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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:halothane
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Accession:CHEBI:5615 term browser browse the term
Definition:A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position.
Synonyms:related_synonym: 1,1,1-trifluoro-2-bromo-2-chloroethane;   1,1,1-trifluoro-2-chloro-2-bromoethane;   1-bromo-1-chloro-2,2,2-trifluoroethane;   2,2,2-trifluoro-1-chloro-1-bromoethane;   2-bromo-2-chloro-1,1,1-trifluoroethane;   Fluothane;   Formula=C2HBrClF3;   InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H;   InChIKey=BCQZXOMGPXTTIC-UHFFFAOYSA-N;   Narcotane;   Phthorothanum;   Rhodialothan;   SMILES=[H]C(Cl)(Br)C(F)(F)F;   bromochlorotrifluoroethane
 xref: Beilstein:1736947;   CAS:151-67-7;   DrugBank:DB01159;   Drug_Central:1356;   Gmelin:793752;   KEGG:C07515;   KEGG:D00542
 xref_mesh: MESH:D006221
 xref: PMID:7519986;   VSDB:1806;   Wikipedia:Halothane

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halothane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Halothane binds to ALB protein CTD PMID:17242087 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Calr calreticulin affects metabolic processing EXP Halothane metabolite affects the metabolism of CALR CTD PMID:1504264 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Halothane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cd69 Cd69 molecule increases expression ISO Halothane results in increased expression of CD69 protein CTD PMID:21245496 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Halothane results in decreased expression of CXCL1 mRNA CTD PMID:15564938 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Halothane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
decreases expression		 EXP
ISO		 Halothane results in increased expression of CXCL2 mRNA
[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA; [Progesterone co-treated with Halothane] results in increased expression of CXCL2 protein; Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]]; gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]
Halothane results in increased expression of CXCL2 mRNA; Halothane results in increased expression of CXCL2 protein
Halothane results in decreased expression of CXCL2 mRNA		 CTD PMID:10422944, PMID:15564938, PMID:19633216, PMID:21501669, PMID:22157104, PMID:24598351, PMID:24747151 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Halothane results in increased expression of CXCL1 mRNA; Halothane results in increased expression of CXCL1 protein
Estradiol inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]]; gadolinium chloride inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; Mifepristone inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]; U 0126 inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]		 CTD PMID:21501669, PMID:22157104, PMID:24598351 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions
increases metabolic processing		 ISO diisopropyl 1,3-dithiol-2-ylidenemalonate results in increased expression of [CYB5A protein results in increased metabolism of Halothane] CTD PMID:3689822 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Halothane CTD PMID:11684365 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases response to substance
multiple interactions
increases oxidation
affects metabolic processing		 ISO
EXP		 CYP2E1 protein results in increased metabolism of Halothane
CYP2E1 protein results in increased susceptibility to Halothane
Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane]
CYP2E1 protein affects the metabolism of Halothane		 CTD PMID:9103523, PMID:10805064, PMID:11684365, PMID:12464242, PMID:12803597 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Halothane results in increased expression of FOS protein CTD PMID:7970238 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO Halothane results in increased expression of GPT protein
eritoran inhibits the reaction [Halothane results in increased expression of GPT protein]		 CTD PMID:24598351, PMID:24747151 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO Halothane results in increased expression of HMGB1 protein CTD PMID:21245496, PMID:24747151 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
increases expression
multiple interactions		 EXP
ISO		 Halothane results in decreased expression of ICAM1 mRNA; Halothane results in decreased expression of ICAM1 protein
Halothane results in increased expression of ICAM1 mRNA
[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA; [U 0126 co-treated with Halothane] results in increased expression of ICAM1 mRNA; Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]]; gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]; Mifepristone inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of ICAM1 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of ICAM1 mRNA]; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]		 CTD PMID:15564938, PMID:21501669, PMID:22157104 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ifng interferon gamma multiple interactions
increases response to substance
increases expression		 ISO
EXP		 PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]; TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein]
IFNG protein results in increased susceptibility to Halothane
Halothane results in increased expression of IFNG mRNA		 CTD PMID:10422944, PMID:21245496 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression		 ISO Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]]; Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein] CTD PMID:19633216, PMID:21501669 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP
ISO		 Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]; Halothane affects the reaction [IL1B protein affects the susceptibility to Potassium Chloride]; Halothane inhibits the reaction [IL1B protein results in increased abundance of Cyclic GMP]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Halothane inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Halothane results in increased expression of IL1B mRNA
Estradiol inhibits the reaction [Halothane results in increased expression of IL1B mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL1B mRNA]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL1B mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of IL1B mRNA]		 CTD PMID:10422944, PMID:11506125, PMID:21501669, PMID:24747151 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Halothane results in increased expression of IL6 mRNA
Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL6 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of IL6 mRNA]		 CTD PMID:21501669 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 affects response to substance ISO KCNJ2 affects the susceptibility to Halothane CTD PMID:17546530 NCBI chr10:99,429,337...99,442,520
Ensembl chr10:99,437,436...99,439,114 		JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 multiple interactions ISO Halothane promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 6:122,417,079...122,549,532
Ensembl chr 6:122,419,046...122,545,899 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions ISO Halothane promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476 		JBrowse link
G Kcnk9 potassium two pore domain channel subfamily K member 9 multiple interactions ISO Halothane promotes the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:11249964 NCBI chr 7:113,894,918...113,938,397
Ensembl chr 7:113,903,557...113,937,941 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK1 protein] CTD PMID:22157104 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression
decreases expression		 ISO Halothane results in increased expression of MAPK14 mRNA
Halothane results in decreased expression of MAPK14 protein		 CTD PMID:24598351 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK3 protein] CTD PMID:22157104 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mir106b microRNA 106b decreases expression ISO Halothane results in decreased expression of MIR106B mRNA CTD PMID:24598351 NCBI chr12:19,307,752...19,307,833
Ensembl chr12:19,307,752...19,307,833 		JBrowse link
G Mir21 microRNA 21 affects expression ISO Halothane affects the expression of MIR21A mRNA CTD PMID:24598351 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301 		JBrowse link
G Mpo myeloperoxidase decreases activity EXP Halothane results in decreased activity of MPO protein CTD PMID:15564938 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions		 EXP Halothane results in increased phosphorylation of NFKBIA protein
Propofol inhibits the reaction [Halothane results in increased phosphorylation of NFKBIA protein]		 CTD PMID:16965849 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Propofol inhibits the reaction [Halothane results in increased expression of NOS2 protein] CTD PMID:11506125, PMID:16965849 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Pomc proopiomelanocortin increases secretion EXP Halothane results in increased secretion of POMC protein CTD PMID:2846107 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Prf1 perforin 1 affects response to substance
multiple interactions		 ISO PRF1 protein affects the susceptibility to Halothane
PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]		 CTD PMID:21245496 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Halothane inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA] CTD PMID:11506125 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO Halothane results in decreased phosphorylation of PTK2 protein CTD PMID:18215454 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119 		JBrowse link
G Ren renin multiple interactions ISO [Halothane co-treated with Nitroprusside] results in increased activity of REN protein CTD PMID:3281763 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
increases response to substance
multiple interactions		 ISO Halothane results in increased activity of RYR1 protein
RYR1 protein mutant form results in increased susceptibility to Halothane
[Halothane results in increased activity of RYR1 protein] which affects the localization of Calcium		 CTD PMID:14641996, PMID:15210166, PMID:21485675 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Halothane results in increased expression of S100A8 mRNA CTD PMID:24747151, PMID:28138970 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Halothane results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases expression		 ISO Halothane results in increased expression of and results in increased phosphorylation of STAT3 protein
Halothane results in increased expression of STAT3 mRNA		 CTD PMID:24598351 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein] CTD PMID:21245496 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression		 EXP
ISO		 Halothane results in increased expression of TNF mRNA
Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]]; Mifepristone inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of TNF mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of TNF mRNA]
Halothane results in decreased expression of TNF mRNA		 CTD PMID:10422944, PMID:15564938, PMID:21501669, PMID:22157104, PMID:24598351 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      molecular entity 19767
        polyatomic entity 19677
          heteroatomic molecular entity 19594
            halide 17964
              organohalogen compound 17699
                haloalkane 11644
                  halothane 42
                    (R)-halothane 0
                    (S)-halothane 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            heteroorganic entity 19142
                              organohalogen compound 17699
                                haloalkane 11644
                                  halothane 42
                                    (R)-halothane 0
                                    (S)-halothane 0
paths to the root

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