CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: harman
Accession: CHEBI:5623
browse the term
Definition: An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.
Synonyms: exact_synonym: 1-methyl-9H-pyrido[3,4-b]indole
related_synonym: 1-methyl-2-carboline; 1-methyl-9H-beta-carboline; 1-methyl-beta-carboline; 1-methylnorharman; Formula=C12H10N2; InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3; InChIKey=PSFDQSOCUJVVGF-UHFFFAOYSA-N; L-methylpyridobindole; SMILES=Cc1nccc2c3ccccc3[nH]c12; aribin; aribine; harmane; locuturin; locuturine; loturine; passiflorin
xref: Beilstein:143898; CAS:486-84-0; KEGG:C09209; KNApSAcK:C00001736; LINCS:LSM-19989
xref_mesh: MESH:C005010
xref: PMID:11473435; PMID:19645722; PMID:20732341; PMID:22757671; PMID:22981972; PMID:23544153; PMID:24103378; PMID:24300779; PMID:24486683; Reaxys:143898
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]
CTD
PMID:20732341
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Casp3
caspase 3
increases cleavage increases expression
ISO
harman results in increased cleavage of CASP3 protein harman results in increased expression of CASP3 mRNA
CTD
PMID:35985368
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
increases expression
ISO
harman results in increased expression of CASP7 mRNA
CTD
PMID:35985368
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
increases expression
ISO
harman results in increased expression of CASP9 mRNA
CTD
PMID:35985368
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
decreases activity
ISO
harman results in decreased activity of CAT protein
CTD
PMID:35985368
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases activity increases expression
ISO EXP
AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein] harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein
CTD
PMID:20732341
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Hmox1
heme oxygenase 1
increases expression
ISO
harman results in increased expression of HMOX1 mRNA
CTD
PMID:35985368
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Maoa
monoamine oxidase A
decreases activity
ISO
harman results in decreased activity of MAOA protein
CTD
PMID:28057462
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression
ISO
harman results in increased expression of NFE2L2 protein
CTD
PMID:35985368
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
harman results in increased expression of NQO1 mRNA
CTD
PMID:35985368
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
harman results in increased cleavage of PARP1 protein
CTD
PMID:35985368
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Slc22a1
solute carrier family 22 member 1
multiple interactions decreases activity
ISO
harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] harman results in decreased activity of SLC22A1 protein
CTD
PMID:30189235
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2
solute carrier family 22 member 2
decreases activity multiple interactions
ISO
harman results in decreased activity of SLC22A2 protein harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
CTD
PMID:30189235
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Taar1
trace-amine-associated receptor 1
increases activity multiple interactions
ISO
harman results in increased activity of TAAR1 protein [harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD
PMID:19725810
NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]
CTD
PMID:12107048
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cdh1
cadherin 1
increases expression
ISO
Harmaline results in increased expression of CDH1 protein
CTD
PMID:35963316
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases activity decreases stability
ISO
[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] Harmaline results in decreased activity of CYP1A1 protein Harmaline results in decreased stability of CYP1A1 protein
CTD
PMID:22037238
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Eng
endoglin
decreases expression multiple interactions
ISO
Harmaline results in decreased expression of ENG mRNA Doxorubicin promotes the reaction [Harmaline results in decreased expression of ENG mRNA]
CTD
PMID:35963316
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
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Ifng
interferon gamma
increases secretion
ISO
Harmaline results in increased secretion of IFNG protein
CTD
PMID:35963316
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1b
interleukin 1 beta
multiple interactions
ISO
Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
CTD
PMID:12065299
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il4
interleukin 4
affects secretion multiple interactions
ISO
Harmaline affects the secretion of IL4 protein Doxorubicin affects the reaction [Harmaline results in decreased secretion of IL4 protein]
CTD
PMID:35963316
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Kdr
kinase insert domain receptor
multiple interactions decreases expression
ISO
Doxorubicin promotes the reaction [Harmaline results in decreased expression of KDR mRNA]
CTD
PMID:35963316
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Maoa
monoamine oxidase A
decreases activity
EXP ISO
Harmaline results in decreased activity of MAOA protein
CTD
PMID:15178694 PMID:24373881 PMID:28302559
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Harmaline results in decreased expression of MKI67 protein
CTD
PMID:35963316
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
Harmaline results in decreased expression of MMP2 protein
CTD
PMID:35963316
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]
CTD
PMID:12065299 PMID:12107048
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions decreases expression
ISO
Doxorubicin promotes the reaction [Harmaline results in decreased expression of PTGS2 mRNA]
CTD
PMID:35963316
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]
CTD
PMID:12065299 PMID:12107048
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Vegfa
vascular endothelial growth factor A
multiple interactions decreases expression
ISO
Doxorubicin promotes the reaction [Harmaline results in decreased expression of VEGFA mRNA] Harmaline results in decreased expression of VEGFA mRNA; Harmaline results in decreased expression of VEGFA protein
CTD
PMID:35963316
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Casp3
caspase 3
increases activity increases expression
ISO
harmalol results in increased activity of CASP3 protein harmalol results in increased expression of CASP3 mRNA
CTD
PMID:27590872
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases stability decreases activity
ISO
[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] harmalol results in decreased stability of CYP1A1 protein harmalol results in decreased activity of CYP1A1 protein
CTD
PMID:22037238
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Tp53
tumor protein p53
increases expression
ISO
harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein
CTD
PMID:27590872
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ache
acetylcholinesterase
decreases activity
ISO
Harmine results in decreased activity of ACHE protein
CTD
PMID:34078836
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
CTD
PMID:22001777
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Axin2
axin 2
multiple interactions
ISO
Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA]
CTD
PMID:20519739
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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Bcl2l11
Bcl2-like 11
multiple interactions
ISO
Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein]
CTD
PMID:30171258
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
decreases expression
EXP
harmine decreases expression of camk2d protein after myocardial infarction in rat heart left ventricle
RGD
PMID:26067684
RGD:11097969
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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Ccna1
cyclin A1
increases expression
ISO
Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein
CTD
PMID:25751815
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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Ccne2
cyclin E2
increases expression
ISO
Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein
CTD
PMID:25751815
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cdc25a
cell division cycle 25A
increases expression
ISO
Harmine results in increased expression of CDC25A mRNA
CTD
PMID:25751815
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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Cdc25c
cell division cycle 25C
increases expression
ISO
Harmine results in increased expression of CDC25C mRNA
CTD
PMID:25751815
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdk1
cyclin-dependent kinase 1
increases expression
ISO
Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein
CTD
PMID:25751815
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
decreases phosphorylation
EXP
Harmine results in decreased phosphorylation of CDKN1B protein
CTD
PMID:26953159
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
decreases expression
ISO
Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein
CTD
PMID:25751815
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
decreases expression
ISO
Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein
CTD
PMID:25751815
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Cdkn2b
cyclin-dependent kinase inhibitor 2B
decreases expression
ISO
Harmine results in decreased expression of CDKN2B mRNA
CTD
PMID:25751815
NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
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Chd4
chromodomain helicase DNA binding protein 4
multiple interactions increases phosphorylation
ISO
AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]
CTD
PMID:27805061
NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
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Cidea
cell death-inducing DFFA-like effector a
multiple interactions increases expression
ISO
Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA] Harmine results in increased expression of CIDEA protein
CTD
PMID:27805061
NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases activity decreases stability
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] Harmine results in decreased activity of CYP1A1 protein
CTD
PMID:22001777
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Dio2
iodothyronine deiodinase 2
increases expression
ISO
Harmine results in increased expression of DIO2 protein
CTD
PMID:27805061
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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Dyrk1a
dual specificity tyrosine phosphorylation regulated kinase 1A
multiple interactions decreases expression affects binding decreases activity
ISO EXP
Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] harmine decreases expression of dyrk1a protein after myocardial infarction in rat heart left ventricle Harmine binds to DYRK1A protein Harmine results in decreased activity of DYRK1A protein
CTD RGD
PMID:21573099 PMID:25751815 PMID:26067684
RGD:11097969
NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
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E2f1
E2F transcription factor 1
increases expression
ISO
Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein
CTD
PMID:25751815
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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E2f2
E2F transcription factor 2
increases expression
ISO
Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein
CTD
PMID:25751815
NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
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E2f7
E2F transcription factor 7
increases expression
ISO
Harmine results in increased expression of E2F7 mRNA
CTD
PMID:25751815
NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
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E2f8
E2F transcription factor 8
increases expression
ISO
Harmine results in increased expression of E2F8 mRNA
CTD
PMID:25751815
NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
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Fabp4
fatty acid binding protein 4
multiple interactions
ISO
[phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA
CTD
PMID:20519739
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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Foxm1
forkhead box M1
increases expression
ISO
Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein
CTD
PMID:25751815
NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
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Id2
inhibitor of DNA binding 2
multiple interactions
ISO
Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]
CTD
PMID:20519739
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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Ins1
insulin 1
multiple interactions
ISO
Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein]
CTD
PMID:27805061
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Ins2
insulin 2
increases expression
ISO
Harmine results in increased expression of INS mRNA
CTD
PMID:25751815
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Lepr
leptin receptor
multiple interactions
ISO
Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein]
CTD
PMID:27805061
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Mafa
MAF bZIP transcription factor A
increases expression
ISO
Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein
CTD
PMID:25751815
NCBI chr 7:107,432,292...107,435,084
Ensembl chr 7:107,433,605...107,434,690
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Maoa
monoamine oxidase A
decreases activity
EXP ISO
Harmine results in decreased activity of MAOA protein
CTD
PMID:24373881 PMID:28302559
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Harmine results in increased phosphorylation of MAPK1 protein
CTD
PMID:27805061
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Harmine results in increased phosphorylation of MAPK3 protein
CTD
PMID:27805061
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapt
microtubule-associated protein tau
multiple interactions
ISO
Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
CTD
PMID:21573099
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression
ISO
Harmine results in increased expression of MYC protein
CTD
PMID:25751815
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nfatc1
nuclear factor of activated T-cells 1
affects localization
ISO
Harmine affects the localization of NFATC1 protein
CTD
PMID:25751815
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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Nfatc2
nuclear factor of activated T-cells 2
affects localization
ISO
Harmine affects the localization of NFATC2 protein
CTD
PMID:25751815
NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325
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Nfatc3
nuclear factor of activated T-cells 3
affects localization
ISO
Harmine affects the localization of NFATC3 protein
CTD
PMID:25751815
NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
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Nfatc4
nuclear factor of activated T-cells 4
affects localization
ISO
Harmine affects the localization of NFATC4 protein
CTD
PMID:25751815
NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]
CTD
PMID:30171258
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pdx1
pancreatic and duodenal homeobox 1
increases expression
ISO
Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein
CTD
PMID:25751815
NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
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Pln
phospholamban
increases expression
EXP
harmine increases expression of Pln protein after myocardial infarction in rat heart left ventricle
RGD
PMID:26067684
RGD:11097969
NCBI chr20:32,629,537...32,639,559
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions increases expression
ISO
[phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA Harmine results in increased expression of PPARG protein
CTD
PMID:20519739 PMID:27805061
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppargc1a
PPARG coactivator 1 alpha
increases expression multiple interactions
ISO
Harmine results in increased expression of PPARGC1A protein Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]
CTD
PMID:27805061
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Prdm16
PR/SET domain 16
increases expression multiple interactions
ISO
Harmine results in increased expression of PRDM16 protein Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA]
CTD
PMID:27805061
NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601
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Ucp1
uncoupling protein 1
increases expression multiple interactions
ISO
Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]
CTD
PMID:27805061
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
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Wnt3a
Wnt family member 3A
multiple interactions
ISO
Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA]
CTD
PMID:20519739
NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324
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