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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:halothane
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Accession:CHEBI:5615 term browser browse the term
Definition:A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position.
Synonyms:related_synonym: 1,1,1-trifluoro-2-bromo-2-chloroethane;   1,1,1-trifluoro-2-chloro-2-bromoethane;   1-bromo-1-chloro-2,2,2-trifluoroethane;   2,2,2-trifluoro-1-chloro-1-bromoethane;   2-bromo-2-chloro-1,1,1-trifluoroethane;   Fluothane;   Formula=C2HBrClF3;   InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H;   InChIKey=BCQZXOMGPXTTIC-UHFFFAOYSA-N;   Narcotane;   Phthorothanum;   Rhodialothan;   SMILES=[H]C(Cl)(Br)C(F)(F)F;   bromochlorotrifluoroethane
 xref: Beilstein:1736947;   CAS:151-67-7;   DrugBank:DB01159;   Drug_Central:1356;   Gmelin:793752;   KEGG:C07515;   KEGG:D00542
 xref_mesh: MESH:D006221
 xref: PMID:7519986;   VSDB:1806;   Wikipedia:Halothane


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halothane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Halothane binds to ALB protein CTD PMID:17242087 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [Ryanodine co-treated with Halothane] results in increased expression of BAX mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of BAX mRNA] CTD PMID:32795494 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO [Ryanodine co-treated with Halothane] results in increased expression of BCL2L11 mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of BCL2L11 mRNA] CTD PMID:32795494 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Calr calreticulin affects metabolic processing EXP Halothane metabolite affects the metabolism of CALR CTD PMID:1504264 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Halothane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd69 Cd69 molecule increases expression ISO Halothane results in increased expression of CD69 protein CTD PMID:21245496 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Halothane results in decreased expression of CXCL1 mRNA CTD PMID:15564938 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Halothane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
decreases expression
EXP
ISO
Halothane results in increased expression of CXCL2 mRNA
[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA; [Progesterone co-treated with Halothane] results in increased expression of CXCL2 protein; Dantrolene inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]]; gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]
Halothane results in increased expression of CXCL2 mRNA; Halothane results in increased expression of CXCL2 protein
Halothane results in decreased expression of CXCL2 mRNA
CTD PMID:10422944 PMID:15564938 PMID:19633216 PMID:21501669 PMID:22157104 More... NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Halothane results in increased expression of CXCL1 mRNA; Halothane results in increased expression of CXCL1 protein
Estradiol inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]]; gadolinium chloride inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; Mifepristone inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]; U 0126 inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]
CTD PMID:21501669 PMID:22157104 PMID:24598351 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions
increases metabolic processing
ISO diisopropyl 1,3-dithiol-2-ylidenemalonate results in increased expression of [CYB5A protein results in increased metabolism of Halothane] CTD PMID:3689822 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Halothane CTD PMID:11684365 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases response to substance
multiple interactions
increases oxidation
affects metabolic processing
ISO
EXP
CYP2E1 protein results in increased metabolism of Halothane
CYP2E1 protein results in increased susceptibility to Halothane
Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane]
CYP2E1 protein affects the metabolism of Halothane
CTD PMID:9103523 PMID:10805064 PMID:11684365 PMID:12464242 PMID:12803597 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Halothane CTD PMID:8886607 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Halothane results in increased expression of DDIT3 mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of DDIT3 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of DDIT3 mRNA]
CTD PMID:32795494 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A increases expression
multiple interactions
ISO Halothane results in increased expression of FKBP1A mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1A mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of FKBP1A mRNA]
CTD PMID:32795494 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions
increases expression
ISO [Ryanodine co-treated with Halothane] results in increased expression of FKBP1B mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1B mRNA] CTD PMID:32795494 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Halothane results in increased expression of FOS protein CTD PMID:7970238 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions
ISO Halothane results in increased expression of GPT protein
Dantrolene inhibits the reaction [Halothane results in increased expression of GPT protein]; eritoran inhibits the reaction [Halothane results in increased expression of GPT protein]; Ryanodine promotes the reaction [Halothane results in increased expression of GPT protein]
CTD PMID:24598351 PMID:24747151 PMID:32795494 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO Halothane results in increased expression of HMGB1 protein CTD PMID:21245496 PMID:24747151 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Halothane results in increased expression of HMOX1 mRNA
[Ryanodine co-treated with Halothane] results in increased expression of HMOX1 mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of HMOX1 mRNA]
CTD PMID:32795494 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions
increases expression
ISO Dantrolene inhibits the reaction [Halothane results in increased expression of HOMER1 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of HOMER1 mRNA] CTD PMID:32795494 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
increases expression
multiple interactions
EXP
ISO
Halothane results in decreased expression of ICAM1 mRNA; Halothane results in decreased expression of ICAM1 protein
Halothane results in increased expression of ICAM1 mRNA
[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA; [U 0126 co-treated with Halothane] results in increased expression of ICAM1 mRNA; Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]]; gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]; Mifepristone inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of ICAM1 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of ICAM1 mRNA]; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]
CTD PMID:15564938 PMID:21501669 PMID:22157104 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions
increases response to substance
increases expression
ISO
EXP
PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]; TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein]
IFNG protein results in increased susceptibility to Halothane
Halothane results in increased expression of IFNG mRNA
CTD PMID:10422944 PMID:21245496 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
ISO Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]]; Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein] CTD PMID:19633216 PMID:21501669 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP
ISO
Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]; Halothane affects the reaction [IL1B protein affects the susceptibility to Potassium Chloride]; Halothane inhibits the reaction [IL1B protein results in increased abundance of Cyclic GMP]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Halothane inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Halothane results in increased expression of IL1B mRNA
[Ryanodine co-treated with Halothane] results in increased expression of IL1B mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of IL1B mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of IL1B mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL1B mRNA]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL1B mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of IL1B mRNA]
CTD PMID:10422944 PMID:11506125 PMID:21501669 PMID:24747151 PMID:32795494 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Halothane results in increased expression of IL6 mRNA
Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL6 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of IL6 mRNA]
CTD PMID:21501669 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
ISO Halothane results in increased expression of ITGAM mRNA
Ryanodine promotes the reaction [Halothane results in increased expression of ITGAM mRNA]
CTD PMID:32795494 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression ISO Halothane results in increased expression of ITPR1 mRNA CTD PMID:32795494 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 increases expression ISO Halothane results in increased expression of ITPR3 mRNA CTD PMID:32795494 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 affects response to substance ISO KCNJ2 affects the susceptibility to Halothane CTD PMID:17546530 NCBI chr10:96,060,849...96,071,401
Ensembl chr10:96,060,821...96,071,445
JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 multiple interactions ISO Halothane promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 6:117,690,052...117,826,120
Ensembl chr 6:117,694,222...117,825,695
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions ISO Halothane promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
JBrowse link
G Kcnk9 potassium two pore domain channel subfamily K member 9 multiple interactions ISO Halothane promotes the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:11249964 NCBI chr 7:104,429,186...104,473,924
Ensembl chr 7:104,437,934...104,473,175
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK1 protein] CTD PMID:22157104 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression
decreases expression
ISO Halothane results in increased expression of MAPK14 mRNA
Halothane results in decreased expression of MAPK14 protein
CTD PMID:24598351 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK3 protein] CTD PMID:22157104 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mir106b microRNA 106b decreases expression ISO Halothane results in decreased expression of MIR106B mRNA CTD PMID:24598351 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425
JBrowse link
G Mir21 microRNA 21 affects expression ISO Halothane affects the expression of MIR21A mRNA CTD PMID:24598351 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mpo myeloperoxidase decreases activity EXP Halothane results in decreased activity of MPO protein CTD PMID:15564938 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
EXP Halothane results in increased phosphorylation of NFKBIA protein
Propofol inhibits the reaction [Halothane results in increased phosphorylation of NFKBIA protein]
CTD PMID:16965849 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Propofol inhibits the reaction [Halothane results in increased expression of NOS2 protein] CTD PMID:11506125 PMID:16965849 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pomc proopiomelanocortin increases secretion EXP Halothane results in increased secretion of POMC protein CTD PMID:2846107 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prf1 perforin 1 affects response to substance
multiple interactions
ISO PRF1 protein affects the susceptibility to Halothane
PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]
CTD PMID:21245496 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Halothane inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA] CTD PMID:11506125 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO Halothane results in decreased phosphorylation of PTK2 protein CTD PMID:18215454 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ren renin multiple interactions ISO [Halothane co-treated with Nitroprusside] results in increased activity of REN protein CTD PMID:3281763 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
increases expression
increases response to substance
multiple interactions
ISO Halothane results in increased activity of RYR1 protein
Halothane results in increased expression of RYR1 mRNA
RYR1 protein mutant form results in increased susceptibility to Halothane
[Halothane results in increased activity of RYR1 protein] which affects the localization of Calcium
CTD PMID:14641996 PMID:15210166 PMID:21485675 PMID:32795494 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression
multiple interactions
ISO Halothane results in increased expression of S100A8 mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of S100A8 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of S100A8 mRNA]
CTD PMID:24747151 PMID:28138970 PMID:32795494 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression
multiple interactions
ISO Halothane results in increased expression of S100A9 mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of S100A9 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of S100A9 mRNA]
CTD PMID:24747151 PMID:32795494 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases expression
ISO Halothane results in increased expression of and results in increased phosphorylation of STAT3 protein
Halothane results in increased expression of STAT3 mRNA
CTD PMID:24598351 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein] CTD PMID:21245496 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression
EXP
ISO
Halothane results in increased expression of TNF mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]]; Mifepristone inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of TNF mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of TNF mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of TNF mRNA]
Halothane results in decreased expression of TNF mRNA
CTD PMID:10422944 PMID:15564938 PMID:21501669 PMID:22157104 PMID:24598351 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
ISO Dantrolene inhibits the reaction [Halothane results in increased expression of VCAM1 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of VCAM1 mRNA] CTD PMID:32795494 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      molecular entity 19819
        polyatomic entity 19740
          heteroatomic molecular entity 19682
            halide 18142
              organohalogen compound 17920
                organochlorine compound 17731
                  halothane 54
                    (R)-halothane 0
                    (S)-halothane 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  halohydrocarbon 14049
                                    haloalkane 11706
                                      halothane 54
                                        (R)-halothane 0
                                        (S)-halothane 0
paths to the root