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ONTOLOGY REPORT - ANNOTATIONS


Term:harman
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Accession:CHEBI:5623 term browser browse the term
Definition:An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.
Synonyms:exact_synonym: 1-methyl-9H-pyrido[3,4-b]indole
 related_synonym: 1-Methylnorharman;   1-methyl-2-carboline;   1-methyl-9H-beta-carboline;   1-methyl-beta-carboline;   Aribin;   Aribine;   Formula=C12H10N2;   InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3;   InChIKey=PSFDQSOCUJVVGF-UHFFFAOYSA-N;   L-methylpyridobindole;   Locuturin;   Locuturine;   Loturine;   Passiflorin;   SMILES=Cc1nccc2c3ccccc3[nH]c12;   harmane
 xref: Beilstein:143898 "ChemIDplus";   CAS:486-84-0 "ChemIDplus";   CAS:486-84-0 "KEGG COMPOUND";   CAS:486-84-0 "NIST Chemistry WebBook";   KEGG:C09209;   KNApSAcK:C00001736;   LINCS:LSM-19989
 xref_mesh: MESH:C005010
 xref: PMID:11473435 "Europe PMC";   PMID:19645722 "Europe PMC";   PMID:20732341 "Europe PMC";   PMID:22757671 "Europe PMC";   PMID:22981972 "Europe PMC";   PMID:23544153 "Europe PMC";   PMID:24103378 "Europe PMC";   PMID:24300779 "Europe PMC";   PMID:24486683 "Europe PMC";   Reaxys:143898 "Reaxys"


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harman term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:6480464
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Taar1 trace-amine-associated receptor 1 JBrowse link 1 22,595,477 22,596,475 RGD:6480464
harmaline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
harmalol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
harmine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:6480464
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Ccna1 cyclin A1 JBrowse link 2 144,456,689 144,503,570 RGD:6480464
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:6480464
G Cdc25a cell division cycle 25A JBrowse link 8 117,953,223 117,971,552 RGD:6480464
G Cdc25c cell division cycle 25C JBrowse link 18 27,528,768 27,550,316 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Cdkn1c cyclin-dependent kinase inhibitor 1C JBrowse link 1 216,661,067 216,663,791 RGD:6480464
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6480464
G Cdkn2b cyclin-dependent kinase inhibitor 2B JBrowse link 5 107,834,353 107,857,428 RGD:6480464
G Chd4 chromodomain helicase DNA binding protein 4 JBrowse link 4 157,612,531 157,645,660 RGD:6480464
G Cidea cell death-inducing DFFA-like effector a JBrowse link 18 63,082,861 63,108,450 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Dio2 iodothyronine deiodinase 2 JBrowse link 6 114,475,156 114,489,443 RGD:6480464
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A JBrowse link 11 34,858,339 34,958,733 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6480464
G E2f2 E2F transcription factor 2 JBrowse link 5 154,516,611 154,540,228 RGD:6480464
G E2f7 E2F transcription factor 7 JBrowse link 7 53,275,659 53,318,261 RGD:6480464
G E2f8 E2F transcription factor 8 JBrowse link 1 104,185,436 104,203,683 RGD:6480464
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6480464
G Foxm1 forkhead box M1 JBrowse link 4 161,685,236 161,697,633 RGD:6480464
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Mafa MAF bZIP transcription factor A JBrowse link 7 116,779,368 116,781,815 RGD:6480464
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nfatc1 nuclear factor of activated T-cells 1 JBrowse link 18 77,203,517 77,322,690 RGD:6480464
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:6480464
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:6480464
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link 12 9,496,044 9,501,211 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Prdm16 PR/SET domain 16 JBrowse link 5 171,662,277 171,711,561 RGD:6480464
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6480464
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        antimicrobial agent 17154
          antiviral agent 3607
            anti-HIV agent 1025
              harman 52
                harmaline 6
                harmalol 3
                harmine + 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  organic heteropolycyclic compound 17427
                                    organic heterotricyclic compound 13734
                                      pyridoindole 113
                                        beta-carbolines 96
                                          harmala alkaloid 52
                                            harman 52
                                              harmaline 6
                                              harmalol 3
                                              harmine + 43
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.