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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:radicicol
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Accession:CHEBI:556075 term browser browse the term
Definition:An antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90).
Synonyms:exact_synonym: (1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
 related_synonym: Formula=C18H17ClO6;   InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1;   InChIKey=WYZWZEOGROVVHK-GTMNPGAYSA-N;   Monorden;   SMILES=C[C@@H]1C[C@H]2O[C@@H]2\\C=C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1
 alt_id: CHEBI:47650;   CHEBI:47652;   CHEBI:68728
 xref: CAS:12772-57-5;   DrugBank:DB03758
 xref_mesh: MESH:C035359
 xref: PDBeChem:RDC;   PMID:16232632;   PMID:16920739;   PMID:18667483;   PMID:20093793;   PMID:20961859;   PMID:21800052;   Reaxys:15865423;   Wikipedia:Radicicol


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radicicol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases expression
multiple interactions
ISO monorden results in decreased expression of AHR protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [monorden results in decreased expression of AHR protein]
CTD PMID:20057149 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Casp3 caspase 3 multiple interactions ISO monorden inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] CTD PMID:12530016 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Eln elastin increases expression ISO monorden results in increased expression of ELN protein CTD PMID:21880723 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO monorden analog results in decreased expression of ESR1 protein; monorden results in decreased expression of ESR1 protein CTD PMID:11448926 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP monorden inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of GJA1 protein] CTD PMID:29155206 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [monorden co-treated with cobaltous chloride] results in increased expression of HIF1A protein CTD PMID:29155206 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO monorden analog results in increased expression of HSPA1A protein; monorden results in increased expression of HSPA1A protein CTD PMID:11448926 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP monorden inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
decreases expression
ISO monorden results in decreased activity of KCNH2 protein
monorden results in decreased expression of KCNH2 protein modified form
CTD PMID:12775586 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP monorden inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:15583003 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions EXP monorden promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Pgr progesterone receptor decreases expression ISO monorden analog results in decreased expression of PGR protein alternative form CTD PMID:11448926 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation ISO monorden affects the phosphorylation of RB1 protein CTD PMID:21880723 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rngtt RNA guanylyltransferase and 5'-phosphatase decreases expression ISO monorden results in decreased expression of RNGTT protein CTD PMID:30166341 NCBI chr 5:48,561,325...48,779,214
Ensembl chr 5:48,561,339...48,779,207
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions EXP monorden inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          macrolide antibiotic 392
            radicicol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic ester 14077
                                        lactone 5979
                                          macrocyclic lactone 1731
                                            macrolide 1598
                                              macrolide antibiotic 392
                                                radicicol 15
paths to the root

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