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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:radicicol
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Accession:CHEBI:556075 term browser browse the term
Definition:An antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90).
Synonyms:exact_synonym: (1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
 related_synonym: Formula=C18H17ClO6;   InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1;   InChIKey=WYZWZEOGROVVHK-GTMNPGAYSA-N;   Monorden;   SMILES=C[C@@H]1C[C@H]2O[C@@H]2\\C=C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1
 alt_id: CHEBI:47650;   CHEBI:47652;   CHEBI:68728
 xref: CAS:12772-57-5;   DrugBank:DB03758
 xref_mesh: MESH:C035359
 xref: PDBeChem:RDC;   PMID:16232632;   PMID:16920739;   PMID:18667483;   PMID:20093793;   PMID:20961859;   PMID:21800052;   Reaxys:15865423;   Wikipedia:Radicicol


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radicicol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases expression
multiple interactions
ISO monorden results in decreased expression of AHR protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [monorden results in decreased expression of AHR protein]
CTD PMID:20057149 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Casp3 caspase 3 multiple interactions ISO monorden inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] CTD PMID:12530016 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Eln elastin increases expression ISO monorden results in increased expression of ELN protein CTD PMID:21880723 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO monorden analog results in decreased expression of ESR1 protein; monorden results in decreased expression of ESR1 protein CTD PMID:11448926 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP monorden inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of GJA1 protein] CTD PMID:29155206 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [monorden co-treated with cobaltous chloride] results in increased expression of HIF1A protein CTD PMID:29155206 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO monorden analog results in increased expression of HSPA1A protein; monorden results in increased expression of HSPA1A protein CTD PMID:11448926
G Il1b interleukin 1 beta multiple interactions EXP monorden inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
decreases expression
ISO monorden results in decreased activity of KCNH2 protein
monorden results in decreased expression of KCNH2 protein modified form
CTD PMID:12775586 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP monorden inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:15583003 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions EXP monorden promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
JBrowse link
G Pgr progesterone receptor decreases expression ISO monorden analog results in decreased expression of PGR protein alternative form CTD PMID:11448926 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation ISO monorden affects the phosphorylation of RB1 protein CTD PMID:21880723 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rngtt RNA guanylyltransferase and 5'-phosphatase decreases expression ISO monorden results in decreased expression of RNGTT protein CTD PMID:30166341 NCBI chr 5:47,706,929...47,913,297
Ensembl chr 5:47,706,799...47,913,295
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions EXP monorden inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          macrolide antibiotic 397
            radicicol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic ester 15884
                                        lactone 11242
                                          macrocyclic lactone 5532
                                            macrolide 5480
                                              macrolide antibiotic 397
                                                radicicol 15
paths to the root