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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:halothane
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Accession:CHEBI:5615 term browser browse the term
Definition:A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position.
Synonyms:related_synonym: 1,1,1-trifluoro-2-bromo-2-chloroethane;   1,1,1-trifluoro-2-chloro-2-bromoethane;   1-bromo-1-chloro-2,2,2-trifluoroethane;   2,2,2-trifluoro-1-chloro-1-bromoethane;   2-bromo-2-chloro-1,1,1-trifluoroethane;   Fluothane;   Formula=C2HBrClF3;   InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H;   InChIKey=BCQZXOMGPXTTIC-UHFFFAOYSA-N;   Narcotane;   Phthorothanum;   Rhodialothan;   SMILES=[H]C(Cl)(Br)C(F)(F)F;   bromochlorotrifluoroethane
 xref: Beilstein:1736947;   CAS:151-67-7;   DrugBank:DB01159;   Drug_Central:1356;   Gmelin:793752;   KEGG:C07515;   KEGG:D00542
 xref_mesh: MESH:D006221
 xref: PMID:7519986;   VSDB:1806;   Wikipedia:Halothane

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halothane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Halothane binds to ALB protein CTD PMID:17242087 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO [Ryanodine co-treated with Halothane] results in increased expression of BAX mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of BAX mRNA] CTD PMID:32795494 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression		 ISO [Ryanodine co-treated with Halothane] results in increased expression of BCL2L11 mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of BCL2L11 mRNA] CTD PMID:32795494 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Calr calreticulin affects metabolic processing EXP Halothane metabolite affects the metabolism of CALR CTD PMID:1504264 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Halothane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd69 Cd69 molecule increases expression ISO Halothane results in increased expression of CD69 protein CTD PMID:21245496 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Halothane results in decreased expression of CXCL1 mRNA CTD PMID:15564938 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Halothane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
decreases expression		 EXP
ISO		 Halothane results in increased expression of CXCL2 mRNA
[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA; [Progesterone co-treated with Halothane] results in increased expression of CXCL2 protein; Dantrolene inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]]; gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]
Halothane results in increased expression of CXCL2 mRNA; Halothane results in increased expression of CXCL2 protein
Halothane results in decreased expression of CXCL2 mRNA		 CTD PMID:10422944 PMID:15564938 PMID:19633216 PMID:21501669 PMID:22157104 More... NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Halothane results in increased expression of CXCL1 mRNA; Halothane results in increased expression of CXCL1 protein
Estradiol inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]]; gadolinium chloride inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; Mifepristone inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]; U 0126 inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]		 CTD PMID:21501669 PMID:22157104 PMID:24598351 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions
increases metabolic processing		 ISO diisopropyl 1,3-dithiol-2-ylidenemalonate results in increased expression of [CYB5A protein results in increased metabolism of Halothane] CTD PMID:3689822 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Halothane CTD PMID:11684365 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases response to substance
multiple interactions
increases oxidation
affects metabolic processing		 ISO
EXP		 CYP2E1 protein results in increased metabolism of Halothane
CYP2E1 protein results in increased susceptibility to Halothane
Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane]
CYP2E1 protein affects the metabolism of Halothane		 CTD PMID:9103523 PMID:10805064 PMID:11684365 PMID:12464242 PMID:12803597 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Halothane CTD PMID:8886607 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO Halothane results in increased expression of DDIT3 mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of DDIT3 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of DDIT3 mRNA]		 CTD PMID:32795494 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A increases expression
multiple interactions		 ISO Halothane results in increased expression of FKBP1A mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1A mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of FKBP1A mRNA]		 CTD PMID:32795494 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions
increases expression		 ISO [Ryanodine co-treated with Halothane] results in increased expression of FKBP1B mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1B mRNA] CTD PMID:32795494 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Halothane results in increased expression of FOS protein CTD PMID:7970238 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO Halothane results in increased expression of GPT protein
Dantrolene inhibits the reaction [Halothane results in increased expression of GPT protein]; eritoran inhibits the reaction [Halothane results in increased expression of GPT protein]; Ryanodine promotes the reaction [Halothane results in increased expression of GPT protein]		 CTD PMID:24598351 PMID:24747151 PMID:32795494 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO Halothane results in increased expression of HMGB1 protein CTD PMID:21245496 PMID:24747151 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO Halothane results in increased expression of HMOX1 mRNA
[Ryanodine co-treated with Halothane] results in increased expression of HMOX1 mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of HMOX1 mRNA]		 CTD PMID:32795494 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions
increases expression		 ISO Dantrolene inhibits the reaction [Halothane results in increased expression of HOMER1 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of HOMER1 mRNA] CTD PMID:32795494 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
increases expression
multiple interactions		 EXP
ISO		 Halothane results in decreased expression of ICAM1 mRNA; Halothane results in decreased expression of ICAM1 protein
Halothane results in increased expression of ICAM1 mRNA
[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA; [U 0126 co-treated with Halothane] results in increased expression of ICAM1 mRNA; Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]]; gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]; Mifepristone inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of ICAM1 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of ICAM1 mRNA]; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]		 CTD PMID:15564938 PMID:21501669 PMID:22157104 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions
increases response to substance
increases expression		 ISO
EXP		 PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]; TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein]
IFNG protein results in increased susceptibility to Halothane
Halothane results in increased expression of IFNG mRNA		 CTD PMID:10422944 PMID:21245496 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression		 ISO Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]]; Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein] CTD PMID:19633216 PMID:21501669 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP
ISO		 Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]; Halothane affects the reaction [IL1B protein affects the susceptibility to Potassium Chloride]; Halothane inhibits the reaction [IL1B protein results in increased abundance of Cyclic GMP]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Halothane inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Halothane results in increased expression of IL1B mRNA
[Ryanodine co-treated with Halothane] results in increased expression of IL1B mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of IL1B mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of IL1B mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL1B mRNA]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL1B mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of IL1B mRNA]		 CTD PMID:10422944 PMID:11506125 PMID:21501669 PMID:24747151 PMID:32795494 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Halothane results in increased expression of IL6 mRNA
Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL6 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of IL6 mRNA]		 CTD PMID:21501669 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions		 ISO Halothane results in increased expression of ITGAM mRNA
Ryanodine promotes the reaction [Halothane results in increased expression of ITGAM mRNA]		 CTD PMID:32795494 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression ISO Halothane results in increased expression of ITPR1 mRNA CTD PMID:32795494 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 increases expression ISO Halothane results in increased expression of ITPR3 mRNA CTD PMID:32795494 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 affects response to substance ISO KCNJ2 affects the susceptibility to Halothane CTD PMID:17546530 NCBI chr10:96,060,849...96,071,401
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 multiple interactions ISO Halothane promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 6:117,690,052...117,826,120
Ensembl chr 6:117,694,222...117,825,695 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions ISO Halothane promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Kcnk9 potassium two pore domain channel subfamily K member 9 multiple interactions ISO Halothane promotes the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:11249964 NCBI chr 7:104,429,186...104,473,924
Ensembl chr 7:104,437,934...104,473,175 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK1 protein] CTD PMID:22157104 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression
decreases expression		 ISO Halothane results in increased expression of MAPK14 mRNA
Halothane results in decreased expression of MAPK14 protein		 CTD PMID:24598351 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK3 protein] CTD PMID:22157104 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mir106b microRNA 106b decreases expression ISO Halothane results in decreased expression of MIR106B mRNA CTD PMID:24598351 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425 		JBrowse link
G Mir21 microRNA 21 affects expression ISO Halothane affects the expression of MIR21A mRNA CTD PMID:24598351 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mpo myeloperoxidase decreases activity EXP Halothane results in decreased activity of MPO protein CTD PMID:15564938 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions		 EXP Halothane results in increased phosphorylation of NFKBIA protein
Propofol inhibits the reaction [Halothane results in increased phosphorylation of NFKBIA protein]		 CTD PMID:16965849 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Propofol inhibits the reaction [Halothane results in increased expression of NOS2 protein] CTD PMID:11506125 PMID:16965849 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pomc proopiomelanocortin increases secretion EXP Halothane results in increased secretion of POMC protein CTD PMID:2846107 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prf1 perforin 1 affects response to substance
multiple interactions		 ISO PRF1 protein affects the susceptibility to Halothane
PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]		 CTD PMID:21245496 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Halothane inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA] CTD PMID:11506125 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO Halothane results in decreased phosphorylation of PTK2 protein CTD PMID:18215454 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ren renin multiple interactions ISO [Halothane co-treated with Nitroprusside] results in increased activity of REN protein CTD PMID:3281763 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
increases expression
increases response to substance
multiple interactions		 ISO Halothane results in increased activity of RYR1 protein
Halothane results in increased expression of RYR1 mRNA
RYR1 protein mutant form results in increased susceptibility to Halothane
[Halothane results in increased activity of RYR1 protein] which affects the localization of Calcium		 CTD PMID:14641996 PMID:15210166 PMID:21485675 PMID:32795494 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression
multiple interactions		 ISO Halothane results in increased expression of S100A8 mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of S100A8 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of S100A8 mRNA]		 CTD PMID:24747151 PMID:28138970 PMID:32795494 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression
multiple interactions		 ISO Halothane results in increased expression of S100A9 mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of S100A9 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of S100A9 mRNA]		 CTD PMID:24747151 PMID:32795494 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases expression		 ISO Halothane results in increased expression of and results in increased phosphorylation of STAT3 protein
Halothane results in increased expression of STAT3 mRNA		 CTD PMID:24598351 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein] CTD PMID:21245496 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression		 EXP
ISO		 Halothane results in increased expression of TNF mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]]; Mifepristone inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of TNF mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of TNF mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of TNF mRNA]
Halothane results in decreased expression of TNF mRNA		 CTD PMID:10422944 PMID:15564938 PMID:21501669 PMID:22157104 PMID:24598351 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression		 ISO Dantrolene inhibits the reaction [Halothane results in increased expression of VCAM1 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of VCAM1 mRNA] CTD PMID:32795494 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      molecular entity 19819
        polyatomic entity 19740
          heteroatomic molecular entity 19682
            halide 18142
              organohalogen compound 17920
                organochlorine compound 17731
                  halothane 54
                    (R)-halothane 0
                    (S)-halothane 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  halohydrocarbon 14049
                                    haloalkane 11706
                                      halothane 54
                                        (R)-halothane 0
                                        (S)-halothane 0
paths to the root