 protein CTD PMID:32645460 NCBI chr 1:159,059,226...159,132,351
Ensembl chr 1:159,062,484...159,147,096
JBrowse link
G AKT1S1 AKT1 substrate 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein] CTD PMID:22689575 NCBI chr19:49,869,033...49,878,356
Ensembl chr19:49,869,033...49,878,459
JBrowse link
G ALB albumin decreases uptake EXP bafilomycin A1 results in decreased uptake of ALB protein CTD PMID:16313995 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression EXP bafilomycin A1 results in increased expression of APAF1 protein CTD PMID:28483490 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions ISO bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr 3:57,227,729...57,273,471
Ensembl chr 3:57,227,726...57,278,105
JBrowse link
G ASIC1 acid sensing ion channel subunit 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [Freund's Adjuvant results in increased expression of ASIC1 mRNA] CTD PMID:16769263 NCBI chr12:50,057,596...50,083,622
Ensembl chr12:50,057,548...50,083,611
JBrowse link
G ATG5 autophagy related 5 multiple interactions EXP ATG5 protein affects the reaction [bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]] CTD PMID:29938581 NCBI chr 6:106,184,476...106,325,789
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP bafilomycin A1 inhibits the reaction [Hydroxychloroquine results in increased activity of BAX protein] CTD PMID:12813466 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression ISO bafilomycin A1 results in decreased expression of BCL2 mRNA CTD PMID:31310755 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression
EXP
ISO
bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BECN1 protein]
[Swainsonine co-treated with bafilomycin A1] results in increased expression of BECN1 protein; bafilomycin A1 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BECN1 protein]
bafilomycin A1 results in increased expression of BECN1 protein
CTD PMID:32645460 PMID:33186601 PMID:33242459 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein multiple interactions EXP bafilomycin A1 inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA] CTD PMID:23111315 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BID BH3 interacting domain death agonist increases expression
multiple interactions
increases cleavage
ISO
EXP
bafilomycin A1 results in increased expression of BID protein modified form
vistusertib affects the reaction [bafilomycin A1 results in increased cleavage of BID protein]
bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein]
CTD PMID:26853465 PMID:28378122 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BNIP3 BCL2 interacting protein 3 increases expression
multiple interactions
EXP bafilomycin A1 results in increased expression of BNIP3 mRNA; bafilomycin A1 results in increased expression of BNIP3 protein
BNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; capivasertib affects the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; Gefitinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; Lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; vistusertib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]
CTD PMID:25981168 PMID:26853465 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,966,455...131,982,013
JBrowse link
G C1QTNF9B C1q and TNF related 9B multiple interactions ISO bafilomycin A1 promotes the reaction [C1QTNF9 protein results in increased expression of MAP1LC3B protein modified form] CTD PMID:32278738 NCBI chr13:23,891,099...23,897,502
Ensembl chr13:23,891,099...23,897,502
Ensembl chr13:23,891,099...23,897,502
JBrowse link
G CASP3 caspase 3 decreases activity
increases cleavage
multiple interactions
increases activity
EXP
ISO
bafilomycin A1 results in decreased activity of CASP3 protein
bafilomycin A1 results in increased cleavage of CASP3 protein
bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]
bafilomycin A1 results in increased activity of CASP3 protein
[Swainsonine co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein; bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]
[bafilomycin A1 co-treated with Cannabidiol] results in increased cleavage of CASP3 protein; [bafilomycin A1 co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; [bafilomycin A1 co-treated with methanandamide] results in increased cleavage of CASP3 protein; [Cannabidiol co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein; bafilomycin A1 inhibits the reaction [Soot analog results in increased expression of CASP3 protein]; bafilomycin A1 inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [[bafilomycin A1 co-treated with Cannabidiol] results in increased cleavage of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [[bafilomycin A1 co-treated with methanandamide] results in increased cleavage of CASP3 protein]; vistusertib affects the reaction [bafilomycin A1 results in increased cleavage of CASP3 protein]
CTD PMID:20876807 PMID:23380477 PMID:24321340 PMID:24889822 PMID:25266202 PMID:25981168 PMID:26853465 PMID:28063998 PMID:28378122 PMID:29111403 PMID:30240709 PMID:32708634 PMID:33076330 PMID:33186601 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP4 caspase 4 increases activity EXP bafilomycin A1 results in increased activity of CASP4 protein CTD PMID:20371669 NCBI chr11:104,942,866...104,968,596
Ensembl chr11:104,942,866...104,969,366
JBrowse link
G CASP7 caspase 7 increases activity
decreases activity
EXP bafilomycin A1 results in increased activity of CASP7 protein
bafilomycin A1 results in decreased activity of CASP7 protein
CTD PMID:20371669 PMID:25981168 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 multiple interactions ISO bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]
bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]
CTD PMID:28378122 PMID:29111403 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions ISO
EXP
bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]
bafilomycin A1 inhibits the reaction [Soot analog results in increased expression of CASP9 protein]
CTD PMID:28378122 PMID:30240709 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of CCND1 protein] CTD PMID:33359579 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDC25C cell division cycle 25C multiple interactions EXP bafilomycin A1 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein] CTD PMID:29074359 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CTSB cathepsin B multiple interactions EXP bafilomycin A1 inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; bafilomycin A1 inhibits the reaction [Hydroxychloroquine affects the localization of CTSB protein] CTD PMID:12813466 PMID:23380477 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions EXP bafilomycin A1 inhibits the reaction [CpG ODN 2216 results in increased expression of CXCL10 protein]; bafilomycin A1 inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; bafilomycin A1 inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein] CTD PMID:26682054 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G DDIT4 DNA damage inducible transcript 4 multiple interactions
increases expression
ISO [EGF protein co-treated with bafilomycin A1] results in increased expression of DDIT4 protein
bafilomycin A1 results in increased expression of DDIT4 protein
CTD PMID:22689575 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,924...72,276,036
Ensembl chr10:72,273,924...72,276,036
JBrowse link
G EGF epidermal growth factor multiple interactions ISO [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine; [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Aspartic Acid; [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Taurine; [EGF protein co-treated with bafilomycin A1] results in increased expression of DDIT4 protein; bafilomycin A1 inhibits the reaction [EGF protein results in increased activity of and results in increased phosphorylation of RPS6KB1 protein]; bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine] CTD PMID:22689575 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP bafilomycin A1 inhibits the reaction [Arsenic Trioxide results in decreased expression of EGFR protein] CTD PMID:30237564 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:22689575 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G EPOR erythropoietin receptor multiple interactions EXP bafilomycin A1 inhibits the reaction [Aristolochic Acids results in increased degradation of and results in decreased expression of EPOR protein] CTD PMID:26136230 NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342
JBrowse link
G FASLG Fas ligand multiple interactions ISO bafilomycin A1 inhibits the reaction [FASL protein affects the localization of Calcium]
bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of FASLG protein]
CTD PMID:20200208 PMID:28378122 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FMC1 formation of mitochondrial complex V assembly factor 1 homolog multiple interactions EXP bafilomycin A1 inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of FMC1 protein] CTD PMID:29371327 NCBI chr 7:139,340,472...139,346,328
Ensembl chr 7:139,339,457...139,346,328
JBrowse link
G FOXO1 forkhead box O1 multiple interactions ISO bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]] CTD PMID:24889822 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP bafilomycin A1 results in increased expression of HIF1A protein
HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; HIF1A mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of HIF1A protein]
CTD PMID:25981168 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 decreases expression
multiple interactions
EXP bafilomycin A1 results in decreased expression of HMOX1 protein
[bafilomycin A1 co-treated with methanandamide] results in increased expression of HMOX1 protein; [bafilomycin A1 co-treated with tin protoporphyrin IX] promotes the reaction [Cannabidiol results in increased expression of HMOX1 protein]; bafilomycin A1 inhibits the reaction [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in increased expression of HMOX1 protein]
CTD PMID:29796178 PMID:33076330 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IFNG interferon gamma decreases expression ISO bafilomycin A1 results in decreased expression of IFNG mRNA CTD PMID:16932910 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
bafilomycin A1 results in decreased expression of IL1B mRNA
[bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of IL1B protein; bafilomycin A1 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with aluminum sulfate] results in increased secretion of IL1B protein]
CTD PMID:16932910 PMID:24158569 PMID:32645460 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases expression ISO bafilomycin A1 results in increased expression of IL6 mRNA CTD PMID:16932910 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions ISO
EXP
bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of EIF4EBP1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of RPS6KB1 protein]
bafilomycin A1 promotes the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]
CTD PMID:22689575 PMID:32283200 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G LRRK2 leucine rich repeat kinase 2 increases response to substance EXP LRRK2 gene mutant form results in increased susceptibility to bafilomycin A1 CTD PMID:25017139 NCBI chr12:40,224,890...40,369,285
Ensembl chr12:40,196,744...40,369,285
JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha multiple interactions
increases expression
ISO
EXP
bafilomycin A1 promotes the reaction [Uranium results in increased expression of MAP1LC3A protein]
bafilomycin A1 results in increased expression of MAP1LC3A protein modified form
CTD PMID:30871063 PMID:31120128 NCBI chr20:34,546,823...34,560,345
Ensembl chr20:34,546,854...34,560,345
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
increases lipidation
increases expression
increases cleavage
decreases degradation
EXP
ISO
[di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone co-treated with bafilomycin A1] results in increased expression of MAP1LC3B mRNA; [TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form; Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]]; ATG5 protein affects the reaction [bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]]; bafilomycin A1 affects the reaction [Ammonium Chloride results in increased metabolism of MAP1LC3B protein]; bafilomycin A1 affects the reaction [AZD4547 affects the expression of MAP1LC3B protein modified form]; bafilomycin A1 affects the reaction [AZD8186 affects the expression of MAP1LC3B protein modified form]; bafilomycin A1 inhibits the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [capivasertib results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [metarrestin results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [Resveratrol results in increased expression of MAP1LC3B protein alternative form]; bafilomycin A1 promotes the reaction [vistusertib results in increased expression of MAP1LC3B protein modified form]; di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]; Resveratrol promotes the reaction [[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form]
bafilomycin A1 results in increased lipidation of MAP1LC3B protein
[Doxorubicin co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein; [Glycyrrhizic Acid co-treated with bafilomycin A1] results in increased lipidation of MAP1LC3B protein; bafilomycin A1 promotes the reaction [C1QTNF9 protein results in increased expression of MAP1LC3B protein modified form]
bafilomycin A1 results in increased expression of MAP1LC3B protein modified form
bafilomycin A1 promotes the reaction [Triiodothyronine results in increased lipidation of MAP1LC3B protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased lipidation of MAP1LC3B protein]
bafilomycin A1 results in increased cleavage of MAP1LC3B protein
bafilomycin A1 results in decreased degradation of MAP1LC3B protein modified form
bafilomycin A1 results in increased expression of MAP1LC3B protein; bafilomycin A1 results in increased expression of MAP1LC3B protein alternative form; bafilomycin A1 results in increased expression of MAP1LC3B protein modified form
CTD PMID:23880069 PMID:24145604 PMID:25301941 PMID:26459185 PMID:26853465 PMID:27305347 PMID:29248574 PMID:29524503 PMID:29908302 PMID:29938581 PMID:30209975 PMID:31310755 PMID:32278738 PMID:32525084 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases expression
EXP bafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]; bafilomycin A1 inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]
bafilomycin A1 results in increased expression of MAPK1 protein modified form
CTD PMID:20371669 PMID:28483490 PMID:32645460 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases expression
EXP bafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK3 protein]; bafilomycin A1 inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]
bafilomycin A1 results in increased expression of MAPK3 protein modified form
CTD PMID:20371669 PMID:28483490 PMID:32645460 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation ISO bafilomycin A1 results in increased phosphorylation of MAPK8 protein CTD PMID:31310755 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation ISO bafilomycin A1 results in decreased phosphorylation of MTOR protein CTD PMID:31310755 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G NDRG1 N-myc downstream regulated 1 multiple interactions EXP NDRG1 protein results in decreased susceptibility to [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone co-treated with bafilomycin A1] CTD PMID:24532803 NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022
Ensembl chr 8:133,237,175...133,302,022
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
multiple interactions
EXP bafilomycin A1 results in increased expression of NFE2L2 protein
bafilomycin A1 promotes the reaction [[Particulate Matter co-treated with Vitamin D] results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [[Silicon Dioxide co-treated with Vitamin D] results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [Particulate Matter results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [Silicon Dioxide results in increased expression of NFE2L2 protein]
CTD PMID:30698894 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions
increases expression
EXP bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein]
bafilomycin A1 results in increased expression of NLRP3 protein
CTD PMID:32645460 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NR5A1 nuclear receptor subfamily 5 group A member 1 decreases expression EXP bafilomycin A1 results in decreased expression of NR5A1 protein CTD PMID:29524503 NCBI chr 9:124,481,236...124,507,399
Ensembl chr 9:124,481,236...124,507,420
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases expression
EXP
ISO
bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; bafilomycin A1 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; BNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; HIF1A mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]
bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
bafilomycin A1 results in increased expression of PARP1 protein modified form
CTD PMID:20876807 PMID:21616090 PMID:24321340 PMID:25981168 PMID:28063998 PMID:29111403 PMID:31310755 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions EXP bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of PCNA mRNA] CTD PMID:33359579 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO bafilomycin A1 affects the localization of and results in increased activity of RELA protein CTD PMID:10339586 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
ISO bafilomycin A1 inhibits the reaction [EGF protein results in increased activity of and results in increased phosphorylation of RPS6KB1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of RPS6KB1 protein]
bafilomycin A1 results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:22689575 PMID:31310755 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions EXP bafilomycin A1 inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA] CTD PMID:23111315 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] CTD PMID:24889822 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC17A7 solute carrier family 17 member 7 multiple interactions ISO bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]; bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Zinc]; bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]] CTD PMID:15860731 NCBI chr19:49,429,401...49,441,527
Ensembl chr19:49,429,401...49,442,360
JBrowse link
G SLC30A3 solute carrier family 30 member 3 multiple interactions ISO bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]] CTD PMID:15860731 NCBI chr 2:27,253,684...27,275,863
Ensembl chr 2:27,253,684...27,275,817
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP bafilomycin A1 inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide] CTD PMID:26750564 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SNAI1 snail family transcriptional repressor 1 multiple interactions
increases expression
EXP bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]
bafilomycin A1 results in increased expression of SNAI1 protein
CTD PMID:32645460 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNCA synuclein alpha multiple interactions
increases expression
ISO [bafilomycin A1 co-treated with Rotenone] results in increased expression of SNCA protein
bafilomycin A1 results in increased expression of SNCA protein
CTD PMID:26031332 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SORT1 sortilin 1 decreases expression ISO bafilomycin A1 results in decreased expression of SORT1 protein CTD PMID:25805502 NCBI chr 1:109,309,575...109,397,940
Ensembl chr 1:109,309,568...109,397,918
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
increases expression
ISO
EXP
[bafilomycin A1 co-treated with Rotenone] results in increased expression of SQSTM1 protein; bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Streptozocin results in increased expression of SQSTM1 protein]]; bafilomycin A1 inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Streptozocin promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]
bafilomycin A1 promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]
[Resveratrol co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Silicon Dioxide co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Silicon Dioxide co-treated with Vitamin D co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [TNF protein co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Vitamin D co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Sorafenib results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [metarrestin results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SQSTM1 protein]; Fingolimod Hydrochloride affects the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; sodium arsenite promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]
CTD PMID:21778691 PMID:21858812 PMID:23151917 PMID:24145604 PMID:24238063 PMID:24889822 PMID:25939952 PMID:25943029 PMID:26031332 PMID:27305347 PMID:28125038 PMID:29248574 PMID:29524503 PMID:30698894 PMID:32186374 PMID:32645460 PMID:33359579 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G TBK1 TANK binding kinase 1 multiple interactions ISO bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein] CTD PMID:25780039 NCBI chr12:64,452,105...64,502,114
Ensembl chr12:64,452,092...64,502,114
Ensembl chr12:64,452,092...64,502,114
JBrowse link
G TLR8 toll like receptor 8 multiple interactions EXP bafilomycin A1 inhibits the reaction [resiquimod results in increased activity of TLR8 protein] CTD PMID:21398612 NCBI chr  X:12,906,620...12,923,169
Ensembl chr  X:12,906,620...12,923,169
JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
ISO
EXP
bafilomycin A1 results in increased expression of TNF mRNA
[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form; [TNF protein co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; Resveratrol promotes the reaction [[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form]
CTD PMID:16932910 PMID:24145604 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 increases expression
multiple interactions
ISO bafilomycin A1 results in increased expression of TOMM20 protein
Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of TOMM20 protein]
CTD PMID:30209975 NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP [bafilomycin A1 co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; bafilomycin A1 inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein] CTD PMID:23380477 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 multiple interactions ISO bafilomycin A1 affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]] CTD PMID:29128638 NCBI chr12:131,894,622...131,923,150
Ensembl chr12:131,894,622...131,923,150
JBrowse link
G VDAC1 voltage dependent anion channel 1 multiple interactions
increases expression
ISO Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of VDAC1 protein] CTD PMID:30209975 NCBI chr 5:133,971,871...134,070,987
Ensembl chr 5:133,971,871...134,004,975
JBrowse link
G VDR vitamin D receptor multiple interactions EXP [bafilomycin A1 co-treated with Vitamin D] results in increased expression of VDR protein; [Silicon Dioxide co-treated with Vitamin D co-treated with bafilomycin A1] results in increased expression of VDR protein CTD PMID:30698894 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
G VIM vimentin multiple interactions
increases expression
EXP bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]
bafilomycin A1 results in increased expression of VIM protein
CTD PMID:32645460 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
bryostatin 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIRC3 baculoviral IAP repeat containing 3 increases expression EXP bryostatin 1 results in increased expression of BIRC3 mRNA CTD PMID:14527959 NCBI chr11:102,317,373...102,339,403
Ensembl chr11:102,317,450...102,339,403
JBrowse link
G CD22 CD22 molecule increases expression EXP bryostatin 1 results in increased expression of CD22 protein CTD PMID:10741703 NCBI chr19:35,329,187...35,347,361
Ensembl chr19:35,319,261...35,347,361
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein] CTD PMID:10516758 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP bryostatin 1 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G IL10 interleukin 10 decreases expression EXP bryostatin 1 analog results in decreased expression of IL10 mRNA; bryostatin 1 results in decreased expression of IL10 mRNA CTD PMID:15614042 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12B interleukin 12B decreases expression
increases expression
EXP bryostatin 1 analog results in decreased expression of IL12B mRNA
bryostatin 1 results in increased expression of IL12B mRNA
CTD PMID:15614042 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G ITGAX integrin subunit alpha X increases expression EXP bryostatin 1 results in increased expression of ITGAX protein CTD PMID:10741703 NCBI chr16:31,355,167...31,382,999
Ensembl chr16:31,355,134...31,382,997
Ensembl chr16:31,355,134...31,382,997
JBrowse link
G PRKCA protein kinase C alpha multiple interactions
decreases expression
EXP [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein
bryostatin 1 results in decreased expression of PRKCA protein
CTD PMID:8892972 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCB protein kinase C beta multiple interactions
decreases expression
EXP [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form
bryostatin 1 results in decreased expression of PRKCB protein; bryostatin 1 results in decreased expression of PRKCB protein alternative form
CTD PMID:8892972 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G PRKCG protein kinase C gamma multiple interactions
decreases expression
EXP [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein
bryostatin 1 results in decreased expression of PRKCG protein
CTD PMID:8892972 NCBI chr19:53,882,197...53,907,652
Ensembl chr19:53,879,190...53,907,652
JBrowse link
bryostatin 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor increases expression EXP bryostatin 2 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
concanamycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO concanamycin A inhibits the reaction [enterotoxin C, staphylococcal results in increased expression of BAX protein] CTD PMID:27742270 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BNIP3 BCL2 interacting protein 3 increases expression
multiple interactions
EXP concanamycin A results in increased expression of BNIP3 mRNA
lapatinib inhibits the reaction [concanamycin A results in increased expression of BNIP3 mRNA]
CTD PMID:25981168 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,966,455...131,982,013
JBrowse link
G CASP3 caspase 3 multiple interactions ISO concanamycin A inhibits the reaction [enterotoxin C, staphylococcal analog results in increased activity of CASP3 protein]; concanamycin A inhibits the reaction [enterotoxin C, staphylococcal results in increased activity of CASP3 protein] CTD PMID:27742270 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions ISO concanamycin A inhibits the reaction [enterotoxin C, staphylococcal analog results in increased activity of CASP9 protein]; concanamycin A inhibits the reaction [enterotoxin C, staphylococcal results in increased activity of CASP9 protein] CTD PMID:27742270 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP concanamycin A results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP concanamycin A results in increased expression of HIF1A protein
lapatinib inhibits the reaction [concanamycin A results in increased expression of HIF1A protein]
CTD PMID:25981168 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP [lapatinib co-treated with concanamycin A] results in increased cleavage of PARP1 protein CTD PMID:25981168 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
latrunculin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta decreases response to substance EXP ACTB protein mutant form results in decreased susceptibility to latrunculin A CTD PMID:16685646 NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902
Ensembl chr 7:5,526,409...5,563,902
JBrowse link
G CASP3 caspase 3 increases activity EXP latrunculin A results in increased activity of CASP3 protein CTD PMID:16723733 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CDH1 cadherin 1 decreases uptake EXP latrunculin A results in decreased uptake of CDH1 protein modified form CTD PMID:20547569 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CTNNA1 catenin alpha 1 multiple interactions ISO latrunculin A affects the reaction [FSCN1 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]]; latrunculin A affects the reaction [FSCN2 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 NCBI chr 5:138,753,425...138,935,034
Ensembl chr 5:138,610,967...138,935,034
JBrowse link
G DIAPH1 diaphanous related formin 1 affects localization ISO latrunculin A affects the localization of DIAPH1 protein CTD PMID:22918941 NCBI chr 5:141,515,016...141,619,055
Ensembl chr 5:141,515,016...141,619,055
JBrowse link
G FSCN1 fascin actin-bundling protein 1 multiple interactions ISO latrunculin A affects the reaction [FSCN1 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 NCBI chr 7:5,592,816...5,606,655
Ensembl chr 7:5,592,816...5,606,655
JBrowse link
G FSCN2 fascin actin-bundling protein 2, retinal multiple interactions ISO latrunculin A affects the reaction [FSCN2 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 NCBI chr17:81,513,019...81,537,130
Ensembl chr17:81,528,377...81,537,130
Ensembl chr17:81,528,377...81,537,130
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP latrunculin A inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; latrunculin A inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G ITGB1 integrin subunit beta 1 decreases activity EXP latrunculin A results in decreased activity of ITGB1 protein CTD PMID:16723733 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,900,318...33,005,792
Ensembl chr10:32,900,318...33,005,792
JBrowse link
G PRLR prolactin receptor decreases uptake EXP latrunculin A results in decreased uptake of PRLR protein CTD PMID:20547569 NCBI chr 5:35,048,756...35,230,724
Ensembl chr 5:35,048,756...35,230,487
JBrowse link
latrunculin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO latrunculin B inhibits the reaction [RHOA protein results in increased expression of ACTA2 mRNA]
latrunculin B results in decreased expression of ACTA2 mRNA
CTD PMID:11035001 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G AURKB aurora kinase B multiple interactions EXP latrunculin B inhibits the reaction [Silver results in increased phosphorylation of AURKB protein] CTD PMID:28499611 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G GATA4 GATA binding protein 4 multiple interactions ISO latrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein] CTD PMID:11739382 NCBI chr 8:11,676,931...11,760,002
Ensembl chr 8:11,676,959...11,760,002
JBrowse link
G GDF15 growth differentiation factor 15 increases expression
multiple interactions
EXP latrunculin B results in increased expression of GDF15 mRNA; latrunculin B results in increased expression of GDF15 protein
[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]
CTD PMID:23996089 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G IFNG interferon gamma multiple interactions EXP latrunculin B promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
latrunculin B promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]; latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]
CTD PMID:11502570 PMID:12799187 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:11739382 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:11739382 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MYOD1 myogenic differentiation 1 decreases expression ISO latrunculin B results in decreased expression of MYOD1 protein CTD PMID:15252113 NCBI chr11:17,719,571...17,722,136
Ensembl chr11:17,719,571...17,722,136
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP
ISO
[latrunculin B results in decreased activity of SRF protein] which results in increased expression of NOS2 protein; latrunculin B promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]; latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]
CTD PMID:11502570 PMID:12799187 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PPP1R9A protein phosphatase 1 regulatory subunit 9A affects localization ISO latrunculin B affects the localization of PPP1R9A protein CTD PMID:12052877 NCBI chr 7:94,907,202...95,296,415
Ensembl chr 7:94,907,202...95,296,415
JBrowse link
G RHOA ras homolog family member A multiple interactions ISO latrunculin B inhibits the reaction [RHOA protein results in increased expression of ACTA2 mRNA] CTD PMID:11035001 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G SRF serum response factor multiple interactions
decreases activity
EXP [latrunculin B results in decreased activity of SRF protein] which results in increased expression of NOS2 protein CTD PMID:11502570 NCBI chr 6:43,171,269...43,181,506
Ensembl chr 6:43,171,269...43,181,506
JBrowse link
G TAGLN transgelin decreases expression ISO latrunculin B results in decreased expression of TAGLN mRNA CTD PMID:11035001 NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP latrunculin B promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
manoalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1B interleukin 1 beta multiple interactions EXP manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:7575673 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP manoalide inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:7575673 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
monensin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha multiple interactions EXP Monensin inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G BNIP3 BCL2 interacting protein 3 increases expression EXP Monensin results in increased expression of BNIP3 protein CTD PMID:30718715 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,966,455...131,982,013
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP Lithium inhibits the reaction [Monensin results in increased activity of CASP3 protein] CTD PMID:20799912 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 multiple interactions
increases activity
EXP Lithium inhibits the reaction [Monensin results in increased activity of CASP7 protein] CTD PMID:20799912 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions EXP Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G EGF epidermal growth factor multiple interactions ISO [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G IL6 interleukin 6 decreases secretion EXP Monensin results in decreased secretion of IL6 protein CTD PMID:11216681 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Monensin results in increased cleavage of PARP1 protein CTD PMID:30718715 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G SLC6A2 solute carrier family 6 member 2 multiple interactions EXP Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr16:55,655,928...55,706,192
Ensembl chr16:55,655,604...55,706,192
JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions EXP Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link
G SLC6A4 solute carrier family 6 member 4 multiple interactions EXP Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]] CTD PMID:29908239 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP Monensin inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide] CTD PMID:26750564 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G TRPM2 transient receptor potential cation channel subfamily M member 2 decreases expression
increases expression
multiple interactions
EXP Monensin results in decreased expression of TRPM2 protein alternative form
Monensin results in increased expression of TRPM2 protein alternative form
Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form]
CTD PMID:20799912 NCBI chr21:44,350,112...44,442,807
Ensembl chr21:44,350,163...44,443,081
JBrowse link
G ZEB1 zinc finger E-box binding homeobox 1 increases response to substance EXP ZEB1 protein results in increased susceptibility to Monensin CTD PMID:30718715 NCBI chr10:31,318,417...31,529,804
Ensembl chr10:31,318,495...31,529,814
JBrowse link
oridonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin multiple interactions EXP oridonin binds to and affects the folding of ALB protein CTD PMID:25816984 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; oridonin inhibits the reaction [Kainic Acid results in increased expression of BAX mRNA] CTD PMID:31430510 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP
ISO
oridonin analog results in decreased expression of BCL2 protein; oridonin results in decreased expression of BCL2 protein
oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 mRNA]; oridonin inhibits the reaction [Kainic Acid results in decreased expression of BCL2 mRNA]
CTD PMID:16019488 PMID:31430510 PMID:31594861 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP oridonin analog results in decreased expression of BIRC5 protein CTD PMID:31594861 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CASP3 caspase 3 increases cleavage
multiple interactions
EXP
ISO
oridonin results in increased cleavage of CASP3 protein
oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; oridonin inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]
CTD PMID:16019488 PMID:31430510 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of CAT protein]; oridonin inhibits the reaction [Kainic Acid results in decreased activity of CAT protein] CTD PMID:31430510 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCND1 cyclin D1 decreases expression EXP oridonin analog results in decreased expression of CCND1 protein CTD PMID:31594861 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDH1 cadherin 1 increases expression
multiple interactions
EXP oridonin results in increased expression of CDH1 mRNA; oridonin results in increased expression of CDH1 protein
oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]
CTD PMID:30243739 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH2 cadherin 2 decreases expression
multiple interactions
EXP oridonin results in decreased expression of CDH2 mRNA; oridonin results in decreased expression of CDH2 protein
oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 protein]
CTD PMID:30243739 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G EGF epidermal growth factor multiple interactions EXP oridonin analog inhibits the reaction [EGF protein promotes the reaction [EGFR protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGF protein promotes the reaction [SRC protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein] CTD PMID:31594861 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP oridonin analog inhibits the reaction [EGF protein promotes the reaction [EGFR protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGFR protein results in increased phosphorylation of STAT3 protein] CTD PMID:31594861 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G GLUL glutamate-ammonia ligase multiple interactions ISO oridonin inhibits the reaction [Kainic Acid results in decreased expression of GLUL mRNA] CTD PMID:31430510 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,381,704...182,392,206
Ensembl chr 1:182,381,704...182,392,206
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of GSR protein]; oridonin inhibits the reaction [Kainic Acid results in decreased activity of GSR protein] CTD PMID:31430510 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
ISO oridonin results in increased expression of HMOX1 mRNA; oridonin results in increased expression of HMOX1 protein
oridonin results in increased expression of and results in increased activity of HMOX1 protein
CTD PMID:18351433 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IFNG interferon gamma decreases expression
multiple interactions
ISO
EXP
oridonin results in decreased expression of IFNG protein
oridonin analog inhibits the reaction [IFNG protein results in increased phosphorylation of STAT3 protein]
CTD PMID:18351433 PMID:31594861 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 increases expression ISO oridonin results in increased expression of IL10 protein CTD PMID:18351433 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of IL1B protein] CTD PMID:31430510 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 decreases expression ISO oridonin results in decreased expression of IL2 protein CTD PMID:18351433 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL6 interleukin 6 multiple interactions ISO
EXP
oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of IL6 protein]
oridonin analog inhibits the reaction [IL6 protein affects the localization of STAT3 protein]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [JAK1 protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT1 protein binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT3 protein binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein results in increased expression of STAT3 mRNA]; oridonin analog inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD PMID:31430510 PMID:31594861 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JAK1 Janus kinase 1 multiple interactions EXP oridonin analog inhibits the reaction [IL6 protein promotes the reaction [JAK1 protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [JAK1 protein results in increased phosphorylation of STAT3 protein] CTD PMID:31594861 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,229...65,067,754
JBrowse link
G MKI67 marker of proliferation Ki-67 decreases expression EXP oridonin analog results in decreased expression of MKI67 protein CTD PMID:31594861 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression EXP oridonin analog results in decreased expression of MMP2 protein CTD PMID:31594861 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression EXP oridonin analog results in decreased expression of MMP9 protein CTD PMID:31594861 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP oridonin analog results in decreased expression of MYC protein CTD PMID:31594861 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
EXP oridonin results in increased cleavage of PARP1 protein
oridonin analog results in decreased expression of and results in increased cleavage of PARP1 protein
CTD PMID:16019488 PMID:31594861 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of PTGS2 protein] CTD PMID:31430510 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RANGAP1 Ran GTPase activating protein 1 multiple interactions EXP oridonin results in decreased expression of and affects the localization of RANGAP1 protein CTD PMID:25746355 NCBI chr22:41,244,779...41,302,369
Ensembl chr22:41,244,779...41,286,187
Ensembl chr22:41,244,779...41,286,187
JBrowse link
G SMAD2 SMAD family member 2 multiple interactions EXP oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:30243739 NCBI chr18:47,808,957...47,931,188
Ensembl chr18:47,808,957...47,931,146
JBrowse link
G SMAD3 SMAD family member 3 multiple interactions EXP oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:30243739 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169
Ensembl chr15:67,063,763...67,195,169
JBrowse link
G SNAI1 snail family transcriptional repressor 1 decreases expression
multiple interactions
EXP oridonin results in decreased expression of SNAI1 mRNA; oridonin results in decreased expression of SNAI1 protein
oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 protein]
CTD PMID:30243739 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNAI2 snail family transcriptional repressor 2 decreases expression
multiple interactions
EXP oridonin results in decreased expression of SNAI2 mRNA; oridonin results in decreased expression of SNAI2 protein
oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI2 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI2 protein]
CTD PMID:30243739 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP oridonin analog inhibits the reaction [EGF protein promotes the reaction [SRC protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [SRC protein results in increased phosphorylation of STAT3 protein] CTD PMID:31594861 NCBI chr20:37,344,690...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT1 protein binds to STAT3 protein]] CTD PMID:31594861 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions
EXP
ISO
oridonin analog results in decreased phosphorylation of STAT3 protein
oridonin analog binds to and results in decreased stability of STAT3 protein; oridonin analog inhibits the reaction [EGF protein promotes the reaction [EGFR protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGF protein promotes the reaction [SRC protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [EGFR protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [IFNG protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [IL6 protein affects the localization of STAT3 protein]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [JAK1 protein modified form binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT1 protein binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein promotes the reaction [STAT3 protein binds to STAT3 protein]]; oridonin analog inhibits the reaction [IL6 protein results in increased expression of STAT3 mRNA]; oridonin analog inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [JAK1 protein results in increased phosphorylation of STAT3 protein]; oridonin analog inhibits the reaction [SRC protein results in increased phosphorylation of STAT3 protein]
CTD PMID:31594861 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
multiple interactions
ISO
EXP
oridonin results in increased expression of TGFB1 protein
oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 protein]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 protein]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI2 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI2 protein]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of VIM mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of VIM protein]; oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 mRNA]; oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
CTD PMID:18351433 PMID:30243739 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA] CTD PMID:31430510 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of TNF protein] CTD PMID:31430510 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VIM vimentin multiple interactions
decreases expression
EXP oridonin inhibits the reaction [TGFB1 protein results in decreased expression of VIM mRNA]; oridonin inhibits the reaction [TGFB1 protein results in decreased expression of VIM protein]
oridonin results in decreased expression of VIM mRNA; oridonin results in decreased expression of VIM protein
CTD PMID:30243739 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
patulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
EXP Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of AKT1 protein] CTD PMID:29604266 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Patulin results in increased expression of ATF3 mRNA CTD PMID:21844328 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression ISO Patulin results in increased expression of BAX protein CTD PMID:19000704 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2L11 BCL2 like 11 increases expression EXP Patulin results in increased expression of BCL2L11 mRNA CTD PMID:21844328 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G BID BH3 interacting domain death agonist increases expression EXP Patulin results in increased expression of BID mRNA CTD PMID:21844328 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G CASP3 caspase 3 increases activity EXP
ISO
Patulin results in increased activity of CASP3 protein CTD PMID:19000704 PMID:25577197 PMID:26095701 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase decreases activity
increases activity
decreases response to substance
multiple interactions
ISO
EXP
Patulin results in decreased activity of CAT protein
Patulin results in increased activity of CAT protein
CAT protein results in decreased susceptibility to Patulin
crocin inhibits the reaction [Patulin results in increased activity of CAT protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Patulin results in decreased activity of CAT protein]
CTD PMID:17090621 PMID:21964610 PMID:26095701 PMID:26584762 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression ISO Patulin results in increased expression of CDKN1A protein CTD PMID:19000704 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CLDN1 claudin 1 affects localization EXP Patulin affects the localization of CLDN1 protein CTD PMID:19013514 NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446
JBrowse link
G CLDN3 claudin 3 affects localization EXP Patulin affects the localization of CLDN3 protein CTD PMID:19013514 NCBI chr 7:73,768,997...73,770,270
Ensembl chr 7:73,768,997...73,770,270
JBrowse link
G CLDN4 claudin 4 affects localization EXP Patulin affects the localization of CLDN4 protein CTD PMID:19013514 NCBI chr 7:73,830,996...73,832,690
Ensembl chr 7:73,799,542...73,832,693
Ensembl chr 7:73,799,542...73,832,693
JBrowse link
G CLK1 CDC like kinase 1 decreases expression EXP Patulin results in decreased expression of CLK1 mRNA CTD PMID:27913847 NCBI chr 2:200,853,009...200,864,658
Ensembl chr 2:200,853,009...200,864,744
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Patulin inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein] CTD PMID:18308354 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Patulin results in increased expression of DDIT3 mRNA CTD PMID:21844328 PMID:25577197 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Patulin results in increased expression of FOS protein CTD PMID:21964610 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GSR glutathione-disulfide reductase decreases activity ISO Patulin results in decreased activity of GSR protein CTD PMID:21964610 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Patulin results in increased expression of HSPA5 protein CTD PMID:25577197 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G IFNG interferon gamma multiple interactions
decreases expression
decreases secretion
EXP [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IFNG protein
Patulin results in decreased expression of IFNG mRNA
Patulin results in decreased secretion of IFNG protein
CTD PMID:12112629 PMID:18214930 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 multiple interactions EXP [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL10 protein CTD PMID:18214930 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL13 interleukin 13 multiple interactions EXP [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein CTD PMID:18214930 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP Patulin inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein] CTD PMID:18308354 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL4 interleukin 4 affects secretion
multiple interactions
increases expression
EXP Patulin affects the secretion of IL4 protein
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein
Patulin results in increased expression of IL4 mRNA
CTD PMID:12112629 PMID:18214930 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Patulin results in increased expression of JUN protein CTD PMID:21964610 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP
ISO
Patulin results in increased phosphorylation of MAPK1 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK1 protein]
CTD PMID:17090621 PMID:21964610 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
EXP
ISO
Patulin results in increased phosphorylation of MAPK3 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK3 protein]
CTD PMID:17090621 PMID:21964610 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
EXP Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of MTOR protein] CTD PMID:29604266 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G OCLN occludin increases degradation
multiple interactions
EXP Patulin results in increased degradation of OCLN protein
1,10-phenanthroline inhibits the reaction [Patulin results in increased degradation of OCLN protein]; Zinc Sulfate inhibits the reaction [Patulin results in increased degradation of OCLN protein]
CTD PMID:19013514 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104
JBrowse link
G ODC1 ornithine decarboxylase 1 increases activity ISO Patulin results in increased activity of ODC1 protein CTD PMID:19000704 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression EXP Patulin results in increased expression of PMAIP1 mRNA CTD PMID:21844328 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,948...59,904,306
Ensembl chr18:59,899,948...59,904,306
JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A increases expression EXP Patulin results in increased expression of PPP1R15A mRNA; Patulin results in increased expression of PPP1R15A protein CTD PMID:21844328 PMID:25577197 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,421...48,876,058
JBrowse link
G SOD1 superoxide dismutase 1 decreases response to substance EXP SOD1 protein results in decreased susceptibility to Patulin CTD PMID:17090621 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SQSTM1 sequestosome 1 decreases expression
multiple interactions
EXP Patulin results in decreased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [Patulin results in decreased expression of SQSTM1 protein]
CTD PMID:29604266 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP Patulin results in decreased expression of TJP1 protein CTD PMID:19013514 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,865
Ensembl chr15:29,699,367...29,968,865
JBrowse link
G TP53 tumor protein p53 increases expression ISO
EXP
Patulin results in increased expression of TRP53; Patulin results in increased expression of TRP53 protein
Patulin results in increased expression of TP53 protein
CTD PMID:19000704 PMID:19744505 PMID:26095701 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G XBP1 X-box binding protein 1 increases splicing EXP Patulin results in increased splicing of XBP1 mRNA CTD PMID:21844328 PMID:25577197 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
ryanodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions ISO [Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Ryanodine inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:17079870 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase multiple interactions ISO [bastadin 12 co-treated with Ryanodine co-treated with Dizocilpine Maleate] inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein] CTD PMID:27718046 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] CTD PMID:21113126 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G FASLG Fas ligand multiple interactions ISO Ryanodine inhibits the reaction [FASL protein affects the localization of Calcium] CTD PMID:20200208 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B multiple interactions ISO Ryanodine inhibits the reaction [FKBP1B gene mutant form inhibits the reaction [Acetylcholine affects the localization of and affects the abundance of Calcium]] CTD PMID:17261647 NCBI chr 2:24,033,205...24,067,743
Ensembl chr 2:24,049,701...24,063,681
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 multiple interactions ISO NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 protein] CTD PMID:23183170 NCBI chr12:52,022,832...52,059,507
Ensembl chr12:52,022,832...52,059,507
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions ISO Ryanodine promotes the reaction [Mustard Gas results in increased activity of PLAU protein] CTD PMID:9101041 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G RYR1 ryanodine receptor 1 multiple interactions EXP
ISO
Triclosan promotes the reaction [Ryanodine binds to RYR1 protein]
2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR1 protein]; chlorantranilipole promotes the reaction [Ryanodine binds to RYR1 protein]; flubendiamide promotes the reaction [Ryanodine binds to RYR1 protein]
CTD PMID:18795164 PMID:18954145 PMID:30329129 NCBI chr19:38,433,691...38,587,564
Ensembl chr19:38,433,691...38,587,564
Ensembl chr19:38,433,691...38,587,564
JBrowse link
G RYR2 ryanodine receptor 2 affects binding
multiple interactions
ISO Ryanodine binds to RYR2 protein
decamethrin promotes the reaction [Ryanodine binds to RYR2 protein]
2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR2 protein]
CTD PMID:11278295 PMID:18954145 PMID:31166131 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein] CTD PMID:23183170 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
thromboxane B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin increases chemical synthesis
increases abundance
multiple interactions
EXP F2 protein results in increased chemical synthesis of Thromboxane B2
F2 protein results in increased abundance of Thromboxane B2
Indomethacin inhibits the reaction [F2 protein results in increased abundance of Thromboxane B2]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [F2 protein results in increased abundance of Thromboxane B2]
CTD PMID:10027849 PMID:16293890 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G IL1B interleukin 1 beta increases abundance
multiple interactions
EXP IL1B protein results in increased abundance of Thromboxane B2
Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased abundance of Thromboxane B2]
CTD PMID:15337628 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL4 interleukin 4 multiple interactions EXP [Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2] CTD PMID:23688403 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G PLA2G2A phospholipase A2 group IIA multiple interactions
increases abundance
EXP varespladib inhibits the reaction [PLA2G2A protein results in increased abundance of Thromboxane B2] CTD PMID:10027849 NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP
ISO
[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2; arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2]
[N-caffeoyldopamine results in decreased activity of PTGS1 protein] which results in decreased abundance of Thromboxane B2
CTD PMID:17319684 PMID:20933508 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid inhibits the reaction [[Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2]; [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Thromboxane B2; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2; [Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2
[N-caffeoyldopamine results in decreased activity of PTGS2 protein] which results in decreased abundance of Thromboxane B2; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Thromboxane B2; PTGS2 gene mutant form inhibits the reaction [Nanotubes, Carbon inhibits the reaction [OVAL protein results in increased abundance of Thromboxane B2]]; PTGS2 gene mutant form inhibits the reaction [OVAL protein results in increased abundance of Thromboxane B2]
CTD PMID:8621535 PMID:17319684 PMID:18834901 PMID:19934399 PMID:23642096 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G TBXAS1 thromboxane A synthase 1 multiple interactions EXP [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2 CTD PMID:2572437 NCBI chr 7:139,778,242...140,020,293
Ensembl chr 7:139,777,051...140,020,325
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases abundance
increases secretion
EXP 1-carboxyheptylimidazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [TNF protein results in increased abundance of Thromboxane B2]; Ketoconazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; Terbinafine inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; wedelolactone inhibits the reaction [TNF protein results in increased abundance of Thromboxane B2] CTD PMID:16784723 PMID:27793764 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24487
    chemical entity 24455
      molecular entity 24418
        polyatomic entity 24346
          heteroatomic molecular entity 23950
            hydroxides 22473
              organic hydroxy compound 20747
                alcohol 15785
                  hemiacetal 180
                    1-(1-hydroxyalkyl)-sn-glycerol 0
                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-1-hydroxy-1-methoxypropan-2-yl 2,6-dichlorobenzoate 0
                    hemiketal + 148
                    lactol + 180
Path 2
Term Annotations click to browse term
  CHEBI ontology 24487
    subatomic particle 24444
      composite particle 24444
        hadron 24444
          baryon 24444
            nucleon 24444
              atomic nucleus 24444
                atom 24444
                  main group element atom 24301
                    p-block element atom 24301
                      p-block molecular entity 24294
                        chalcogen molecular entity 23366
                          oxygen molecular entity 23244
                            hydroxides 22473
                              organic hydroxy compound 20747
                                alcohol 15785
                                  hemiacetal 180
                                    1-(1-hydroxyalkyl)-sn-glycerol 0
                                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-1-hydroxy-1-methoxypropan-2-yl 2,6-dichlorobenzoate 0
                                    hemiketal + 148
                                    lactol + 180
paths to the root