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ONTOLOGY REPORT - ANNOTATIONS


Term:radicicol
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Accession:CHEBI:556075 term browser browse the term
Definition:An antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90).
Synonyms:exact_synonym: (1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
 related_synonym: Formula=C18H17ClO6;   InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1;   InChIKey=WYZWZEOGROVVHK-GTMNPGAYSA-N;   Monorden;   SMILES=C[C@@H]1C[C@H]2O[C@@H]2\\C=C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1
 alt_id: CHEBI:47650;   CHEBI:47652;   CHEBI:68728
 xref: CAS:12772-57-5 "ChemIDplus";   DrugBank:DB03758
 xref_mesh: MESH:C035359
 xref: PDBeChem:RDC;   PMID:16232632 "Europe PMC";   PMID:16920739 "Europe PMC";   PMID:18667483 "Europe PMC";   PMID:20093793 "Europe PMC";   PMID:20961859 "Europe PMC";   PMID:21800052 "Europe PMC";   Reaxys:15865423 "Reaxys";   Wikipedia:Radicicol


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radicicol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Eln elastin JBrowse link 12 24,978,478 25,021,864 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G P2rx1 purinergic receptor P2X 1 JBrowse link 10 59,566,268 59,581,328 RGD:6480464
G Pgr progesterone receptor JBrowse link 8 7,128,656 7,187,796 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rngtt RNA guanylyltransferase and 5'-phosphatase JBrowse link 5 48,561,325 48,779,214 RGD:6480464
G Vldlr very low density lipoprotein receptor JBrowse link 1 245,236,819 245,273,688 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        antimicrobial agent 17148
          macrolide antibiotic 323
            radicicol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic ester 13930
                                        lactone 5862
                                          macrocyclic lactone 1516
                                            macrolide 1455
                                              macrolide antibiotic 323
                                                radicicol 15
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